Cagrilintide vs Tesofensine
Side-by-side comparison of Cagrilintide and Tesofensine: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Cagrilintide
Tesofensine
Cagrilintide
Cagrilintide (also known as AM833, development code NN9838) is a long-acting amylin analog developed by Novo Nordisk as a next-generation weight-management therapy, designed to be co-administered with the GLP-1 receptor…
Lowest listed price: $49.99 across 3 listings
Full Cagrilintide profileTesofensine
Tesofensine (NS2330) is an orally-administered small-molecule triple monoamine reuptake inhibitor — it blocks the reuptake of noradrenaline, dopamine, and serotonin, placing it in the same broad pharmacologic class as…
Lowest listed price: $79.99 across 2 listings
Full Tesofensine profileSide-by-side comparison
| Attribute | Cagrilintide | Tesofensine |
|---|---|---|
| Category | Metabolic & Weight Loss | Weight Loss |
| Research Stage | Phase 3 | Preclinical |
| Mechanism of Action | Cagrilintide engages both amylin and calcitonin receptor signaling with careful receptor selectivity profiling. Native amylin binds primarily to amylin receptors - heterodimeric complexes of the calcitonin receptor (CTR) with one of three receptor… | Tesofensine blocks the presynaptic reuptake of three monoamine neurotransmitters: noradrenaline (norepinephrine), dopamine, and serotonin. By inhibiting the neurotransmitter transporters (NET, DAT, and SERT respectively), tesofensine raises synaptic… |
| Half-Life | ~159 hours (approximately 7 days) | — |
| Typical Dose Range | — | 0.25 mg - 1 mg daily (oral) |
| Dosing Frequency | Once weekly | — |
| Administration | — | — |
| Side Effects | Cagrilintide's side-effect profile is dominated by gastrointestinal effects similar to but distinct from GLP-1 agonists, with some amylin-specific considerations. Most Common Side Effects (from trials): Gastrointestinal (dose-dependent): - Nausea: in the Phase… | Tesofensine's side effect profile reflects its monoamine-enhancing mechanism. Most effects are predictable extensions of NE, DA, and 5-HT elevation. The cardiovascular profile is the dominant clinical concern and the primary reason regulators have not approved… |
| Molecular Weight | 4409 g/mol | 328.3 g/mol |
| Common Vial Sizes | — | — |
Price History
2 data points- OF
- Half Nattys
Price tracking
Cagrilintide: potential benefits
- Weight loss
- Appetite suppression (via different pathway than GLP-1)
- Glucagon suppression
- Complementary to GLP-1 agonists
Tesofensine: potential benefits
- Significant weight loss (10-15% body weight)
- Appetite suppression
- Increased metabolic rate
- Enhanced dopamine-driven motivation
Frequently asked
What's the difference between Cagrilintide and Tesofensine?
Cagrilintide is a metabolic & weight loss that cagrilintide engages both amylin and calcitonin receptor signaling with careful receptor selectivity profiling. native amylin binds primarily to amylin receptors - heterodimeric…. Tesofensine is a weight loss that tesofensine blocks the presynaptic reuptake of three monoamine neurotransmitters: noradrenaline (norepinephrine), dopamine, and serotonin. by inhibiting the neurotransmitter…. The two differ in mechanism, half-life (~159 hours (approximately 7 days) vs not reported), and typical dose range.
Which has the longer half-life, Cagrilintide or Tesofensine?
Cagrilintide has a half-life of ~159 hours (approximately 7 days). Tesofensine has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Cagrilintide or Tesofensine?
Lowest listed price on BodyHackGuide: Cagrilintide from $49.99, Tesofensine from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Cagrilintide and Tesofensine?
Stacking depends on mechanism overlap, safety profile, and goals. Cagrilintide and Tesofensine should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.