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5.  NA-Semax Amidate 

# NA-Semax Amidate

Nootropic Peptide Preclinical 

Download  PDF

Also known as: NA-Semax Amide, N-Acetyl Semax Amide, NA-Semax-NH2, Acetyl-Semax-Amide 

NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. Direct pharmacokinetic comparisons in peer-reviewed literature remain absent — this framing is honest about the evidence base..

Half-Life:  ~30-45 minutes (estimated, longer than standard Semax) MW:  ~855.0 g/mol (C39H54N10O10S; monoisotopic ~854.4) [2 PubMed Results](https://pubmed.ncbi.nlm.nih.gov/?term=NA-Semax%20Amidate)

Last reviewed: Sep 12, 2026 

[

2

PubMed Results



](https://pubmed.ncbi.nlm.nih.gov/?term=NA-Semax%20Amidate)[

Nootropic Peptide

Category



](/wiki#cat-nootropic-peptide)

Preclinical

Research Stage

OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare PricesRelated

## Overview

### At A Glance

Mechanism 

Mechanism (inherited from parent Semax - the N-acetyl / C-amidate analog itself has not been directly studied):… 

Half-Life 

~30-45 minutes (estimated, longer than standard Semax)

Safety Notes 

Common 

Mild nasal irritation 

### Mechanism of Action

**Mechanism (inherited from parent Semax - the N-acetyl / C-amidate analog itself has not been directly studied):**

-   BDNF upregulation in hippocampus + cortex - a single intranasal dose of Semax raises hippocampal BDNF protein and TrkB expression in rodents, alongside improved learning (\[Dolotov et al., 2006; PMID 16996037\])
-   Dopaminergic + serotonergic modulation - Semax raises striatal serotonin turnover (5-HIAA) and potentiates amphetamine-evoked striatal dopamine release in rodents (\[Eremin et al., 2005; PMID 16362768\])
-   NE turnover modulation
-   Anti-inflammatory (IL-6, TNF- suppression)

**Pharmacokinetic improvements (theoretical, not measured for this analog):**

-   **N-acetyl group** - intended to block aminopeptidase cleavage at the N-terminus
-   **C-terminal amide** - intended to block carboxypeptidase cleavage at the C-terminus
-   **Net result** - reportedly 2-4x longer functional duration vs. unmodified Semax (vendor + community claim, not peer-reviewed)

Note: every mechanism above is extrapolated from published research on Semax itself. NA-Semax Amidate has no pharmacology or human clinical data of its own - the acetyl and amide modifications have not been separately characterized.

### Overview

NA-Semax Amidate is the **C-terminally amidated [NA-Semax](/compound/na-semax)** — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides.

The practical effect is a peptide with **dosing-frequency use**: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. Direct pharmacokinetic comparisons in peer-reviewed literature remain absent — this framing is honest about the evidence base.

## Chemical Information

IUPAC Name

Not yet available 

CAS Number

Not yet available 

Molecular Formula

C40H57N13O10

Molecular Mass

~855.0 g/mol (C39H54N10O10S; monoisotopic ~854.4)

Amino Acid Sequence

Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2 (Ac-MEHFPGP-NH2)

## Dosing & Protocols

### Dosing Summary

Dose

200-1200 mcg/day

Route

Intranasal

Frequency

1-2x daily

Duration

14-30 day cycles

### Beginner Protocol

### Intermediate Protocol

### Advanced Protocol

### Stacking Notes

[Full NA-Semax Amidate Dosing Guide](/guides/dosage/na-semax-amidate) [Open Reconstitution Calculator](/tools/reconstitution)

### Unlock Dosing Protocols

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-   View beginner, intermediate & advanced protocols 
-   See weight-based dosing calculations 
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## Research

[2 PubMed Results](https://pubmed.ncbi.nlm.nih.gov/?term=NA-Semax%20Amidate)

### Safety & Side Effects

**Research use only - not FDA approved.** NA-Semax Amidate is a chemically modified peptide sold strictly for laboratory research. It has no approved human indication and no published human safety data for this specific N-acetyl-amidate analog. The notes below are extrapolated from the parent peptide Semax and from anecdotal user reports - not from controlled studies of this compound.

