--- title: "TB-500 Dosage Guide [2026] | BodyHackGuide" url: https://www.bodyhackguide.co/guides/dosage/tb-500 description: "Complete TB-500 dosage guide with protocols, calculator, safety info, and where to buy. Updated for 2026." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Injury, Repair & Recovery Preclinical # TB-500 Dosage Guide: Protocols, Calculator & Safety Everything you need to know about TB-500 dosing: protocols, safety, and where to buy. Dose Range 2000-5000 mcg (2-5 mg) subcutaneous 2x weekly loading; 2000 mcg (2 mg) weekly maintenance Frequency 2x per week during loading; 1x per week maintenance Cycle Length 4–8 weeks loading, then 2–4 weeks maintenance Half-Life Plasma half-life is short - full-length thymosin beta-4 clears on the order of hours, while the short LKKTETQ actin-binding fragment clears within minutes. Tissue-level regenerative effects persist substantially longer than plasma exposure. ## Administration Routes Subcutaneous Intramuscular ### Quick Reconstitution Calculator Calculate syringe units instantly Syringe Draw 10.0 units 2500 mcg/ml · 0.100 ml draw Full Tool (https://www.bodyhackguide.co/tools/reconstitution) For laboratory research use only. This tool performs reconstitution math (concentration and syringe-unit conversion) and is not dosing guidance for humans or animals. ## Dosing Protocols Beginner 2.5 mg subcutaneous injection twice per week for 4–6 weeks. Space injections 3–4 days apart. Standard 5 mg subcutaneous twice per week for 6 weeks loading, then 2.5 mg once per week for 4 weeks maintenance. Advanced 5 mg subcutaneous twice per week for 8 weeks, stacked with BPC-157 (500 mcg 2x/day). Transition to 5 mg once weekly for ongoing maintenance. ## Weight-Based Dosing Not typically weight-based. Standard flat dosing of 2–5 mg per injection. ## Commonly Stacked With Commonly paired with BPC-157 (the "Wolverine stack"). The evidence for the pair is one rat Achilles tendon study of BPC-157 with a product the authors call synthetic thymosin beta-4 (TB-500), in which the combination added nothing over either peptide alone (PMID: 42542926), and one uncontrolled knee-pain series that combined BPC-157 with thymosin beta-4 in four of sixteen patients, form unstated (PMID: 34324435); the FDA file also holds a FAERS report of significant adverse reactions after a BPC-157 plus TB-500 research vial, causality not established. Pairing with GHK-Cu rests on mechanism alone; no study of that pair was located. The Tissue Repair Bench (https://www.bodyhackguide.co/stack/tissue-repair-bench) lays the evidence out name by name, without dosing. **Related Compounds** - TB-500 is most commonly stacked with BPC-157 (https://www.bodyhackguide.co/compound/bpc-157) but appears in broader tissue-regeneration protocols: GHK-Cu (https://www.bodyhackguide.co/compound/ghk-cu) for collagen remodeling, MOTS-c (https://www.bodyhackguide.co/compound/mots-c) for mitochondrial support during high-repair phases, IGF-1 LR3 (https://www.bodyhackguide.co/compound/igf-1-lr3) for local anabolism, and the CJC-1295 (https://www.bodyhackguide.co/compound/cjc-1295) + Ipamorelin (https://www.bodyhackguide.co/compound/ipamorelin) GH stack for systemic IGF-1 elevation. Senolytic adjuncts: Fisetin (https://www.bodyhackguide.co/compound/fisetin) and the Dasatinib (https://www.bodyhackguide.co/compound/dasatinib) + quercetin combo are proposed on mechanism for chronic-injury sites; no study of any of these with TB-500 was located. ## Side Effects & Safety Generally well-tolerated. Occasional mild headache, nausea, or lethargy. Localized irritation at injection site. Rare: flu-like symptoms, temporary fatigue during initial use. Contraindications Active cancer (theoretical concern with tissue growth promotion). Pregnancy or breastfeeding. Known hypersensitivity to thymosin beta-4 fragments. Check interactions with the Interaction Checker → (https://www.bodyhackguide.co/tools/interaction-checker) ## Additional