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![SR-9009 (stenabolic) molecular structure](/assets/peptide-structure-placeholder-DUmZBF_j.png)

# SR-9009 (stenabolic)

Metabolic Preclinical 

Download  PDF

Also known as: SR9009, Stenabolic, SR-9009, Rev-erb agonist SR9009 

SR-9009, sold as stenabolic, is a synthetic agonist of the nuclear receptors REV-ERB-alpha and REV-ERB-beta. It came out of Thomas Burris and Theodore Kamenecka laboratory work at the Scripps Research Institute and was first described in a 2012 Nature paper as a tool for pharmacologically shifting the circadian clock and the metabolism it controls (PMID: 22460951).

Half-Life:  Not established in humans; no human pharmacokinetic study has been published. In the mouse experiments that produced the metabolic findings the compound was given by intraperitoneal injection rather than orally (PMID: 22460951) Route:  Intraperitoneal injection (rodent studies), Oral (as sold on the research chemical market) MW:  437.94 g/mol CAS:  1379686-30-2 

Last reviewed: Sep 7, 2026 

[

Metabolic

Category



](/wiki#cat-metabolic)

Preclinical

Research Stage

OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices2 Related

## Overview

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### At A Glance

Mechanism 

SR-9009 is a synthetic agonist at REV-ERB-alpha (NR1D1) and REV-ERB-beta (NR1D2), heme-binding nuclear receptors that act as transcriptional repressors within the core circadian clock. Agonist binding increases their repressive activity on target promoters, altering the daily exp… 

Half-Life 

Not established in humans; no human pharmacokinetic study has been published. In the mouse experiments that produced the metabolic findings the compound was given by intraperitoneal injection rather than orally (PMID: 22460951)

Routes 

Intraperitoneal injection (rodent studies) Oral (as sold on the research chemical market) 

Potential Benefits 

Increased energy expenditure and reduced fat mass in diet-induced obese mice, with plasma cholesterol down 47 percent, triglycerides down 12 percent and glucose down 19 percent (PMID: 22460951) Increased exercise capacity in mice after pharmacological activation of Rev-erb-alpha, alongside greater muscle mitochondrial content (PMID: 23852339) Altered the circadian pattern of clock and metabolic gene expression in mouse hypothalamus, liver, muscle and adipose tissue (PMID: 22460951) Reduced weight gain and insulin resistance in mice exposed to constant light in a later rodent study (PMID: 39800061) 

### Overview

SR-9009, sold as stenabolic, is a synthetic agonist of the nuclear receptors REV-ERB-alpha and REV-ERB-beta. It came out of Thomas Burris and Theodore Kamenecka laboratory work at the Scripps Research Institute and was first described in a 2012 Nature paper as a tool for pharmacologically shifting the circadian clock and the metabolism it controls (PMID: 22460951). It was never a pharmaceutical company development candidate, has never entered human trials, and has no approval anywhere. Anti-doping laboratories describe it plainly as a compound that failed to reach FDA approval and whose illegal distribution raised concern (PMID: 38735208). REV-ERB proteins sit inside the core circadian clock and repress the genes that drive the daily cycle of activity and fuel use. Activating them with a drug changes the timing and level of metabolic gene expression in liver, muscle and fat. In the original mouse work this raised energy expenditure, and in diet-induced obese mice it reduced fat mass with drops in plasma cholesterol, triglycerides, free fatty acids and glucose (PMID: 22460951). A separate group showed that REV-ERB-alpha controls mitochondrial biogenesis in oxidative muscle and that pharmacological activation increased exercise capacity in mice (PMID: 23852339). There is a serious problem with the mechanism story. When researchers built mice lacking both REV-ERB-alpha and REV-ERB-beta, SR-9009 still reduced cell viability, rewired cellular metabolism and altered gene transcription in cells that had no target left to act on. The authors concluded that the effects of SR-9009 cannot be used as a stand-in for REV-ERB activity (PMID: 31127047). In other words, some of what the compound does in cells is off-target, and which of the metabolic effects are REV-ERB-dependent is unsettled. There are no human data of any kind. No pharmacokinetics, no safety study, no efficacy trial. In the mouse studies that produced the metabolic results, the compound was given by intraperitoneal injection rather than by mouth (PMID: 22460951), which matters because SR-9009 is sold as an oral liquid and as capsules. It is prohibited in sport. WADA lists Rev-erb-alpha agonists including SR9009 and SR9011 under section S4.4, metabolic modulators, and horse and camel racing authorities have developed detection methods for it (PMID: 38735208; PMID: 42530886). When 44 products marketed online as SARMs were chemically analyzed, SR9009 was one of the unapproved drugs found in products that did not list it on the label (PMID: 29183075). What is sold as stenabolic, in liquid or capsule form, is a research chemical with no pharmacopoeial standard, no established human dose and no published human exposure. Buyers are the first humans on record taking it, and there is no monitoring of what happens next.

