--- title: "Retatrutide Dosage Calculator: Units & Titration Chart" url: https://www.bodyhackguide.co/tools/dosage/retatrutide description: "Free Retatrutide dosage calculator. Convert any weekly dose to insulin units and ml, see the once weekly titration schedule, and find out how long a vial lasts." lang: en --- Skip to content Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Retatrutide Dosage Calculator LY3437943 (investigational) Retatrutide (the triple GLP-1/GIP/glucagon agonist, code-named LY3437943) is still investigational. There's no FDA label yet, so the numbers below come from Eli Lilly's phase 2 trials rather than a pharmacy insert. In the obesity trial, people started at 2 mg once weekly and stepped up every 4 weeks or so toward a 4, 8, or 12 mg maintenance dose. The 12 mg group lost about 24% of their body weight by week 48. Enter your vial size and target dose and the calculator tells you exactly what to draw. Common Retatrutide doses (once weekly) mg ml mg Concentration 5.00 mg/ml 5000 mcg/ml Volume per Dose 0.400 ml Draw this amount Syringe Draw 40 IU 100-unit insulin syringe Supply per Vial 5.0 weeks At 2 mg/week Draw to 0 10 20 30 40 50 60 70 80 90 100 40.0 units Draw to this line ## Retatrutide Titration Schedule & Dose Chart Syringe units below assume a 10 mg vial in 2 ml of BAC water (5.0 mg/ml). Adjust the calculator above for your own mix. | Week | Weekly Dose | Volume | Syringe Draw | | --- | --- | --- | --- | | 1-4 | 2 mg | 0.40 ml | 40 IU | | 5-8 | 4 mg | 0.80 ml | 80 IU | | 9-12 | 8 mg | 1.60 ml | 160 IU | | 13+ | 12 mg | 2.40 ml | 240 IU | Maximum studied dose: 12 mg once weekly. Step up only if side effects are tolerable. Retatrutide is investigational and not FDA-approved. These figures come from published clinical-trial data, not a pharmacy label, and are for research and educational purposes only. This is not medical advice. ## Retatrutide Dosing FAQ ### How do you dose retatrutide? ### What is the retatrutide titration schedule? ### How many units is a 4 mg dose of retatrutide? ### How long does a retatrutide vial last? ### Is retatrutide approved? ## Research basis - Jastreboff AM et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity. NEJM 2023;389(6):514-526.: https://doi.org/10.1056/NEJMoa2301972 - Rosenstock J et al. Retatrutide for type 2 diabetes: a phase 2 trial. Lancet 2023;402(10401):529-544.: https://doi.org/10.1016/S0140-6736(23)01053-X ### More Retatrutide Resources Retatrutide compound page: https://www.bodyhackguide.co/compound/retatrutide Retatrutide dosage guide & protocols: https://www.bodyhackguide.co/guides/dosage/retatrutide How to reconstitute Retatrutide: https://www.bodyhackguide.co/tools/reconstitution/retatrutide Where to buy Retatrutide: https://www.bodyhackguide.co/buy/retatrutide Retatrutide vs Tirzepatide: full comparison: https://www.bodyhackguide.co/compare/retatrutide-vs-tirzepatide Free 2026 Peptide Cheat Sheet (PDF) Reconstitution math, concentration charts, half-lives, and vendor links. The reference we wish we had on day one. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) Image: BodyHackGuide (https://www.bodyhackguide.co/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide #### Explore - Compare prices: https://www.bodyhackguide.co/compare - Research suppliers: https://www.bodyhackguide.co/vendors - Deals: https://www.bodyhackguide.co/deals - Coupons: https://www.bodyhackguide.co/coupons - Nootropics: https://www.bodyhackguide.co/nootropics - Brain health: https://www.bodyhackguide.co/brain-health - Blog: https://www.bodyhackguide.co/blog - Guides: https://www.bodyhackguide.co/guides #### Tools - Reconstitution: https://www.bodyhackguide.co/tools/reconstitution - Half-life visualizer: https://www.bodyhackguide.co/tools/halflife - COA lookup: https://www.bodyhackguide.co/tools/coa - Cost calculator: https://www.bodyhackguide.co/tools/cost-calculator - Stack builder: https://www.bodyhackguide.co/stack-builder - All tools →: https://www.bodyhackguide.co/tools #### Trust & vendors - Vendor directory: https://www.bodyhackguide.co/vendors - Trust scorecard: https://www.bodyhackguide.co/vendors/scorecard - Vendor trust badge: https://www.bodyhackguide.co/vendors/get-vetted - Scoring methodology: https://www.bodyhackguide.co/vendors/methodology - Peptide cheatsheet: https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download #### Company - About: https://www.bodyhackguide.co/about - Affiliate disclosure: https://www.bodyhackguide.co/affiliate-disclosure - Editorial standards: https://www.bodyhackguide.co/editorial-standards - Creators: https://www.bodyhackguide.co/creators - Coaches: https://www.bodyhackguide.co/coaches - Privacy: https://www.bodyhackguide.co/privacy - Terms: https://www.bodyhackguide.co/terms - Full site directory →: https://www.bodyhackguide.co/site-directory **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology), and we earn a commission from purchases made through our links at no extra cost to you. Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell, distribute, or promote any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. · Terms (https://www.bodyhackguide.co/terms) · Privacy (https://www.bodyhackguide.co/privacy) ## Structured data ```json [ { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "How do you dose retatrutide?", "acceptedAnswer": { "@type": "Answer", "text": "It's a once-weekly subcutaneous injection. In the trials almost everyone started at 2 mg and stayed there about 4 weeks before going up, and that slow ramp is what kept the nausea in check. The maintenance doses studied were 4 mg, 8 mg, and 12 mg. Bigger doses meant more weight loss but also more stomach trouble. Set your target dose in the calculator to see the exact syringe volume." } }, { "@type": "Question", "name": "What is the retatrutide titration schedule?", "acceptedAnswer": { "@type": "Answer", "text": "Roughly: 2 mg/week for weeks 1 to 4, then 4 mg through week 8, 8 mg through week 12, and 12 mg from week 13 on. You only step up every 4 weeks if the side effects are tolerable. Plenty of people stop at 4 or 8 mg once that dose is doing the job. Nothing says you have to reach 12 mg." } }, { "@type": "Question", "name": "How many units is a 4 mg dose of retatrutide?", "acceptedAnswer": { "@type": "Answer", "text": "Depends how you mixed the vial. A 10 mg vial in 2 ml of bacteriostatic water comes out to 5 mg/ml, so 4 mg is 0.8 ml, or 80 units on a 100-unit insulin syringe. Use more or less water and that number shifts. The calculator handles whatever mix you actually used." } }, { "@type": "Question", "name": "How long does a retatrutide vial last?", "acceptedAnswer": { "@type": "Answer", "text": "Divide the vial size by your weekly dose. A 10 mg vial at 2 mg/week is five weeks; at 4 mg/week it's about two and a half. One catch: reconstituted retatrutide only keeps about 4 weeks in the fridge (2 to 8°C), so a low-dose vial can expire before you finish it. Mix a smaller vial or a more concentrated solution if you're dosing low." } }, { "@type": "Question", "name": "Is retatrutide approved?", "acceptedAnswer": { "@type": "Answer", "text": "No. As of 2026 it's still in clinical trials, not approved by the FDA, and not sold in pharmacies. Everything here comes from published phase 2 research and is for education only. 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