--- title: "ProVigorous Blend: Research & Side Effects | BodyHackGuide" url: https://www.bodyhackguide.co/compound/provigorous-blend description: "ProVigorous Blend: mechanism, clinical studies & side effects. Compare 1 current vendor prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # ProVigorous Blend Performance: https://www.bodyhackguide.co/wiki#cat-performance Status No published studies of the blend,, not approved for human use Evidence Not graded on a research bench yet ProVigorous Blend is a liquid sold for research in a 20 mL vial whose label lists L-arginine 100 mg, L-citrulline 100 mg, L-carnitine 250 mg/mL, an MIC complex of methionine, inositol and choline 120 mg/mL, N-acetyl-L-tyrosine 20 mg, ATP 40 mg and AMP 5 mg/mL. Reviewed 4 November 2026 01 Overview ## What ProVigorous Blend is The label mixes amounts in mg with amounts in mg/mL and does not say whether the mg figures are per mL or per vial. A PubMed search on 27 October 2026 found no published study of ProVigorous Blend or of this combination, so the evidence comes from separate studies of each ingredient, most of them using oral doses (PMID: 22137067, PMID: 32359762). The FDA has approved no product with this composition (Drugs@FDA, searched 27 October 2026). ### How it works ### What the label lists ProVigorous Blend's label gives these amounts for a 20 mL vial, with the units exactly as printed: L-arginine 100 mg, L-citrulline 100 mg, L-carnitine 250 mg/mL, MIC complex (methionine, inositol and choline) 120 mg/mL, N-acetyl-L-tyrosine 20 mg, ATP 40 mg and AMP 5 mg/mL. The label does not say whether the amounts given in mg are per mL or per vial, and it does not give the split of methionine, inositol and choline within the MIC complex. No study of these ingredients together was found in PubMed on 27 October 2026, so this section describes each one on its own. BodyHackGuide's Vasodrive Amino Blend (https://www.bodyhackguide.co/compound/vasodrive-blend) page covers a related blend of arginine, citrulline, ornithine and glutamine. Read the full mechanism Show less ### L-arginine and L-citrulline L-arginine is the substrate of nitric oxide synthase, the enzyme that makes nitric oxide (PMID: 22137067). Taken by mouth, much of a dose of L-arginine is removed by the enzyme arginase in the gut before it reaches the circulation, while L-citrulline is readily absorbed and partly converted to L-arginine; in a crossover study of 20 healthy volunteers, oral L-citrulline raised plasma L-arginine more than oral L-arginine did (PMID: 17662090). Given intravenously, arginine reaches the blood directly: the FDA label for intravenous arginine hydrochloride (R-Gene 10) says the infusion often produces a pronounced rise in plasma growth hormone in people with intact pituitary function, the basis of its approved use as a diagnostic test (R-Gene 10 label, FDA, version of 2 April 2024). BodyHackGuide's L-citrulline (https://www.bodyhackguide.co/compound/l-citrulline) guide covers citrulline in detail. ### L-carnitine The carnitine system carries fatty acids, as acylcarnitine esters, across the mitochondrial membrane for breakdown (beta-oxidation) (PMID: 29551309). Oral L-carnitine supplements are 14 to 18 percent bioavailable, and the kidneys reabsorb filtered carnitine efficiently until blood levels rise, after which clearance increases and blood levels fall back quickly (PMID: 15591001). In healthy men given 5-hour intravenous L-carnitine infusions, muscle carnitine rose only when insulin was also held high; with fasting insulin levels, high blood carnitine did not change muscle carnitine (PMID: 16368715). A follow-up study found that only insulin concentrations of about 90 mU/L or more stimulated muscle carnitine uptake (PMID: 17047160). Both studies come from the Greenhaff group at the University of Nottingham. BodyHackGuide's L-carnitine (https://www.bodyhackguide.co/compound/l-carnitine) guide covers oral use. ### MIC complex: methionine, inositol and choline BodyHackGuide covers the methionine, inositol and choline combination in its Lipo-C (https://www.bodyhackguide.co/compound/lipo-c) guide. Methionine is an essential amino acid whose metabolism forms homocysteine as an intermediate (PMID: 15870821). Inositol, most often as myo-inositol, has been tested in randomized trials in women with polycystic ovary syndrome (PMID: 36703143), and choline is an essential nutrient with roles from cell structure to neurotransmitter