--- title: "PDRN: Dosage, Side Effects & Prices | BodyHackGuide" url: https://www.bodyhackguide.co/compound/pdrn description: "PDRN: dosing protocols, mechanism & side effects. Compare 1 current vendor prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # PDRN Skin & Hair: https://www.bodyhackguide.co/wiki#cat-skin-&-hair Status Phase 4,, not approved for human use Evidence Not graded on a research bench yet PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. Reviewed 28 October 2026 01 Overview ## What PDRN is It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. It is one of the few compounds in this catalog with a substantial published clinical (Phase 4) evidence base in aesthetic applications. ### How it works PDRN exerts effects through two primary mechanisms: (1) Adenosine A2A receptor agonism — PDRN is hydrolyzed to deoxyadenosine fragments that activate A2A receptors on fibroblasts, endothelial cells, and macrophages. A2A activation stimulates VEGF production (angiogenesis), collagen type I and III synthesis, and anti-inflammatory cytokine profiles (increased IL-10, decreased TNF-α). (2) Salvage pathway activation — DNA-derived nucleotides from PDRN are incorporated into the tissue nucleotide salvage pathway, providing precursors for DNA repair and cellular proliferation in wound healing. Together, these mechanisms accelerate fibroblast proliferation, neocollagenesis, angiogenesis, and tissue regeneration. ### Benefits listed - Wound healing acceleration - enhanced angiogenesis, fibroblast proliferation, and collagen synthesis - Diabetic foot ulcer healing - supported by a randomized, double-blind, placebo-controlled trial (complete healing 37.3% vs 18.9% for placebo) [PMID:24483158] - Skin rejuvenation - clinical studies suggest improved texture and elasticity, though a 2024 systematic review found the aesthetic evidence base inconsistent [PMID:39198280] - Hair loss - preliminary evidence only; a small uncontrolled study in female pattern hair loss reported improved hair count and thickness (not established for androgenetic alopecia) [PMID:25524027] Show 2 more Show less - Anti-inflammatory tissue remodeling - reduction of pro-inflammatory cytokines via adenosine A2A receptor signaling - Aesthetic skin treatments - widely used in South Korean and European clinical practice 02 Research Free with email ## What the research shows No research bench grades PDRN yet. Benches compare compounds people pair, with the evidence for each. ### Unlock the research summary Enter your email to keep reading. It is free, and it opens these sections on every compound page in this browser. - A summary of the key research - A link to the PubMed results You also get the free peptide cheat sheet by email. Unsubscribe anytime. Have an account? Sign in (https://www.bodyhackguide.co/auth) 03 Safety ## PDRN side effects and interactions ### Side effects #### Common - Mild injection site bruising and swelling - Transient redness - Well tolerated in aesthetic clinical literature #### Serious events - Allergic reaction risk (salmon-derived product) - No serious systemic adverse events in published aesthetic medicine RCTs ### Interactions Not in our record Our record lists no interactions for PDRN. That means none are recorded here, not that none exist. This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. Order Bloodwork (https://anabolicinsights.ai/?ref=nwm2zjb) 04 Dosing Free with email ## PDRN dosage and protocols Dosing Weekly ### Unlock the Dosing section - Route and how often 05 Prices ## PDRN prices 1 listing from 1 vendor, opening in the Featured order. Pack prices $34.95 Lowest per mg Not listed Vendors 1 Listings 1 (topical) Prices as the vendors list them, last recorded 22 April 2026. Form Sort | Vendor | Product | Price | Buy | | --- | --- | --- | --- | | Image: Ion Peptide logo (https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Ion Peptide: https://www.bodyhackguide.co/vendors/ion-peptide | PDRN Pink Cream topical, 1 jar In stock | $34.95 No mg count | Buy PDRN Pink Cream at Ion Peptide: https://ionpeptide.com/product/pdrn-pink-face-cream/?ref=reddit15 | Vendors selling PDRN(1: trust score, certificates, payment, shipping) - Ion Peptide (https://www.bodyhackguide.co/vendors/ion-peptide)1 