FOXO4-DRI vs Glutathione
Side-by-side comparison of FOXO4-DRI and Glutathione: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
FOXO4-DRI
Glutathione
FOXO4-DRI
FOXO4-DRI is a synthetic 46-amino-acid D-retro-inverso peptide designed to disrupt the interaction between the FOXO4 transcription factor and p53, with the specific goal of inducing apoptosis selectively in senescent…
Lowest listed price: $99.99 across 4 listings
Full FOXO4-DRI profileGlutathione
Glutathione is the body's most abundant intracellular antioxidant — a three-amino-acid peptide made of glutamate, cysteine, and glycine (Glu-Cys-Gly), present in millimolar concentrations inside every cell of your body.…
Lowest listed price: $29.00 across 8 listings
Full Glutathione profileSide-by-side comparison
| Attribute | FOXO4-DRI | Glutathione |
|---|---|---|
| Category | Recovery | Recovery |
| Research Stage | Preclinical | Clinical |
| Mechanism of Action | FOXO4-DRI works by disrupting the protein-protein interaction between FOXO4 (Forkhead box O4) and p53 in senescent cells, which releases p53 from nuclear sequestration and allows it to translocate to the mitochondrial outer membrane where it triggers the… | Glutathione's mechanisms extend far beyond the simple "antioxidant" label that dominates popular marketing. Understanding these mechanisms matters because they determine where supplementation is likely to help and where it is unlikely to make any difference.… |
| Half-Life | Not established in humans; no published human pharmacokinetic data. The D-retro-inverso construction confers resistance to human proteases, which in preclinical models extends the in vivo half-life from minutes (typical for comparable L-amino-acid peptides) to hours ([Baar et al., 2017](https://pubmed.ncbi.nlm.nih.gov/28340339/)). | Short: on the order of minutes for intravenous glutathione (intact GSH is cleared rapidly from plasma and cellular uptake of intact GSH is limited). Oral bioavailability is low, so tissue glutathione levels depend mainly on endogenous synthesis from cysteine, glycine, and glutamate rather than on the half-life of administered GSH. |
| Typical Dose Range | No validated human dose. Self-report: 2-15 mg SC per dose (typically 5 mg), pulsed 3-7 days every 2-6 months; no human PK data. The 5 mg/kg figure seen in some sources is a mouse research dose (Baar 2017), not a human dose. | 250 mg - 1000 mg daily (oral, IV, or nebulized) |
| Dosing Frequency | — | — |
| Administration | — | — |
| Side Effects | The side effect profile of FOXO4-DRI in humans is not documented because no clinical trials have been conducted. Rodent studies from the Baar et al. 2017 publication and subsequent work report generally acceptable tolerability at doses producing senolytic… | Glutathione has an excellent overall safety profile at typical supplement and medical doses. Serious adverse events are rare, and most side effects are mild and self-limited. That said, "safe" is not "sideeffect-free," and specific formulations and routes… |
| Molecular Weight | 5358.2 g/mol (Methods, PMID: 28340339) | 307.32 g/mol (C10H17N3O6S) |
| Common Vial Sizes | — | — |
Price History
4 data points- Half Nattys
- Ion Peptide
- Disguised Alpha
- LB
Price History
4 data points- Half Nattys
- Ion Peptide
- BHG Labs
FOXO4-DRI: potential benefits
- Selective senescent cell clearance
- Potential reversal of aging markers
- Reduced chronic inflammation
- Improved tissue function
- Hair regrowth (animal studies)
- Organ rejuvenation potential
Glutathione: potential benefits
- Powerful antioxidant protection
- Liver detoxification support
- Immune system enhancement
- Skin brightening and anti-aging
- Heavy metal chelation support
- Reduced oxidative stress
Frequently asked
What's the difference between FOXO4-DRI and Glutathione?
FOXO4-DRI is a recovery that foxo4-dri works by disrupting the protein-protein interaction between foxo4 (forkhead box o4) and p53 in senescent cells, which releases p53 from nuclear sequestration and allows…. Glutathione is a recovery that glutathione's mechanisms extend far beyond the simple "antioxidant" label that dominates popular marketing. understanding these mechanisms matters because they determine where…. The two differ in mechanism, half-life (Not established in humans; no published human pharmacokinetic data. The D-retro-inverso construction confers resistance to human proteases, which in preclinical models extends the in vivo half-life from minutes (typical for comparable L-amino-acid peptides) to hours ([Baar et al., 2017](https://pubmed.ncbi.nlm.nih.gov/28340339/)). vs Short: on the order of minutes for intravenous glutathione (intact GSH is cleared rapidly from plasma and cellular uptake of intact GSH is limited). Oral bioavailability is low, so tissue glutathione levels depend mainly on endogenous synthesis from cysteine, glycine, and glutamate rather than on the half-life of administered GSH.), and typical dose range.
Which has the longer half-life, FOXO4-DRI or Glutathione?
FOXO4-DRI has a half-life of Not established in humans; no published human pharmacokinetic data. The D-retro-inverso construction confers resistance to human proteases, which in preclinical models extends the in vivo half-life from minutes (typical for comparable L-amino-acid peptides) to hours ([Baar et al., 2017](https://pubmed.ncbi.nlm.nih.gov/28340339/)).. Glutathione has a half-life of Short: on the order of minutes for intravenous glutathione (intact GSH is cleared rapidly from plasma and cellular uptake of intact GSH is limited). Oral bioavailability is low, so tissue glutathione levels depend mainly on endogenous synthesis from cysteine, glycine, and glutamate rather than on the half-life of administered GSH.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, FOXO4-DRI or Glutathione?
Lowest listed price on BodyHackGuide: FOXO4-DRI from $99.99, Glutathione from $29.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack FOXO4-DRI and Glutathione?
Stacking depends on mechanism overlap, safety profile, and goals. FOXO4-DRI and Glutathione should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.