Oxytocin vs Selank
Side-by-side comparison of Oxytocin and Selank: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Oxytocin
Selank
Oxytocin
Oxytocin is a nine-amino-acid cyclic peptide hormone (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2) synthesized in magnocellular neurons of the hypothalamic paraventricular (PVN) and supraoptic nuclei (SON), then transported…
Lowest listed price: $34.99 across 4 listings
Full Oxytocin profileSelank
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, 750 Da molecular weight) developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin…
Lowest listed price: $25.00 across 6 listings
Full Selank profileSide-by-side comparison
| Attribute | Oxytocin | Selank |
|---|---|---|
| Category | Hormones & Endocrine (Non-GH) | Nootropics |
| Research Stage | FDA-Approved | Approved (Russia, as anxiolytic and nootropic medication) |
| Mechanism of Action | Oxytocin signals primarily through the oxytocin receptor (OXTR), a single G-protein-coupled receptor (GPCR) encoded on chromosome 3p25.3 in humans. OXTR couples predominantly to Gαq/11 signaling, activating phospholipase C, generating IP3 and DAG, raising… | Primary Mechanism: Multi-System Neurochemical Modulation Selank does not have a single clean receptor-binding mechanism. Unlike benzodiazepines (GABA-A positive allosteric modulators), SSRIs (serotonin reuptake inhibition), or buspirone (5-HT1A partial… |
| Half-Life | ~1-6 minutes (plasma); central/behavioral effects outlast plasma clearance, typically ~30-120 minutes after intranasal dosing | ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation) |
| Typical Dose Range | — | 250-750 mcg intranasal daily (0.15% solution: 2-3 drops per nostril 2-3x daily); typical course is 14-21 days |
| Dosing Frequency | As needed (on-demand), timed 20-45 minutes before a target social/intimate window; research protocols have used up to 2-3x daily (commonly 24 IU twice daily) intranasally | Intranasal 1–3 times daily |
| Administration | — | Intranasal |
| Side Effects | Oxytocin has a favorable safety profile at typical behavioral-research doses (intranasal 24-48 IU, subcutaneous 2-10 IU). Most side effects are mild and transient. Common (any oxytocin use): - Mild flushing or warm sensation - transient, reflecting modest… | Overall Safety Profile Selank has one of the best safety profiles in the anxiolytic space. Over 15+ years of Russian clinical use and research, the compound has been associated with essentially no serious adverse events at therapeutic doses. This compares… |
| Molecular Weight | 1007.19 g/mol | 751.9 Da |
| Common Vial Sizes | — | 5mg, 10mg |
Price History
3 data points- Half Nattys
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Price History
5 data points- OF
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Oxytocin: potential benefits
- Social and emotional bonding (subtle, context-dependent)
- Situational social-anxiety relief
- Enhanced intimacy and post-orgasm bonding
- Labor induction and milk let-down (approved obstetric use)
- Trauma-focused therapy adjunct (investigational)
Selank: potential benefits
- Anxiolytic effects comparable to benzodiazepines but without sedation or dependence in Russian clinical trials (PMID: 18454096)
- Positive allosteric modulation of brain GABA receptors through a non-benzodiazepine binding site (PMID: 30255741)
- Immunomodulation via Th1/Th2 cytokine balance and IL-6 regulation in patients with anxiety-asthenic disorders (PMID: 18577961)
- Cognitive and memory support linked to BDNF upregulation in the hippocampus in preclinical models (PMID: 18841804)
- Modulation of the endogenous enkephalin-opioid system supporting mood and stress tolerance (PMID: 22550852)
- Anti-inflammatory and adaptogenic effects through normalization of stress-induced cytokine dysregulation
- Non-addictive anxiolytic profile - no tolerance, withdrawal, or dependence reported across years of Russian clinical use
Frequently asked
What's the difference between Oxytocin and Selank?
Oxytocin is a hormones & endocrine (non-gh) that oxytocin signals primarily through the oxytocin receptor (oxtr), a single g-protein-coupled receptor (gpcr) encoded on chromosome 3p25.3 in humans. oxtr couples predominantly to…. Selank is a nootropics that primary mechanism: multi-system neurochemical modulation selank does not have a single clean receptor-binding mechanism. unlike benzodiazepines (gaba-a positive allosteric…. The two differ in mechanism, half-life (~1-6 minutes (plasma); central/behavioral effects outlast plasma clearance, typically ~30-120 minutes after intranasal dosing vs ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation)), and typical dose range.
Which has the longer half-life, Oxytocin or Selank?
Oxytocin has a half-life of ~1-6 minutes (plasma); central/behavioral effects outlast plasma clearance, typically ~30-120 minutes after intranasal dosing. Selank has a half-life of ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Oxytocin or Selank?
Lowest listed price on BodyHackGuide: Oxytocin from $34.99, Selank from $25.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Oxytocin and Selank?
Stacking depends on mechanism overlap, safety profile, and goals. Oxytocin and Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.