ITPP vs SS-31
Side-by-side comparison of ITPP and SS-31: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
ITPP
SS-31
ITPP
ITPP (myo-inositol trispyrophosphate, sometimes written myo-inositol tripyrophosphate or OXY111A in NormOxys trial documents) is a small-molecule allosteric effector of hemoglobin designed to increase the amount of…
Lowest listed price: $119.99 across 1 listing
Full ITPP profileSS-31
SS-31 (elamipretide; MTP-131; formerly Bendavia; chemical sequence D-Arg-Dmt-Lys-Phe-NH2 with dimethyltyrosine at position 2) is a first-in-class aromatic-cationic tetrapeptide designed to selectively target the inner…
Lowest listed price: $72.00 across 4 listings
Full SS-31 profileSide-by-side comparison
| Attribute | ITPP | SS-31 |
|---|---|---|
| Category | Performance | Mitochondrial Peptides |
| Research Stage | Preclinical | Clinical/Approved |
| Mechanism of Action | The mechanism of ITPP is elegant and narrow. Hemoglobin inside a red blood cell exists in equilibrium between a high-oxygen-affinity R-state (relaxed, binds O2 tightly) and a low-oxygen-affinity T-state (tense, releases O2). Under normal physiology, a small… | SS-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high concentration of cardiolipin, a signature mitochondrial anionic phospholipid - to… |
| Half-Life | — | ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding |
| Typical Dose Range | Research compound — IV infusion in studies, no established oral doses | 20-60 mg |
| Dosing Frequency | — | Once daily subcutaneous (some protocols use 5-6 days per week) |
| Administration | — | — |
| Side Effects | The honest answer is that the side-effect profile of ITPP in humans is poorly characterized because so few humans have taken it outside corporate trials. Reported and theoretical risks include: Reported in clinical and preclinical settings: - Transient… | SS-31 (elamipretide) has been generally well-tolerated across clinical trials spanning over a decade of human exposure, with adverse event profiles dominated by injection site reactions rather than systemic toxicity. This favorable safety profile reflects both… |
| Molecular Weight | 660.03 g/mol | 639.8 g/mol |
| Common Vial Sizes | — | — |
Price tracking
Price History
2 data points- Ion Peptide
- BHG Labs
ITPP: potential benefits
- Enhanced tissue oxygenation
- Improved aerobic performance
- Anti-tumor effects (reduces tumor hypoxia)
- Potential altitude sickness relief
- Improved exercise capacity
SS-31: potential benefits
- No structured benefit list published.
Frequently asked
What's the difference between ITPP and SS-31?
ITPP is a performance that the mechanism of itpp is elegant and narrow. hemoglobin inside a red blood cell exists in equilibrium between a high-oxygen-affinity r-state (relaxed, binds o2 tightly) and a…. SS-31 is a mitochondrial peptides that ss-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high…. The two differ in mechanism, half-life (not reported vs ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding), and typical dose range.
Which has the longer half-life, ITPP or SS-31?
ITPP has a half-life of not reported. SS-31 has a half-life of ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, ITPP or SS-31?
Lowest listed price on BodyHackGuide: ITPP from $119.99, SS-31 from $72.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack ITPP and SS-31?
Stacking depends on mechanism overlap, safety profile, and goals. ITPP and SS-31 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.