synthesis (PMID: 19906248). See the inositol (https://www.bodyhackguide.co/compound/inositol) and choline (https://www.bodyhackguide.co/compound/choline) guides. ### N-acetyl-L-tyrosine Tyrosine is the precursor of the neurotransmitters dopamine and norepinephrine (PMID: 26424423). N-acetyl-L-tyrosine is an acetylated form used in intravenous nutrition solutions because acetylation makes tyrosine more soluble (PMID: 7815670). In a study of 11 healthy volunteers given 5 g of N-acetyl-L-tyrosine or of N-acetylcysteine by 4-hour intravenous infusion, plasma tyrosine rose by 25 percent with N-acetyl-L-tyrosine while 56 percent of the infused amount appeared in urine within 4 hours (PMID: 2507878). In another infusion study, N-acetyl-L-tyrosine did not raise plasma tyrosine in healthy people or in patients with liver failure, and most of it was lost in urine (PMID: 7705801). BodyHackGuide covers the oral forms in its N-acetyl-L-tyrosine (https://www.bodyhackguide.co/nootropic/nalt) and L-tyrosine (https://www.bodyhackguide.co/compound/l-tyrosine) guides. ### ATP and AMP Outside cells, ATP (adenosine triphosphate) and its breakdown product adenosine act on purinergic P1 and P2 receptors, and a cascade of enzymes on cell surfaces (ectonucleotidases) breaks extracellular ATP down (PMID: 10473017). Bolus injections of ATP and adenosine are used to diagnose and treat paroxysmal supraventricular tachycardia, a fast heart rhythm (PMID: 10473017). During 30-hour intravenous ATP infusions in lung cancer patients, ATP was taken up by red blood cells, whose ATP content rose 53 to 69 percent above baseline, and plasma uric acid rose (PMID: 10853877). Taken by mouth, ATP was not bioavailable: in a crossover trial in 8 healthy volunteers, blood ATP did not rise after 5,000 mg given in enteric-coated pellets or through a tube into the small intestine, while uric acid, the end product of ATP breakdown, rose by about 50 percent with release in the upper small intestine (PMID: 22510240). In people, AMP (adenosine monophosphate) is used as an inhaled bronchial challenge test because it narrows the airways in people with asthma but not in people without it (PMID: 16458886); as a treatment, a 1985 controlled trial gave it by injection into muscle for shingles (PMID: 3968773). ### Oral studies and an injection Route changes what reaches the blood for several of these ingredients: oral arginine is partly removed by gut arginase (PMID: 17662090), oral carnitine is 14 to 18 percent bioavailable (PMID: 15591001), oral ATP did not raise blood ATP (PMID: 22510240), and infused N-acetyl-L-tyrosine was largely lost in urine (PMID: 2507878). Because ProVigorous Blend is sold as a solution in a vial, oral supplement studies of its ingredients do not show what an injection of it would do, and no study measuring that was found in PubMed on 27 October 2026. ### Studied for - Nitric oxide physiology - Sports nutrition - Fatty acid metabolism - Parenteral nutrition - Purinergic signaling - Cancer cachexia ### Benefits listed - L-arginine: systolic and diastolic blood pressure in a 2011 meta-analysis of 11 oral trials (PMID: 22137067) - L-arginine: aerobic and anaerobic test performance in a 2020 meta-analysis of oral studies whose methods a 2025 published comment criticized (PMID: 32370176, PMID: 40733000) - L-citrulline: strength and power output in a 2019 meta-analysis of 12 oral studies (PMID: 30895562) - L-carnitine: body weight and fat mass in a 2020 meta-analysis of 37 oral trials (PMID: 32359762) Show 3 more Show less - Myo-inositol: menstrual cycle regularity in women with polycystic ovary syndrome in a 2023 meta-analysis of oral trials (PMID: 36703143) - Intravenous ATP: body weight, muscle strength and quality of life in a 58-patient lung cancer trial (PMID: 10675381) - Intramuscular AMP: pain and skin healing in a 32-patient shingles trial from 1985 (PMID: 3968773) 02 Research Free with email ## What the research shows No research bench grades ProVigorous Blend yet. Benches compare compounds people pair, with the evidence for each. ### Unlock the research summary Enter your email to keep reading. It is free, and it opens these sections on every compound page in this browser. - A summary of the key research - Safety and side effects You also get the free peptide cheat sheet by email. Unsubscribe anytime. Have an account? Sign in (https://www.bodyhackguide.co/auth) 03 Safety ## ProVigorous Blend side effects and