DMHA vs SS-31
Side-by-side comparison of DMHA and SS-31: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
DMHA
SS-31
DMHA
DMHA (octodrine) - chemically 2-amino-6-methylheptane, also sold as 2-aminoisoheptane or 1,5-dimethylhexylamine - is an aliphatic-amine central nervous system stimulant and a close structural analog of DMAA…
No vendor price on file.
Full DMHA profileSS-31
SS-31 (elamipretide; MTP-131; formerly Bendavia; chemical sequence D-Arg-Dmt-Lys-Phe-NH2 with dimethyltyrosine at position 2) is a first-in-class aromatic-cationic tetrapeptide designed to selectively target the inner…
Lowest listed price: $72.00 across 4 listings
Full SS-31 profileSide-by-side comparison
| Attribute | DMHA | SS-31 |
|---|---|---|
| Category | Energy & Performance | Mitochondrial Peptides |
| Research Stage | Historical pharmaceutical; no modern clinical trials | Clinical/Approved |
| Mechanism of Action | DMHA (octodrine; 2-amino-6-methylheptane / 1,5-dimethylhexylamine) is a simple aliphatic amine that behaves as an indirect sympathomimetic - structurally and pharmacologically a close cousin of DMAA (1,3-dimethylamylamine). Agents in this class raise synaptic… | SS-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high concentration of cardiolipin, a signature mitochondrial anionic phospholipid - to… |
| Half-Life | Not formally characterized in humans. After ingestion, octodrine is rapidly metabolized to heptaminol, which becomes the predominant compound detected in blood and urine within hours [PMID:39401652]. Users commonly report perceptible stimulant effects lasting roughly 3-6 hours, but this is anecdotal rather than measured pharmacokinetics. | ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding |
| Typical Dose Range | 75-200 mg per dose (anecdotal pre-workout range; ~75,000-200,000 mcg). Historical pharmaceutical unit dose was 8-33 mg. No approved or clinically validated dose exists. | 20-60 mg |
| Dosing Frequency | Acute, single-session (pre-workout) use rather than a daily or continuous compound. Users typically leave rest days between doses to limit tolerance buildup and cardiovascular strain; there is no evidence base for any regular dosing schedule. | Once daily subcutaneous (some protocols use 5-6 days per week) |
| Administration | — | — |
| Side Effects | Reported and expected effects reflect its sympathomimetic activity: elevated blood pressure and heart rate, palpitations or tachycardia, chest tightness, shortness of breath (dyspnoea), overheating (hyperthermia), anxiety and jitteriness, headache, insomnia,… | SS-31 (elamipretide) has been generally well-tolerated across clinical trials spanning over a decade of human exposure, with adverse event profiles dominated by injection site reactions rather than systemic toxicity. This favorable safety profile reflects both… |
| Molecular Weight | 129.24 g/mol (free base; molecular formula C8H19N). Commonly supplied as a salt (e.g., hydrochloride or, historically, camphorsulfonate), which increases the labeled mass per dose. | 639.8 g/mol |
| Common Vial Sizes | — | — |
Price History
2 data points- Ion Peptide
- BHG Labs
DMHA: potential benefits
- Increased energy and perceived training intensity - the reason it is added to pre-workout products (reported by users; not established in any controlled trial)
- Sharper focus and heightened alertness from central nervous system stimulation
- Appetite suppression, which is why it appears in 'fat-burner' formulas
- Mild mood lift or euphoria reported anecdotally
- Users often describe a longer, 'smoother' stimulant feel than caffeine alone - again anecdotal, not clinically demonstrated
SS-31: potential benefits
- No structured benefit list published.
Frequently asked
What's the difference between DMHA and SS-31?
DMHA is a energy & performance that dmha (octodrine; 2-amino-6-methylheptane / 1,5-dimethylhexylamine) is a simple aliphatic amine that behaves as an indirect sympathomimetic - structurally and pharmacologically a…. SS-31 is a mitochondrial peptides that ss-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high…. The two differ in mechanism, half-life (Not formally characterized in humans. After ingestion, octodrine is rapidly metabolized to heptaminol, which becomes the predominant compound detected in blood and urine within hours [PMID:39401652]. Users commonly report perceptible stimulant effects lasting roughly 3-6 hours, but this is anecdotal rather than measured pharmacokinetics. vs ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding), and typical dose range.
Which has the longer half-life, DMHA or SS-31?
DMHA has a half-life of Not formally characterized in humans. After ingestion, octodrine is rapidly metabolized to heptaminol, which becomes the predominant compound detected in blood and urine within hours [PMID:39401652]. Users commonly report perceptible stimulant effects lasting roughly 3-6 hours, but this is anecdotal rather than measured pharmacokinetics.. SS-31 has a half-life of ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack DMHA and SS-31?
Stacking depends on mechanism overlap, safety profile, and goals. DMHA and SS-31 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.