5-Amino-1MQ vs Tesofensine
Side-by-side comparison of 5-Amino-1MQ and Tesofensine: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
5-Amino-1MQ
Tesofensine
5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to…
Lowest listed price: $29.99 across 14 listings
Full 5-Amino-1MQ profileTesofensine
Tesofensine (NS2330) is an orally-administered small-molecule triple monoamine reuptake inhibitor — it blocks the reuptake of noradrenaline, dopamine, and serotonin, placing it in the same broad pharmacologic class as…
Lowest listed price: $79.99 across 2 listings
Full Tesofensine profileSide-by-side comparison
| Attribute | 5-Amino-1MQ | Tesofensine |
|---|---|---|
| Category | Weight Loss | Weight Loss |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | 5-Amino-1MQ works by inhibiting nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to the nitrogen of nicotinamide (vitamin B3 amide), producing 1-methylnicotinamide (1-MNA) and… | Tesofensine blocks the presynaptic reuptake of three monoamine neurotransmitters: noradrenaline (norepinephrine), dopamine, and serotonin. By inhibiting the neurotransmitter transporters (NET, DAT, and SERT respectively), tesofensine raises synaptic… |
| Half-Life | ~6–12 hours (oral) | — |
| Typical Dose Range | 50 mg - 150 mg daily (oral or injection) | 0.25 mg - 1 mg daily (oral) |
| Dosing Frequency | Once daily oral | — |
| Administration | Oral | — |
| Side Effects | The side effect profile of 5-amino-1MQ in humans is not documented because there are no human clinical trials. Rodent studies report generally good tolerability at doses producing metabolic and muscle benefits, without obvious signs of hepatotoxicity,… | Tesofensine's side effect profile reflects its monoamine-enhancing mechanism. Most effects are predictable extensions of NE, DA, and 5-HT elevation. The cardiovascular profile is the dominant clinical concern and the primary reason regulators have not approved… |
| Molecular Weight | 159.21 g/mol | 298.24 g/mol |
| Common Vial Sizes | 50mg capsules, 100mg capsules | — |
Price History
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Price tracking
5-Amino-1MQ: potential benefits
- Enhanced fat metabolism and weight loss
- Increased NAD+ levels in adipose tissue
- Improved cellular energy production
- Anti-aging properties via sirtuin activation
Tesofensine: potential benefits
- Significant weight loss (10-15% body weight)
- Appetite suppression
- Increased metabolic rate
- Enhanced dopamine-driven motivation
Frequently asked
What's the difference between 5-Amino-1MQ and Tesofensine?
5-Amino-1MQ is a weight loss that 5-amino-1mq works by inhibiting nicotinamide n-methyltransferase (nnmt), an enzyme that catalyzes the transfer of a methyl group from s-adenosyl-l-methionine (sam) to the nitrogen…. Tesofensine is a weight loss that tesofensine blocks the presynaptic reuptake of three monoamine neurotransmitters: noradrenaline (norepinephrine), dopamine, and serotonin. by inhibiting the neurotransmitter…. The two differ in mechanism, half-life (~6–12 hours (oral) vs not reported), and typical dose range.
Which has the longer half-life, 5-Amino-1MQ or Tesofensine?
5-Amino-1MQ has a half-life of ~6–12 hours (oral). Tesofensine has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, 5-Amino-1MQ or Tesofensine?
Lowest listed price on BodyHackGuide: 5-Amino-1MQ from $29.99, Tesofensine from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack 5-Amino-1MQ and Tesofensine?
Stacking depends on mechanism overlap, safety profile, and goals. 5-Amino-1MQ and Tesofensine should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Before you buy 5-Amino-1MQ or Tesofensine
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Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.