interactions ### Side effects #### Common - Intravenous arginine hydrochloride: nausea and vomiting, headache, numbness, local vein irritation and flushing in about 3 percent of patients across 1,670 infusions (R-Gene 10 label, FDA) - Intravenous ATP: mild, transient side effects in 36 percent of 176 infusion courses, which resolved within minutes of slowing the infusion (PMID: 10853877) - Levocarnitine: transient nausea and vomiting, and body odor (Carnitor label, FDA) #### Serious events - Oral L-arginine after a first heart attack: 6 deaths in the L-arginine group against none on placebo in a 153-patient trial (PMID: 16391217) - Intravenous arginine hydrochloride: extravasation with skin necrosis needing surgery, anaphylaxis, and deaths from overdose in children (R-Gene 10 label, FDA) - Injectable levocarnitine: anaphylaxis, laryngeal edema and bronchospasm, mostly in dialysis patients, and seizures (Carnitor label, FDA) ### Who should not use it Contraindications In the VINTAGE MI trial, more patients died on oral L-arginine than on placebo after a recent first heart attack, and the trial stopped enrolling (PMID: 16391217). Read all the contraindications and cautions Show less Oral L-arginine lowered blood pressure by about 5.4/2.7 mmHg in a meta-analysis (PMID: 22137067) and L-citrulline lowered systolic pressure by about 4.1 mmHg in another (PMID: 30788274), so low blood pressure and drugs that lower it (including nitrates and PDE5 inhibitors) are mechanism-based reasons for caution. The R-Gene 10 label says the nitrogen load of intravenous arginine should be considered in patients with impaired kidney function and its chloride content in patients with electrolyte imbalance (R-Gene 10 label, FDA), and carnitine is cleared through the kidneys (PMID: 15591001). The FDA label for levocarnitine reports seizures, and more frequent or more severe seizures in people with pre-existing seizure disorders (Carnitor label, FDA). Heart rhythm disorders call for caution: injected ATP and adenosine act on heart rhythm, which is why bolus injections are used to diagnose and treat paroxysmal supraventricular tachycardia (PMID: 10473017). Inhaled AMP narrows the airways in people with asthma but not in people without it, which is why it is used as a bronchial challenge test (PMID: 16458886). Gout or high uric acid is another reason for caution: intravenous ATP raised plasma uric acid in lung cancer patients (PMID: 10853877), and ATP released in the small intestine raised uric acid in healthy volunteers (PMID: 22510240). The R-Gene 10 label carries a warning about children: overdose of intravenous arginine in children has caused death (R-Gene 10 label, FDA). ### Interactions 2 pairings in our record: 1 with a caution and 1 to monitor. - Nitrates, PDE5 inhibitors and blood-pressure medicines Caution Oral L-arginine and L-citrulline lowered blood pressure in meta-analyses (PMID: 22137067, PMID: 30788274), and nitroglycerin acts through conversion to nitric oxide (PMID: 1928201); additive blood-pressure lowering is a mechanism-based caution, and no study of these combinations with ProVigorous Blend was found in PubMed on 27 October 2026. - Warfarin and other coumarin anticoagulants Monitor The FDA label for levocarnitine reports INR rises in patients on warfarin (Carnitor label, FDA), and case reports describe L-carnitine strengthening the anticoagulant acenocoumarol (PMID: 8429297, PMID: 15340883). This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. Order Bloodwork (https://anabolicinsights.ai/?ref=nwm2zjb) 04 Prices ## ProVigorous Blend prices 1 listing from 1 vendor, opening in the Featured order. Pack prices $69.99 Lowest per mg Not listed Vendors 1 Listings 1 (liquid) Prices as the vendors list them, last recorded 4 November 2026. Form Sort | Vendor | Product | Price | Buy | | --- | --- | --- | --- | | Image: Disguised Alpha logo (https://disguisedalpha.com/wp-content/uploads/2026/10/disguised-logo-3x.webp) Disguised Alpha: https://www.bodyhackguide.co/vendors/disguised-alpha | ProVigorous blend (arginine, citrulline, carnitine, MIC, N-acetyl-tyrosine, ATP, AMP), 20 mL liquid, 20 mL In stock | $69.99 No mg count | Buy ProVigorous blend (arginine, citrulline, carnitine, MIC, N-acetyl-tyrosine, ATP, AMP), 20 mL at Disguised Alpha: https://disguisedalpha.com/product/provigorous/?coupon=reddit | Vendors selling ProVigorous Blend(1: trust score, certificates, payment, shipping) - Disguised Alpha (https://www.bodyhackguide.co/vendors/disguised-alpha)1 listing, from $69.99 Trust Score 50/100 (https://www.bodyhackguide.co/vendor-trust-scorecard), 0 of 36 certificate records read, pays by card, crypto, bank transfer, ships to the US, the EU, the UK Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. How we score these vendors (https://www.bodyhackguide.co/vendors/scorecard) Review ProVigorous Blend ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with ProVigorous Blend. 