--- title: "NA-Semax: Dosage & Side Effects | BodyHackGuide" url: https://www.bodyhackguide.co/compound/na-semax description: "NA-Semax: dosing protocols, mechanism & side effects, 3 PubMed results." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # NA-Semax Nootropic Peptide: https://www.bodyhackguide.co/wiki#cat-nootropic-peptide Status Preclinical,, not approved for human use Evidence Not graded on a research bench yet NA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s. Reviewed 25 October 2026 01 Overview ## What NA-Semax is The aspartate addition at the N-terminus is reported to improve metabolic stability against aminopeptidase cleavage, extending the in vivo half-life from minutes (parent Semax) to plausibly tens of minutes after intranasal dosing. Read the full overview Show less As of 2026, NA-Semax sits in the same research-peptide tier as standard Semax — it is **not FDA-approved** for any indication and is sold as a research chemical with limited peer-reviewed primary literature on the acetylated variant specifically. Most published Semax pharmacology applies by analogy, with the caveat that the half-life difference may shift optimal dosing frequency. Reported nonclinical pharmacology mirrors Semax: BDNF upregulation, dopaminergic modulation in mesolimbic circuits, and increased serotonin and dopamine turnover in the cortex and hippocampus. The N-acetyl modification is reported to improve blood-brain-barrier transport, though direct PK comparisons in published literature remain thin. ### How it works **Mechanism of action - pharmacological summary (research-use-only):** Almost all mechanistic data come from the parent peptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro); the N-acetylated analogue has no dedicated published pharmacology of its own, so the profile below is inferred from Semax, with N-terminal acetylation added for enzymatic stability. Read the full mechanism Show less - **BDNF / neurotrophin modulation** - parent Semax is reported to raise brain-derived neurotrophic factor and related neurotrophins (NGF, NT-3) and their receptors in cortex and hippocampus, a neuroplasticity pathway characterized mainly in rodent ischemia models (Stavchansky 2011, PMID 22295573). Benefits for human cognition or mood have not been demonstrated in controlled trials. - **Monoaminergic modulation** - Semax raises striatal serotonin turnover (5-HIAA) and potentiates amphetamine-evoked dopamine release, but does not raise baseline dopamine on its own (Eremin 2005, PMID 16362768). There is no published evidence for D2-receptor sensitization or a discrete VTANAc "drive" circuit. - **Anti-inflammatory** - in rat cerebral ischemia-reperfusion, Semax blunts the ischemia-induced rise in proinflammatory transcripts including Il1a, Il1b and Il6 plus the chemokines Ccl3/Cxcl2; TNF- message was expressed too weakly to quantify in that study (Dergunova 2021, PMID 34097675). - **Aminopeptidase resistance** - N-terminal acetylation is expected to slow aminopeptidase cleavage and extend in-vivo persistence versus unmodified Semax, but no published head-to-head pharmacokinetic comparison exists, so the magnitude is unverified. 02 Research Free with email ## What the research shows No research bench grades NA-Semax yet. Benches compare compounds people pair, with the evidence for each. ### Unlock the Research section Enter your email to keep reading. It is free, and it opens these sections on every compound page in this browser. - Safety and side effects - A link to the PubMed results You also get the free peptide cheat sheet by email. Unsubscribe anytime. Have an account? Sign in (https://www.bodyhackguide.co/auth) 03 Safety ## NA-Semax side effects and interactions ### Side effects Low risk Stop use if - Pregnancy/lactation - Active mania - Known peptide allergy #### Common - Mild nasal irritation - Brief alertness spike #### Less common - Headache at high doses - Sleep disruption if dosed late ### Who should not use it Contraindications **Research-use-only; not for human or veterinary use.