--- title: "Oleamide: Dosing & Vendor Prices | BodyHackGuide" description: "Oleamide: dosing protocols, mechanism & side effects, 62 PubMed results. Compare current vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Oleamide" } ] }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Oleamide", "description": "Oleamide is a fatty acid primary amide that your brain naturally produces during sleep deprivation — your body's endogenous sleep-promoting lipid signal. First identified in 1995 by Cravatt and colleagues at Scripps Research Institute as the major sleep-inducing factor accumulating in cerebrospinal fluid during prolonged wakefulness. 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First identified in 1995 by Cravatt and colleagues at Scripps Research Institute as the major sleep-inducing factor accumulating in cerebrospinal fluid during prolonged wakefulness. Unlike pharmaceutical sleep aids that override sleep architecture, oleamide works WITH the body's natural sleep mechanisms by potentiating GABA-A receptor activity and modulating serotonin receptors. Subjective effects are typically described as \"natural drowsiness\" rather than the sedated/drugged feeling from benzodiazepines or antihistamines. As a supplement, oleamide is sold as research-only and not FDA-approved. 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Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Oleamide used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "Oleamide is a fatty acid primary amide that your brain naturally produces during sleep deprivation — your body's endogenous sleep-promoting lipid signal. First identified in 1995 by Cravatt and colleagues at Scripps Research Institute as the major sleep-inducing factor accumulating in cerebrospinal fluid during prolonged wakefulness. Unlike pharmaceutical sleep aids that override sleep architecture, oleamide works WITH the body's natural sleep mechanisms by potentiating GABA-A receptor activity and modulating serotonin receptors. Subjective effects are typically described as \"natural drowsiness\" rather than the sedated/drugged feeling from benzodiazepines or antihistamines. As a supplement, oleamide is sold as research-only and not FDA-approved. The peer-reviewed literature on supplementation outcomes is modest, but the underlying biochemistry is well-characterized." } }, { "@type": "Question", "name": "What forms does Oleamide come in?", "acceptedAnswer": { "@type": "Answer", "text": "Oleamide is available in vials, capsules, and sprays forms." } }, { "@type": "Question", "name": "How much does Oleamide cost?", "acceptedAnswer": { "@type": "Answer", "text": "Pricing varies by vendor and form." } }, { "@type": "Question", "name": "How do I compare Oleamide vendors?", "acceptedAnswer": { "@type": "Answer", "text": "Compare prices, payment methods, shipping, and COA scores across 0 vendors." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompound%2Foleamide) 100K+ researchers trust BodyHackGuide. Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 3. [Compounds](/compare) 5. Oleamide [🛒 Where to buy Oleamide](/buy/oleamide)[🏷️ Oleamide coupon codes](/coupons/oleamide)[📋 Oleamide protocol](/protocol/oleamide)[🔄 Alternatives to Oleamide](/alternatives-to/oleamide)[⚠️ Oleamide side effects](/side-effects/oleamide) 1. [Home](/) 3. [Compounds](/compare) 5. Oleamide # Oleamide Nootropic Lipid Preclinical Download PDF Also known as: Oleamide, 9-Octadecenamide, Cis-9-Octadecenamide, ODA Oleamide is a fatty acid primary amide that your brain naturally produces during sleep deprivation — your body's endogenous sleep-promoting lipid signal. First identified in 1995 by Cravatt and colleagues at Scripps Research Institute as the major sleep-inducing factor accumulating in cerebrospinal fluid during prolonged wakefulness. Unlike pharmaceutical sleep aids that override sleep architecture, oleamide works WITH the body's natural sleep mechanisms by potentiating GABA-A receptor activity and modulating serotonin receptors. Half-Life: ~30-60 minutes (rapidly metabolized by FAAH) MW: 281.48 g/mol [62 PubMed Results](https://pubmed.ncbi.nlm.nih.gov/?term=Oleamide) Last reviewed: Sep 12, 2026 [ 62 PubMed Results ](https://pubmed.ncbi.nlm.nih.gov/?term=Oleamide)[ Nootropic Lipid Category ](/wiki#cat-nootropic-lipid) Preclinical Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare PricesRelated ## Overview ### At A Glance Mechanism Mechanism of action — pharmacological summary:… Half-Life ~30-60 minutes (rapidly metabolized by FAAH) Safety Notes Common Mild morning grogginess at high doses (rare) ### Mechanism of Action **Mechanism of action — pharmacological summary:** - **GABA-A receptor potentiator** — positive allosteric modulator at GABA-A, similar mechanism to apigenin (without benzodiazepine-like efficacy) - **5-HT2A/2C modulator** — interacts with serotonin signaling, contributing to sleep-onset effects - **Endocannabinoid crossover** — weak FAAH inhibition, modest effects on anandamide tone - **Endogenous