05 Chemistry ## Chemistry and structure Half-life No published human value for ProVigorous Blend. Values for single ingredients: after a slow intravenous injection of levocarnitine, the apparent terminal elimination half-life was 17.4 hours, uncorrected for the body's own carnitine (Carnitor label, FDA); after 30-hour intravenous ATP infusions in lung cancer patients, the extra ATP in red blood cells disappeared with a half-time of about 5.9 hours, measured in 5 patients (PMID: 10853877). 06 Related ## Related to ProVigorous Blend ### In the same category - ACE-031Phase 2 ACE-031 (international nonproprietary name ramatercept) is a dimeric fusion protein that joins the extracellular domain of human activin receptor type IIB to the Fc region of human IgG1, developed by Acceleron Pharma as a decoy receptor that traps myostatin and related growth factors before they can suppress muscle growth.: https://www.bodyhackguide.co/compound/ace-031 - ITPPPreclinical ITPP (myo-inositol trispyrophosphate, sometimes written myo-inositol tripyrophosphate or OXY111A in NormOxys trial documents) is a small-molecule allosteric effector of hemoglobin designed to increase the amount of oxygen red blood cells release to tissues.: https://www.bodyhackguide.co/compound/itpp - L-CitrullinePhase 3 L-citrulline is a non-protein amino acid, found in high concentrations in watermelon, that the small intestine makes and the kidneys convert into arginine, the amino acid the body uses to make nitric oxide.: https://www.bodyhackguide.co/compound/l-citrulline - LGD-4033 (Ligandrol)Phase 2 LGD-4033, usually sold as ligandrol, is a nonsteroidal selective androgen receptor modulator that Viking Therapeutics took into clinical development under the code VK5211 (NCT02578095).: https://www.bodyhackguide.co/compound/lgd-4033 - Ostarine (Enobosarm, MK-2866)Phase 3 Ostarine is the market name for enobosarm, a nonsteroidal selective androgen receptor modulator first developed by GTx Inc under the codes GTx-024, MK-2866 and S-22.: https://www.bodyhackguide.co/compound/ostarine - PEG-MGFPreclinical PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage.: https://www.bodyhackguide.co/compound/peg-mgf All compounds (https://www.bodyhackguide.co/wiki) ### Compare ProVigorous Blend - Alternatives to ProVigorous Blend: https://www.bodyhackguide.co/alternatives-to/provigorous-blend ### Research tools - Peptide Calculator Reconstitution and syringe units: https://www.bodyhackguide.co/tools/reconstitution - Reconstitution Guide How to mix, step by step: https://www.bodyhackguide.co/guides/how-to-reconstitute-peptides - Nasal Spray Calc mL per actuation: https://www.bodyhackguide.co/tools/intranasal - Half-Life Visualizer Decay curves: https://www.bodyhackguide.co/tools/halflife All articles (https://www.bodyhackguide.co/blog) 07 Questions ## Frequently asked questions What is ProVigorous Blend? ProVigorous Blend is a liquid sold for research in a 20 mL vial whose label lists L-arginine, L-citrulline, L-carnitine, an MIC complex of methionine, inositol and choline, N-acetyl-L-tyrosine, ATP and AMP. The ProVigorous Blend label mixes amounts in mg and in mg/mL, so the amount of several ingredients per mL is unclear. Has ProVigorous Blend been studied? No study of ProVigorous Blend or of its combination of ingredients was found in PubMed on 27 October 2026. The evidence for ProVigorous Blend's ingredients comes from separate studies of each compound, most of them using oral doses (PMID: 22137067, PMID: 32359762). Why does the route matter for ProVigorous Blend's ingredients? Oral ATP did not raise blood ATP in 8 healthy volunteers, while intravenous ATP raised ATP in red blood cells in cancer patients (PMID: 22510240, PMID: 10853877). Oral L-arginine is partly removed by gut arginase before it reaches the blood (PMID: 17662090). In two short infusion studies, intravenous N-acetyl-L-tyrosine raised plasma tyrosine by 25 percent or not at all, and much of it was