--- title: "NSI-189: Dosing & Vendor Prices | BodyHackGuide" url: https://www.bodyhackguide.co/compound/nsi-189 description: "NSI-189: dosing protocols, mechanism & side effects, 3 PubMed results. Compare 1 current vendor prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Image: NSI-189 molecular structure (https://www.bodyhackguide.co/assets/peptide-structure-placeholder-DUmZBF_j.png) # NSI-189 Nootropics (https://www.bodyhackguide.co/wiki#cat-nootropics)Phase 2 NSI-189 is a novel synthetic compound developed by Neuralstem Inc. that stimulates neurogenesis in the human hippocampus. Image: Disguised Alpha logo (https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Lowest price $84.99 capsules (20 mg) at Disguised Alpha Buy at Disguised Alpha: https://disguisedalpha.com/product/nsi-189/?coupon=reddit CAS: 1270138-40-3 3 PubMed results (https://pubmed.ncbi.nlm.nih.gov/?term=NSI-189%20neuralstem%20hippocampal%20neurogenesis%20depression) Last reviewed: May 4, 2026 ## Overview ### At A Glance Mechanism NSI-189 stimulates proliferation and differentiation of human hippocampal neural stem cells through a mechanism distinct from BDNF or classical antidepressants. Rodent studies show a 20% increase in hippocampal volume after 6 weeks of treatment. It is not a receptor agonist or re… Potential Benefits Increased hippocampal neurogenesis Antidepressant effects Enhanced synaptic plasticity Improved cognitive function Long-lasting mood improvement Potential PTSD treatment Safety Notes Common Transient cognitive changes during initial use (cognitive shifting) Anxiety in first weeks Sleep changes Emotional blunting (initial phase) ### Overview NSI-189 is a novel synthetic compound developed by Neuralstem Inc. that stimulates neurogenesis in the human hippocampus. Phase 2 trials for major depressive disorder showed improvements in subjective cognitive function, depression scores, and positive affect despite not reaching primary endpoints. It has a dedicated following in the biohacking community for its reported hippocampal neurogenesis, emotional blunting reversal, and unique cognitive profile unlike any other nootropic. ### Potential Research Fields Major depressive disorder Cognitive impairment PTSD Alzheimer's disease Neurogenesis ## Chemical Information IUPAC Name benzyl N-[2-(piperazin-1-yl)pyrimidin-5-yl]carbamate CAS Number 1270138-40-3 Molecular Formula C16H19N5O2 Molecular Mass 313.36 g/mol Image: NSI-189 molecular structure (https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/44/PNG?image_size=300x300) View on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/44 ## Dosing & Protocols ### Unlock the dosing protocols Enter your email to keep reading. It is free, and it opens these tabs on every compound page in this browser. - Dose, route, how often and how long - A titration schedule - Reconstitution and handling notes - Stacking notes You also get the free peptide cheat sheet by email. Unsubscribe anytime. Have an account? Sign in (https://www.bodyhackguide.co/auth) ## Research ### Unlock the Research tab - Safety and side effects - A link to the PubMed results ## Interactions ### Interaction Matrix ### Contraindications Pregnancy or breastfeeding. Active mania or bipolar disorder (limited data). Concurrent SSRI use requires medical supervision. Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $84.99 Best $/mg — Vendors 1 Listings 1 capsule Form Sort | Vendor | Product | Form | Qty | Price | $/mg | Coupon | | | --- | --- | --- | --- | --- | --- | --- | --- | | Image: Disguised Alpha logo (https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha (https://www.bodyhackguide.co/vendors/disguised-alpha) 50: https://www.bodyhackguide.co/vendor-trust-scorecard 🇺🇸 US 🇪🇺 EU 🇬🇧 UK | NSI-189 Capsules 20 mg | capsule | capsules (20 mg) ● In Stock | $84.99 BEST | — | — | Buy: https://disguisedalpha.com/product/nsi-189/?coupon=reddit | ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with NSI-189. Current low $84.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet Tracking since Sep 5, 2026 · 1 data point ### Vendors Selling NSI-189 #### Disguised Alpha 1 listing · from $84.99 https://www.bodyhackguide.co/vendors/disguised-alpha How we score these vendors Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. View Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ### Related Compounds View All (https://www.bodyhackguide.co/wiki) ### 9-Me-BC (9-Methyl-β-carboline) Nootropics Preclinical 9-Methyl--carboline (9-Me-BC) is a synthetic -carboline alkaloid that has drawn nootropic-community interest for a preclinical property that is genuinely unusual among -carbolines: in rodent and cell-culture studies it appears to stimulate the dopaminergic phenotype - raising tyrosine hydroxylase, the number of differentiated dopamine neurons and dopamine content - while also showing neuroprotective, neurorestorative and anti-inflammatory effects, plus in-vitro MAO-A/MAO-B inhibition [PMID:17913302, PMID:20374418, PMID:32285253]. t½ Not characterized in humans (no pharmacokinetic data). Community/anecdotal only: ~5-25 mg per day, oral. No validated or approved human dose exists. 