** No formal contraindication data exist for N-acetyl-Semax. As a precaution, this compound should not be used by: - Pregnant or breastfeeding individuals (no reproductive or developmental safety data). - Anyone with a known hypersensitivity to Semax, ACTH(4-10)-fragment peptides, or product excipients. - People with active psychiatric instability (e.g., mania or psychosis) or poorly controlled anxiety, given the activating/stimulatory profile of the parent peptide. - Anyone with significant nasal or sinus pathology if using the intranasal route. Read all the contraindications and cautions Show less No human drug-interaction studies have been performed. The monoaminergic activity seen with parent Semax - potentiation of amphetamine-evoked dopamine release (Eremin 2005, PMID 16362768) - is a theoretical basis for caution when combined with stimulants or other monoaminergic/serotonergic agents. ### Interactions Not in our record Our record lists no interactions for NA-Semax. That means none are recorded here, not that none exist. This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. Order Bloodwork (https://anabolicinsights.ai/?ref=nwm2zjb) 04 Dosing Free with email ## NA-Semax dosage and protocols ### Unlock the dosing protocols - Dose, route, how often and how long - Beginner, intermediate and advanced protocols - Stacking notes 05 Prices ## NA-Semax prices No listings We do not track a vendor for NA-Semax yet, so this page states no price. 06 Chemistry ## Chemistry and structure Molecular formula C40H56N12O11 Molecular mass ~856.0 g/mol (C39H53N9O11S) Amino acid sequence Ac-Met-Glu-His-Phe-Pro-Gly-Pro (Ac-MEHFPGP) 07 Related ## Related to NA-Semax ### In the same category - AdalankPreclinical / Research compound Adalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).: https://www.bodyhackguide.co/compound/adalank - AdamaxPreclinical / Research compound Adamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.: https://www.bodyhackguide.co/compound/adamax - CerebrolysinClinical Cerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins.: https://www.bodyhackguide.co/compound/cerebrolysin - CortexinMarketed in Russia/CIS Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions.: https://www.bodyhackguide.co/compound/cortexin - NA-Semax AmidatePreclinical NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides.: https://www.bodyhackguide.co/compound/na-semax-amidate - P-21Preclinical P-21 is a synthetic cyclic dipeptide — Cyclo(L-prolyl-glycine) — derived from the Selank/Semax C-terminal Pro-Gly-Pro motif.: https://www.bodyhackguide.co/compound/p21 All compounds (https://www.bodyhackguide.co/wiki) ### Compare NA-Semax - Alternatives to NA-Semax: https://www.bodyhackguide.co/alternatives-to/na-semax ### Research tools - Peptide Calculator Reconstitution and syringe units: https://www.bodyhackguide.co/tools/reconstitution - Reconstitution Guide How to mix, step by step: https://www.bodyhackguide.co/guides/how-to-reconstitute-peptides - Nasal Spray Calc mL per actuation: https://www.bodyhackguide.co/tools/intranasal - Half-Life Visualizer Decay curves: https://www.bodyhackguide.co/tools/halflife All articles (https://www.bodyhackguide.co/blog) 08 Questions ## Frequently asked questions What is NA-Semax used for in research? NA-Semax is the **N-acetyl-l-aspartyl variant of Semax (https://www.bodyhackguide.co/compound/semax)** — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s. The aspartate addition at the N-terminus is reported to improve metabolic stability against aminopeptidase cleavage, extending the in vivo half-life from minutes (parent Semax) to plausibly tens of minutes after intranasal dosing. What forms does NA-Semax come in? NA-Semax is available in vials, capsules, and sprays forms. How much does NA-Semax cost? BodyHackGuide tracks no vendor for NA-Semax yet, so no price is stated. How do I compare NA-Semax vendors? Compare prices, payment methods, shipping, and COA scores across 0 vendors. Related ## Articles on NA-Semax - The Best Peptide Nasal Sprays of 2026, Ranked by Evidence Peptides, 21 April 2026: https://www.bodyhackguide.co/blog/best-peptide-nasal-sprays-2026 Free 2026 Peptide Cheat Sheet (PDF) 38 compounds and blends: vial sizes, BAC water volumes, dosing ranges and bloodwork markers. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). 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