lost in urine (PMID: 2507878, PMID: 7705801); in adults on continuous intravenous nutrition, about 35 percent of N-acetyl-L-tyrosine was lost in urine (PMID: 14621123). Do the L-arginine and L-citrulline in ProVigorous Blend improve exercise performance? A 2020 meta-analysis found that oral L-arginine improved aerobic and anaerobic test performance, but a 2025 published comment argued that the meta-analysis contains errors that distort its estimates (PMID: 32370176, PMID: 40733000). A 2019 meta-analysis found a small benefit of oral L-citrulline on strength and power output (PMID: 30895562), and a 2022 meta-analysis found no benefit of oral L-citrulline on aerobic performance (PMID: 36079738). The exercise meta-analyses of oral L-arginine and oral L-citrulline did not test ProVigorous Blend or injected arginine or citrulline. What safety warnings apply to injected arginine and carnitine? The FDA label for intravenous arginine hydrochloride (R-Gene 10) warns of tissue damage when the hypertonic solution leaks outside the vein and of deaths from overdose in children (R-Gene 10 label, FDA). For injectable levocarnitine, the FDA label reports anaphylaxis, mostly in dialysis patients, and seizures (Carnitor label, FDA). In the VINTAGE MI trial, oral L-arginine after a heart attack was linked to more deaths than placebo (PMID: 16391217). Is ProVigorous Blend FDA approved? ProVigorous Blend is not FDA approved, and Drugs@FDA lists no approved product with its composition (searched 27 October 2026). The FDA defines a dietary supplement as a product intended for ingestion, so the oral supplement status of arginine, citrulline or carnitine does not extend to an injectable solution such as ProVigorous Blend (FDA, Questions and Answers on Dietary Supplements). How many vendors sell ProVigorous Blend, and what does it cost per mg? 1 of the vendors BodyHackGuide tracks list ProVigorous Blend (1 listing). The lowest listed price BodyHackGuide has recorded for ProVigorous Blend is $69.99. No ProVigorous Blend listing recorded as in stock carries a milligram count, so BodyHackGuide states no price per milligram for ProVigorous Blend. Which vendors have third-party COAs for ProVigorous Blend on file at BodyHackGuide? BodyHackGuide holds no third-party certificate records for ProVigorous Blend. Each vendor page on BodyHackGuide shows how many certificate records BodyHackGuide holds for that vendor. Free 2026 Peptide Cheat Sheet (PDF) 38 compounds and blends: vial sizes, BAC water volumes, dosing ranges and bloodwork markers. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. 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The label mixes amounts in mg with amounts in mg/mL and does not say whether the mg figures are per mL or per vial. A PubMed search on 27 October 2026 found no published study of ProVigorous Blend or of this combination, so the evidence comes from separate studies of each ingredient, most of them using oral doses (PMID: 22137067, PMID: 32359762). The FDA has approved no product with this composition (Drugs@FDA, searched 27 October 2026).", "activeIngredient": "ProVigorous Blend", "mechanismOfAction": "What the label lists ProVigorous Blend's label gives these amounts for a 20 mL vial, with the units exactly as printed: L-arginine 100 mg, L-citrulline 100 mg, L-carnitine 250 mg/mL, MIC complex (methionine, inositol and choline) 120 mg/mL, N-acetyl-L-tyrosine 20 mg, ATP 40 mg and AMP 5 mg/mL. The label does not say whether the amounts given in mg are per mL or per vial, and it does not give the split of methionine, inositol and choline within the MIC complex. No study of these ingredients together was found in PubMed on 27 October 2026, so this section describes each one on its own. BodyHackGuide's Vasodrive Amino Blend page covers a related blend of arginine, citrulline, ornithine and glutamine. L-arginine and L-citrulline L-arginine is the substrate of nitric oxide synthase, the enzyme that makes nitric oxide (PMID: 22137067). Taken by mouth, much of a dose of L-arginine is removed by the enzyme arginase in the gut before it reaches the circulation, while L-citrulline is readily absorbed and partly converted to L-arginine; in a crossover study of 20 healthy volunteers, oral L-citrulline raised plasma L-arginine more than oral L-arginine did (PMID: 17662090). Given intravenously, arginine reaches the blood directly: the FDA label for intravenous arginine hydrochloride (R-Gene 