--- title: "TAK-653: Dosing & Vendor Prices | BodyHackGuide" url: https://www.bodyhackguide.co/compound/tak-653 description: "TAK-653: dosing protocols, mechanism & side effects. Compare 1 current vendor prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # TAK-653 Nootropics (https://www.bodyhackguide.co/wiki#cat-nootropics)Phase II Clinical Trials TAK-653 is a novel positive allosteric modulator (PAM) of AMPA-type glutamate receptors developed by Takeda Pharmaceuticals. It enhances glutamatergic neurotransmission without directly activating the receptor, offering a more controlled mechanism for cognitive enhancement and antidepressant effects. Image: BHG Labs logo (https://bhglabs.co/store/wp-content/uploads/2026/06/logo-full.png) Lowest price $79.99 1 bottle at BHG Labs Buy at BHG Labs: https://bhglabs.co/product/tak-653/?ref=zmgqyxku&coupon=BHG20 Half-life: 6-10 hours (estimated) Route: Oral MW: 282.27 CAS: 1531665-83-2 Last reviewed: Oct 2, 2026 ## Overview ### At A Glance Mechanism TAK-653 acts as a positive allosteric modulator (PAM) of AMPA receptors, binding to a site distinct from the glutamate binding site. It increases the receptor's sensitivity to glutamate, improving excitatory postsynaptic currents (EPSCs) and promoting long-term potentiation (LTP)… Half-Life 6-10 hours (estimated) Dosing Once daily Dose Range 0.1 mg - 6 mg Routes Oral Potential Benefits Cognitive enhancement and improved learning Antidepressant effects (treatment-resistant depression) Enhanced synaptic plasticity and LTP Increased BDNF expression Improved working memory and executive function Potential neuroprotective properties ### Overview TAK-653 is a novel positive allosteric modulator (PAM) of AMPA-type glutamate receptors developed by Takeda Pharmaceuticals. It enhances glutamatergic neurotransmission without directly activating the receptor, offering a more controlled mechanism for cognitive enhancement and antidepressant effects. Originally developed for treatment-resistant depression, it has gained interest in the research community for its potential nootropic and neuroplasticity-promoting properties. ## Chemical Information IUPAC Name Not yet available CAS Number 1531665-83-2 Molecular Formula C16H11FN2O2 Molecular Mass 282.27 g/mol ## Dosing & Protocols ### Unlock the Dosing tab Enter your email to keep reading. It is free, and it opens these tabs on every compound page in this browser. - Dose, route, how often and how long You also get the free peptide cheat sheet by email. Unsubscribe anytime. Have an account? Sign in (https://www.bodyhackguide.co/auth) ## Research ### Unlock the Research tab - Safety and side effects - A link to the PubMed results ## Interactions ### Interaction Matrix ### Contraindications History of seizure disorders or epilepsy. Concurrent use of other glutamatergic agents or excitatory compounds. Traumatic brain injury (acute phase). Pregnancy or breastfeeding. Known hypersensitivity to benzamide derivatives. Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $79.99 Best $/mg — Vendors 1 Listings 1 capsule Form Sort | Vendor | Product | Form | Qty | Price | $/mg | Coupon | | | --- | --- | --- | --- | --- | --- | --- | --- | | Image: BHG Labs logo (https://bhglabs.co/store/wp-content/uploads/2026/06/logo-full.png) BHG Labs (https://www.bodyhackguide.co/vendors/bhg-labs) 70: https://www.bodyhackguide.co/vendor-trust-scorecard 🇺🇸 US | TAK-653 | capsule | 1 bottle ● In Stock | $79.99 BEST | — | BHG20 | Buy: https://bhglabs.co/product/tak-653/?ref=zmgqyxku&coupon=BHG20 | ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with TAK-653. Current low $79.