--- title: "L-Glutamine Dosage Guide [2026] | BodyHackGuide" url: https://www.bodyhackguide.co/guides/dosage/l-glutamine description: "Complete L-Glutamine dosage guide with protocols, calculator, safety info, and where to buy. Updated for 2026." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Supplement Approved (prescription) # L-Glutamine Dosage Guide: Protocols, Calculator & Safety Everything you need to know about L-Glutamine dosing: protocols, safety, and where to buy. Half-Life About 1 hour (terminal elimination half-life after an intravenous bolus, from published studies summarized in the Endari prescribing information, FDA label version of 20 June 2025); after a single oral dose of 0.1 g per kilogram, plasma levels peak at about 30 minutes ## Administration Routes Oral Enteral Intravenous Dosage Calculator Calculate exact dosing for L-Glutamine. https://www.bodyhackguide.co/tools/dosage Dosing data for L-Glutamine is being researched. Check the compound page (https://www.bodyhackguide.co/compound/l-glutamine) for the latest information. ## Side Effects & Safety \## Prescription use in sickle cell disease In the two placebo-controlled trials behind the Endari approval (187 patients on Endari, 111 on placebo), the adverse reactions seen in more than 10 percent of patients on Endari were constipation (21 versus 18 percent on placebo), nausea (19 versus 14 percent), headache (18 versus 15 percent), abdominal pain (17 versus 16 percent), cough (16 versus 14 percent), pain in the arms or legs (13 versus 7 percent), back pain (12 versus 5 percent) and chest pain (12 versus 8 percent); 2.7 percent stopped treatment because of an adverse reaction, and three deaths occurred on Endari against none on placebo, none judged related to treatment (Endari FDA label). The phase 3 trial reported low-grade nausea, noncardiac chest pain, fatigue and musculoskeletal pain more often with glutamine than with placebo (PMID: 30021096). ## Critical illness In the REDOXS trial of 1,223 ventilated patients with multiorgan failure, glutamine given intravenously and enterally was linked to a trend toward higher 28-day mortality and to significantly higher in-hospital and 6-month mortality (PMID: 23594003). A post hoc analysis found the greatest potential for harm in patients who already had kidney dysfunction at enrollment (PMID: 24803474). In the MetaPlus trial, a tube-feeding formula enriched with glutamine and other nutrients was linked to higher 6-month mortality in medical patients (PMID: 25096691). Other large trials found no difference in mortality (PMID: 21415104; PMID: 36082909), and the burns trial found no substantial difference in serious adverse events (PMID: 36082909). ## Oral use in other trials In the post-infectious IBS trial, adverse events and study-drug discontinuation were low and similar with glutamine and placebo, with no serious adverse events (PMID: 30108163), and the low FODMAP add-on trial reported no serious adverse events (PMID: 34977110). Early studies in healthy volunteers found no clinical toxicity and no rise in ammonia or glutamate after oral glutamine loads or glutamine-enriched intravenous nutrition (PMID: 2119459; PMID: 2122714). In a small trial of glutamine-supplemented intravenous nutrition in adults with inflammatory bowel disease, three central catheter infections occurred in the glutamine group and none in the control group, a difference that was not statistically significant (risk ratio 7.00, 95 percent confidence interval 0.40 to 122.44) (PMID: 26853855). ## Liver disease In people with liver cirrhosis, a 20 g oral glutamine load roughly doubled arterial ammonia, which did not happen in healthy controls (PMID: 24078984). Contraindications The Endari prescribing information lists no contraindications (Endari FDA label). Cautions in the literature: - Critical illness with multiorgan failure: high-dose glutamine (0.35 g per kilogram per day intravenously plus 30 g per day enterally in the REDOXS trial) was linked to higher mortality (PMID: 23594003; PMID: 24803474), with the greatest potential for harm in patients with kidney dysfunction at enrollment (PMID: 24803474). - Liver cirrhosis: a 20 g oral glutamine load raised arterial ammonia and the share of patients with minimal hepatic encephalopathy (PMID: 24078984). - Kidney or liver impairment: Endari pharmacokinetics have not been studied in these groups, and the phase 3 trial excluded patients with renal insufficiency or uncontrolled liver disease (Endari FDA label). - Pregnancy and breastfeeding: the Endari label reports no human data on use in pregnancy and no animal reproduction studies, and no data on presence in human milk (Endari FDA label). Check interactions with the Interaction Checker → (https://www.bodyhackguide.co/tools/interaction-checker) ## Frequently Asked Questions What is the recommended L-Glutamine dosage? Dosage for L-Glutamine varies by protocol. Consult a qualified healthcare provider. How often should I take L-Glutamine? Administration frequency depends on the specific protocol. Consult current research literature. Does L-Glutamine need to be cycled? Cycling requirements depend on the protocol. Follow established research guidelines. What are L-Glutamine side effects? Where can I buy L-Glutamine? Visit our vendor directory to compare the vendors we track and their Trust Scores. L-Glutamine Full Profile Research data, mechanisms, and pricing https://www.bodyhackguide.co/compound/l-glutamine Interaction Checker Check drug & compound interactions https://www.bodyhackguide.co/tools/interaction-checker Free 2026 Peptide Cheat Sheet (PDF) 38 compounds and blends: vial sizes, BAC water volumes, dosing ranges and bloodwork markers. