--- title: "PDRN: Dosing & Vendor Prices — BodyHackGuide" description: "PDRN: dosing protocols, mechanism & side effects. Compare 1 verified vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "PDRN" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "PDRN", "description": "PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. 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Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is PDRN used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. 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A2A activation stimulates VEGF production (angiogenesis), collagen type I and III synthesis, and anti-inflammatory cytokine profiles (increased IL-10, decreased TNF-α). (2) Salvage pathway activation — DNA-derived nucleotides from PDRN are incorporated into the tissue nucleotide salvage pathway, providing precursors for DNA repair and cellular proliferation in wound healing. Together, these mechanisms accelerate fibroblast proliferation, neocollagenesis, angiogenesis, and tissue regeneration.", "dosageForm": "topical", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is PDRN used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. 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BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. 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PDRN # PDRN Skin & Hair Phase 4 Download PDF Also known as: Polydeoxyribonucleotide, Placentex, Nucleofill, Salmon DNA, Nucleotide polymer PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. Half-Life: Short (oligonucleotides degraded rapidly; tissue effects persist longer) Route: Subcutaneous, Intradermal, Topical MW: No single value - PDRN is a heterogeneous mixture of deoxyribonucleotide polymers (chain lengths ~50-2000 bp, roughly 50-1500 kDa) rather than one defined molecule \[PMID:19860658\]. Last reviewed: Sep 4, 2026 [ Skin & Hair Category ](/wiki#cat-skin-&-hair) Phase 4 Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices1 Related ## Overview ### Best Price Available ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Ion Peptide $34.95 1 jar · topical [Buy Now](https://ionpeptide.com/product/pdrn-pink-face-cream/?ref=reddit15) Compare 1 vendor ### At A Glance Mechanism PDRN exerts effects through two primary mechanisms: (1) Adenosine A2A receptor agonism — PDRN is hydrolyzed to deoxyadenosine fragments that activate A2A receptors on fibroblasts, endothelial cells, and macrophages. A2A activation stimulates VEGF production (angiogenesis), collag… Half-Life Short (oligonucleotides degraded rapidly; tissue effects persist longer) Dosing weekly Dose Range 0mcg Routes Subcutaneous Intradermal Topical Potential Benefits Wound healing acceleration - enhanced angiogenesis, fibroblast proliferation, and collagen synthesis Diabetic foot ulcer healing - supported by a randomized, double-blind, placebo-controlled trial (complete healing 37.3% vs 18.9% for placebo) \[PMID:24483158\] Skin rejuvenation - clinical studies suggest improved texture and elasticity, though a 2024 systematic review found the aesthetic evidence base inconsistent \[PMID:39198280\] Hair loss - preliminary evidence only; a small uncontrolled study in female pattern hair loss reported improved hair count and thickness (not established for androgenetic alopecia) \[PMID:25524027\] Anti-inflammatory tissue remodeling - reduction of pro-inflammatory cytokines via adenosine A2A receptor signaling Aesthetic skin treatments - widely used in South Korean and European clinical practice Safety Notes Common Mild injection site bruising and swelling Transient redness Well tolerated in aesthetic clinical literature Serious Allergic reaction risk (salmon-derived product) No serious systemic adverse events in published aesthetic medicine RCTs ### Overview PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. It is one of the few compounds in this catalog with a substantial published clinical (Phase 4) evidence base in aesthetic applications. ## Chemical Information IUPAC Name Not yet available CAS Number Not yet available Molecular Formula Not yet available Molecular Mass No single value - PDRN is a heterogeneous mixture of deoxyribonucleotide polymers (chain lengths ~50-2000 bp, roughly 50-1500 kDa) rather than one defined molecule \[PMID:19860658\]. ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions Interaction and contraindication data is being compiled for PDRN. Check back soon. General Safety Note Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented. Best Price $34.95 Best $/mg — Vendors 1 Listings 1 topical [Sign in for alerts ](/auth) Form Alltopical Sort Price $/mg Vendor Vendor Product Form Qty Price $/mg Coupon ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) [Ion Peptide](/vendor/ion-peptide) [70 ](/vendor-trust-scorecard) 🇺🇸 US 🌍 International PDRN Pink Cream topical 1 jar ● In Stock $34.95 BEST — — [Buy](https://ionpeptide.com/product/pdrn-pink-face-cream/?ref=reddit15) Get PDRN Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $34.95 [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with PDRN. [Sign in](/auth) Current low $34.95 as of Apr 22, 2026 7-day low — no 7d data yet 30-day low — no 30d data yet 30-day change — baseline building Tracking since Apr 22, 2026 · 1 data point ### Vendors Selling PDRN [ ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) #### Ion Peptide 4.5 1 listing · from $34.95 ](/vendor/ion-peptide) How we score these vendors Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. [View Scorecard](/vendors/scorecard) ### Related Compounds [View All](/wiki) [ ### Acetyl Hexapeptide-8 Skin & Hair Marketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug. Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. t½ Short (topical application, no systemic absorption at cosmetic doses) 0 Preclinical View Profile ](/compound/acetyl-hexapeptide-8)[ ### AHK-Cu Skin & Hair Preclinical AHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper). t½ Unknown (topical half-life, follicular retention not well characterized) 0 Preclinical View Profile ](/compound/ahk-cu)[ ### Melanotan 2 Skin & Hair Discontinued (early clinical) A synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression.. t½ ~1–2 hours 100-1,000 mcg per injection Preclinical View Profile ](/compound/melanotan-2)[ ### Minoxidil Skin & Hair FDA-Approved Minoxidil is an FDA-approved treatment for pattern hair loss. t½ Oral minoxidil plasma half-life is approximately 3-4 hours; the hair-growth (pharmacodynamic) effect is independent of plasma level and depends on ongoing daily use. Oral low-dose minoxidil (off-label): 625-5000 mcg/day (0.625-5 mg). Topical minoxidil is dosed by concentration (2% or 5%), not by mcg -- roughly 10-20 mg of minoxidil is delivered per topical application, with only ~1.4% absorbed systemically. Preclinical View Profile ](/compound/minoxidil)[ ### Snap-8 Skin & Hair Preclinical Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox). t½ Not characterized (topical peptide) 0 Preclinical View Profile ](/compound/snap-8) [ View Full Dosage Guide → Protocols, calculator & safety for PDRN ](/guides/dosage/pdrn) ### Related Articles [All Posts](/blog) [ #### Ion Peptide Review 2026: BPC-157, GLP-1s, Buccal Strips & Bioregulators A complete look at Ion Peptide (ionpeptide.com) — 92 products spanning research peptides, GLP-1 agonists, NAD+/B12/glutathione buccal strips, copper peptide topicals, Khavinson bioregulators, and PDRN. We cover pricing, testing, shipping, unique offerings, and how they compare to other vendors on BodyHackGuide. 4/21/2026 ](/blog/ion-peptide-review-2026) ### Best Price ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Ion Peptide $34.95 [Buy Now](https://ionpeptide.com/product/pdrn-pink-face-cream/?ref=reddit15) 1 vendors · 1 listings ### Research Score 45 0 PubMed studies ### Quality Indicators Data Completeness 63% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Studies Interactions Vendor Listings ### Quick Facts Half-Life Short (oligonucleotides degraded rapidly; tissue effects persist longer) Molecular Weight No single value - PDRN is a heterogeneous mixture of deoxyribonucleotide polymers (chain lengths ~50-2000 bp, roughly 50-1500 kDa) rather than one defined molecule \[PMID:19860658\]. Administration Subcutaneous, Intradermal, Topical Trial Phase Phase 4 ### Safety Profile Common Side Effects - • Mild injection site bruising and swelling - • Transient redness - • Well tolerated in aesthetic clinical literature [Full Dosage Guide](/guides/dosage/pdrn)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is PDRN used for in research? PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. It is one of the few compounds in this catalog with a substantial published clinical (Phase 4) evidence base in aesthetic applications. What forms does PDRN come in? PDRN is available in topical form. How much does PDRN cost? Prices start at $34.95 across 1 verified vendor. How do I compare PDRN vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### Acetyl Hexapeptide-8 Skin & Hair Marketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug. Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. t½ Short (topical application, no systemic absorption at cosmetic doses) 0 Preclinical View Profile ](/compound/acetyl-hexapeptide-8)[ ### AHK-Cu Skin & Hair Preclinical AHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper). t½ Unknown (topical half-life, follicular retention not well characterized) 0 Preclinical View Profile ](/compound/ahk-cu)[ ### Melanotan 2 Skin & Hair Discontinued (early clinical) A synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression.. t½ ~1–2 hours 100-1,000 mcg per injection Preclinical View Profile ](/compound/melanotan-2)[ ### Minoxidil Skin & Hair FDA-Approved Minoxidil is an FDA-approved treatment for pattern hair loss. t½ Oral minoxidil plasma half-life is approximately 3-4 hours; the hair-growth (pharmacodynamic) effect is independent of plasma level and depends on ongoing daily use. Oral low-dose minoxidil (off-label): 625-5000 mcg/day (0.625-5 mg). Topical minoxidil is dosed by concentration (2% or 5%), not by mcg -- roughly 10-20 mg of minoxidil is delivered per topical application, with only ~1.4% absorbed systemically. Preclinical View Profile ](/compound/minoxidil)[ ### Snap-8 Skin & Hair Preclinical Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox). t½ Not characterized (topical peptide) 0 Preclinical View Profile ](/compound/snap-8) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-pdrn) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. [Order Bloodwork](https://anabolicinsights.ai/?ref=nwm2zjb) ![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub — compound pricing, brain health protocols, dosing tools, and vendor reviews. 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