6 PubMed View Profile https://www.bodyhackguide.co/compound/9-mbc ### Aniracetam Nootropics Approved (Italy) Aniracetam is a pyrrolidinone in the racetam family, developed by Hoffmann-La Roche under the code Ro 13-5057. t½ About half an hour for the parent drug in humans. Plasma elimination half-life was 0.47 to 0.49 hours after a single 400 mg oral dose in 20 healthy male volunteers (PMID: 19025058). Aniracetam is extensively metabolized to N-anisoyl-GABA and anisic acid; in six elderly hospitalized patients with cerebrovascular disease and reduced creatinine clearance, metabolite half-life was 4 to 7 times longer than in young volunteers (PMID: 9062694). Preclinical View Profile https://www.bodyhackguide.co/compound/aniracetam ### Bemethyl (bemitil) Nootropics Approved (Russia) Bemethyl, known in the Russian literature as bemitil and sold in the region under names including Metaprot, Bemactor and Antihot, is 2-ethylthiobenzimidazole, normally handled as the hydrobromide salt. t½ Not established in humans; in healthy volunteers given a single 250 mg oral dose of the Metaprot capsule form, peak serum ethylthiobenzimidazole averaged 0.91 microg/mL at about 1.06 h, and no terminal half-life was reported (PMID: 21870773) Preclinical View Profile https://www.bodyhackguide.co/compound/bemethyl ### Bromantane Nootropics Russia Approved Bromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten. 34 PubMed View Profile https://www.bodyhackguide.co/compound/bromantane ### Cyclazodone Nootropics Preclinical Cyclazodone is the N-cyclopropyl derivative of pemoline, a 4-oxazolidinone stimulant. Preclinical View Profile https://www.bodyhackguide.co/compound/cyclazodone ### Dihexa Nootropics Preclinical Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. t½ Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. 5 to 40 mg oral per day (anecdotal range; no established human dose) 1 PubMed View Profile https://www.bodyhackguide.co/compound/dihexa View Full Dosage Guide → Protocols, calculator & safety for NSI-189 https://www.bodyhackguide.co/guides/dosage/nsi-189 ### Lowest Price Disguised Alpha $84.99 1 vendor · 1 listing ### Research Score 60 3 PubMed results ### Quality Indicators Data Completeness 88% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Results Interactions Vendor Listings Research Volume 3 PubMed results Limited research available ### Quick Facts Molecular Weight 313.36 g/mol CAS Number 1270138-40-3 Trial Phase Phase 2 ### Safety Profile Low Risk Common Side Effects - • Transient cognitive changes during initial use (cognitive shifting) - • Anxiety in first weeks - • Sleep changes - • Emotional blunting (initial phase) Stop Use If - Active psychosis — hippocampal neurogenesis changes may worsen - Bipolar disorder (monitor closely) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is NSI-189 used for in research? What forms does NSI-189 come in? NSI-189 is available in capsule form. How much does NSI-189 cost? Prices start at $84.99 across 1 vendor. How do I compare NSI-189 vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. ## Research Tools ### Peptide Calculator Reconstitution & syringe units https://www.bodyhackguide.co/tools/reconstitution ### Reconstitution Guide How to mix, step by step https://www.bodyhackguide.co/guides/how-to-reconstitute-peptides ### Nasal Spray Calc mL per actuation https://www.bodyhackguide.co/tools/intranasal ### Half-Life Visualizer Decay curves https://www.bodyhackguide.co/tools/halflife ## Related Compounds ### 9-Me-BC (9-Methyl-β-carboline) Nootropics Preclinical ### Aniracetam Nootropics Approved (Italy) ### Bemethyl (bemitil) Nootropics Approved (Russia) ### Bromantane Nootropics Russia Approved ### Cyclazodone Nootropics Preclinical ### Dihexa Nootropics Preclinical Free 2026 Peptide Cheat Sheet (PDF) 38 compounds and blends: vial sizes, BAC water volumes, dosing ranges and bloodwork markers. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. Image: BodyHackGuide (https://www.bodyhackguide.co/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide #### Explore - Compare prices: https://www.bodyhackguide.co/compare - Vendors: https://www.bodyhackguide.co/vendors - Deals: https://www.bodyhackguide.co/deals - Coupons: https://www.bodyhackguide.co/coupons - Nootropics: https://www.bodyhackguide.co/nootropics - Brain health: https://www.bodyhackguide.co/brain-health - Blog: https://www.bodyhackguide.co/blog - Guides: https://www.bodyhackguide.co/guides #### Tools - Reconstitution: https://www.bodyhackguide.co/tools/reconstitution - Half-life visualizer: https://www.bodyhackguide.co/tools/halflife - COA reader: https://www.bodyhackguide.co/tools/coa - Cost calculator: https://www.bodyhackguide.co/tools/cost-calculator - Stack builder: https://www.bodyhackguide.co/stack-builder - All tools: https://www.bodyhackguide.co/tools #### Trust & vendors - Vendor directory: https://www.bodyhackguide.co/vendors - Trust scorecard: https://www.bodyhackguide.co/vendors/scorecard - Vendor trust badge: https://www.bodyhackguide.co/vendors/get-vetted - Scoring methodology: https://www.bodyhackguide.co/vendors/methodology - Peptide cheat sheet: https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download #### Company - About: https://www.bodyhackguide.co/about - Affiliate disclosure: https://www.bodyhackguide.co/affiliate-disclosure - Editorial standards: https://www.bodyhackguide.co/editorial-standards - Creators: https://www.bodyhackguide.co/creators - Coaches: https://www.bodyhackguide.co/coaches - 1-on-1 coaching: https://www.bodyhackguide.co/coaching - Privacy: https://www.bodyhackguide.co/privacy - Terms: https://www.bodyhackguide.co/terms - Full site directory: https://www.bodyhackguide.co/site-directory **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology), and we earn a commission from purchases made through some of our links at no extra cost to you. 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