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) Image: BodyHackGuide (https://www.bodyhackguide.co/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide #### Explore - Compare prices: https://www.bodyhackguide.co/compare - Vendors: https://www.bodyhackguide.co/vendors - Deals: https://www.bodyhackguide.co/deals - Coupons: https://www.bodyhackguide.co/coupons - Nootropics: https://www.bodyhackguide.co/nootropics - Brain health: https://www.bodyhackguide.co/brain-health - Blog: https://www.bodyhackguide.co/blog - Guides: https://www.bodyhackguide.co/guides #### Tools - Reconstitution: https://www.bodyhackguide.co/tools/reconstitution - Half-life visualizer: https://www.bodyhackguide.co/tools/halflife - COA reader: https://www.bodyhackguide.co/tools/coa - Cost calculator: https://www.bodyhackguide.co/tools/cost-calculator - Stack builder: https://www.bodyhackguide.co/stack-builder - All tools: https://www.bodyhackguide.co/tools #### Trust & vendors - Vendor directory: https://www.bodyhackguide.co/vendors - Trust scorecard: https://www.bodyhackguide.co/vendors/scorecard - Vendor trust badge: https://www.bodyhackguide.co/vendors/get-vetted - Scoring methodology: https://www.bodyhackguide.co/vendors/methodology - Peptide cheat sheet: https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download #### Company - About: https://www.bodyhackguide.co/about - Affiliate disclosure: https://www.bodyhackguide.co/affiliate-disclosure - Editorial standards: https://www.bodyhackguide.co/editorial-standards - Creators: https://www.bodyhackguide.co/creators - Coaches: https://www.bodyhackguide.co/coaches - 1-on-1 coaching: https://www.bodyhackguide.co/coaching - Privacy: https://www.bodyhackguide.co/privacy - Terms: https://www.bodyhackguide.co/terms - Full site directory: https://www.bodyhackguide.co/site-directory **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology), and we earn a commission from purchases made through some of our links at no extra cost to you. Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. · Terms (https://www.bodyhackguide.co/terms) · Privacy (https://www.bodyhackguide.co/privacy) ## Structured data ```json [ { "@context": "https://schema.org", "@type": "Article", "headline": "L-Glutamine Dosage Guide [2026]", "description": "Complete L-Glutamine dosage guide with protocols, calculator, safety info, and where to buy. 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Consult a qualified healthcare provider." } }, { "@type": "Question", "name": "How often should I take L-Glutamine?", "acceptedAnswer": { "@type": "Answer", "text": "Administration frequency depends on the specific protocol. Consult current research literature." } }, { "@type": "Question", "name": "Does L-Glutamine need to be cycled?", "acceptedAnswer": { "@type": "Answer", "text": "Cycling requirements depend on the protocol. Follow established research guidelines." } }, { "@type": "Question", "name": "What are L-Glutamine side effects?", "acceptedAnswer": { "@type": "Answer", "text": "## Prescription use in sickle cell disease\n\nIn the two placebo-controlled trials behind the Endari approval (187 patients on Endari, 111 on placebo), the adverse reactions seen in more than 10 percent of patients on Endari were constipation (21 versus 18 percent on placebo), nausea (19 versus 14 percent), headache (18 versus 15 percent), abdominal pain (17 versus 16 percent), cough (16 versus 14 percent), pain in the arms or legs (13 versus 7 percent), back pain (12 versus 5 percent) and chest pain (12 versus 8 percent); 2.7 percent stopped treatment because of an adverse reaction, and three deaths occurred on Endari against none on placebo, none judged related to treatment (Endari FDA label). The phase 3 trial reported low-grade nausea, noncardiac chest pain, fatigue and musculoskeletal pain more often with glutamine than with placebo (PMID: 30021096).\n\n## Critical illness\n\nIn the REDOXS trial of 1,223 ventilated patients with multiorgan failure, glutamine given intravenously and enterally was linked to a trend toward higher 28-day mortality and to significantly higher in-hospital and 6-month mortality (PMID: 23594003). A post hoc analysis found the greatest potential for harm in patients who already had kidney dysfunction at enrollment (PMID: 24803474). In the MetaPlus trial, a tube-feeding formula enriched with glutamine and other nutrients was linked to higher 6-month mortality in medical patients (PMID: 25096691). Other large trials found no difference in mortality (PMID: 21415104; PMID: 36082909), and the burns trial found no substantial difference in serious adverse events (PMID: 36082909).\n\n## Oral use in other trials\n\nIn the post-infectious IBS trial, adverse events and study-drug discontinuation were low and similar with glutamine and placebo, with no serious adverse events (PMID: 30108163), and the low FODMAP add-on trial reported no serious adverse events (PMID: 34977110). Early studies in healthy volunteers found no clinical toxicity and no rise in ammonia or glutamate after oral glutamine loads or glutamine-enriched intravenous nutrition (PMID: 2119459; PMID: 2122714). In a small trial of glutamine-supplemented intravenous nutrition in adults with inflammatory bowel disease, three central catheter infections occurred in the glutamine group and none in the control group, a difference that was not statistically significant (risk ratio 7.00, 95 percent confidence interval 0.40 to 122.44) (PMID: 26853855).\n\n## Liver disease\n\nIn people with liver cirrhosis, a 20 g oral glutamine load roughly doubled arterial ammonia, which did not happen in healthy controls (PMID: 24078984)." } }, { "@type": "Question", "name": "Where can I buy L-Glutamine?", "acceptedAnswer": { "@type": "Answer", "text": "Visit our vendor directory to compare the vendors we track and their Trust Scores." } } ] }, { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Guides", "item": "https://www.bodyhackguide.co/guides" }, { "@type": "ListItem", "position": 3, "name": "Dosage Guides", "item": "https://www.bodyhackguide.co/guides" }, { "@type": "ListItem", "position": 4, "name": "L-Glutamine Dosage", "item": "https://www.bodyhackguide.co/guides/dosage/l-glutamine" } ] } ] ```