**Reported / anticipated effects (mostly anecdotal, intranasal route):**

-   Transient nasal or throat irritation and rhinorrhea (runny nose) after intranasal dosing
-   Mild headache
-   Mild fatigue, or conversely an initial alertness/stimulation spike
-   Lightheadedness in some users, more likely at higher doses

**Important framing:** Semax has a decades-long history of clinical use in Russia with a generally mild reported safety profile, but that record does **not** automatically transfer to this modified analog. The N-acetyl and C-amide changes alter the molecule, and its safety, long-term effects, and true duration have not been formally studied. Absence of reported serious effects here reflects absence of study, not proof of safety.

[Browse Studies on PubMed](https://pubmed.ncbi.nlm.nih.gov/?term=NA-Semax%20Amidate)

### Unlock Research Data

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## Interactions

### Contraindications

**Do not use outside of a research setting.** NA-Semax Amidate is not a medicine and has not been evaluated for human use; the points below are conservative precautions, not trial-derived medical contraindications for this compound.

-   **Pregnancy and lactation** - avoid; there are no reproductive or developmental safety data for this analog.
-   **Known peptide or Semax hypersensitivity** - discontinue immediately if any allergic or hypersensitivity reaction occurs.
-   **Mania or bipolar-spectrum instability** - caution; nootropic, dopaminergic-modulating peptides may theoretically aggravate activation, though this is not established for this compound.
-   **Concurrent CNS-active medications or stimulants** - no interaction data exist for this analog; combining is untested.

These precautions are extrapolated from the parent peptide Semax and from general peptide-research safety practice, not from any published study of NA-Semax Amidate itself.

Research Disclaimer

This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.

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### Related Compounds

[View All](/wiki)

[

### Adalank

Nootropic Peptide Preclinical / Research compound 

Adalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).

t½ The commonly cited ~72-hour "functional duration" is an unverified community/vendor claim, not a measured value - no pharmacokinetic study of Adalank has ever been run. The figure is extrapolated from parent Adamax marketing claims. Actual serum half-life is unknown; there is no published PK data.  200-1200 mcg per dose (intranasal or subcutaneous), 1-2x daily 

Preclinical View Profile 

](/compound/adalank)[

### Adamax

Nootropic Peptide Preclinical / Research compound 

Adamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.

t½ No pharmacokinetic data. Community reports describe a subjectively long duration of effect (~2-3 days), supporting every-other-day or 3x/week dosing; serum half-life not characterized.  500-2000 mcg subcutaneous (community research dosing) 

Preclinical View Profile 

](/compound/adamax)[

### Cerebrolysin

Nootropic Peptide Clinical 

Cerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins.

t½ ~2-4 hours (multi-component peptide mix) 

85 PubMed View Profile 

](/compound/cerebrolysin)[

### Cortexin

Nootropic Peptide Marketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved) 

Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors.

t½ ~2-3 hours (estimated from analog peptide preparations) 

18 PubMed View Profile 

](/compound/cortexin)[

### NA-Semax

Nootropic Peptide Preclinical 

NA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.

t½ ~20-30 minutes (intranasal, estimated from analog data) 

3 PubMed View Profile 

](/compound/na-semax)[

### P-21

Nootropic Peptide Preclinical 

P-21 is a synthetic cyclic dipeptide — Cyclo(L-prolyl-glycine) — derived from the Selank/Semax C-terminal Pro-Gly-Pro motif.

t½ Not formally characterized in published work. P021 has only been studied in rodents (oral/dietary and subcutaneous dosing); no human pharmacokinetic data exist. 

4 PubMed View Profile 

](/compound/p21)

[

View Full Dosage Guide →

Protocols, calculator & safety for NA-Semax Amidate



](/guides/dosage/na-semax-amidate)

### Related Articles

[All Posts](/blog)

[

#### The Best Peptide Nasal Sprays of 2026, Ranked by Evidence

An evidence-tiered review of 10 peptide nasal sprays. S tier: Semax, Selank, oxytocin. A tier: PT-141, DSIP, Epithalon. B tier: Noopept, NAD+, 5-Amino-1MQ. C tier: Melanotan-II. It covers human-trial counts, PMID citations, safety, and pre-made vs DIY tradeoffs.

4/21/2026 ](/blog/best-peptide-nasal-sprays-2026)

### Research Score

60 

2 PubMed results

### Quality Indicators

Data Completeness

75% 

Description 

Mechanism of Action 

Chemical Data 

Dosing Protocols 

Safety Profile 

PubMed Results 

Interactions 

Vendor Listings 

Research Volume

2 PubMed results 

Limited research available

### Quick Facts

Half-Life

~30-45 minutes (estimated, longer than standard Semax)

Molecular Weight

~855.0 g/mol (C39H54N10O10S; monoisotopic ~854.4)

Trial Phase

Preclinical

### Safety Profile

Low Risk 

Common Side Effects

-   •  Mild nasal irritation

Stop Use If

-   Pregnancy/lactation
-   Mania
-   Peptide allergy

[Full Dosage Guide](/guides/dosage/na-semax-amidate)[Calculate Your Dose](/tools/reconstitution)

Research Disclaimer

This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

## Frequently Asked Questions

What is NA-Semax Amidate used for in research?