listing, from $34.95 Trust Score 70/100 (https://www.bodyhackguide.co/vendor-trust-scorecard), no certificate records on file, pays by card, crypto, ACH, ships to the US, international destinations Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. How we score these vendors (https://www.bodyhackguide.co/vendors/scorecard) Review PDRN ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with PDRN. 06 Chemistry ## Chemistry and structure Molecular mass No single value - PDRN is a heterogeneous mixture of deoxyribonucleotide polymers (chain lengths ~50-2000 bp, roughly 50-1500 kDa) rather than one defined molecule [PMID:19860658]. Half-life Short (oligonucleotides degraded rapidly; tissue effects persist longer) 07 Related ## Related to PDRN ### In the same category - Acetyl Hexapeptide-8Marketed topical cosmetic ingredient Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction.: https://www.bodyhackguide.co/compound/acetyl-hexapeptide-8 - AHK-CuPreclinical AHK-Cu is a copper chelating tripeptide related to but distinct from GHK-Cu.: https://www.bodyhackguide.co/compound/ahk-cu - Melanotan 2Discontinued A synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression.: https://www.bodyhackguide.co/compound/melanotan-2 - MinoxidilFDA-Approved Minoxidil is an FDA-approved treatment for pattern hair loss. Originally an oral blood-pressure drug, its hair-growth side effect led to the topical products (Rogaine) at 2% and 5%.: https://www.bodyhackguide.co/compound/minoxidil - Palmitoyl Pentapeptide-4Marketed topical cosmetic ingredient with a small set of human cosmetic trials Palmitoyl pentapeptide-4 is the cosmetic ingredient Pal-KTTKS, a five-amino-acid fragment of the type I collagen propeptide with a 16-carbon palmitic acid chain attached, sold to formulators under the trade name Matrixyl (PubChem CID 9897237; PMID: 8486721).: https://www.bodyhackguide.co/compound/palmitoyl-pentapeptide-4 - PTD-DBMPreclinical PTD-DBM is a synthetic peptide that joins a protein transduction domain, which carries the peptide into cells, to the Dishevelled-binding motif (DBM) of the protein CXXC5, and it was built to block CXXC5 from binding Dishevelled so that Wnt/beta-catenin signalling stays switched on.: https://www.bodyhackguide.co/compound/ptd-dbm All compounds (https://www.bodyhackguide.co/wiki) ### Compare PDRN - Alternatives to PDRN: https://www.bodyhackguide.co/alternatives-to/pdrn ### Research tools - Peptide Calculator Reconstitution and syringe units: https://www.bodyhackguide.co/tools/reconstitution - Reconstitution Guide How to mix, step by step: https://www.bodyhackguide.co/guides/how-to-reconstitute-peptides - Nasal Spray Calc mL per actuation: https://www.bodyhackguide.co/tools/intranasal - Half-Life Visualizer Decay curves: https://www.bodyhackguide.co/tools/halflife All articles (https://www.bodyhackguide.co/blog) 08 Questions ## Frequently asked questions What is PDRN used for in research? PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. It is one of the few compounds in this catalog with a substantial published clinical (Phase 4) evidence base in aesthetic applications. What forms does PDRN come in? PDRN is available in topical form. How do I compare PDRN vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. How many vendors sell PDRN, and what does it cost per mg? 1 of the vendors BodyHackGuide tracks list PDRN (1 listing). The lowest listed price BodyHackGuide has recorded for PDRN is $34.95. No PDRN listing recorded as in stock carries a milligram count, so BodyHackGuide states no price per milligram for PDRN. Which vendors have third-party COAs for PDRN on file at BodyHackGuide? BodyHackGuide holds no third-party certificate records for PDRN. Each vendor page on BodyHackGuide shows how many certificate records BodyHackGuide holds for that vendor. Related ## Articles on PDRN - Ion Peptide Review 2026: BPC-157, GLP-1s, Buccal Strips & Bioregulators vendor-reviews, 21 April 2026: https://www.bodyhackguide.co/blog/ion-peptide-review-2026 Free 2026 Peptide Cheat Sheet (PDF) 38 compounds and blends: vial sizes, BAC water volumes, dosing ranges and bloodwork markers. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. 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