### Potential Research Fields

Circadian biology Nuclear receptor pharmacology Energy metabolism Sports drug testing 

## Chemical Information

IUPAC Name

Not yet available 

CAS Number

1379686-30-2

Molecular Formula

C20H24ClN3O4S

Molecular Mass

437.94 g/mol

![SR-9009 (stenabolic) molecular structure](https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/57394020/PNG)

[View on PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/57394020)

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## Interactions

### Contraindications

No human data exist, so no evidence-based contraindications can be stated. Mechanism-based caution applies to anyone with a circadian or sleep disorder, since the drug is designed to shift clock gene expression (PMID: 22460951), and the documented REV-ERB-independent cytotoxicity in cell studies is an unresolved safety question (PMID: 31127047). Prohibited at all times in tested human and equine sport (PMID: 38735208).

Research Disclaimer

This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.

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#### Disguised Alpha

2 listings · from $59.99 





](/vendor/disguised-alpha)

How we score these vendors

Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.

[View Scorecard](/vendors/scorecard)

### Related Compounds

[View All](/wiki)

[

### AICAR (acadesine)

Metabolic Phase 3 

AICAR is a nucleoside analog of adenosine.

t½ Intact acadesine was measurable in plasma for only about 2 hours after a short intravenous infusion in four healthy men, with total plasma clearance of 2.2 L/h/kg and negligible protein binding; radiolabeled drug-derived material had an apparent terminal half-life of about one week, reflecting metabolites rather than parent compound (PMID: 8227467) 

Preclinical View Profile 

](/compound/aicar)[

### Amlexanox

Metabolic FDA Approved 

Amlexanox is an old anti-inflammatory drug with a second life.

t½ Not established in published human pharmacokinetic studies for the oral capsule form; a validated plasma assay has been used for preclinical pharmacokinetics in rats (PMID: 34842293) 

Preclinical View Profile 

](/compound/amlexanox)[

### Berberine

Metabolic Preclinical 

Berberine is an isoquinoline alkaloid — a naturally occurring plant secondary metabolite with a characteristic yellow color — extracted from the roots, rhizomes, stems, and bark of several plant genera including Berberis (barberry, Oregon grape), Coptis (goldthread), Hydrastis (goldenseal), Phellodendron (Amur cork tree), and Tinospora (guduchi).

Preclinical View Profile 

](/compound/berberine)[

### Cardarine (GW501516)

Metabolic Discontinued 

Cardarine is the market name for GW501516, a synthetic agonist of the nuclear receptor PPAR-delta developed by GlaxoSmithKline as a treatment for low HDL cholesterol and the lipid problems that travel with metabolic syndrome.

t½ Not reported in the published human trials; the phase 1 and phase 2 studies described lipid outcomes over two to twelve weeks of oral dosing without publishing a terminal half-life (PMID: 17110604; PMID: 22814748) 

Preclinical View Profile 

](/compound/cardarine)[

### Metformin

Metabolic Preclinical 

Metformin is a biguanide-class oral antihyperglycemic medication that has been in continuous clinical use since 1957 (in France under the brand name Glucophage) and is now the most-prescribed diabetes medication worldwide with over 150 million prescriptions annually.

