Kisspeptin-10 (KSPTN) Dosage Guide: Protocols, Calculator & Safety
Everything you need to know about Kisspeptin-10 (KSPTN) dosing — protocols, safety, and where to buy.
Dose Range
20-100
Frequency
No validated schedule for self-use. In research, kisspeptin has been given as a single IV bolus, as a continuous IV infusion over hours, or (kisspeptin-54) as a single subcutaneous injection to trigger ovulation. Single or pulsatile dosing is favored pharmacologically because continuous exposure desensitizes the receptor.
Cycle Length
Not applicable in the usual sense - human studies use single doses or short infusions (minutes to hours), not multi-week cycles. No evidence supports prolonged continuous dosing, which risks receptor desensitization. Research use only.
Half-Life
Kisspeptin-10: very short, reported on the order of ~4 minutes (rapid plasma clearance). Kisspeptin-54 is longer-acting (tens of minutes). The brief half-life is why human studies dose it intravenously by bolus or continuous infusion.
Administration Routes
Quick Reconstitution Calculator
Calculate syringe units instantly
Syringe Draw
10.0 units
2500 mcg/ml · 0.100 ml draw
For laboratory research use only. This tool performs reconstitution math (concentration and syringe-unit conversion) and is not dosing guidance for humans or animals.
Dosing Protocols
Research use only - this is not a directive for human use. There is no established at-home or self-administration protocol for kisspeptin, and every human study to date has delivered it intravenously in a monitored clinical setting because of its minutes-long half-life. For orientation, the lowest-intensity exposures in the literature are single intravenous boluses of kisspeptin-10 around 0.3 mcg/kg, which reliably produced a brief LH rise in men [PMID:23153270]. At a research bench, the conservative approach is the lowest characterized dose, a single administration, and direct measurement of the LH/testosterone response - rather than assuming a subcutaneous injection reproduces intravenous data, which it may not given the rapid clearance.
Higher single-bolus exposures in the literature reach about 1 mcg/kg of kisspeptin-10 intravenously, which raised LH across adult, middle-aged and older men (with the testosterone response strongest in younger men) [PMID:30590872]. Kisspeptin-54, the longer 54-amino-acid form, has been infused intravenously at roughly 1 nmol/kg/h for about 75 minutes in brain-imaging and sexual-response studies [PMID:36287566]. These are controlled research parameters, not recommendations. Repeated or continuous dosing risks KISS1R desensitization, so more-frequent administration does not linearly increase the effect and can blunt it.
The most intensive published regimens use continuous intravenous infusion of kisspeptin-10 (for example about 4 mcg/kg/h for up to 11 hours), which increased LH pulse frequency and raised testosterone in hypogonadal men with type 2 diabetes [PMID:23153270]. In IVF, kisspeptin-54 has been given as a single subcutaneous dose to trigger oocyte maturation in place of hCG, chosen specifically for its lower ovarian-hyperstimulation risk [PMID:28393578]. These are specialist clinical-research procedures that require hormone monitoring and fall outside unsupervised use. There is no validated advanced stack or long-cycle protocol for kisspeptin; its pharmacology - pulsatile signaling, rapid clearance, and desensitization with overexposure - argues against chronic tonic dosing.
Side Effects & Safety
Contraindications
Research use only; not for human consumption. Kisspeptin directly stimulates the reproductive hormone axis, so it should not be used by anyone pregnant, breastfeeding, or trying to conceive outside medical supervision, nor by anyone with hormone-sensitive conditions (for example certain reproductive cancers) without specialist oversight. Its action on the HPG axis makes it inappropriate for minors. Anyone on hormonal therapy, fertility treatment, or with pituitary or reproductive disorders should not use it outside a controlled clinical setting. No validated dosing exists for self-administration.
Additional Notes
Doses in the literature are weight-based and intravenous: kisspeptin-10 IV boluses of about 0.3 to 1 mcg/kg, or IV infusions around 4 mcg/kg/h; kisspeptin-54 IV infusion around 1 nmol/kg/h, or a single subcutaneous dose in IVF. For a 70-90 kg subject a 0.3-1 mcg/kg bolus is roughly 20-100 mcg, which is the basis for the listed range - but that is an intravenous research figure, and the minutes-long half-life means a subcutaneous injection of the same amount will not reproduce the same exposure. Kisspeptin-10 and kisspeptin-54 are not interchangeable milligram-for-milligram. Reconstitute with bacteriostatic water, keep material cold, and treat all handling as laboratory research.
Where to Buy Kisspeptin-10 (KSPTN)
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Frequently Asked Questions
What is the recommended Kisspeptin-10 (KSPTN) dosage?
The typical dose range for Kisspeptin-10 (KSPTN) is 20-100. It is usually administered No validated schedule for self-use. In research, kisspeptin has been given as a single IV bolus, as a continuous IV infusion over hours, or (kisspeptin-54) as a single subcutaneous injection to trigger ovulation. Single or pulsatile dosing is favored pharmacologically because continuous exposure desensitizes the receptor.. Always start with the lowest effective dose.
How often should I take Kisspeptin-10 (KSPTN)?
No validated schedule for self-use. In research, kisspeptin has been given as a single IV bolus, as a continuous IV infusion over hours, or (kisspeptin-54) as a single subcutaneous injection to trigger ovulation. Single or pulsatile dosing is favored pharmacologically because continuous exposure desensitizes the receptor.
Does Kisspeptin-10 (KSPTN) need to be cycled?
Yes, typical cycle length is Not applicable in the usual sense - human studies use single doses or short infusions (minutes to hours), not multi-week cycles. No evidence supports prolonged continuous dosing, which risks receptor desensitization. Research use only..
What are Kisspeptin-10 (KSPTN) side effects?
Because kisspeptin works through the body's own reproductive axis, tolerability in short-term clinical studies has been good and no serious adverse events were reported at the doses tested [PMID:36287566, PMID:28186349]. Reported or plausible effects include transient flushing or warmth, mild infusion- or injection-site reactions, headache, and short-lived changes in LH/testosterone or, in women, cycle timing. High or continuous dosing can desensitize the kisspeptin receptor and paradoxically blunt the LH response. Long-term and repeated-dose safety in humans has not been established, and there is no safety data for unsupervised subcutaneous self-administration.
Where can I buy Kisspeptin-10 (KSPTN)?
Compare 2 listings from 1 vendor on our price comparison page — starting from $29.00.
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