Phenylpiracetam vs PE-22-28
Side-by-side comparison of Phenylpiracetam and PE-22-28: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Phenylpiracetam
PE-22-28
Phenylpiracetam
Phenylpiracetam is a Russian-developed phenyl derivative of piracetam with a dramatically higher potency and stimulant profile. Approved in Russia as Phenotropil/Carphedon for cognitive impairment and stroke recovery.…
Lowest listed price: $84.99 across 1 listing
Full Phenylpiracetam profilePE-22-28
PE-22-28 is a synthetic seven-amino-acid peptide (sequence PAGASRLLLLTGEIDLP derivative, commonly truncated to PE-22-28 as shorthand for "position 22-28" within the parent humanin-family sequence) that was designed as an…
Lowest listed price: $54.99 across 1 listing
Full PE-22-28 profileSide-by-side comparison
| Attribute | Phenylpiracetam | PE-22-28 |
|---|---|---|
| Category | Nootropics | Nootropics |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | Phenylpiracetam's phenyl group addition dramatically increases lipophilicity and blood-brain barrier penetration compared to piracetam. It upregulates dopamine, norepinephrine, and serotonin receptor density — rather than triggering release — explaining the… | PE-22-28 is a synthetic 7-amino-acid peptide (sequence GVSWGLR) and a shortened analog of spadin. Its proposed mechanism is inhibition of the TREK-1 (TWIK-related K+) channel, a two-pore-domain potassium channel (K2P2.1 / KCNK2) implicated in mood regulation.… |
| Half-Life | — | Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242]. |
| Typical Dose Range | — | 250-2000 mcg subcutaneous per dose (empirical research-chemical community range; no clinically validated human dose exists; effective preclinical rodent doses were far lower, ~3 mcg/kg). |
| Dosing Frequency | — | Once daily or every other day (research-chemical community protocols; no validated clinical dosing schedule). |
| Administration | — | — |
| Side Effects | Insomnia (if taken late), headache, slight anxiety at initiation, overstimulation at high doses. Generally well-tolerated. | No human side-effect data exist for PE-22-28 because it has never been tested in people. What can be said comes from rodent studies of PE-22-28, spadin and their analogs, plus general considerations for injected research peptides. In the preclinical work, the… |
| Molecular Weight | 218.25 g/mol | 773.9 g/mol |
| Common Vial Sizes | — | — |
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Phenylpiracetam: potential benefits
- Cognitive stimulation
- Physical performance
- Memory enhancement
- Cold tolerance
- Motivation
- Anti-convulsant
PE-22-28: potential benefits
- Antidepressant-like effects in rodent models of depression (preclinical only)
- Potent, selective inhibition of the TREK-1 (K2P2.1) potassium channel (IC50 ~0.12 nM)
- Rapid-onset (~4-day) antidepressant profile in animals, unlike the multi-week lag of SSRIs
- Increased hippocampal neurogenesis in mice
- Increased cortical synaptogenesis (PSD-95) and BDNF expression in preclinical studies
- No human-validated benefits; not approved for any use (research use only)
Frequently asked
What's the difference between Phenylpiracetam and PE-22-28?
Phenylpiracetam is a nootropics that phenylpiracetam's phenyl group addition dramatically increases lipophilicity and blood-brain barrier penetration compared to piracetam. it upregulates dopamine, norepinephrine, and…. PE-22-28 is a nootropics that pe-22-28 is a synthetic 7-amino-acid peptide (sequence gvswglr) and a shortened analog of spadin. its proposed mechanism is inhibition of the trek-1 (twik-related k+) channel, a…. The two differ in mechanism, half-life (not reported vs Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].), and typical dose range.
Which has the longer half-life, Phenylpiracetam or PE-22-28?
Phenylpiracetam has a half-life of not reported. PE-22-28 has a half-life of Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Phenylpiracetam or PE-22-28?
Lowest listed price on BodyHackGuide: Phenylpiracetam from $84.99, PE-22-28 from $54.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Phenylpiracetam and PE-22-28?
Stacking depends on mechanism overlap, safety profile, and goals. Phenylpiracetam and PE-22-28 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.