10) says the infusion often produces a pronounced rise in plasma growth hormone in people with intact pituitary function, the basis of its approved use as a diagnostic test (R-Gene 10 label, FDA, version of 2 April 2024). BodyHackGuide's L-citrulline guide covers citrulline in detail. L-carnitine The carnitine system carries fatty acids, as acylcarnitine esters, across the mitochondrial membrane for breakdown (beta-oxidation) (PMID: 29551309). Oral L-carnitine supplements are 14 to 18 percent bioavailable, and the kidneys reabsorb filtered carnitine efficiently until blood levels rise, after which clearance increases and blood levels fall back quickly (PMID: 15591001). In healthy men given 5-hour intravenous L-carnitine infusions, muscle carnitine rose only when insulin was also held high; with fasting insulin levels, high blood carnitine did not change muscle carnitine (PMID: 16368715). A follow-up study found that only insulin concentrations of about 90 mU/L or more stimulated muscle carnitine uptake (PMID: 17047160). Both studies come from the Greenhaff group at the University of Nottingham. BodyHackGuide's L-carnitine guide covers oral use. MIC complex: methionine, inositol and choline BodyHackGuide covers the methionine, inositol and choline combination in its Lipo-C guide. Methionine is an essential amino acid whose metabolism forms homocysteine as an intermediate (PMID: 15870821). Inositol, most often as myo-inositol, has been tested in randomized trials in women with polycystic ovary syndrome (PMID: 36703143), and choline is an essential nutrient with roles from cell structure to neurotransmitter synthesis (PMID: 19906248). See the inositol and choline guides. N-acetyl-L-tyrosine Tyrosine is the precursor of the neurotransmitters dopamine and norepinephrine (PMID: 26424423). N-acetyl-L-tyrosine is an acetylated form used in intravenous nutrition solutions because acetylation makes tyrosine more soluble (PMID: 7815670). In a study of 11 healthy volunteers given 5 g of N-acetyl-L-tyrosine or of N-acetylcysteine by 4-hour intravenous infusion, plasma tyrosine rose by 25 percent with N-acetyl-L-tyrosine while 56 percent of the infused amount appeared in urine within 4 hours (PMID: 2507878). In another infusion study, N-acetyl-L-tyrosine did not raise plasma tyrosine in healthy people or in patients with liver failure, and most of it was lost in urine (PMID: 7705801). BodyHackGuide covers the oral forms in its N-acetyl-L-tyrosine and L-tyrosine guides. ATP and AMP Outside cells, ATP (adenosine triphosphate) and its breakdown product adenosine act on purinergic P1 and P2 receptors, and a cascade of enzymes on cell surfaces (ectonucleotidases) breaks extracellular ATP down (PMID: 10473017). Bolus injections of ATP and adenosine are used to diagnose and treat paroxysmal supraventricular tachycardia, a fast heart rhythm (PMID: 10473017). During 30-hour intravenous ATP infusions in lung cancer patients, ATP was taken up by red blood cells, whose ATP content rose 53 to 69 percent above baseline, and plasma uric acid rose (PMID: 10853877). Taken by mouth, ATP was not bioavailable: in a crossover trial in 8 healthy volunteers, blood ATP did not rise after 5,000 mg given in enteric-coated pellets or through a tube into the small intestine, while uric acid, the end product of ATP breakdown, rose by about 50 percent with release in the upper small intestine (PMID: 22510240). In people, AMP (adenosine monophosphate) is used as an inhaled bronchial challenge test because it narrows the airways in people with asthma but not in people without it (PMID: 16458886); as a treatment, a 1985 controlled trial gave it by injection into muscle for shingles (PMID: 3968773). Oral studies and an injection Route changes what reaches the blood for several of these ingredients: oral arginine is partly removed by gut arginase (PMID: 17662090), oral carnitine is 14 to 18 percent bioavailable (PMID: 15591001), oral ATP did not raise blood ATP (PMID: 22510240), and infused N-acetyl-L-tyrosine was largely lost in urine (PMID: 2507878). Because ProVigorous Blend is sold as a solution in a vial, oral supplement studies of its ingredients do not show what an injection of it would do, and no study measuring that was found in PubMed on 27 October 2026.", "dosageForm": "liquid", "legalStatus": "Not approved for human use (research chemical)", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is ProVigorous