--- title: "Snap-8: Dosing & Vendor Prices — BodyHackGuide" description: "Snap-8: dosing protocols, mechanism & side effects. Compare 2 verified vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Snap-8" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "Snap-8", "description": "Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox). Where Botox cleaves SNAP-25 systemically and irreversibly via enzymatic activity, Snap-8 competes with SNAP-25 for a place in the SNARE complex that enables acetylcholine release at the neuromuscular junction. This competitive inhibition reduces muscle contraction at the application site without systemic toxin effects. Snap-8 is used in cosmetic research as a topical anti-wrinkle agent, particularly for expression lines (forehead, periorbital). Purity-verified Snap-8 raw powder is also used in cosmetic compounding research.", "url": "https://www.bodyhackguide.co/compound/snap-8", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "149.00", "highPrice": "199.99", "priceCurrency": "USD", "offerCount": "2", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "149.00", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://ionpeptide.com/product/snap-8-raw-1g/?ref=reddit15", "seller": { "@type": "Organization", "name": "Ion Peptide", "url": "https://ionpeptide.com" }, "name": "Snap-8 1000mg powder" }, { "@type": "Offer", "price": "199.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://optimumformula.co/product/double-diamond-balm/", "seller": { "@type": "Organization", "name": "Optimum Formula", "url": "https://optimumformula.co" } } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Snap-8", "description": "Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox). Where Botox cleaves SNAP-25 systemically and irreversibly via enzymatic activity, Snap-8 competes with SNAP-25 for a place in the SNARE complex that enables acetylcholine release at the neuromuscular junction. This competitive inhibition reduces muscle contraction at the application site without systemic toxin effects. Snap-8 is used in cosmetic research as a topical anti-wrinkle agent, particularly for expression lines (forehead, periorbital). Purity-verified Snap-8 raw powder is also used in cosmetic compounding research.", "lastReviewed": "2026-09-04T09:44:22.498Z", "url": "https://www.bodyhackguide.co/compound/snap-8", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "Snap-8", "alternateName": [ "Acetyl Glutamyl Heptapeptide-1", "SNAP-8", "Leuphasyl", "anti-wrinkle peptide" ], "description": "Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox). Where Botox cleaves SNAP-25 systemically and irreversibly via enzymatic activity, Snap-8 competes with SNAP-25 for a place in the SNARE complex that enables acetylcholine release at the neuromuscular junction. This competitive inhibition reduces muscle contraction at the application site without systemic toxin effects. Snap-8 is used in cosmetic research as a topical anti-wrinkle agent, particularly for expression lines (forehead, periorbital). Purity-verified Snap-8 raw powder is also used in cosmetic compounding research.", "activeIngredient": "Snap-8", "administrationRoute": "Topical", "mechanismOfAction": "Snap-8 (INCI Acetyl Octapeptide-3; CAS 868844-74-0) is a synthetic octapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, whose sequence mimics the N-terminal domain of SNAP-25. SNAP-25, together with Syntaxin-1 and VAMP/synaptobrevin, forms the SNARE complex required for synaptic-vesicle fusion and neurotransmitter release (acetylcholine at the neuromuscular junction; catecholamines at other synapses). By competing with endogenous SNAP-25 for its position in the SNARE complex, Snap-8 is proposed to destabilize complex assembly and partially and reversibly reduce neurotransmitter release, thereby softening the muscle contractions that drive dynamic expression lines. It is often described as a topical, needle-free analogue of botulinum toxin, but the two are not equivalent: botulinum toxin is injected and enzymatically cleaves SNAP-25, whereas Snap-8 is a topical peptide that only competitively interferes with the complex and reduces, rather than abolishes, signaling. A key real-world limitation is delivery: Snap-8 is a large, hydrophilic, charged peptide that penetrates the stratum corneum poorly, so any in-vivo effect is highly dependent on the formulation and delivery method rather than on the raw peptide itself. This is a cosmetic/research model, not an approved therapeutic, and stand-alone controlled trials demonstrating