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet Tracking since Jul 1, 2026 · 1 data point ### Vendors Selling TAK-653 #### BHG Labs 4.8 1 listing · from $79.99 https://www.bodyhackguide.co/vendors/bhg-labs How we score these vendors Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. View Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ### Related Compounds View All (https://www.bodyhackguide.co/wiki) ### 9-Me-BC (9-Methyl-β-carboline) Nootropics Preclinical 9-Methyl--carboline (9-Me-BC) is a synthetic -carboline alkaloid that has drawn nootropic-community interest for a preclinical property that is genuinely unusual among -carbolines: in rodent and cell-culture studies it appears to stimulate the dopaminergic phenotype - raising tyrosine hydroxylase, the number of differentiated dopamine neurons and dopamine content - while also showing neuroprotective, neurorestorative and anti-inflammatory effects, plus in-vitro MAO-A/MAO-B inhibition [PMID:17913302, PMID:20374418, PMID:32285253]. t½ Not characterized in humans (no pharmacokinetic data). Community/anecdotal only: ~5-25 mg per day, oral. No validated or approved human dose exists. 6 PubMed View Profile https://www.bodyhackguide.co/compound/9-mbc ### Aniracetam Nootropics Approved (Italy) Aniracetam is a pyrrolidinone in the racetam family, developed by Hoffmann-La Roche under the code Ro 13-5057. t½ About half an hour for the parent drug in humans. Plasma elimination half-life was 0.47 to 0.49 hours after a single 400 mg oral dose in 20 healthy male volunteers (PMID: 19025058). Aniracetam is extensively metabolized to N-anisoyl-GABA and anisic acid; in six elderly hospitalized patients with cerebrovascular disease and reduced creatinine clearance, metabolite half-life was 4 to 7 times longer than in young volunteers (PMID: 9062694). Preclinical View Profile https://www.bodyhackguide.co/compound/aniracetam ### Bemethyl (bemitil) Nootropics Approved (Russia) Bemethyl, known in the Russian literature as bemitil and sold in the region under names including Metaprot, Bemactor and Antihot, is 2-ethylthiobenzimidazole, normally handled as the hydrobromide salt. t½ Not established in humans; in healthy volunteers given a single 250 mg oral dose of the Metaprot capsule form, peak serum ethylthiobenzimidazole averaged 0.91 microg/mL at about 1.06 h, and no terminal half-life was reported (PMID: 21870773) Preclinical View Profile https://www.bodyhackguide.co/compound/bemethyl ### Bromantane Nootropics Russia Approved Bromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten. 34 PubMed View Profile https://www.bodyhackguide.co/compound/bromantane ### Cyclazodone Nootropics Preclinical Cyclazodone is the N-cyclopropyl derivative of pemoline, a 4-oxazolidinone stimulant. Preclinical View Profile https://www.bodyhackguide.co/compound/cyclazodone ### Dihexa Nootropics Preclinical Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. t½ Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. 5 to 40 mg oral per day (anecdotal range; no established human dose) 1 PubMed View Profile https://www.bodyhackguide.co/compound/dihexa View Full Dosage Guide → Protocols, calculator & safety for TAK-653 https://www.bodyhackguide.co/guides/dosage/tak-653 ### Related Articles All Posts (https://www.bodyhackguide.co/blog) #### TAK-653 (Osavampator / NBI-1065845): The Complete Research Reference TAK-653 (also called osavampator or NBI-1065845) is an investigational AMPA-receptor positive allosteric modulator designed to enhance glutamate signaling without the seizure liability of older ampakines. This reference covers its mechanism, the real Phase 1 and Phase 2 clinical evidence, how it differs from ketamine and older ampakines, community-reported use, honest safety framing, and where to source it. Research-use-only; not an approved drug. 7/1/2026 https://www.bodyhackguide.co/blog/tak-653-research-guide #### BHG Labs review: a small, COA-backed nootropics and peptides vendor (2026) BHG Labs is a small, US-focused research-chemical vendor selling atomized nasal sprays, single-compound nootropic capsules, and lyophilized peptides, all lot-numbered and third-party COA-linked. Everything is research-use-only. The catalog is curated rather than huge, and there's no large public review history yet, so it suits experienced self-experimenters more than first-timers. Code BHG20 takes 20% off. 6/30/2026 https://www.bodyhackguide.co/blog/bhg-labs-review #### Ion Peptide Review 2026: BPC-157, GLP-1s, Buccal Strips & Bioregulators A complete look at Ion Peptide (ionpeptide.com), whose 92 products span research peptides, GLP-1 agonists, NAD+/B12/glutathione buccal strips, copper peptide topicals, Khavinson bioregulators, and PDRN. We cover pricing, testing, shipping, what they stock that others don't, and how they compare to other vendors on BodyHackGuide. 