--- title: "P-21 Amidate: Dosing & Vendor Prices | BodyHackGuide" description: "P-21 Amidate: dosing protocols, mechanism & side effects, 1 PubMed results. Compare current vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "P-21 Amidate" } ] }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "P-21 Amidate", "description": "P-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank. The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides. The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses. Peer-reviewed comparative data for the amidate form remains thin — most published P-21 research uses the unmodified cyclic form.", "lastReviewed": "2026-09-14T19:40:22.325Z", "url": "https://www.bodyhackguide.co/compound/p21-amidate", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "P-21 Amidate", "alternateName": [ "P21 Amide", "P-21 Amide", "P-21-NH2", "Cyclo-Pro-Gly-Amide" ], "description": "P-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank. The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides. The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses. Peer-reviewed comparative data for the amidate form remains thin — most published P-21 research uses the unmodified cyclic form.", "activeIngredient": "P-21 Amidate", "mechanismOfAction": "Mechanism (P-21 / P021): P-21 is a small-molecule mimetic of a biologically active region of human ciliary neurotrophic factor (CNTF) - an adamantylated peptide amide, Ac-DGGL(A)G-NH2. Its reported actions come from preclinical (rodent) studies: Increases brain-derived neurotrophic factor (BDNF) expression by inhibiting the leukemia inhibitory factor (LIF) signaling pathway [PMID:27400746] Enhances hippocampal (dentate gyrus) neurogenesis and synaptic plasticity [PMID:25046994] Lowers tau hyperphosphorylation indirectly: increased BDNF reduces glycogen synthase kinase-3 (GSK-3, a major tau kinase) activity [PMID:27400746] Blood-brain-barrier permeable and orally bioavailable, unlike native CNTF or BDNF [PMID:27400746] On the \"Amidate\" label: Base P021 is already C-terminally amidated (the -NH2 in Ac-DGGL(A)G-NH2). Vendor claims that \"P-21 Amidate\" is a chemically distinct, more stable, or more potent form than standard P-21 are unverified marketing differentiation and are not supported by the published literature. All evidence is from animal models - there are no human pharmacokinetic, efficacy, or safety studies. Research use only.", "legalStatus": "Not approved for human use (research chemical)", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is P-21 Amidate used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "P-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank. The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides. The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses. Peer-reviewed comparative data for the amidate form remains thin — most published P-21 research uses the unmodified cyclic form." } }, { "@type": "Question", "name": "What forms does P-21 Amidate come in?", "acceptedAnswer": { "@type": "Answer", "text": "P-21 Amidate is available in vials, capsules, and sprays forms." } }, { "@type": "Question", "name": "How much does P-21 Amidate cost?", "acceptedAnswer": { "@type": "Answer", "text": "Pricing varies by vendor and form." } }, { "@type": "Question", "name": "How do I compare P-21 Amidate vendors?", "acceptedAnswer": { "@type": "Answer", "text": "Compare prices, payment methods, shipping, and COA scores across 0 vendors." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, vendor price comparisons, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+, enter siteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompound%2Fp21-amidate) Compare notes with other researchers. Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 3. [Compounds](/compare) 5. P-21 Amidate [🛒 Where to buy P-21 Amidate](/buy/p21-amidate)[🏷️ P-21 Amidate coupon codes](/coupons/p21-amidate)[📋 P-21 Amidate protocol](/protocol/p21-amidate)[🔄 Alternatives to P-21 Amidate](/alternatives-to/p21-amidate)[⚠️ P-21 Amidate side effects](/side-effects/p21-amidate) 1. [Home](/) 3. [Compounds](/compare) 5. P-21 Amidate # P-21 Amidate Nootropic Peptide Preclinical Download PDF Also known as: P21 Amide, P-21 Amide, P-21-NH2, Cyclo-Pro-Gly-Amide P-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank. The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides. The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses. Half-Life: No established human PK - unknown. P-21 (P021) is a preclinical compound; rodent studies used chronic oral or subcutaneous dosing and demonstrated oral bioavailability and blood-brain-barrier penetration, but no validated human half-life data exist. MW: ~592.7 g/mol (free base; molecular formula C28H44N6O8) [1 PubMed Results](https://pubmed.ncbi.nlm.nih.gov/?term=P-21%20Amidate) Last reviewed: Sep 13, 2026 [ 1 PubMed Results ](https://pubmed.ncbi.nlm.nih.gov/?term=P-21%20Amidate)[ Nootropic Peptide Category ](/wiki#cat-nootropic-peptide) Preclinical Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare PricesRelated ## Overview ### At A Glance Mechanism Mechanism (P-21 / P021):… Half-Life No established human PK - unknown. P-21 (P021) is a preclinical compound; rodent studies used chronic oral or subcutaneous dosing and demonstrated oral bioavailability and blood-brain-barrier penetration, but no validated human half-life data exist. ### Mechanism of Action **Mechanism (P-21 / P021):** P-21 is a small-molecule mimetic of a biologically active region of human ciliary neurotrophic factor (CNTF) - an adamantylated peptide amide, Ac-DGGL(A)G-NH2. Its reported actions come from preclinical (rodent) studies: - Increases brain-derived neurotrophic factor (BDNF) expression by inhibiting the leukemia inhibitory factor (LIF) signaling pathway \[PMID:27400746\] - Enhances hippocampal (dentate gyrus) neurogenesis and synaptic plasticity \[PMID:25046994\] - Lowers tau hyperphosphorylation indirectly: increased BDNF reduces glycogen synthase kinase-3 (GSK-3, a major tau kinase) activity \[PMID:27400746\] - Blood-brain-barrier permeable and orally bioavailable, unlike native CNTF or BDNF \[PMID:27400746\] **On the "Amidate" label:** Base P021 is already C-terminally amidated (the -NH2 in Ac-DGGL(A)G-NH2). Vendor claims that "P-21 Amidate" is a chemically distinct, more stable, or more potent form than standard P-21 are unverified marketing differentiation and are not supported by the published literature. All evidence is from animal models - there are no human pharmacokinetic, efficacy, or safety studies. Research use only. ### Overview P-21 Amidate is the **amide-modified variant of [P-21](/compound/p21)**, the cyclic dipeptide derived from [Selank](/compound/selank). The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides. The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses. Peer-reviewed comparative data for the amidate form remains thin — most published P-21 research uses the unmodified cyclic form. ## Chemical Information IUPAC Name Not yet available CAS Number Not yet available Molecular Formula C7H11N3O2 Molecular Mass 592.69 g/mol Amino Acid Sequence Ac-DGGL(A)G-NH2 ## Dosing & Protocols ### Dosing Summary Dose 100-600 mcg/day Route Oral / Intranasal Frequency 1-2x daily Duration 14-30 day cycles ### Beginner Protocol ### Intermediate Protocol ### Advanced Protocol ### Stacking Notes ### Additional Dosage Notes [Full P-21 Amidate Dosing Guide](/guides/dosage/p21-amidate) [Open Reconstitution Calculator](/tools/reconstitution) ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) Join other researchers already signed up ## Research [1 PubMed Results](https://pubmed.ncbi.nlm.nih.gov/?term=P-21%20Amidate) ### Key Research Findings No human clinical trials have been conducted on P-21 (P021); the evidence base is entirely preclinical. In rodent models, chronic oral P021 increased BDNF, enhanced dentate-gyrus neurogenesis and synaptic plasticity, reduced tau hyperphosphorylation via decreased GSK-3 activity, and improved cognition - reported in a triple-transgenic Alzheimer's model \[PMID:25046994\] and an aged-rat cognitive-aging model \[PMID:24702821\], and reviewed for Alzheimer's drug development \[PMID:27400746\]. A 2024 study in a CDKL5-deficiency model showed in-vitro benefit but limited in-vivo effect, with no increase in brain BDNF in that model \[PMID:39592934\]. No human pharmacokinetic, efficacy, or safety data exist. Research use only. [Browse Studies on PubMed](https://pubmed.ncbi.nlm.nih.gov/?term=P-21%20Amidate) ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) Join other researchers already signed up ## Interactions Interaction and contraindication data is being compiled for P-21 Amidate. Check back soon. General Safety Note Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented. [Sign in for alerts ](/auth) No listings found for P-21 Amidate. Get P-21 Amidate Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with P-21 Amidate. [Sign in](/auth) ### Related Compounds [View All](/wiki) [ ### Adalank Nootropic Peptide Preclinical / Research compound Adalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog). t½ The commonly cited ~72-hour "functional duration" is an unverified community/vendor claim, not a measured value - no pharmacokinetic study of Adalank has ever been run. The figure is extrapolated from parent Adamax marketing claims. Actual serum half-life is unknown; there is no published PK data. 200-1200 mcg per dose (intranasal or subcutaneous), 1-2x daily Preclinical View Profile ](/compound/adalank)[ ### Adamax Nootropic Peptide Preclinical / Research compound Adamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax. t½ No pharmacokinetic data. Community reports describe a subjectively long duration of effect (~2-3 days), supporting every-other-day or 3x/week dosing; serum half-life not characterized. 