Apigenin vs Pinealon
Side-by-side comparison of Apigenin and Pinealon: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Apigenin
Pinealon
Apigenin
Apigenin is a plant-derived flavone (4',5,7-trihydroxyflavone) that occurs widely in the plant kingdom as a constituent of leaves, flowers, and seeds. Structurally it is a flavone — distinguished from flavonols like…
No vendor price on file.
Full Apigenin profilePinealon
Pinealon is a synthetic tripeptide — glutamyl-aspartyl-arginine (Glu-Asp-Arg, or EDR) — developed by the St Petersburg Institute of Bioregulation and Gerontology (IBG) under the leadership of Professor Vladimir…
Lowest listed price: $45.00 across 3 listings
Full Pinealon profileSide-by-side comparison
| Attribute | Apigenin | Pinealon |
|---|---|---|
| Category | Flavonoid | Nootropics |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | Apigenin exerts its biological effects through multiple pathways reflecting its broad receptor and enzyme interactions. CD38 inhibition: Escande and colleaguesidentified apigenin as an inhibitor of CD38, a membrane-bound ectoenzyme that hydrolyzes NAD+ to… | The proposed mechanism of Pinealon is rooted in the Khavinson school's broader theory of short-peptide tissue-specific bioregulation. The full theory is worth understanding because it underlies all twelve Russian bioregulator compounds in this catalog. The… |
| Half-Life | — | Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing. |
| Typical Dose Range | — | Subcutaneous (primary route): 2-10 mg/day, typically 3-5 mg, in pulsed 10-20 day cycles, 2-4 cycles/year. Intranasal: 150-800 mcg per nostril daily. Research use only; oral dosing is not recommended because the peptide is largely degraded by GI proteases. |
| Dosing Frequency | — | Once daily during a cycle (morning preferred); some advanced users split into AM + midday doses. Not dosed continuously year-round - cycles are pulsed. |
| Administration | — | — |
| Side Effects | Apigenin is generally well-tolerated in both dietary and supplemental contexts. Common and uncommon adverse effects include: Gastrointestinal effects (most common): Mild nausea, bloating, or loose stools occur in a small percentage of users, typically mild and… | The side-effect profile of Pinealon, based on the available Russian clinical literature and user-reported experience, is described as mild and uncommon. Whether this reflects genuinely low toxicity or inadequate reporting in the available studies is a… |
| Molecular Weight | — | 418.40 g/mol (C15H26N6O8) |
| Common Vial Sizes | — | — |
Price History
2 data points- Ion Peptide
- Disguised Alpha
Apigenin: potential benefits
- No structured benefit list published.
Pinealon: potential benefits
- Neuroprotection against oxidative and hypoxic stress (preclinical models)
- Antioxidant support - reduced oxidative DNA damage in aged neurons (in vitro)
- Cognitive and memory support in aging populations (small Russian clinical reports)
- Reduced neuronal apoptosis and support of dendritic-tree integrity in cell models
- Investigated for neuroprotection in Alzheimer's-model systems (preclinical)
Frequently asked
What's the difference between Apigenin and Pinealon?
Apigenin is a flavonoid that apigenin exerts its biological effects through multiple pathways reflecting its broad receptor and enzyme interactions. cd38 inhibition: escande and colleaguesidentified apigenin…. Pinealon is a nootropics that the proposed mechanism of pinealon is rooted in the khavinson school's broader theory of short-peptide tissue-specific bioregulation. the full theory is worth understanding because…. The two differ in mechanism, half-life (not reported vs Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing.), and typical dose range.
Which has the longer half-life, Apigenin or Pinealon?
Apigenin has a half-life of not reported. Pinealon has a half-life of Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack Apigenin and Pinealon?
Stacking depends on mechanism overlap, safety profile, and goals. Apigenin and Pinealon should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.