--- title: "PEG-MGF: Dosage, Side Effects & Prices | BodyHackGuide" url: https://www.bodyhackguide.co/compound/peg-mgf description: "PEG-MGF: dosing protocols, mechanism & side effects. Compare 1 current vendor prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # PEG-MGF Performance: https://www.bodyhackguide.co/wiki#cat-performance Status Preclinical,, not approved for human use Evidence Not graded on a research bench yet PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage. Reviewed 28 October 2026 01 Overview ## What PEG-MGF is MGF differs from systemic IGF-1 in that it has a unique E-domain peptide (the Ec peptide, or MGF peptide) that activates satellite cells (muscle stem cells) rather than IGF-1 receptor signaling. Pegylation (attachment of polyethylene glycol chains) dramatically extends MGF's plasma half-life from minutes to approximately 24 hours, enabling systemic administration in research protocols. PEG-MGF is researched primarily for its muscle satellite cell activation, tissue repair, and recovery applications. ### How it works PEG-MGF is the PEGylated form of Mechano Growth Factor (MGF), a synthetic peptide corresponding to the C-terminal 24 amino acids of the unique E-domain of IGF-1Ec, an alternatively spliced variant of the IGF-1 gene expressed in skeletal muscle after mechanical loading or damage. The MGF E-peptide acts on muscle satellite (stem) cells and myoblasts: in vitro it increases their proliferation while DELAYING terminal differentiation, expanding the myoblast/satellite-cell pool available for repair and myonuclear addition. Blocking the IGF-1 receptor does not abolish this effect, indicating the E-peptide signals through a receptor distinct from IGF-1R (the specific receptor has not been definitively identified). This separates MGF's proliferative action from the differentiation and metabolic signaling of mature IGF-1. In preclinical models MGF/IGF-1Ec is also reported to be cytoprotective - pretreatment before myocardial infarction improves cardiac function, and it is neuroprotective during cerebral ischemia - but these effects are NOT mediated by the fibroblast growth factor receptor (MGF is a variant of IGF-1, not an FGF). PEGylation is intended to slow proteolytic clearance and extend the peptide's otherwise very short half-life. Important caveat: no endogenous MGF E-peptide has ever been isolated from cells, conditioned media, or animal tissue, and the human pharmacology of the synthetic (and PEGylated) peptide is uncharacterized. ### Benefits listed - Increases satellite-cell and myoblast proliferation, expanding the cell pool available for muscle repair (in vitro and animal studies) - May accelerate muscle repair after exercise-induced damage or injury (preclinical) - Pro-survival, anti-apoptotic signaling reported in muscle and other cell types (preclinical) - Preclinical cytoprotection: MGF pretreatment improved cardiac function after experimental myocardial infarction (mechanism distinct from IGF-1R, NOT via fibroblast growth factor receptor) Show 2 more Show less - Preclinical neuroprotection during cerebral ischemia - PEGylation is intended to extend native MGF's very short half-life to allow less frequent research dosing 02 Research Free with email ## What the research shows No research bench grades PEG-MGF yet. Benches compare compounds people pair, with the evidence for each. ### Unlock the research summary Enter your email to keep reading. It is free, and it opens these sections on every compound page in this browser. - A summary of the key research - A link to the PubMed results You also get the free peptide cheat sheet by email. Unsubscribe anytime. Have an account? Sign in (https://www.bodyhackguide.co/auth) 03 Safety ## PEG-MGF side effects and interactions ### Side effects #### Common - Injection-site reactions (redness, itching, swelling) - Post-injection fatigue or lethargy (anecdotal) - No controlled human data - tolerability is not established #### Serious events - No controlled human safety data of any kind - Theoretical mitogenic/proliferative risk - MGF is a proliferation-promoting growth-factor peptide; caution in anyone with active or prior malignancy - Unlike IGF-1 or IGF-1 LR3, the MGF E-peptide signals through a non-IGF-1R receptor and is not expected to cause classic insulin-like hypoglycemia, but its metabolic effects in humans are unknown - WADA prohibited: S2 category (peptide hormones, growth factors and mimetics) ### Interactions Not in our record Our record lists no interactions for PEG-MGF. That means none are recorded here, not that none exist. This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. Order Bloodwork (https://anabolicinsights.ai/?ref=nwm2zjb) 04 Dosing Free with email ## PEG-MGF dosage and protocols Dose range 200 mcg Dosing Twice weekly Common vials 2mg ### Unlock the Dosing section - Route and how often - Common vial sizes 05 Prices ## PEG-MGF prices 1 listing from 1 vendor, opening in the Featured order. Pack prices $39.00 Lowest per mg $19.50/mg Vendors 1 Listings 1 (vial) Prices as the vendors list them, last recorded 22 April 2026. Form Sort | Vendor | Product | Price | Buy | | --- | --- | --- | --- | | Image: Ion Peptide logo (https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Ion Peptide: https://www.bodyhackguide.co/vendors/ion-peptide | PEG-MGF 2mg vial, 1 vial In stock | $19.50/mg $39.00 Lowest per mg | Buy PEG-MGF 2mg at Ion Peptide: https://ionpeptide.com/product/peg-mgf/?ref=reddit15 | Vendors selling PEG-MGF(1: trust score, certificates, payment, shipping) - Ion Peptide (https://www.bodyhackguide.co/vendors/ion-peptide)1 listing, from $39.00 Trust Score 70/100 (https://www.bodyhackguide.co/vendor-trust-scorecard), no certificate records