Botox-like efficacy for Snap-8 specifically have not been published.", "dosageForm": "vial, powder, topical", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Snap-8 and how is it different from Argireline?", "acceptedAnswer": { "@type": "Answer", "text": "Snap-8 (INCI: Acetyl Octapeptide-3, CAS 868844-74-0) is a synthetic octapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2. It is an elongated version of Argireline (Acetyl Hexapeptide), extending the same SNAP-25-derived sequence by two residues (Ala-Asp). Both are marketed as topical, needle-free 'Botox-mimetic' cosmetic peptides that interfere with SNARE-complex formation to soften dynamic expression lines." } }, { "@type": "Question", "name": "Does Snap-8 actually work like Botox?", "acceptedAnswer": { "@type": "Answer", "text": "The mechanism is plausible and shares a target with botulinum toxin (the SNARE protein SNAP-25), but the two are not equivalent. Botulinum toxin is injected and enzymatically cleaves SNAP-25; Snap-8 is a topical peptide that only competes for a position in the SNARE complex and reduces, rather than abolishes, neurotransmitter release. There are no stand-alone controlled human trials proving Botox-like efficacy for Snap-8 specifically." } }, { "@type": "Question", "name": "Is there clinical evidence for Snap-8?", "acceptedAnswer": { "@type": "Answer", "text": "According to PubMed, the only indexed clinical study naming acetyl octapeptide-3 is a 12-week microneedle-patch trial in which it was one of several active ingredients; the combination reduced fine lines/wrinkles by about 25.8% [PMID:31134751], so Snap-8's individual effect cannot be isolated. The closely related peptide Argireline has a randomized, placebo-controlled trial showing about 48.9% subjective wrinkle reduction [PMID:23417317]. Most Snap-8-specific claims come from manufacturer in-vivo testing rather than independent trials." } }, { "@type": "Question", "name": "How is Snap-8 used?", "acceptedAnswer": { "@type": "Answer", "text": "It is a topical cosmetic ingredient, typically formulated at low peptide concentrations in a serum or cream and applied twice daily. It is not dosed in micrograms and is not intended for injection or systemic use. On this site it is offered as a research-use-only raw peptide." } }, { "@type": "Question", "name": "Why might a Snap-8 product underperform?", "acceptedAnswer": { "@type": "Answer", "text": "Snap-8 is a large, hydrophilic, charged peptide that penetrates the stratum corneum poorly [PMID:29371611]. Real-world results depend heavily on formulation and delivery (penetration enhancers, microneedling, occlusion). A poorly formulated product may deliver very little active peptide to its site of action." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. 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Where Botox cleaves SNAP-25 systemically and irreversibly via enzymatic activity, Snap-8 competes with SNAP-25 for a place in the SNARE complex that enables acetylcholine release at the neuromuscular junction. This competitive inhibition reduces muscle contraction at the application site without systemic toxin effects. Snap-8 is used in cosmetic research as a topical anti-wrinkle agent, particularly for expression lines (forehead, periorbital). Purity-verified Snap-8 raw powder is also used in cosmetic compounding research.", "url": "https://www.bodyhackguide.co/compound/snap-8", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "149.00", "highPrice": "199.99", "priceCurrency": "USD", "offerCount": "2", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "149.00", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://ionpeptide.com/product/snap-8-raw-1g/?ref=reddit15", "seller": { "@type": "Organization", "name": "Ion Peptide", "url": "https://ionpeptide.com" }, "name": "Snap-8 1000mg powder" }, { "@type": "Offer", "price": "199.