fatty acid amide** — same chemical class as anandamide, palmitoylethanolamide (PEA), and oleoylethanolamide (OEA) - **Metabolism** — rapidly hydrolyzed by FAAH (fatty acid amide hydrolase), explaining short subjective duration ### Overview Oleamide is a **fatty acid primary amide** that your brain naturally produces during sleep deprivation — your body's endogenous sleep-promoting lipid signal. First identified in 1995 by Cravatt and colleagues at Scripps Research Institute as the major sleep-inducing factor accumulating in cerebrospinal fluid during prolonged wakefulness. Unlike pharmaceutical sleep aids that override sleep architecture, oleamide works WITH the body's natural sleep mechanisms by potentiating GABA-A receptor activity and modulating serotonin receptors. Subjective effects are typically described as "natural drowsiness" rather than the sedated/drugged feeling from benzodiazepines or antihistamines. As a supplement, oleamide is sold as research-only and **not FDA-approved**. The peer-reviewed literature on supplementation outcomes is modest, but the underlying biochemistry is well-characterized. ## Chemical Information IUPAC Name Not yet available CAS Number Not yet available Molecular Formula C18H35NO Molecular Mass 281.48 g/mol ## Dosing & Protocols ### Dosing Summary Dose 100-300mg/day Route Oral / Sublingual Frequency Once daily evening Duration Continuous or 4-week cycles ### Beginner Protocol ### Intermediate Protocol ### Advanced Protocol ### Stacking Notes [Full Oleamide Dosing Guide](/guides/dosage/oleamide) [Open Reconstitution Calculator](/tools/reconstitution) ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research [62 PubMed Results](https://pubmed.ncbi.nlm.nih.gov/?term=Oleamide) [Browse Studies on PubMed](https://pubmed.ncbi.nlm.nih.gov/?term=Oleamide) ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions Interaction and contraindication data is being compiled for Oleamide. Check back soon. General Safety Note Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented. [Sign in for alerts ](/auth) No listings found for Oleamide. Get Oleamide Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Oleamide. [Sign in](/auth) [ View Full Dosage Guide → Protocols, calculator & safety for Oleamide ](/guides/dosage/oleamide) ### Related Articles [All Posts](/blog) [ #### The Biohacker's Complete Nootropic Stack Guide 10 research-backed nootropic stacks for every goal: focus, memory, anxiety, sleep, motivation, creativity, and more. Complete dosing protocols, timing, cycling, and product recommendations. 4/1/2026 ](/blog/complete-nootropic-stack-guide)[ #### Best Nootropics for Sleep: A 2026 Research Guide The best nootropics for sleep go beyond melatonin. This guide covers apigenin, oleamide, kavain, magnesium L-threonate, DSIP, ashwagandha, and Selank, with 9 PubMed citations, the science of sleep architecture and the glymphatic system, and 5 stacks for every level. 4/1/2026 ](/blog/best-nootropics-for-sleep) ### Research Score 66 62 PubMed results ### Quality Indicators Data Completeness 75% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Results Interactions Vendor Listings Research Volume 62 PubMed results Well-researched compound ### Quick Facts Half-Life ~30-60 minutes (rapidly metabolized by FAAH) Molecular Weight 281.48 g/mol Trial Phase Preclinical ### Safety Profile Low Risk Common Side Effects - • Mild morning grogginess at high doses (rare) Stop Use If - Pregnancy/lactation - Severe liver disease (FAAH-dependent metabolism) - Concurrent benzodiazepine therapy without clinician oversight [Full Dosage Guide](/guides/dosage/oleamide)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is Oleamide used for in research? Oleamide is a **fatty acid primary amide** that your brain naturally produces during sleep deprivation — your body's endogenous sleep-promoting lipid signal. First identified in 1995 by Cravatt and colleagues at Scripps Research Institute as the major sleep-inducing factor accumulating in cerebrospinal fluid during prolonged wakefulness. Unlike pharmaceutical sleep aids that override sleep architecture, oleamide works WITH the body's natural sleep mechanisms by potentiating GABA-A receptor activity and modulating serotonin receptors. Subjective effects are typically described as "natural drowsiness" rather than the sedated/drugged feeling from benzodiazepines or antihistamines. As a supplement, oleamide is sold as research-only and **not FDA-approved**. The peer-reviewed literature on supplementation outcomes is modest, but the underlying biochemistry is well-characterized. What forms does Oleamide come in? Oleamide is available in vials, capsules, and sprays forms. How much does Oleamide cost? Pricing varies by vendor and form. How do I compare Oleamide vendors? Compare prices, payment methods, shipping, and COA scores across 0 vendors. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-oleamide) ### Need bloodwork before starting? 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