500-2000 mcg subcutaneous (community research dosing) Preclinical View Profile ](/compound/adamax)[ ### Cerebrolysin Nootropic Peptide Clinical Cerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins. t½ ~2-4 hours (multi-component peptide mix) 85 PubMed View Profile ](/compound/cerebrolysin)[ ### Cortexin Nootropic Peptide Marketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved) Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors. t½ ~2-3 hours (estimated from analog peptide preparations) 18 PubMed View Profile ](/compound/cortexin)[ ### NA-Semax Nootropic Peptide Preclinical NA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s. t½ ~20-30 minutes (intranasal, estimated from analog data) 3 PubMed View Profile ](/compound/na-semax)[ ### NA-Semax Amidate Nootropic Peptide Preclinical NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. t½ ~30-45 minutes (estimated, longer than standard Semax) 2 PubMed View Profile ](/compound/na-semax-amidate) [ View Full Dosage Guide → Protocols, calculator & safety for P-21 Amidate ](/guides/dosage/p21-amidate) ### Research Score 60 1 PubMed results ### Quality Indicators Data Completeness 75% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Results Interactions Vendor Listings Research Volume 1 PubMed results Limited research available ### Quick Facts Half-Life No established human PK - unknown. P-21 (P021) is a preclinical compound; rodent studies used chronic oral or subcutaneous dosing and demonstrated oral bioavailability and blood-brain-barrier penetration, but no validated human half-life data exist. Molecular Weight 592.69 g/mol Trial Phase Preclinical ### Safety Profile Moderate Risk Stop Use If - Pregnancy or breastfeeding - Known peptide allergy [Full Dosage Guide](/guides/dosage/p21-amidate)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is P-21 Amidate used for in research? P-21 Amidate is the **amide-modified variant of [P-21](/compound/p21)**, the cyclic dipeptide derived from [Selank](/compound/selank). The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides. The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses. Peer-reviewed comparative data for the amidate form remains thin — most published P-21 research uses the unmodified cyclic form. What forms does P-21 Amidate come in? P-21 Amidate is available in vials, capsules, and sprays forms. How much does P-21 Amidate cost? Pricing varies by vendor and form. How do I compare P-21 Amidate vendors? Compare prices, payment methods, shipping, and COA scores across 0 vendors. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### Adalank Nootropic Peptide Preclinical / Research compound Adalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog). t½ The commonly cited ~72-hour "functional duration" is an unverified community/vendor claim, not a measured value - no pharmacokinetic study of Adalank has ever been run. The figure is extrapolated from parent Adamax marketing claims. Actual serum half-life is unknown; there is no published PK data. 200-1200 mcg per dose (intranasal or subcutaneous), 1-2x daily Preclinical View Profile ](/compound/adalank)[ ### Adamax Nootropic Peptide Preclinical / Research compound Adamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax. t½ No pharmacokinetic data. Community reports describe a subjectively long duration of effect (~2-3 days), supporting every-other-day or 3x/week dosing; serum half-life not characterized. 500-2000 mcg subcutaneous (community research dosing) Preclinical View Profile ](/compound/adamax)[ ### Cerebrolysin Nootropic Peptide Clinical Cerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins. t½ ~2-4 hours (multi-component peptide mix) 85 PubMed View Profile ](/compound/cerebrolysin)[ ### Cortexin Nootropic Peptide Marketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved) Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors. t½ ~2-3 hours (estimated from analog peptide preparations) 18 PubMed View Profile ](/compound/cortexin)[ ### NA-Semax Nootropic Peptide Preclinical NA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s. t½ ~20-30 minutes (intranasal, estimated from analog data) 3 PubMed View Profile ](/compound/na-semax)[ ### NA-Semax Amidate Nootropic Peptide Preclinical NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. t½ ~30-45 minutes (estimated, longer than standard Semax) 2 PubMed View Profile ](/compound/na-semax-amidate) Free 2026 Peptide Cheat Sheet (PDF) Reconstitution math, concentration charts, half-lives, and vendor links. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-p21-amidate) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. [Order Bloodwork](https://anabolicinsights.ai/?ref=nwm2zjb) ![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. 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