4/21/2026 https://www.bodyhackguide.co/blog/ion-peptide-review-2026 ### Lowest Price BHG Labs $79.99 1 vendor · 1 listing ### Research Score 30 0 PubMed results ### Quality Indicators Data Completeness 88% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Results Interactions Vendor Listings ### Quick Facts Half-Life 6-10 hours (estimated) Molecular Weight 282.27 g/mol Administration Oral CAS Number 1531665-83-2 Trial Phase Phase II Clinical Trials 0 Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is TAK-653 used for in research? What forms does TAK-653 come in? TAK-653 is available in capsule form. How much does TAK-653 cost? Prices start at $79.99 across 1 vendor. How do I compare TAK-653 vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. ## Research Tools ### Peptide Calculator Reconstitution & syringe units https://www.bodyhackguide.co/tools/reconstitution ### Reconstitution Guide How to mix, step by step https://www.bodyhackguide.co/guides/how-to-reconstitute-peptides ### Nasal Spray Calc mL per actuation https://www.bodyhackguide.co/tools/intranasal ### Half-Life Visualizer Decay curves https://www.bodyhackguide.co/tools/halflife ## Related Compounds ### 9-Me-BC (9-Methyl-β-carboline) Nootropics Preclinical ### Aniracetam Nootropics Approved (Italy) ### Bemethyl (bemitil) Nootropics Approved (Russia) ### Bromantane Nootropics Russia Approved ### Cyclazodone Nootropics Preclinical ### Dihexa Nootropics Preclinical ## Research Benches Reference pages that put TAK-653 next to the compounds people pair it with: roles, evidence, overlap and conflicts. No dosing. Research use only. AMPA + Racetam Study Set TAK-653 and nefiracetam, plus the choline people add underneath them research bench · no dosing https://www.bodyhackguide.co/stack/ampa-racetam-study-set Free 2026 Peptide Cheat Sheet (PDF) 38 compounds and blends: vial sizes, BAC water volumes, dosing ranges and bloodwork markers. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. Image: BodyHackGuide (https://www.bodyhackguide.co/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide #### Explore - Compare prices: https://www.bodyhackguide.co/compare - Vendors: https://www.bodyhackguide.co/vendors - Deals: https://www.bodyhackguide.co/deals - Coupons: https://www.bodyhackguide.co/coupons - Nootropics: https://www.bodyhackguide.co/nootropics - Brain health: https://www.bodyhackguide.co/brain-health - Blog: https://www.bodyhackguide.co/blog - Guides: https://www.bodyhackguide.co/guides #### Tools - Reconstitution: https://www.bodyhackguide.co/tools/reconstitution - Half-life visualizer: https://www.bodyhackguide.co/tools/halflife - COA reader: https://www.bodyhackguide.co/tools/coa - Cost calculator: https://www.bodyhackguide.co/tools/cost-calculator - Stack builder: https://www.bodyhackguide.co/stack-builder - All tools: https://www.bodyhackguide.co/tools #### Trust & vendors - Vendor directory: https://www.bodyhackguide.co/vendors - Trust scorecard: https://www.bodyhackguide.co/vendors/scorecard - Vendor trust badge: https://www.bodyhackguide.co/vendors/get-vetted - Scoring methodology: https://www.bodyhackguide.co/vendors/methodology - Peptide cheat sheet: https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download #### Company - About: https://www.bodyhackguide.co/about - Affiliate disclosure: https://www.bodyhackguide.co/affiliate-disclosure - Editorial standards: https://www.bodyhackguide.co/editorial-standards - Creators: https://www.bodyhackguide.co/creators - Coaches: https://www.bodyhackguide.co/coaches - 1-on-1 coaching: https://www.bodyhackguide.co/coaching - Privacy: https://www.bodyhackguide.co/privacy - Terms: https://www.bodyhackguide.co/terms - Full site directory: https://www.bodyhackguide.co/site-directory **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology), and we earn a commission from purchases made through some of our links at no extra cost to you. 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