on file, pays by card, crypto, ACH, ships to the US, international destinations Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. How we score these vendors (https://www.bodyhackguide.co/vendors/scorecard) Review PEG-MGF ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with PEG-MGF. 06 Chemistry ## Chemistry and structure Molecular mass Free peptide approximately 2,867-2,868 Da (24-aa MGF E-peptide). The total mass of PEG-MGF is greater and is not standardized - it depends on the size of the attached PEG chain. Amino acid sequence YQPPSTNKNTKSQRRKGSTFEERK - the human MGF / IGF-1Ec C-terminal 24-amino-acid E-domain peptide (Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys). PEG-MGF is this same peptide covalently conjugated to a polyethylene glycol (PEG) moiety to slow proteolytic degradation. Half-life Native MGF: very short (minutes) due to rapid proteolysis. PEG-MGF: PEGylation is intended to extend this substantially (community estimates up to roughly 1 day), but there are no published human pharmacokinetic data to confirm a specific value. 07 Related ## Related to PEG-MGF ### In the same category - ACE-031Phase 2 ACE-031 (international nonproprietary name ramatercept) is a dimeric fusion protein that joins the extracellular domain of human activin receptor type IIB to the Fc region of human IgG1, developed by Acceleron Pharma as a decoy receptor that traps myostatin and related growth factors before they can suppress muscle growth.: https://www.bodyhackguide.co/compound/ace-031 - ITPPPreclinical ITPP (myo-inositol trispyrophosphate, sometimes written myo-inositol tripyrophosphate or OXY111A in NormOxys trial documents) is a small-molecule allosteric effector of hemoglobin designed to increase the amount of oxygen red blood cells release to tissues.: https://www.bodyhackguide.co/compound/itpp - L-CitrullinePhase 3 L-citrulline is a non-protein amino acid, found in high concentrations in watermelon, that the small intestine makes and the kidneys convert into arginine, the amino acid the body uses to make nitric oxide.: https://www.bodyhackguide.co/compound/l-citrulline - LGD-4033 (Ligandrol)Phase 2 LGD-4033, usually sold as ligandrol, is a nonsteroidal selective androgen receptor modulator that Viking Therapeutics took into clinical development under the code VK5211 (NCT02578095).: https://www.bodyhackguide.co/compound/lgd-4033 - Ostarine (Enobosarm, MK-2866)Phase 3 Ostarine is the market name for enobosarm, a nonsteroidal selective androgen receptor modulator first developed by GTx Inc under the codes GTx-024, MK-2866 and S-22.: https://www.bodyhackguide.co/compound/ostarine - RAD-140 (Testolone)Phase 1 RAD-140, sold as testolone and given the international nonproprietary name vosilasarm, is a nonsteroidal selective androgen receptor modulator developed at Radius Health, whose scientists reported the first-in-human trial, and first described in the medicinal chemistry literature as a compound with an oxadiazole core designed for oral androgen receptor activity with tissue selectivity.: https://www.bodyhackguide.co/compound/rad-140 All compounds (https://www.bodyhackguide.co/wiki) ### Compare PEG-MGF - Alternatives to PEG-MGF: https://www.bodyhackguide.co/alternatives-to/peg-mgf ### Research tools - Peptide Calculator Reconstitution and syringe units: https://www.bodyhackguide.co/tools/reconstitution - Reconstitution Guide How to mix, step by step: https://www.bodyhackguide.co/guides/how-to-reconstitute-peptides - Nasal Spray Calc mL per actuation: https://www.bodyhackguide.co/tools/intranasal - Half-Life Visualizer Decay curves: https://www.bodyhackguide.co/tools/halflife All articles (https://www.bodyhackguide.co/blog) 08 Questions ## Frequently asked questions What is PEG-MGF used for in research? PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage. MGF differs from systemic IGF-1 in that it has a unique E-domain peptide (the Ec peptide, or MGF peptide) that activates satellite cells (muscle stem cells) rather than IGF-1 receptor signaling. Pegylation (attachment of polyethylene glycol chains) dramatically extends MGF's plasma half-life from minutes to approximately 24 hours, enabling systemic administration in research protocols. PEG-MGF is researched primarily for its muscle satellite cell activation, tissue repair, and recovery applications. What forms does PEG-MGF come in? PEG-MGF is available in vial form. How do I compare PEG-MGF vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. How many vendors sell PEG-MGF, and what does it cost per mg? 1 of the vendors BodyHackGuide tracks list PEG-MGF (1 listing). Among BodyHackGuide's PEG-MGF listings recorded as in stock with a milligram count, the lowest price per milligram is $19.50/mg at Ion Peptide and the median is $19.50/mg. The PEG-MGF prices on BodyHackGuide are vendors' listed prices as BodyHackGuide last recorded them, not transactions; the most recent recorded change to a PEG-MGF listing is dated 22 April 2026. Which vendors have third-party COAs for PEG-MGF on file at BodyHackGuide? BodyHackGuide holds 5 third-party certificate records for PEG-MGF, from. No editor has read any of BodyHackGuide's 5 certificate records for PEG-MGF. The laboratory named on BodyHackGuide's PEG-MGF certificate records is Freedom Diagnostics Testing, and the newest test date on them is 18 September 2025. Each vendor page on BodyHackGuide shows how many certificate records BodyHackGuide holds for that vendor and links to each record that has its own page. Free 2026 Peptide Cheat Sheet (PDF) 38 compounds and blends: vial sizes, BAC water volumes, dosing ranges and bloodwork markers. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. 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