Methylene Blue vs Noopept
Side-by-side comparison of Methylene Blue and Noopept: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Methylene Blue
Noopept
Methylene Blue
Methylene blue (methylthioninium chloride) is a phenothiazine dye with a 150-year pharmacology record. It was the first fully synthetic drug ever used in medicine (Ehrlich, 1891 for malaria) and remains on the WHO Model…
Lowest listed price: $19.99 across 3 listings
Full Methylene Blue profileNoopept
Noopept is the common brand and research name for N-phenylacetyl-L-prolylglycine ethyl ester (GVS-111; INN omberacetam), a small dipeptide nootropic developed in the 1990s at the Russian Academy of Medical Sciences'…
Lowest listed price: $49.99 across 1 listing
Full Noopept profileSide-by-side comparison
| Attribute | Methylene Blue | Noopept |
|---|---|---|
| Category | Nootropics | Nootropics |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | Methylene blue (MB) has a multi-target redox mechanism that explains why it appears in such disparate indications as malaria, methemoglobinemia, septic shock, vasoplegia, Alzheimer's (TRx0237), and cognitive enhancement: 1. Alternative mitochondrial electron… | Noopept's mechanism of action is multifaceted and — despite decades of research — incompletely understood. Several convergent pathways have been proposed, each supported by preclinical data but none definitively established as the primary driver of its… |
| Half-Life | — | — |
| Typical Dose Range | 0.5 mg - 4 mg/kg daily (oral) | — |
| Dosing Frequency | — | — |
| Administration | — | — |
| Side Effects | Expected / benign - Blue-green urine and stool — universal, not a problem, clears within 24-48 hours of last dose. - Blue discoloration of sclera and skin at sustained higher doses; reversible. - Metallic taste and mild mucosal tingling at oral doses 30 mg. -… | Noopept is generally well tolerated in the Russian clinical literature, with side effects that are typically mild and transient. However, "well tolerated in Russian open-label trials" is a weaker safety claim than the rigorous multi-phase trial data underlying… |
| Molecular Weight | 319.85 g/mol | 318.37 g/mol |
| Common Vial Sizes | — | — |
Price History
3 data points- Half Nattys
- Ion Peptide
- Disguised Alpha
Price History
2 data pointsMethylene Blue: potential benefits
- Mitochondrial electron transport bypass (Complex I/III)
- Cytochrome c oxidase activation (+30-70%)
- Memory consolidation and retrieval
- Sustained attention and processing speed
- Antioxidant recycling of ascorbate and glutathione
- Tau aggregation inhibition (Alzheimer's-relevant)
- FDA-indicated treatment for methemoglobinemia
- Adjunct for vasoplegic shock (off-label)
Noopept: potential benefits
- Memory enhancement
- BDNF/NGF upregulation
- Neuroprotection
- Focus and learning speed
- Anxiety reduction (moderate)
- Anti-amyloid properties
Frequently asked
What's the difference between Methylene Blue and Noopept?
Methylene Blue is a nootropics that methylene blue (mb) has a multi-target redox mechanism that explains why it appears in such disparate indications as malaria, methemoglobinemia, septic shock, vasoplegia,…. Noopept is a nootropics that noopept's mechanism of action is multifaceted and — despite decades of research — incompletely understood. several convergent pathways have been proposed, each supported by…. The two differ in mechanism, half-life (not reported vs not reported), and typical dose range.
Which has the longer half-life, Methylene Blue or Noopept?
Methylene Blue has a half-life of not reported. Noopept has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Methylene Blue or Noopept?
Lowest listed price on BodyHackGuide: Methylene Blue from $19.99, Noopept from $49.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Methylene Blue and Noopept?
Stacking depends on mechanism overlap, safety profile, and goals. Methylene Blue and Noopept should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy Methylene Blue or Noopept
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.