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://optimumformula.co/product/double-diamond-balm/", "seller": { "@type": "Organization", "name": "Optimum Formula", "url": "https://optimumformula.co" } } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Snap-8", "description": "Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox). Where Botox cleaves SNAP-25 systemically and irreversibly via enzymatic activity, Snap-8 competes with SNAP-25 for a place in the SNARE complex that enables acetylcholine release at the neuromuscular junction. This competitive inhibition reduces muscle contraction at the application site without systemic toxin effects. Snap-8 is used in cosmetic research as a topical anti-wrinkle agent, particularly for expression lines (forehead, periorbital). Purity-verified Snap-8 raw powder is also used in cosmetic compounding research.", "lastReviewed": "2026-09-04T09:44:22.498Z", "url": "https://www.bodyhackguide.co/compound/snap-8", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "Snap-8", "alternateName": [ "Acetyl Glutamyl Heptapeptide-1", "SNAP-8", "Leuphasyl", "anti-wrinkle peptide" ], "description": "Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox). Where Botox cleaves SNAP-25 systemically and irreversibly via enzymatic activity, Snap-8 competes with SNAP-25 for a place in the SNARE complex that enables acetylcholine release at the neuromuscular junction. This competitive inhibition reduces muscle contraction at the application site without systemic toxin effects. Snap-8 is used in cosmetic research as a topical anti-wrinkle agent, particularly for expression lines (forehead, periorbital). Purity-verified Snap-8 raw powder is also used in cosmetic compounding research.", "activeIngredient": "Snap-8", "administrationRoute": "Topical", "mechanismOfAction": "Snap-8 (INCI Acetyl Octapeptide-3; CAS 868844-74-0) is a synthetic octapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, whose sequence mimics the N-terminal domain of SNAP-25. SNAP-25, together with Syntaxin-1 and VAMP/synaptobrevin, forms the SNARE complex required for synaptic-vesicle fusion and neurotransmitter release (acetylcholine at the neuromuscular junction; catecholamines at other synapses). By competing with endogenous SNAP-25 for its position in the SNARE complex, Snap-8 is proposed to destabilize complex assembly and partially and reversibly reduce neurotransmitter release, thereby softening the muscle contractions that drive dynamic expression lines. It is often described as a topical, needle-free analogue of botulinum toxin, but the two are not equivalent: botulinum toxin is injected and enzymatically cleaves SNAP-25, whereas Snap-8 is a topical peptide that only competitively interferes with the complex and reduces, rather than abolishes, signaling. A key real-world limitation is delivery: Snap-8 is a large, hydrophilic, charged peptide that penetrates the stratum corneum poorly, so any in-vivo effect is highly dependent on the formulation and delivery method rather than on the raw peptide itself. This is a cosmetic/research model, not an approved therapeutic, and stand-alone controlled trials demonstrating Botox-like efficacy for Snap-8 specifically have not been published.", "dosageForm": "vial, powder, topical", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Snap-8 and how is it different from Argireline?", "acceptedAnswer": { "@type": "Answer", "text": "Snap-8 (INCI: Acetyl Octapeptide-3, CAS 868844-74-0) is a synthetic octapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2. It is an elongated version of Argireline (Acetyl Hexapeptide), extending the same SNAP-25-derived sequence by two residues (Ala-Asp). Both are marketed as topical, needle-free 'Botox-mimetic' cosmetic peptides that interfere with SNARE-complex formation to soften dynamic expression lines." } }, { "@type": "Question", "name": "Does Snap-8 actually work like Botox?", "acceptedAnswer": { "@type": "Answer", "text": "The mechanism is plausible and shares a target with botulinum toxin (the SNARE protein SNAP-25), but the two are not equivalent. Botulinum toxin is injected and enzymatically cleaves SNAP-25; Snap-8 is a topical peptide that only competes for a position in the SNARE complex and reduces, rather than abolishes, neurotransmitter release. There are no stand-alone controlled human trials proving Botox-like efficacy for Snap-8 specifically." } }, { "@type": "Question", "name": "Is there clinical evidence for Snap-8?", "acceptedAnswer": { "@type": "Answer", "text": "According to PubMed, the only indexed clinical study naming acetyl octapeptide-3 is a 12-week microneedle-patch trial in which it was one of several active ingredients; the combination reduced fine lines/wrinkles by about 25.8% [PMID:31134751], so Snap-8's individual effect cannot be isolated. The closely related peptide Argireline has a randomized, placebo-controlled trial showing about 48.9% subjective wrinkle reduction [PMID:23417317]. Most Snap-8-specific claims come from manufacturer in-vivo testing rather than independent trials." } }, { "@type": "Question", "name": "How is Snap-8 used?", "acceptedAnswer": { "@type": "Answer", "text": "It is a topical cosmetic ingredient, typically formulated at low peptide concentrations in a serum or cream and applied twice daily. It is not dosed in micrograms and is not intended for injection or systemic use. On this site it is offered as a research-use-only raw peptide." } }, { "@type": "Question", "name": "Why might a Snap-8 product underperform?", "acceptedAnswer": { "@type": "Answer", "text": "Snap-8 is a large, hydrophilic, charged peptide that penetrates the stratum corneum poorly [PMID:29371611]. Real-world results depend heavily on formulation and delivery (penetration enhancers, microneedling, occlusion). A poorly formulated product may deliver very little active peptide to its site of action." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompound%2Fsnap-8) 100K+ researchers trust BodyHackGuide — Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 2. [Compounds](/compare) 3. Snap-8 ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Best price right now $0.15/mg · $149.00 for 1000mg at Ion Peptide [Buy at Ion Peptide](https://www.bodyhackguide.co/go/ion-peptide?utm_source=compound-sticky-bar&utm_campaign=90c1e037-2fce-4c1d-a183-6adeca4a1444&utm_medium=best-price-cta) [Where to buy Snap-8](/buy/snap-8) [Snap-8 coupon codes](/coupons/snap-8) [Snap-8 protocol](/protocol/snap-8) [Alternatives to Snap-8](/alternatives-to/snap-8) [Snap-8 side effects](/side-effects/snap-8) 1. [Home](/) 3. [Compounds](/compare) 5. Snap-8 # Snap-8 Skin & Hair Preclinical Download PDF Also known as: Acetyl Glutamyl Heptapeptide-1, SNAP-8, Leuphasyl, anti-wrinkle peptide Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox). Where Botox cleaves SNAP-25 systemically and irreversibly via enzymatic activity, Snap-8 competes with SNAP-25 for a place in the SNARE complex that enables acetylcholine release at the neuromuscular junction. Half-Life: Not characterized (topical peptide) Route: Topical MW: 1075.16 g/mol Last reviewed: Sep 4, 2026 [ Skin & Hair Category ](/wiki#cat-skin-&-hair) Preclinical Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices3 Related ## Overview ### Best Price Available 🔬 Optimum Formula $199.99 30ml · topical [Buy Now](https://optimumformula.co/product/double-diamond-balm/) Coupon: `REDDIT`Copy Compare 2 vendors ### At A Glance Mechanism Snap-8 (INCI Acetyl Octapeptide-3; CAS 868844-74-0) is a synthetic octapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, whose sequence mimics the N-terminal domain of SNAP-25. SNAP-25, together with Syntaxin-1 and VAMP/synaptobrevin, forms the SNARE complex required for synaptic-… Half-Life Not characterized (topical peptide) Dosing twice daily Dose Range 0mcg Routes Topical Common Vials 10mg Potential Benefits Reduction of dynamic expression wrinkles (forehead, crow's feet, glabellar lines) SNARE complex interference — partial, reversible neuromuscular inhibition Topical alternative research model for neuromuscular relaxation without injected toxin Cosmetic peptide compounding research — high-purity raw powder applications Synergy with Argireline (Acetyl Hexapeptide-3) in SNARE-targeting formulations Safety Notes Common Minimal — well tolerated at cosmetic concentrations Mild transient erythema at high concentrations Serious No systemic absorption at cosmetic doses — topical safety profile Not intended for injection ### Overview Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox). Where Botox cleaves SNAP-25 systemically and irreversibly via enzymatic activity, Snap-8 competes with SNAP-25 for a place in the SNARE complex that enables acetylcholine release at the neuromuscular junction. This competitive inhibition reduces muscle contraction at the application site without systemic toxin effects. Snap-8 is used in cosmetic research as a topical anti-wrinkle agent, particularly for expression lines (forehead, periorbital). Purity-verified Snap-8 raw powder is also used in cosmetic compounding research. ### What to Expect - • Snap-8 is a slow, subtle cosmetic effect, not an acute one. Any softening of fine dynamic lines builds over weeks of consistent twice-daily topical use, not days. - • Effect size is modest and highly formulation-dependent; it is not comparable to injected botulinum toxin. - • No systemic or 'frozen-muscle' effect is expected from topical use, because penetration is limited and the mechanism only partially reduces local neurotransmitter release. - • Benefits, if any, reverse after you stop applying it; there is no lasting structural change. - • Evidence for Snap-8 as a single agent is limited to manufacturer testing and one combination-product study, so