NA-Semax Amidate is the **C-terminally amidated [NA-Semax](/compound/na-semax)** — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides.

The practical effect is a peptide with **dosing-frequency use**: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. Direct pharmacokinetic comparisons in peer-reviewed literature remain absent — this framing is honest about the evidence base.

What forms does NA-Semax Amidate come in?

NA-Semax Amidate is available in vials, capsules, and sprays forms.

How much does NA-Semax Amidate cost?

Pricing varies by vendor and form.

How do I compare NA-Semax Amidate vendors?

Compare prices, payment methods, shipping, and COA scores across 0 vendors.

## Research Tools

[

### Peptide Calculator

Reconstitution & syringe units



](/tools/reconstitution)[

### Reconstitution Guide

How to mix, step by step



](/guides/how-to-reconstitute-peptides)[

### Nasal Spray Calc

mL per actuation



](/tools/intranasal)[

### Half-Life Visualizer

Decay curves



](/tools/halflife)

## Related Compounds

[View All](/wiki)

[

### Adalank

Nootropic Peptide Preclinical / Research compound 

Adalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).

t½ The commonly cited ~72-hour "functional duration" is an unverified community/vendor claim, not a measured value - no pharmacokinetic study of Adalank has ever been run. The figure is extrapolated from parent Adamax marketing claims. Actual serum half-life is unknown; there is no published PK data.  200-1200 mcg per dose (intranasal or subcutaneous), 1-2x daily 

Preclinical View Profile 

](/compound/adalank)[

### Adamax

Nootropic Peptide Preclinical / Research compound 

Adamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.

t½ No pharmacokinetic data. Community reports describe a subjectively long duration of effect (~2-3 days), supporting every-other-day or 3x/week dosing; serum half-life not characterized.  500-2000 mcg subcutaneous (community research dosing) 

Preclinical View Profile 

](/compound/adamax)[

### Cerebrolysin

Nootropic Peptide Clinical 

Cerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins.

t½ ~2-4 hours (multi-component peptide mix) 

85 PubMed View Profile 

](/compound/cerebrolysin)[

### Cortexin

Nootropic Peptide Marketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved) 

Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors.

t½ ~2-3 hours (estimated from analog peptide preparations) 

18 PubMed View Profile 

](/compound/cortexin)[

### NA-Semax

Nootropic Peptide Preclinical 

NA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.

t½ ~20-30 minutes (intranasal, estimated from analog data) 

3 PubMed View Profile 

](/compound/na-semax)[

### P-21

Nootropic Peptide Preclinical 

P-21 is a synthetic cyclic dipeptide — Cyclo(L-prolyl-glycine) — derived from the Selank/Semax C-terminal Pro-Gly-Pro motif.

t½ Not formally characterized in published work. P021 has only been studied in rodents (oral/dietary and subcutaneous dosing); no human pharmacokinetic data exist. 

4 PubMed View Profile 

](/compound/p21)

Free 2026 Peptide Cheat Sheet — 50 pages, PDF

Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one.

[Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-na-semax-amidate)

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Trust & vendors

#### Trust & vendors

-   [Vendor directory](/vendors)
-   [Trust scorecard](/vendors/scorecard)
-   [Get BHG verified](/vendors/get-vetted)
-   [Scoring methodology](/vendors/methodology)
-   [Peptide cheatsheet](/guides/peptide-cheat-sheet-download)

Company

#### Company

-   [About](/about)
-   [Affiliate disclosure](/affiliate-disclosure)
-   [Editorial standards](/editorial-standards)
-   [Creators](/creators)
-   [Coaches](/coaches)
-   [Privacy](/privacy)
-   [Terms](/terms)
-   [Full site directory →](/site-directory)

**Ownership & Affiliate Disclosure:** BodyHackGuide and BHG Labs share common ownership. We rank every vendor on the same public, reproducible [methodology](/vendors/methodology), and we earn a commission from purchases made through our links at no extra cost to you. Full details in our [affiliate disclosure](/affiliate-disclosure).

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