P-21 vs Noopept
Side-by-side comparison of P-21 and Noopept: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
P-21
Noopept
P-21
P-21 (also written P021, or Peptide 021) is a synthetic peptidergic compound derived from the neurotrophic region of ciliary neurotrophic factor (CNTF), designed to activate neurogenic and BDNF-producing pathways in the…
Lowest listed price: $59.99 across 1 listing
Full P-21 profileNoopept
Noopept is the common brand and research name for N-phenylacetyl-L-prolylglycine ethyl ester (GVS-111; INN omberacetam), a small dipeptide nootropic developed in the 1990s at the Russian Academy of Medical Sciences'…
Lowest listed price: $49.99 across 1 listing
Full Noopept profileSide-by-side comparison
| Attribute | P-21 | Noopept |
|---|---|---|
| Category | Nootropics | Nootropics |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | P-21 is designed to engage a subset of CNTF's biological activity — specifically the neurogenic and BDNF-inducing effects — while avoiding the JAK/STAT3 activation on peripheral CNTF receptors that causes cachexia and muscle wasting when full-length CNTF is… | Noopept's mechanism of action is multifaceted and — despite decades of research — incompletely understood. Several convergent pathways have been proposed, each supported by preclinical data but none definitively established as the primary driver of its… |
| Half-Life | — | — |
| Typical Dose Range | 500-2000 mcg (0.5-2 mg) daily, most commonly 500-1000 mcg (community/self-experimentation range; no clinical validation) | — |
| Dosing Frequency | Once daily (some users divide into twice daily), typically dosed in the morning | — |
| Administration | — | — |
| Side Effects | The side effect profile of P-21 in humans is not documented because no clinical trials have been conducted. Rodent studies describe generally acceptable tolerability at doses producing cognitive and neurogenic effects, without obvious signs of weight loss,… | Noopept is generally well tolerated in the Russian clinical literature, with side effects that are typically mild and transient. However, "well tolerated in Russian open-label trials" is a weaker safety claim than the rigorous multi-phase trial data underlying… |
| Molecular Weight | 578.67 g/mol (C27H42N6O8) | 318.37 g/mol |
| Common Vial Sizes | — | — |
Price tracking
Price History
2 data pointsP-21: potential benefits
- Enhanced hippocampal neurogenesis (preclinical)
- Improved learning and memory (preclinical, rodent)
- Elevated BDNF and other neurotrophin expression
- Neuroprotective effects in Alzheimer's disease models (preclinical)
- Reduced tau hyperphosphorylation and soluble amyloid-beta in transgenic mice (preclinical)
Noopept: potential benefits
- Memory enhancement
- BDNF/NGF upregulation
- Neuroprotection
- Focus and learning speed
- Anxiety reduction (moderate)
- Anti-amyloid properties
Frequently asked
What's the difference between P-21 and Noopept?
P-21 is a nootropics that p-21 is designed to engage a subset of cntf's biological activity — specifically the neurogenic and bdnf-inducing effects — while avoiding the jak/stat3 activation on peripheral…. Noopept is a nootropics that noopept's mechanism of action is multifaceted and — despite decades of research — incompletely understood. several convergent pathways have been proposed, each supported by…. The two differ in mechanism, half-life (not reported vs not reported), and typical dose range.
Which has the longer half-life, P-21 or Noopept?
P-21 has a half-life of not reported. Noopept has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, P-21 or Noopept?
Lowest listed price on BodyHackGuide: P-21 from $59.99, Noopept from $49.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack P-21 and Noopept?
Stacking depends on mechanism overlap, safety profile, and goals. P-21 and Noopept should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy P-21 or Noopept
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.