Notes Reconstitute with bacteriostatic water. A 5mg vial with 1mL BAC water = 5mg per mL. TB-500 is systemic and does not need to be injected near the injury site. Store reconstituted vials refrigerated (2–8°C) and use within 3–4 weeks. Where to Buy TB-500 Compare 8 listings across 4 vendors, from $29.00 https://www.bodyhackguide.co/compound/tb-500 ## Frequently Asked Questions What is the recommended TB-500 dosage? The typical dose range for TB-500 is 2000-5000 mcg (2-5 mg) subcutaneous 2x weekly loading; 2000 mcg (2 mg) weekly maintenance. It is usually administered 2x per week during loading; 1x per week maintenance. Always start with the lowest effective dose. How often should I take TB-500? Does TB-500 need to be cycled? Yes, typical cycle length is 4–8 weeks loading, then 2–4 weeks maintenance. What are TB-500 side effects? Where can I buy TB-500? Compare 8 listings from 4 vendors on our price comparison page, starting from $29.00. TB-500 Full Profile Research data, mechanisms, and pricing https://www.bodyhackguide.co/compound/tb-500 Interaction Checker Check drug & compound interactions https://www.bodyhackguide.co/tools/interaction-checker ## Related Dosage Guides All Guides (https://www.bodyhackguide.co/guides) ### BPC-157 Injury, Repair & Recovery · Dosage Guide https://www.bodyhackguide.co/guides/dosage/bpc-157 Free 2026 Peptide Cheat Sheet (PDF) 38 compounds and blends: vial sizes, BAC water volumes, dosing ranges and bloodwork markers. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) Image: BodyHackGuide (https://www.bodyhackguide.co/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide #### Explore - Compare prices: https://www.bodyhackguide.co/compare - Vendors: https://www.bodyhackguide.co/vendors - Deals: https://www.bodyhackguide.co/deals - Coupons: https://www.bodyhackguide.co/coupons - Nootropics: https://www.bodyhackguide.co/nootropics - Brain health: https://www.bodyhackguide.co/brain-health - Blog: https://www.bodyhackguide.co/blog - Guides: https://www.bodyhackguide.co/guides #### Tools - Reconstitution: https://www.bodyhackguide.co/tools/reconstitution - Half-life visualizer: https://www.bodyhackguide.co/tools/halflife - COA reader: https://www.bodyhackguide.co/tools/coa - Cost calculator: https://www.bodyhackguide.co/tools/cost-calculator - Stack builder: https://www.bodyhackguide.co/stack-builder - All tools: https://www.bodyhackguide.co/tools #### Trust & vendors - Vendor directory: https://www.bodyhackguide.co/vendors - Trust scorecard: https://www.bodyhackguide.co/vendors/scorecard - Vendor trust badge: https://www.bodyhackguide.co/vendors/get-vetted - Scoring methodology: https://www.bodyhackguide.co/vendors/methodology - Peptide cheat sheet: https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download #### Company - About: https://www.bodyhackguide.co/about - Affiliate disclosure: https://www.bodyhackguide.co/affiliate-disclosure - Editorial standards: https://www.bodyhackguide.co/editorial-standards - Creators: https://www.bodyhackguide.co/creators - Coaches: https://www.bodyhackguide.co/coaches - 1-on-1 coaching: https://www.bodyhackguide.co/coaching - Privacy: https://www.bodyhackguide.co/privacy - Terms: https://www.bodyhackguide.co/terms - Full site directory: https://www.bodyhackguide.co/site-directory **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology), and we earn a commission from purchases made through some of our links at no extra cost to you. Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. · Terms (https://www.bodyhackguide.co/terms) · Privacy (https://www.bodyhackguide.co/privacy) ## Structured data ```json [ { "@context": "https://schema.org", "@type": "Article", "headline": "TB-500 Dosage Guide [2026]", "description": "Complete TB-500 dosage guide with protocols, calculator, safety info, and where to buy. 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