Mazdutide vs 5-Amino-1MQ
Side-by-side comparison of Mazdutide and 5-Amino-1MQ: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Mazdutide
5-Amino-1MQ
Mazdutide
Mazdutide (also known as IBI362, Lilly compound LY3305677) is a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist originally discovered by Eli Lilly and exclusively licensed to Innovent Biologics in 2019…
No vendor price on file.
Full Mazdutide profile5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to…
Lowest listed price: $29.99 across 14 listings
Full 5-Amino-1MQ profileSide-by-side comparison
| Attribute | Mazdutide | 5-Amino-1MQ |
|---|---|---|
| Category | Weight Loss | Weight Loss |
| Research Stage | Approved (China, NMPA 2025); investigational in US/EU | Preclinical |
| Mechanism of Action | Mazdutide engages two distinct receptor systems through a single peptide molecule, each contributing to metabolic effects. GLP-1 Receptor Agonism: Similar to semaglutide and liraglutide. GLP-1 binds to GLP-1 receptor (GLP1R), a Gαs-coupled G-protein-coupled… | 5-Amino-1MQ works by inhibiting nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to the nitrogen of nicotinamide (vitamin B3 amide), producing 1-methylnicotinamide (1-MNA) and… |
| Half-Life | — | ~6–12 hours (oral) |
| Typical Dose Range | Research doses — clinical trial protocols vary | 50 mg - 150 mg daily (oral or injection) |
| Dosing Frequency | — | Once daily oral |
| Administration | — | Oral |
| Side Effects | Mazdutide's side-effect profile is dominated by gastrointestinal effects similar to GLP-1 agonists, with some dual-mechanism-specific considerations from the glucagon component. Most Common Side Effects: Gastrointestinal (dose-dependent): - Nausea: 40-55% at… | The side effect profile of 5-amino-1MQ in humans is not documented because there are no human clinical trials. Rodent studies report generally good tolerability at doses producing metabolic and muscle benefits, without obvious signs of hepatotoxicity,… |
| Molecular Weight | 4563.14 g/mol | 159.21 g/mol |
| Common Vial Sizes | — | 50mg capsules, 100mg capsules |
Price History
5 data points- OF
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- Ion Peptide
- Disguised Alpha
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Mazdutide: potential benefits
- Enhanced weight loss efficacy
- Improved metabolic markers
- Superior glucose control
- Reduced cardiovascular risk factors
5-Amino-1MQ: potential benefits
- Enhanced fat metabolism and weight loss
- Increased NAD+ levels in adipose tissue
- Improved cellular energy production
- Anti-aging properties via sirtuin activation
Frequently asked
What's the difference between Mazdutide and 5-Amino-1MQ?
Mazdutide is a weight loss that mazdutide engages two distinct receptor systems through a single peptide molecule, each contributing to metabolic effects. glp-1 receptor agonism: similar to semaglutide and…. 5-Amino-1MQ is a weight loss that 5-amino-1mq works by inhibiting nicotinamide n-methyltransferase (nnmt), an enzyme that catalyzes the transfer of a methyl group from s-adenosyl-l-methionine (sam) to the nitrogen…. The two differ in mechanism, half-life (not reported vs ~6–12 hours (oral)), and typical dose range.
Which has the longer half-life, Mazdutide or 5-Amino-1MQ?
Mazdutide has a half-life of not reported. 5-Amino-1MQ has a half-life of ~6–12 hours (oral). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack Mazdutide and 5-Amino-1MQ?
Stacking depends on mechanism overlap, safety profile, and goals. Mazdutide and 5-Amino-1MQ should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.