Blend?", "acceptedAnswer": { "@type": "Answer", "text": "ProVigorous Blend is a liquid sold for research in a 20 mL vial whose label lists L-arginine, L-citrulline, L-carnitine, an MIC complex of methionine, inositol and choline, N-acetyl-L-tyrosine, ATP and AMP. The ProVigorous Blend label mixes amounts in mg and in mg/mL, so the amount of several ingredients per mL is unclear." } }, { "@type": "Question", "name": "Has ProVigorous Blend been studied?", "acceptedAnswer": { "@type": "Answer", "text": "No study of ProVigorous Blend or of its combination of ingredients was found in PubMed on 27 October 2026. The evidence for ProVigorous Blend's ingredients comes from separate studies of each compound, most of them using oral doses (PMID: 22137067, PMID: 32359762)." } }, { "@type": "Question", "name": "Why does the route matter for ProVigorous Blend's ingredients?", "acceptedAnswer": { "@type": "Answer", "text": "Oral ATP did not raise blood ATP in 8 healthy volunteers, while intravenous ATP raised ATP in red blood cells in cancer patients (PMID: 22510240, PMID: 10853877). Oral L-arginine is partly removed by gut arginase before it reaches the blood (PMID: 17662090). In two short infusion studies, intravenous N-acetyl-L-tyrosine raised plasma tyrosine by 25 percent or not at all, and much of it was lost in urine (PMID: 2507878, PMID: 7705801); in adults on continuous intravenous nutrition, about 35 percent of N-acetyl-L-tyrosine was lost in urine (PMID: 14621123)." } }, { "@type": "Question", "name": "Do the L-arginine and L-citrulline in ProVigorous Blend improve exercise performance?", "acceptedAnswer": { "@type": "Answer", "text": "A 2020 meta-analysis found that oral L-arginine improved aerobic and anaerobic test performance, but a 2025 published comment argued that the meta-analysis contains errors that distort its estimates (PMID: 32370176, PMID: 40733000). A 2019 meta-analysis found a small benefit of oral L-citrulline on strength and power output (PMID: 30895562), and a 2022 meta-analysis found no benefit of oral L-citrulline on aerobic performance (PMID: 36079738). The exercise meta-analyses of oral L-arginine and oral L-citrulline did not test ProVigorous Blend or injected arginine or citrulline." } }, { "@type": "Question", "name": "What safety warnings apply to injected arginine and carnitine?", "acceptedAnswer": { "@type": "Answer", "text": "The FDA label for intravenous arginine hydrochloride (R-Gene 10) warns of tissue damage when the hypertonic solution leaks outside the vein and of deaths from overdose in children (R-Gene 10 label, FDA). For injectable levocarnitine, the FDA label reports anaphylaxis, mostly in dialysis patients, and seizures (Carnitor label, FDA). In the VINTAGE MI trial, oral L-arginine after a heart attack was linked to more deaths than placebo (PMID: 16391217)." } }, { "@type": "Question", "name": "Is ProVigorous Blend FDA approved?", "acceptedAnswer": { "@type": "Answer", "text": "ProVigorous Blend is not FDA approved, and Drugs@FDA lists no approved product with its composition (searched 27 October 2026). The FDA defines a dietary supplement as a product intended for ingestion, so the oral supplement status of arginine, citrulline or carnitine does not extend to an injectable solution such as ProVigorous Blend (FDA, Questions and Answers on Dietary Supplements)." } }, { "@type": "Question", "name": "How many vendors sell ProVigorous Blend, and what does it cost per mg?", "acceptedAnswer": { "@type": "Answer", "text": "1 of the vendors BodyHackGuide tracks list ProVigorous Blend (1 listing). The lowest listed price BodyHackGuide has recorded for ProVigorous Blend is $69.99. No ProVigorous Blend listing recorded as in stock carries a milligram count, so BodyHackGuide states no price per milligram for ProVigorous Blend." } }, { "@type": "Question", "name": "Which vendors have third-party COAs for ProVigorous Blend on file at BodyHackGuide?", "acceptedAnswer": { "@type": "Answer", "text": "BodyHackGuide holds no third-party certificate records for ProVigorous Blend. Each vendor page on BodyHackGuide shows how many certificate records BodyHackGuide holds for that vendor." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 273 compound profiles, interactive dosing calculators, vendor price comparisons, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. We earn a commission on purchases through some of our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] ```