--- title: "Meldonium: Dosing & Vendor Prices — BodyHackGuide" description: "Meldonium: dosing protocols, mechanism & side effects. Compare 1 verified vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Meldonium" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "Meldonium", "description": "Meldonium, sold as Mildronate, was developed at the Latvian Institute of Organic Synthesis (PMID: 12242052) and is a licensed cardiovascular medicine in Latvia and a number of eastern European and post-Soviet countries. It has never been approved in the United States or the European Union as a whole. Most English-speaking readers first heard of it in 2016, when it appeared on the WADA prohibited list and a wave of positive tests followed. Its mechanism is unusual and worth understanding. Meldonium is the most potent clinically used inhibitor of the carnitine transporter OCTN2, and it also inhibits gamma-butyrobetaine hydroxylase, the enzyme that makes carnitine. Blocking both lowers tissue carnitine, and since carnitine is the shuttle that carries long-chain fatty acids into mitochondria, the cell shifts from burning fat toward burning glucose (PMID: 12242052; PMID: 26850121). Under low-oxygen conditions glucose oxidation needs less oxygen per unit of ATP, which is the basis for the anti-ischemic claim. The best human trial is MILSS I, a randomized, double-blind, placebo-controlled study of 512 patients with stable angina across 72 centers in four countries, testing four daily doses against placebo on top of standard therapy over twelve weeks. The primary endpoint was change in bicycle exercise time. Two lower dose groups did not separate from placebo. The 1000 mg group increased total exercise time by a mean of 35 seconds compared with a 7 second decrease on placebo, and the highest dose group did worse than the middle one (PMID: 22186118). That is a real but modest effect in patients whose exercise was limited by cardiac ischemia. Whether it helps healthy athletes is a different question, and the sports medicine reviews are not encouraging. A narrative review concluded that the performance benefit is speculative and discussed without sound scientific evidence (PMID: 27465696), and a 2026 review revisiting the ergogenic evidence reached similar conclusions (PMID: 42344756). The pharmacokinetics are the strangest part. Because meldonium competes with carnitine for OCTN2-mediated transport, it accumulates in muscle during treatment and then leaves slowly by diffusion. In 32 healthy athlete volunteers given oral meldonium for three weeks, plasma steady state took several days and urinary elimination continued for months after the last dose (PMID: 30328291). In mice, giving carnitine or gamma-butyrobetaine speeds elimination by competing for the same transporter (PMID: 27983775). This is why athletes tested positive long after they stopped, and it is also why meldonium residues have been found in milk as a possible inadvertent doping route (PMID: 34448364). Capsules sold as meldonium dihydrate are a foreign prescription drug being distributed outside any prescribing system.", "url": "https://www.bodyhackguide.co/compound/meldonium", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "69.99", "highPrice": "69.99", "priceCurrency": "USD", "offerCount": "1", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "69.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://disguisedalpha.com/product/meldonium-dihydrate/?coupon=reddit", "seller": { "@type": "Organization", "name": "Disguised Alpha", "url": "https://disguisedalpha.com/?coupon=reddit" } } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Meldonium", "description": "Meldonium, sold as Mildronate, was developed at the Latvian Institute of Organic Synthesis (PMID: 12242052) and is a licensed cardiovascular medicine in Latvia and a number of eastern European and post-Soviet countries. It has never been approved in the United States or the European Union as a whole. Most English-speaking readers first heard of it in 2016, when it appeared on the WADA prohibited list and a wave of positive tests followed. Its mechanism is unusual and worth understanding. Meldonium is the most potent clinically used inhibitor of the carnitine transporter OCTN2, and it also inhibits gamma-butyrobetaine hydroxylase, the enzyme that makes carnitine. Blocking both lowers tissue carnitine, and since carnitine is the shuttle that carries long-chain fatty acids into mitochondria, the cell shifts from burning fat toward burning glucose (PMID: 12242052; PMID: 26850121). Under low-oxygen conditions glucose oxidation needs less oxygen per unit of ATP, which is the basis for the anti-ischemic claim. The best human trial is MILSS I, a randomized, double-blind, placebo-controlled study of 512 patients with stable angina across 72 centers in four countries, testing four daily doses against placebo on top of standard therapy over twelve weeks. The primary endpoint was change in bicycle exercise time. Two lower dose groups did not separate from placebo. The 1000 mg group increased total exercise time by a mean of 35 seconds compared with a 7 second decrease on placebo, and the highest dose group did worse than the middle one (PMID: 22186118). That is a real but modest effect in patients whose exercise was limited by cardiac ischemia. Whether it helps healthy athletes is a different question, and the sports medicine reviews are not encouraging. A narrative review concluded that the performance benefit is speculative and discussed without sound scientific evidence (PMID: 27465696), and a 2026 review revisiting the ergogenic evidence reached similar conclusions (PMID: 42344756). The pharmacokinetics are the strangest part. Because meldonium competes with carnitine for OCTN2-mediated transport, it accumulates in muscle during treatment and then leaves slowly by diffusion. In 32 healthy athlete volunteers given oral meldonium for three weeks, plasma steady state took several days and urinary elimination continued for months after the last dose (PMID: 30328291). In mice, giving carnitine or gamma-butyrobetaine speeds elimination by competing for the same transporter (PMID: 27983775). This is why athletes tested positive long after they stopped, and it is also why meldonium residues have been found in milk as a possible inadvertent doping route (PMID: 34448364). Capsules sold as meldonium dihydrate are a foreign prescription drug being