IGF-1 LR3 vs KPV
Side-by-side comparison of IGF-1 LR3 and KPV: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
IGF-1 LR3
KPV
IGF-1 LR3
IGF-1 LR3 (Long R3 IGF-1) is a synthetic analog of human insulin-like growth factor 1 modified at two positions to dramatically extend its serum half-life and amplify its tissue bioactivity compared to native IGF-1. The…
Lowest listed price: $49.99 across 4 listings
Full IGF-1 LR3 profileKPV
KPV is a three-amino-acid peptide — Lysine-Proline-Valine — that makes up the C-terminal tail of alpha-MSH (alpha-melanocyte-stimulating hormone). With a molecular weight of only 342.4 Da, it is one of the smallest…
Lowest listed price: $34.99 across 6 listings
Full KPV profileSide-by-side comparison
| Attribute | IGF-1 LR3 | KPV |
|---|---|---|
| Category | Growth Hormone / IGF-1 Axis | Recovery |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | IGF-1 Receptor Signaling IGF-1 LR3 binds the IGF-1 receptor (IGF1R) - a transmembrane receptor tyrosine kinase expressed on virtually every cell type in the human body. IGF1R activation triggers two principal intracellular signaling cascades: PI3K / Akt / mTOR… | KPV's mechanism of action has been worked out in detail over the past 20 years, and it is unusual enough to be worth understanding if you are using this compound. Unlike most peptides, KPV does not primarily act through classical G-protein-coupled receptors on… |
| Half-Life | 20-30 hours (community/vendor estimate; no published human PK study of IGF-1 LR3) vs ~12 minutes for native IGF-1 | Not measured: FDA's 2026 review found no pharmacokinetic studies of KPV in animals or people |
| Typical Dose Range | 20-80 mcg per day | 500 mcg-2 mg per dose (standard); up to 5 mg daily in advanced protocols |
| Dosing Frequency | Once daily, typically post-workout or in the morning | Once daily subcutaneous or oral |
| Administration | Subcutaneous, Intramuscular | Subcutaneous, Oral, Topical |
| Side Effects | Acute and Common - Hypoglycemia — The primary acute safety concern. Post-injection blood glucose drops can produce shakiness, sweating, confusion, palpitations, and in severe cases loss of consciousness. Mitigation: 30-40g of fast-digesting carbohydrate within… | KPV's side effect profile, based on the published literature and the research-peptide community's accumulated experience, is notable primarily for what is NOT reported. Across preclinical studies, no serious adverse events have been attributed to KPV. That… |
| Molecular Weight | 9117 Da | 342.43 g/mol |
| Common Vial Sizes | 100mcg, 1mg | 5mg, 10mg |
Price History
3 data points- Half Nattys
- Ion Peptide
- Disguised Alpha
Price History
4 data points- OF
- BM
- Half Nattys
- Ion Peptide
- BHG Labs
IGF-1 LR3: potential benefits
- Muscle hypertrophy
- Recovery
- Protein synthesis
- Fat metabolism
- Glucose uptake
KPV: potential benefits
- Potent anti-inflammatory effects
- Gut healing and barrier repair
- Antimicrobial properties
- Skin wound healing support
- Potential anti-cancer properties (anti-angiogenic in tumors)
Frequently asked
What's the difference between IGF-1 LR3 and KPV?
IGF-1 LR3 is a growth hormone / igf-1 axis that igf-1 receptor signaling igf-1 lr3 binds the igf-1 receptor (igf1r) - a transmembrane receptor tyrosine kinase expressed on virtually every cell type in the human body. igf1r…. KPV is a recovery that kpv's mechanism of action has been worked out in detail over the past 20 years, and it is unusual enough to be worth understanding if you are using this compound. unlike most…. The two differ in mechanism, half-life (20-30 hours (community/vendor estimate; no published human PK study of IGF-1 LR3) vs ~12 minutes for native IGF-1 vs Not measured: FDA's 2026 review found no pharmacokinetic studies of KPV in animals or people), and typical dose range.
Which has the longer half-life, IGF-1 LR3 or KPV?
IGF-1 LR3 has a half-life of 20-30 hours (community/vendor estimate; no published human PK study of IGF-1 LR3) vs ~12 minutes for native IGF-1. KPV has a half-life of Not measured: FDA's 2026 review found no pharmacokinetic studies of KPV in animals or people. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, IGF-1 LR3 or KPV?
Lowest listed price on BodyHackGuide: IGF-1 LR3 from $49.99, KPV from $34.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack IGF-1 LR3 and KPV?
Stacking depends on mechanism overlap, safety profile, and goals. IGF-1 LR3 and KPV should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy IGF-1 LR3 or KPV
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.