Humanin vs Thymalin
Side-by-side comparison of Humanin and Thymalin: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Humanin
Thymalin
Humanin
Humanin is a 24-amino-acid peptide (MAPRGFSCLLLLTSEIDLPVKRRA) encoded within the mitochondrial 16S ribosomal RNA gene and translated from a short open reading frame that was not recognized as biologically active until…
Lowest listed price: $85.60 across 2 listings
Full Humanin profileThymalin
Thymalin is a thymus-derived peptide complex developed in the 1970s by Vladimir Khavinson and the Leningrad (now St. Petersburg) Institute of Bioregulation and Gerontology as part of a broader program to identify…
Lowest listed price: $44.99 across 2 listings
Full Thymalin profileSide-by-side comparison
| Attribute | Humanin | Thymalin |
|---|---|---|
| Category | Recovery | Peptides |
| Research Stage | Preclinical | Clinical (Russia-registered; not FDA-approved) |
| Mechanism of Action | Humanin signals through a heterotrimeric cell-surface receptor complex consisting of ciliary neurotrophic factor receptor alpha (CNTFR-alpha), WSX-1 (also known as IL-27R-alpha), and glycoprotein 130 (gp130) ([Ying et al., 2004]; [Hashimoto et al., 2009]).… | Thymalin's mechanism of action is less precisely defined than that of single-molecule peptides, because the active principle is a mixture of peptides acting through multiple parallel pathways rather than a single well-characterized molecular interaction. The… |
| Half-Life | Short - on the order of minutes. Wild-type 24-amino-acid humanin is rapidly cleared from plasma (rodent data); the S14G analog (HNG) is more metabolically stable. No human pharmacokinetic data exist. | Short for the individual peptides in the mixture (on the order of minutes to a few hours). Biological effects persist for weeks to months after a 10-day course, which is why Thymalin is given in discrete courses rather than continuously. |
| Typical Dose Range | Research compound — no established human doses | 5-15 mg |
| Dosing Frequency | Once daily subcutaneous in anecdotal use (some split twice daily for the short half-life); no validated human regimen | Once daily during a 10-day course; courses repeated 1-4 times per year (commonly biannually). |
| Administration | — | — |
| Side Effects | The side effect profile of humanin in humans is not established because no properly designed clinical trials have been published. The preclinical safety profile in rodents is reassuring: across numerous studies using wild-type humanin and HNG at doses… | Thymalin has a substantial safety record spanning four decades of Russian clinical use across hundreds of thousands of patients, with a relatively clean side-effect profile compared to many immunomodulatory agents. Common side effects (1-10% incidence in… |
| Molecular Weight | 2687.26 Da | Not a single value - Thymalin is a thymic polypeptide EXTRACT (a mixture), not one defined molecule; its components are low-molecular-weight peptides, generally under ~10 kDa. Characterized active dipeptides: KE (Lys-Glu, ~275 Da) and EW (Glu-Trp, ~333 Da). |
| Common Vial Sizes | — | — |
Price History
2 data points- Disguised Alpha
- LB
Price History
2 data points- Ion Peptide
- Disguised Alpha
Humanin: potential benefits
- Cytoprotective effects
- Anti-apoptotic properties
- Neuroprotective potential
- Cardioprotective effects
- Cellular stress resistance
Thymalin: potential benefits
- No structured benefit list published.
Frequently asked
What's the difference between Humanin and Thymalin?
Humanin is a recovery that humanin signals through a heterotrimeric cell-surface receptor complex consisting of ciliary neurotrophic factor receptor alpha (cntfr-alpha), wsx-1 (also known as il-27r-alpha),…. Thymalin is a peptides that thymalin's mechanism of action is less precisely defined than that of single-molecule peptides, because the active principle is a mixture of peptides acting through multiple…. The two differ in mechanism, half-life (Short - on the order of minutes. Wild-type 24-amino-acid humanin is rapidly cleared from plasma (rodent data); the S14G analog (HNG) is more metabolically stable. No human pharmacokinetic data exist. vs Short for the individual peptides in the mixture (on the order of minutes to a few hours). Biological effects persist for weeks to months after a 10-day course, which is why Thymalin is given in discrete courses rather than continuously.), and typical dose range.
Which has the longer half-life, Humanin or Thymalin?
Humanin has a half-life of Short - on the order of minutes. Wild-type 24-amino-acid humanin is rapidly cleared from plasma (rodent data); the S14G analog (HNG) is more metabolically stable. No human pharmacokinetic data exist.. Thymalin has a half-life of Short for the individual peptides in the mixture (on the order of minutes to a few hours). Biological effects persist for weeks to months after a 10-day course, which is why Thymalin is given in discrete courses rather than continuously.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Humanin or Thymalin?
Lowest listed price on BodyHackGuide: Humanin from $85.60, Thymalin from $44.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Humanin and Thymalin?
Stacking depends on mechanism overlap, safety profile, and goals. Humanin and Thymalin should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.