Hawthorn vs Cortagen
Side-by-side comparison of Hawthorn and Cortagen: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Hawthorn
Cortagen
Hawthorn
Hawthorn (Crataegus species — principally Crataegus monogyna, C. laevigata, C. pinnatifida, and C. cuneata) is the most extensively studied cardiovascular botanical in the Western pharmacopoeia and one of very few herbs…
No vendor price on file.
Full Hawthorn profileCortagen
Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is organ-targeted to cardiac and coronary…
Lowest listed price: $79.00 across 1 listing
Full Cortagen profileSide-by-side comparison
| Attribute | Hawthorn | Cortagen |
|---|---|---|
| Category | herb | Longevity |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | Hawthorn's mechanism of action is multi-component and reflects the complex phytochemistry of Crataegus species. The three principal constituent groups — oligomeric proanthocyanidins (OPCs), flavonoids, and pentacyclic triterpenes — act in parallel on distinct… | Cortagen is a synthetic tetrapeptide, Ala-Glu-Asp-Pro (AEDP), created by the Khavinson group through directed synthesis based on the amino-acid composition of Cortexin, a polypeptide complex extracted from the cerebral cortex [PMID:15159690]. It is a… |
| Half-Life | — | Unknown (tetrapeptide; estimated <4 hours) |
| Typical Dose Range | — | — |
| Dosing Frequency | — | once_daily |
| Administration | — | Subcutaneous, Intramuscular |
| Side Effects | Hawthorn has one of the most favorable safety profiles of any cardiovascular herb studied in modern controlled trials — the 2,681-patient SPICE trial documented mild, transient adverse event rates similar to placebo, and post-marketing surveillance from… | — |
| Molecular Weight | — | 430.4 g/mol (C17H26N4O9, PubChem CID 18439621) |
| Common Vial Sizes | — | 20 |
Price tracking
Hawthorn: potential benefits
- No structured benefit list published.
Cortagen: potential benefits
- Peripheral nerve repair - accelerated axon regeneration and faster nerve-conduction recovery after injury in rat models [PMID:11276314; PMID:12134478]
- Neuroprotection and antioxidant activity in the cerebral cortex and in chronic brain-ischemia models (preclinical) [PMID:18239817; PMID:21476278]
- CNS/cognitive support as the synthetic short-peptide analog of the cortex-derived Russian drug Cortexin
- Anti-aging chromatin remodeling - reactivation of age-silenced ribosomal genes in lymphocytes from elderly donors [PMID:15085253; PMID:37042594]
- Mild immune-signaling modulation (IL-2 expression), generally weaker than Vilon or Epithalon [PMID:12447482; PMID:16224591]
- Longevity-protocol stacking as one of the Khavinson short-peptide bioregulators (commonly paired with Epitalon or Pinealon)
Frequently asked
What's the difference between Hawthorn and Cortagen?
Hawthorn is a herb that hawthorn's mechanism of action is multi-component and reflects the complex phytochemistry of crataegus species. the three principal constituent groups — oligomeric…. Cortagen is a longevity that cortagen is a synthetic tetrapeptide, ala-glu-asp-pro (aedp), created by the khavinson group through directed synthesis based on the amino-acid composition of cortexin, a…. The two differ in mechanism, half-life (not reported vs Unknown (tetrapeptide; estimated <4 hours)), and typical dose range.
Which has the longer half-life, Hawthorn or Cortagen?
Hawthorn has a half-life of not reported. Cortagen has a half-life of Unknown (tetrapeptide; estimated <4 hours). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack Hawthorn and Cortagen?
Stacking depends on mechanism overlap, safety profile, and goals. Hawthorn and Cortagen should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy Hawthorn or Cortagen
Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor.
Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.