Preclinical View Profile 

](/compound/metformin)[

### SLU-PP-915

Metabolic Preclinical 

SLU-PP-915 is an experimental agonist of the estrogen-related receptors, a family of three orphan nuclear receptors called ERR-alpha, ERR-beta and ERR-gamma that control genes for mitochondrial biogenesis, oxidative phosphorylation, fatty acid oxidation and the Krebs cycle.

t½ Not established in humans; in mice it is orally bioavailable and active by both oral and intraperitoneal routes, unlike its predecessor SLU-PP-332 (PMID: 41421047) 

Preclinical View Profile 

](/compound/slu-pp-915)

[

View Full Dosage Guide →

Protocols, calculator & safety for SR-9009 (stenabolic)



](/guides/dosage/sr-9009)

### Best Price

![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png)

Disguised Alpha

$59.99

[Buy Now](https://disguisedalpha.com/product/sr9009capsules/?coupon=reddit)

1 vendors · 2 listings

### Research Score

30 

0 PubMed studies

### Quality Indicators

Data Completeness

63% 

Description 

Mechanism of Action 

Chemical Data 

Dosing Protocols 

Safety Profile 

PubMed Studies 

Interactions 

Vendor Listings 

### Quick Facts

Half-Life

Not established in humans; no human pharmacokinetic study has been published. In the mouse experiments that produced the metabolic findings the compound was given by intraperitoneal injection rather than orally (PMID: 22460951)

Molecular Weight

437.94 g/mol

Administration

Intraperitoneal injection (rodent studies), Oral (as sold on the research chemical market)

CAS Number

1379686-30-2

Trial Phase

Preclinical

0

[Full Dosage Guide](/guides/dosage/sr-9009)[Calculate Your Dose](/tools/reconstitution)

Research Disclaimer

This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

## Frequently Asked Questions

What is SR-9009 (stenabolic) used for in research?

SR-9009, sold as stenabolic, is a synthetic agonist of the nuclear receptors REV-ERB-alpha and REV-ERB-beta. It came out of Thomas Burris and Theodore Kamenecka laboratory work at the Scripps Research Institute and was first described in a 2012 Nature paper as a tool for pharmacologically shifting the circadian clock and the metabolism it controls (PMID: 22460951). It was never a pharmaceutical company development candidate, has never entered human trials, and has no approval anywhere. Anti-doping laboratories describe it plainly as a compound that failed to reach FDA approval and whose illegal distribution raised concern (PMID: 38735208).

REV-ERB proteins sit inside the core circadian clock and repress the genes that drive the daily cycle of activity and fuel use. Activating them with a drug changes the timing and level of metabolic gene expression in liver, muscle and fat. In the original mouse work this raised energy expenditure, and in diet-induced obese mice it reduced fat mass with drops in plasma cholesterol, triglycerides, free fatty acids and glucose (PMID: 22460951). A separate group showed that REV-ERB-alpha controls mitochondrial biogenesis in oxidative muscle and that pharmacological activation increased exercise capacity in mice (PMID: 23852339).

There is a serious problem with the mechanism story. When researchers built mice lacking both REV-ERB-alpha and REV-ERB-beta, SR-9009 still reduced cell viability, rewired cellular metabolism and altered gene transcription in cells that had no target left to act on. The authors concluded that the effects of SR-9009 cannot be used as a stand-in for REV-ERB activity (PMID: 31127047). In other words, some of what the compound does in cells is off-target, and which of the metabolic effects are REV-ERB-dependent is unsettled.

There are no human data of any kind. No pharmacokinetics, no safety study, no efficacy trial. In the mouse studies that produced the metabolic results, the compound was given by intraperitoneal injection rather than by mouth (PMID: 22460951), which matters because SR-9009 is sold as an oral liquid and as capsules.

It is prohibited in sport. WADA lists Rev-erb-alpha agonists including SR9009 and SR9011 under section S4.4, metabolic modulators, and horse and camel racing authorities have developed detection methods for it (PMID: 38735208; PMID: 42530886). When 44 products marketed online as SARMs were chemically analyzed, SR9009 was one of the unapproved drugs found in products that did not list it on the label (PMID: 29183075).

