Methylene Blue vs Dihexa
Side-by-side comparison of Methylene Blue and Dihexa: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Methylene Blue
Dihexa
Methylene Blue
Methylene blue (methylthioninium chloride) is a phenothiazine dye with a 150-year pharmacology record. It was the first fully synthetic drug ever used in medicine (Ehrlich, 1891 for malaria) and remains on the WHO Model…
Lowest listed price: $19.99 across 3 listings
Full Methylene Blue profileDihexa
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models…
Lowest listed price: $79.99 across 3 listings
Full Dihexa profileSide-by-side comparison
| Attribute | Methylene Blue | Dihexa |
|---|---|---|
| Category | Nootropics | Nootropics |
| Research Stage | Approved medicine: injection for acquired methemoglobinemia (US and EU) and, in the EU, an oral dye tablet for colonoscopy (Lumeblue); no cognitive or performance use is approved | Preclinical |
| Mechanism of Action | Methylene blue (MB) has a multi-target redox mechanism that explains why it appears in such disparate indications as malaria, methemoglobinemia, septic shock, vasoplegia, Alzheimer's (TRx0237), and cognitive enhancement: 1. Alternative mitochondrial electron… | Dihexa is a small-molecule analog derived from angiotensin IV (AngIV). It retains the Tyr-Ile core of Nle1-AngIV, with an N-terminal hexanoic acid cap and a C-terminal 6-aminohexanoic amide that give it metabolic stability and blood-brain-barrier penetration.… |
| Half-Life | — | Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. |
| Typical Dose Range | 0.5 mg - 4 mg/kg daily (oral) | 5 to 40 mg oral per day (anecdotal range; no established human dose) |
| Dosing Frequency | — | Once daily (oral), typically in the morning |
| Administration | — | Oral, Intranasal, Subcutaneous |
| Side Effects | Expected / benign - Blue-green urine and stool — universal, not a problem, clears within 24-48 hours of last dose. - Blue discoloration of sclera and skin at sustained higher doses; reversible. - Metallic taste and mild mucosal tingling at oral doses 30 mg. -… | No controlled human safety data. Anecdotal user reports include headache, fatigue, irritability or anxiety, insomnia, and vivid dreams, usually at higher doses. The most serious concern is theoretical rather than reported: because dihexa acts on the HGF/c-Met… |
| Molecular Weight | 319.85 g/mol | 504.7 g/mol |
| Common Vial Sizes | — | 50mg, 100mg |
Price History
3 data points- Half Nattys
- Ion Peptide
- Disguised Alpha
Price History
2 data pointsMethylene Blue: potential benefits
- Mitochondrial electron transport bypass (Complex I/III)
- Cytochrome c oxidase activation (+30-70%)
- Memory consolidation and retrieval
- Sustained attention and processing speed
- Antioxidant recycling of ascorbate and glutathione
- Tau aggregation inhibition (Alzheimer's-relevant)
- FDA-indicated treatment for methemoglobinemia
- Adjunct for vasoplegic shock (off-label)
Dihexa: potential benefits
- Synaptogenesis: formation of new dendritic spines and functional synapses (preclinical)
- Memory and spatial-learning support in rodent models
- Potential research application in Alzheimer's and other neurodegenerative disease models
- HGF/c-Met and PI3K/Akt-linked neuroplasticity (mechanism proposed; key paper retracted)
Frequently asked
What's the difference between Methylene Blue and Dihexa?
Methylene Blue is a nootropics that methylene blue (mb) has a multi-target redox mechanism that explains why it appears in such disparate indications as malaria, methemoglobinemia, septic shock, vasoplegia,…. Dihexa is a nootropics that dihexa is a small-molecule analog derived from angiotensin iv (angiv). it retains the tyr-ile core of nle1-angiv, with an n-terminal hexanoic acid cap and a c-terminal…. The two differ in mechanism, half-life (not reported vs Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence.), and typical dose range.
Which has the longer half-life, Methylene Blue or Dihexa?
Methylene Blue has a half-life of not reported. Dihexa has a half-life of Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Methylene Blue or Dihexa?
Lowest listed price on BodyHackGuide: Methylene Blue from $19.99, Dihexa from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Methylene Blue and Dihexa?
Stacking depends on mechanism overlap, safety profile, and goals. Methylene Blue and Dihexa should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy Methylene Blue or Dihexa
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.