--- title: "LGD-4033 Dosage Guide [2026] | BodyHackGuide" url: https://www.bodyhackguide.co/guides/dosage/lgd-4033 description: "Complete LGD-4033 (Ligandrol) dosage guide with protocols, calculator, safety info, and where to buy. Updated for 2026." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Performance Phase 2 # LGD-4033 (Ligandrol) Dosage Guide: Protocols, Calculator & Safety Everything you need to know about LGD-4033 (Ligandrol) dosing: protocols, safety, and where to buy. Half-Life Long elimination half-life in humans with dose-proportional accumulation over 21 days of daily dosing in healthy young men; the report describes the profile without giving a single value in its summary (PMID: 22459616) ## Administration Routes Oral Dosage Calculator Calculate exact dosing for LGD-4033 (Ligandrol). https://www.bodyhackguide.co/tools/dosage Dosing data for LGD-4033 (Ligandrol) is being researched. Check the compound page (https://www.bodyhackguide.co/compound/lgd-4033) for the latest information. ## Side Effects & Safety In the 21-day phase 1 study in healthy young men, adverse event frequency was similar to placebo and no drug-related serious adverse events occurred, but total testosterone, sex hormone binding globulin, HDL cholesterol and triglycerides fell dose-dependently (PMID: 22459616). Outside research settings the picture is worse: biopsy-confirmed cholestatic liver injury has been reported repeatedly (PMID: 32637435, PMID: 36257328, PMID: 39421081), including cases with ductopenia and recovery over about three months (PMID: 34141767). A hospital case series of liver injury from anabolic steroids, SARMs and bodybuilding supplements reported a median 175 days to normal liver biochemistry and one liver transplant among 23 patients (PMID: 38372012). A single-subject report of ligandrol with MK-677 recorded large rises in liver enzymes and falls in HDL cholesterol and testosterone (PMID: 36303408). In male rats, endurance fell and lipid and hormonal profiles worsened (PMID: 40087185). Contraindications Mechanism-based: contraindicated in pregnancy because androgen receptor agonists can virilize a female fetus, and in men with known or suspected prostate cancer. Existing liver disease or raised transaminases is a case-report-based reason to avoid it (PMID: 32637435, PMID: 36257328). Because it suppresses endogenous testosterone and gonadotropins (PMID: 22459616), it works against men being treated for infertility. Prohibited for athletes in tested sport at all times (PMID: 28137616). Check interactions with the Interaction Checker → (https://www.bodyhackguide.co/tools/interaction-checker) ## Frequently Asked Questions What is the recommended LGD-4033 (Ligandrol) dosage? Dosage for LGD-4033 (Ligandrol) varies by protocol. Consult a qualified healthcare provider. How often should I take LGD-4033 (Ligandrol)? Administration frequency depends on the specific protocol. Consult current research literature. Does LGD-4033 (Ligandrol) need to be cycled? Cycling requirements depend on the protocol. Follow established research guidelines. What are LGD-4033 (Ligandrol) side effects? Where can I buy LGD-4033 (Ligandrol)? Compare 1 listings from 1 vendor on our price comparison page, starting from $84.99. LGD-4033 (Ligandrol) Full Profile Research data, mechanisms, and pricing https://www.bodyhackguide.co/compound/lgd-4033 Interaction Checker Check drug & compound interactions https://www.bodyhackguide.co/tools/interaction-checker ## Related Dosage Guides All Guides (https://www.bodyhackguide.co/guides) ### ITPP Performance · Dosage Guide https://www.bodyhackguide.co/guides/dosage/itpp ### PEG-MGF Performance · Dosage Guide https://www.bodyhackguide.co/guides/dosage/peg-mgf ### SLU-PP-332 Performance · Dosage Guide https://www.bodyhackguide.co/guides/dosage/slu-pp-332 Free 2026 Peptide Cheat Sheet (PDF) 38 compounds and blends: vial sizes, BAC water volumes, dosing ranges and bloodwork markers. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) Image: BodyHackGuide (https://www.bodyhackguide.co/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide #### Explore - Compare prices: https://www.bodyhackguide.co/compare - Vendors: https://www.bodyhackguide.co/vendors - Deals: https://www.bodyhackguide.co/deals - Coupons: https://www.bodyhackguide.co/coupons - Nootropics: https://www.bodyhackguide.co/nootropics - Brain health: https://www.bodyhackguide.co/brain-health - Blog: https://www.bodyhackguide.co/blog - Guides: https://www.bodyhackguide.co/guides #### Tools - Reconstitution: https://www.bodyhackguide.co/tools/reconstitution - Half-life visualizer: https://www.bodyhackguide.co/tools/halflife - COA reader: https://www.bodyhackguide.co/tools/coa - Cost calculator: https://www.bodyhackguide.co/tools/cost-calculator - Stack builder: https://www.bodyhackguide.co/stack-builder - All tools: https://www.bodyhackguide.co/tools #### Trust & vendors - Vendor directory: https://www.bodyhackguide.co/vendors - Trust scorecard: https://www.bodyhackguide.co/vendors/scorecard - Vendor trust badge: https://www.bodyhackguide.co/vendors/get-vetted - Scoring methodology: https://www.bodyhackguide.co/vendors/methodology - Peptide cheat sheet: https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download #### Company - About: https://www.bodyhackguide.co/about - Affiliate disclosure: https://www.bodyhackguide.co/affiliate-disclosure - Editorial standards: https://www.bodyhackguide.co/editorial-standards - Creators: https://www.bodyhackguide.co/creators - Coaches: https://www.bodyhackguide.co/coaches - 1-on-1 coaching: https://www.bodyhackguide.co/coaching - Privacy: https://www.bodyhackguide.co/privacy - Terms: https://www.bodyhackguide.co/terms - Full site directory: https://www.bodyhackguide.co/site-directory **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology), and we earn a commission from purchases made through some of our links at no extra cost to you. Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. · Terms (https://www.bodyhackguide.co/terms) · Privacy (https://www.bodyhackguide.co/privacy) ## Structured data ```json [ { "@context": "https://schema.org", "@type": "Article", "headline": "LGD-4033 Dosage Guide [2026]", "description": "Complete LGD-4033 (Ligandrol) dosage guide with protocols, calculator, safety info, and where to buy. 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Outside research settings the picture is worse: biopsy-confirmed cholestatic liver injury has been reported repeatedly (PMID: 32637435, PMID: 36257328, PMID: 39421081), including cases with ductopenia and recovery over about three months (PMID: 34141767). A hospital case series of liver injury from anabolic steroids, SARMs and bodybuilding supplements reported a median 175 days to normal liver biochemistry and one liver transplant among 23 patients (PMID: 38372012). A single-subject report of ligandrol with MK-677 recorded large rises in liver enzymes and falls in HDL cholesterol and testosterone (PMID: 36303408). 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