expectations should be managed accordingly (research-use framing). Individual responses vary. Timeline based on commonly reported research observations. ## Chemical Information IUPAC Name Not yet available CAS Number Not yet available Molecular Formula Not yet available Molecular Mass 1075.16 g/mol (molecular formula C41H70N16O16S) Amino Acid Sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (one-letter: EEMQRRAD; N-terminus acetylated, C-terminus amidated). INCI name: Acetyl Octapeptide-3 (historically also called Acetyl Glutamyl Heptapeptide-1). CAS 868844-74-0. The sequence is derived from the N-terminal domain of SNAP-25 and extends the Argireline (Acetyl Hexapeptide, Ac-EEMQRR-NH2) sequence by two residues (Ala-Asp). ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions Interaction and contraindication data is being compiled for Snap-8. Check back soon. General Safety Note Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented. Best Price $39.00 up to $199.99 Best $/mg $0.1490 Vendors 2 Listings 3 vial, powder, topical [Sign in for alerts ](/auth) Dosage All10mg (1) 1000mg (1) Form Allvialpowdertopical Sort Price $/mg Vendor Vendor Product Form Qty Price $/mg Coupon ![Optimum Formula logo](https://optimumformula.co/wp-content/uploads/2025/07/LOGO-OPTIMUM-NEW.png) [Optimum Formula](/vendor/optimum-formula) [100 ](/vendor-trust-scorecard) 🇺🇸 US Double Diamond Balm topical 30ml ● In Stock $199.99 BEST — REDDIT [Buy](https://optimumformula.co/product/double-diamond-balm/) ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) [Ion Peptide](/vendor/ion-peptide) [70 ](/vendor-trust-scorecard) 🇺🇸 US 🌍 International Snap-8 10mg (injectable) vial 1 vial ● Out of Stock $39.00 $3.900 — [Sign in for stock alert](/auth) ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) [Ion Peptide](/vendor/ion-peptide) [70 ](/vendor-trust-scorecard) 🇺🇸 US 🌍 International Snap-8 Raw 1g powder 1g ● In Stock $149.00 VALUE $0.149 — [Buy](https://ionpeptide.com/product/snap-8-raw-1g/?ref=reddit15) Get Snap-8 Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $39.00 [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Snap-8. [Sign in](/auth) Current low $199.99 as of May 26, 2026 7-day low — no 7d data yet 30-day low — no 30d data yet 30-day change — baseline building Tracking since Apr 22, 2026 · 3 data points ## Price History 2 data points ### Vendors Selling Snap-8 [ ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) #### Ion Peptide 4.5 2 listings · from $39.00 ](/vendor/ion-peptide)[ ![Optimum Formula logo](https://optimumformula.co/wp-content/uploads/2025/07/LOGO-OPTIMUM-NEW.png) #### Optimum Formula 4.9 1 listing · from $199.99 ](/vendor/optimum-formula) How we score these vendors Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. [View Scorecard](/vendors/scorecard) ### Related Compounds [View All](/wiki) [ ### Acetyl Hexapeptide-8 Skin & Hair Marketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug. Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. t½ Short (topical application, no systemic absorption at cosmetic doses) 0 Preclinical View Profile ](/compound/acetyl-hexapeptide-8)[ ### AHK-Cu Skin & Hair Preclinical AHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper). t½ Unknown (topical half-life, follicular retention not well characterized) 0 Preclinical View Profile ](/compound/ahk-cu)[ ### Melanotan 2 Skin & Hair Discontinued (early clinical) A synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression.. t½ ~1–2 hours 100-1,000 mcg per injection Preclinical View Profile ](/compound/melanotan-2)[ ### Minoxidil Skin & Hair FDA-Approved Minoxidil is an FDA-approved treatment for pattern hair loss. t½ Oral minoxidil plasma half-life is approximately 3-4 hours; the hair-growth (pharmacodynamic) effect is independent of plasma level and depends on ongoing daily use. Oral low-dose minoxidil (off-label): 625-5000 mcg/day (0.625-5 mg). Topical minoxidil is dosed by concentration (2% or 5%), not by mcg -- roughly 10-20 mg of minoxidil is delivered per topical application, with only ~1.4% absorbed systemically. Preclinical View Profile ](/compound/minoxidil)[ ### PDRN Skin & Hair Phase 4 PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. t½ Short (oligonucleotides degraded rapidly; tissue effects persist longer) 0 Preclinical View Profile ](/compound/pdrn) [ View Full Dosage Guide → Protocols, calculator & safety for Snap-8 ](/guides/dosage/snap-8) ### Best Price 🔬 Optimum Formula $199.99 [Buy Now](https://optimumformula.co/product/double-diamond-balm/) 2 vendors · 3 listings ### Research Score 45 0 PubMed studies ### Quality Indicators Data Completeness 63% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Studies Interactions Vendor Listings COA Verification 4 Verified COAs 1 Vendors w/ COA Latest test: 3/1/2026 ### Quick Facts Half-Life Not characterized (topical peptide) Molecular Weight 1075.16 g/mol (molecular formula C41H70N16O16S) Administration Topical Trial Phase Preclinical ### Safety Profile Common Side Effects - • Minimal — well tolerated at cosmetic concentrations - • Mild transient erythema at high concentrations [Full Dosage Guide](/guides/dosage/snap-8)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is Snap-8 and how is it different from Argireline? Snap-8 (INCI: Acetyl Octapeptide-3, CAS 868844-74-0) is a synthetic octapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2. It is an elongated version of Argireline (Acetyl Hexapeptide), extending the same SNAP-25-derived sequence by two residues (Ala-Asp). Both are marketed as topical, needle-free 'Botox-mimetic' cosmetic peptides that interfere with SNARE-complex formation to soften dynamic expression lines. Does Snap-8 actually work like Botox? The mechanism is plausible and shares a target with botulinum toxin (the SNARE protein SNAP-25), but the two are not equivalent. Botulinum toxin is injected and enzymatically cleaves SNAP-25; Snap-8 is a topical peptide that only competes for a position in the SNARE complex and reduces, rather than abolishes, neurotransmitter release. There are no stand-alone controlled human trials proving Botox-like efficacy for Snap-8 specifically. Is there clinical evidence for Snap-8? According to PubMed, the only indexed clinical study naming acetyl octapeptide-3 is a 12-week microneedle-patch trial in which it was one of several active ingredients; the combination reduced fine lines/wrinkles by about 25.8% \[PMID:31134751\], so Snap-8's individual effect cannot be isolated. The closely related peptide Argireline has a randomized, placebo-controlled trial showing about 48.9% subjective wrinkle reduction \[PMID:23417317\]. Most Snap-8-specific claims come from manufacturer in-vivo testing rather than independent trials. How is Snap-8 used? It is a topical cosmetic ingredient, typically formulated at low peptide concentrations in a serum or cream and applied twice daily. It is not dosed in micrograms and is not intended for injection or systemic use. On this site it is offered as a research-use-only raw peptide. Why might a Snap-8 product underperform? Snap-8 is a large, hydrophilic, charged peptide that penetrates the stratum corneum poorly \[PMID:29371611\]. Real-world results depend heavily on formulation and delivery (penetration enhancers, microneedling, occlusion). A poorly formulated product may deliver very little active peptide to its site of action. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### Acetyl Hexapeptide-8 Skin & Hair Marketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug. Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. t½ Short (topical application, no systemic absorption at cosmetic doses) 0 Preclinical View Profile ](/compound/acetyl-hexapeptide-8)[ ### AHK-Cu Skin & Hair Preclinical AHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper). t½ Unknown (topical half-life, follicular retention not well characterized) 0 Preclinical View Profile ](/compound/ahk-cu)[ ### Melanotan 2 Skin & Hair Discontinued (early clinical) A synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression.. t½ ~1–2 hours 100-1,000 mcg per injection Preclinical View Profile ](/compound/melanotan-2)[ ### Minoxidil Skin & Hair FDA-Approved Minoxidil is an FDA-approved treatment for pattern hair loss. t½ Oral minoxidil plasma half-life is approximately 3-4 hours; the hair-growth (pharmacodynamic) effect is independent of plasma level and depends on ongoing daily use. Oral low-dose minoxidil (off-label): 625-5000 mcg/day (0.625-5 mg). Topical minoxidil is dosed by concentration (2% or 5%), not by mcg -- roughly 10-20 mg of minoxidil is delivered per topical application, with only ~1.4% absorbed systemically. Preclinical View Profile ](/compound/minoxidil)[ ### PDRN Skin & Hair Phase 4 PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. t½ Short (oligonucleotides degraded rapidly; tissue effects persist longer) 0 Preclinical View Profile ](/compound/pdrn) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-snap-8) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. 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