CDP-Choline vs PE-22-28
Side-by-side comparison of CDP-Choline and PE-22-28: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
CDP-Choline
PE-22-28
CDP-Choline
CDP-choline (cytidine 5'-diphosphocholine, pharmaceutical name citicoline) is a naturally occurring intracellular intermediate in the Kennedy pathway for phosphatidylcholine synthesis — the primary biochemical route by…
Lowest listed price: $69.99 across 1 listing
Full CDP-Choline profilePE-22-28
PE-22-28 is a synthetic seven-amino-acid peptide (sequence PAGASRLLLLTGEIDLP derivative, commonly truncated to PE-22-28 as shorthand for "position 22-28" within the parent humanin-family sequence) that was designed as an…
Lowest listed price: $49.99 across 1 listing
Full PE-22-28 profileSide-by-side comparison
| Attribute | CDP-Choline | PE-22-28 |
|---|---|---|
| Category | Nootropic | Nootropics |
| Research Stage | Approved (prescription medicine in many countries; dietary supplement in the US) | Preclinical |
| Mechanism of Action | CDP-choline operates through a distinctive dual-substrate delivery mechanism that differentiates it from all other cholinergic precursors: oral citicoline is rapidly hydrolyzed to cytidine and choline in the gut, both components are absorbed and cross the… | PE-22-28 is a synthetic 7-amino-acid peptide (sequence GVSWGLR) and a shortened analog of spadin. Its proposed mechanism is inhibition of the TREK-1 (TWIK-related K+) channel, a two-pore-domain potassium channel (K2P2.1 / KCNK2) implicated in mood regulation.… |
| Half-Life | — | Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242]. |
| Typical Dose Range | — | 250-2000 mcg subcutaneous per dose (empirical research-chemical community range; no clinically validated human dose exists; effective preclinical rodent doses were far lower, ~3 mcg/kg). |
| Dosing Frequency | — | Once daily or every other day (research-chemical community protocols; no validated clinical dosing schedule). |
| Administration | — | — |
| Side Effects | CDP-choline has one of the most favorable safety profiles of any cognitive-support compound, with decades of European prescription use and extensive global supplement use documenting low rates of adverse events at therapeutic doses of 250-2,000mg/day. Common… | No human side-effect data exist for PE-22-28 because it has never been tested in people. What can be said comes from rodent studies of PE-22-28, spadin and their analogs, plus general considerations for injected research peptides. In the preclinical work, the… |
| Molecular Weight | 488.32 g/mol | 773.9 g/mol |
| Common Vial Sizes | — | — |
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2 data pointsCDP-Choline: potential benefits
- Acetylcholine support
- Dopamine D2 upregulation (via uridine)
- Focus and attention
- Memory
- Neuroprotection
- Stroke recovery
PE-22-28: potential benefits
- Antidepressant-like effects in rodent models of depression (preclinical only)
- Potent, selective inhibition of the TREK-1 (K2P2.1) potassium channel (IC50 ~0.12 nM)
- Rapid-onset (~4-day) antidepressant profile in animals, unlike the multi-week lag of SSRIs
- Increased hippocampal neurogenesis in mice
- Increased cortical synaptogenesis (PSD-95) and BDNF expression in preclinical studies
- No human-validated benefits; not approved for any use (research use only)
Frequently asked
What's the difference between CDP-Choline and PE-22-28?
CDP-Choline is a nootropic that cdp-choline operates through a distinctive dual-substrate delivery mechanism that differentiates it from all other cholinergic precursors: oral citicoline is rapidly hydrolyzed to…. PE-22-28 is a nootropics that pe-22-28 is a synthetic 7-amino-acid peptide (sequence gvswglr) and a shortened analog of spadin. its proposed mechanism is inhibition of the trek-1 (twik-related k+) channel, a…. The two differ in mechanism, half-life (not reported vs Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].), and typical dose range.
Which has the longer half-life, CDP-Choline or PE-22-28?
CDP-Choline has a half-life of not reported. PE-22-28 has a half-life of Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, CDP-Choline or PE-22-28?
Lowest listed price on BodyHackGuide: CDP-Choline from $69.99, PE-22-28 from $49.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack CDP-Choline and PE-22-28?
Stacking depends on mechanism overlap, safety profile, and goals. CDP-Choline and PE-22-28 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.