CJC-1295 No-DAC (Mod GRF 1-29)
GH SecretagoguePreclinical / Research peptideAlso known as: Mod GRF 1-29, CJC-1295 without DAC, Modified GRF 1-29, CJC No-DAC
CJC-1295 No-DAC (also known as Mod GRF 1-29) is a 29-amino-acid synthetic peptide modeled on the active N-terminal fragment of human Growth Hormone Releasing Hormone (GHRH 1-29). Four amino acid substitutions stabilize the peptide against enzymatic degradation but, unlike CJC-1295 with DAC, this version does NOT carry the Drug Affinity Complex (DAC) - meaning it has a short serum half-life (~30 minutes) and produces a single physiological GH pulse rather than sustained GHRH stimulation. The short pulse profile is closer to natural pulsatile GHRH biology, which makes Mod GRF 1-29 the preferred choice when researchers want to amplify natural GH peaks (e.g., paired with ipamorelin pre-bed) without continuous GHRH receptor stimulation..
Overview
At A Glance
Binds the GHRH receptor on anterior pituitary somatotrophs, triggering Gs-coupled cAMP signaling and pulsatile growth hormone release. Without DAC, the peptide clears within ~30 minutes, producing a single GH pulse and returning the GHRH receptor to baseline sensitivity. This con…
Overview
CJC-1295 No-DAC (also known as Mod GRF 1-29) is a 29-amino-acid synthetic peptide modeled on the active N-terminal fragment of human Growth Hormone Releasing Hormone (GHRH 1-29). Four amino acid substitutions stabilize the peptide against enzymatic degradation but, unlike CJC-1295 with DAC, this version does NOT carry the Drug Affinity Complex (DAC) - meaning it has a short serum half-life (~30 minutes) and produces a single physiological GH pulse rather than sustained GHRH stimulation. The short pulse profile is closer to natural pulsatile GHRH biology, which makes Mod GRF 1-29 the preferred choice when researchers want to amplify natural GH peaks (e.g., paired with ipamorelin pre-bed) without continuous GHRH receptor stimulation.
Potential Research Fields
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
Not yet available
Molecular Mass
Not yet available
Amino Acid Sequence
Dosing & Protocols
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Research
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Interactions
Contraindications
Active malignancy. Pregnancy and breastfeeding. Active diabetic retinopathy. Active acromegaly or pituitary adenoma. Caution in T2D - GH antagonizes insulin action.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
No listings found for CJC-1295 No-DAC (Mod GRF 1-29).
Research Score
0 PubMed studies
Quality Indicators
Data Completeness
50%Quick Facts
Half-Life
~30 minutes (no DAC means no extended binding)
Administration
Subcutaneous
Trial Phase
Preclinical / Research peptide
Safety Profile
Common Side Effects
- • Injection site irritation
- • Transient flushing post-injection
- • Mild headache during first 1-2 weeks
- • Mild water retention with long use
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is CJC-1295 No-DAC (Mod GRF 1-29) used for in research?
CJC-1295 No-DAC (also known as Mod GRF 1-29) is a 29-amino-acid synthetic peptide modeled on the active N-terminal fragment of human Growth Hormone Releasing Hormone (GHRH 1-29). Four amino acid substitutions stabilize the peptide against enzymatic degradation but, unlike CJC-1295 with DAC, this version does NOT carry the Drug Affinity Complex (DAC) - meaning it has a short serum half-life (~30 minutes) and produces a single physiological GH pulse rather than sustained GHRH stimulation.
The short pulse profile is closer to natural pulsatile GHRH biology, which makes Mod GRF 1-29 the preferred choice when researchers want to amplify natural GH peaks (e.g., paired with ipamorelin pre-bed) without continuous GHRH receptor stimulation.
What forms does CJC-1295 No-DAC (Mod GRF 1-29) come in?
CJC-1295 No-DAC (Mod GRF 1-29) is available in vials, capsules, and sprays forms.
How much does CJC-1295 No-DAC (Mod GRF 1-29) cost?
Pricing varies by vendor and form.
How do I compare CJC-1295 No-DAC (Mod GRF 1-29) vendors?
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