Creatine vs SS-31
Side-by-side comparison of Creatine and SS-31: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Creatine
SS-31
Creatine
Creatine is the most-researched nutritional supplement in sports science and has emerged over the past decade as a cornerstone compound in the broader longevity conversation, extending beyond its traditional ergogenic…
No vendor price on file.
Full Creatine profileSS-31
SS-31 (elamipretide; MTP-131; formerly Bendavia; chemical sequence D-Arg-Dmt-Lys-Phe-NH2 with dimethyltyrosine at position 2) is a first-in-class aromatic-cationic tetrapeptide designed to selectively target the inner…
Lowest listed price: $72.00 across 4 listings
Full SS-31 profileSide-by-side comparison
| Attribute | Creatine | SS-31 |
|---|---|---|
| Category | Foundational | Mitochondrial Peptides |
| Research Stage | Marketed dietary supplement with hundreds of randomized trials and a position stand | Clinical/Approved |
| Mechanism of Action | Creatine's mechanism of action centers on the phosphocreatine-creatine kinase energy system, which provides rapid ATP regeneration during high-intensity metabolic demands. Understanding the biochemistry clarifies why creatine benefits certain activities… | SS-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high concentration of cardiolipin, a signature mitochondrial anionic phospholipid - to… |
| Half-Life | — | ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding |
| Typical Dose Range | — | 20-60 mg |
| Dosing Frequency | — | Once daily subcutaneous (some protocols use 5-6 days per week) |
| Administration | — | — |
| Side Effects | Creatine has one of the most favorable safety profiles of any nutritional supplement, with extensive human use experience, multiple long-term safety studies, and consensus from scientific bodies affirming safety in healthy populations. Side effects are… | SS-31 (elamipretide) has been generally well-tolerated across clinical trials spanning over a decade of human exposure, with adverse event profiles dominated by injection site reactions rather than systemic toxicity. This favorable safety profile reflects both… |
| Molecular Weight | — | 639.8 g/mol |
| Common Vial Sizes | — | — |
Price History
2 data points- Ion Peptide
- BHG Labs
Frequently asked
What's the difference between Creatine and SS-31?
Creatine is a foundational that creatine's mechanism of action centers on the phosphocreatine-creatine kinase energy system, which provides rapid atp regeneration during high-intensity metabolic demands.…. SS-31 is a mitochondrial peptides that ss-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high…. The two differ in mechanism, half-life (not reported vs ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding), and typical dose range.
Which has the longer half-life, Creatine or SS-31?
Creatine has a half-life of not reported. SS-31 has a half-life of ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack Creatine and SS-31?
Stacking depends on mechanism overlap, safety profile, and goals. Creatine and SS-31 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.