What is sold as stenabolic, in liquid or capsule form, is a research chemical with no pharmacopoeial standard, no established human dose and no published human exposure. Buyers are the first humans on record taking it, and there is no monitoring of what happens next.

What forms does SR-9009 (stenabolic) come in?

SR-9009 (stenabolic) is available in capsule, liquid forms.

How much does SR-9009 (stenabolic) cost?

Prices start at $59.99 across 1 verified vendor.

How do I compare SR-9009 (stenabolic) vendors?

Compare prices, payment methods, shipping, and COA scores across 1 vendor.

## Research Tools

[

### Peptide Calculator

Reconstitution & syringe units



](/tools/reconstitution)[

### Reconstitution Guide

How to mix, step by step



](/guides/how-to-reconstitute-peptides)[

### Nasal Spray Calc

mL per actuation



](/tools/intranasal)[

### Half-Life Visualizer

Decay curves



](/tools/halflife)

## Related Compounds

[View All](/wiki)

[

### AICAR (acadesine)

Metabolic Phase 3 

AICAR is a nucleoside analog of adenosine.

t½ Intact acadesine was measurable in plasma for only about 2 hours after a short intravenous infusion in four healthy men, with total plasma clearance of 2.2 L/h/kg and negligible protein binding; radiolabeled drug-derived material had an apparent terminal half-life of about one week, reflecting metabolites rather than parent compound (PMID: 8227467) 

Preclinical View Profile 

](/compound/aicar)[

### Amlexanox

Metabolic FDA Approved 

Amlexanox is an old anti-inflammatory drug with a second life.

t½ Not established in published human pharmacokinetic studies for the oral capsule form; a validated plasma assay has been used for preclinical pharmacokinetics in rats (PMID: 34842293) 

Preclinical View Profile 

](/compound/amlexanox)[

### Berberine

Metabolic Preclinical 

Berberine is an isoquinoline alkaloid — a naturally occurring plant secondary metabolite with a characteristic yellow color — extracted from the roots, rhizomes, stems, and bark of several plant genera including Berberis (barberry, Oregon grape), Coptis (goldthread), Hydrastis (goldenseal), Phellodendron (Amur cork tree), and Tinospora (guduchi).

Preclinical View Profile 

](/compound/berberine)[

### Cardarine (GW501516)

Metabolic Discontinued 

Cardarine is the market name for GW501516, a synthetic agonist of the nuclear receptor PPAR-delta developed by GlaxoSmithKline as a treatment for low HDL cholesterol and the lipid problems that travel with metabolic syndrome.

t½ Not reported in the published human trials; the phase 1 and phase 2 studies described lipid outcomes over two to twelve weeks of oral dosing without publishing a terminal half-life (PMID: 17110604; PMID: 22814748) 

Preclinical View Profile 

](/compound/cardarine)[

### Metformin

Metabolic Preclinical 

Metformin is a biguanide-class oral antihyperglycemic medication that has been in continuous clinical use since 1957 (in France under the brand name Glucophage) and is now the most-prescribed diabetes medication worldwide with over 150 million prescriptions annually.

Preclinical View Profile 

](/compound/metformin)[

### SLU-PP-915

Metabolic Preclinical 

SLU-PP-915 is an experimental agonist of the estrogen-related receptors, a family of three orphan nuclear receptors called ERR-alpha, ERR-beta and ERR-gamma that control genes for mitochondrial biogenesis, oxidative phosphorylation, fatty acid oxidation and the Krebs cycle.

t½ Not established in humans; in mice it is orally bioavailable and active by both oral and intraperitoneal routes, unlike its predecessor SLU-PP-332 (PMID: 41421047) 

Preclinical View Profile 

](/compound/slu-pp-915)

Free 2026 Peptide Cheat Sheet — 50 pages, PDF

Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one.

[Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-sr-9009)

### Need bloodwork before starting?

Full hormone + metabolic panels from Anabolic Insights. Code CHONCH  for first-order discount.

[Order Bloodwork](https://anabolicinsights.ai/?ref=nwm2zjb)

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