distributed outside any prescribing system.", "lastReviewed": "2026-09-07T04:47:50.510Z", "url": "https://www.bodyhackguide.co/compound/meldonium", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "Meldonium", "alternateName": [ "Mildronate", "Meldonium dihydrate", "MET-88", "Quaterin", "3-(2,2,2-trimethylhydrazinium)propionate", "THP" ], "description": "Meldonium, sold as Mildronate, was developed at the Latvian Institute of Organic Synthesis (PMID: 12242052) and is a licensed cardiovascular medicine in Latvia and a number of eastern European and post-Soviet countries. It has never been approved in the United States or the European Union as a whole. Most English-speaking readers first heard of it in 2016, when it appeared on the WADA prohibited list and a wave of positive tests followed. Its mechanism is unusual and worth understanding. Meldonium is the most potent clinically used inhibitor of the carnitine transporter OCTN2, and it also inhibits gamma-butyrobetaine hydroxylase, the enzyme that makes carnitine. Blocking both lowers tissue carnitine, and since carnitine is the shuttle that carries long-chain fatty acids into mitochondria, the cell shifts from burning fat toward burning glucose (PMID: 12242052; PMID: 26850121). Under low-oxygen conditions glucose oxidation needs less oxygen per unit of ATP, which is the basis for the anti-ischemic claim. The best human trial is MILSS I, a randomized, double-blind, placebo-controlled study of 512 patients with stable angina across 72 centers in four countries, testing four daily doses against placebo on top of standard therapy over twelve weeks. The primary endpoint was change in bicycle exercise time. Two lower dose groups did not separate from placebo. The 1000 mg group increased total exercise time by a mean of 35 seconds compared with a 7 second decrease on placebo, and the highest dose group did worse than the middle one (PMID: 22186118). That is a real but modest effect in patients whose exercise was limited by cardiac ischemia. Whether it helps healthy athletes is a different question, and the sports medicine reviews are not encouraging. A narrative review concluded that the performance benefit is speculative and discussed without sound scientific evidence (PMID: 27465696), and a 2026 review revisiting the ergogenic evidence reached similar conclusions (PMID: 42344756). The pharmacokinetics are the strangest part. Because meldonium competes with carnitine for OCTN2-mediated transport, it accumulates in muscle during treatment and then leaves slowly by diffusion. In 32 healthy athlete volunteers given oral meldonium for three weeks, plasma steady state took several days and urinary elimination continued for months after the last dose (PMID: 30328291). In mice, giving carnitine or gamma-butyrobetaine speeds elimination by competing for the same transporter (PMID: 27983775). This is why athletes tested positive long after they stopped, and it is also why meldonium residues have been found in milk as a possible inadvertent doping route (PMID: 34448364). Capsules sold as meldonium dihydrate are a foreign prescription drug being distributed outside any prescribing system.", "activeIngredient": "Meldonium", "administrationRoute": "Oral, Intravenous injection", "mechanismOfAction": "Meldonium is a structural analog of gamma-butyrobetaine, the precursor of carnitine. It inhibits gamma-butyrobetaine hydroxylase, reducing carnitine biosynthesis, and it is the most potent clinically used inhibitor of the organic cation transporter OCTN2 (SLC22A5), which handles carnitine uptake into tissues (PMID: 27983775). The combined effect lowers tissue carnitine and its long-chain acylcarnitine derivatives, restricting the carnitine shuttle that moves long-chain fatty acids into mitochondria and shifting myocardial and skeletal muscle energy production from fatty acid oxidation toward glucose oxidation, which requires less oxygen per unit of ATP produced under ischemic conditions (PMID: 12242052). Downstream markers include reduced long-chain acylcarnitines and reduced trimethylamine-N-oxide (PMID: 26850121). The same OCTN2 competition explains its unusually long elimination (PMID: 30328291).", "dosageForm": "capsule", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Meldonium used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "Meldonium, sold as Mildronate, was developed at the Latvian Institute of Organic Synthesis (PMID: 12242052) and is a licensed cardiovascular medicine in Latvia and a number of eastern European and post-Soviet countries. It has never been approved in the United States or the European Union as a whole. Most English-speaking readers first heard of it in 2016, when it appeared on the WADA prohibited list and a wave of positive tests followed. Its mechanism is unusual and worth understanding. Meldonium is the most potent clinically used inhibitor of the carnitine transporter OCTN2, and it also inhibits gamma-butyrobetaine hydroxylase, the enzyme that makes carnitine. Blocking both lowers tissue carnitine, and since carnitine is the shuttle that carries long-chain fatty acids into mitochondria, the cell shifts from burning fat toward burning glucose (PMID: 12242052; PMID: 26850121). Under low-oxygen conditions glucose oxidation needs less oxygen per unit of ATP, which is the basis for the anti-ischemic claim. The best human trial is MILSS I, a randomized, double-blind, placebo-controlled study of 512 patients with stable angina across 72 centers in four countries, testing four daily doses against placebo on top of standard therapy over twelve weeks. The primary endpoint was change in bicycle exercise time. Two lower dose groups did not separate from placebo. The 1000 mg group increased total exercise time by a mean of 35 seconds compared with a 7 second decrease on placebo, and the highest dose group did worse than the middle one (PMID: 22186118). That is a real but modest effect in patients whose exercise was limited by cardiac ischemia. Whether it helps healthy athletes is a different question, and the sports medicine reviews are not encouraging. A narrative review concluded that the performance benefit is speculative and discussed without sound scientific evidence (PMID: 27465696), and a 2026 review revisiting the ergogenic evidence reached similar conclusions (PMID: 42344756). The pharmacokinetics are the strangest part. Because meldonium competes with carnitine for OCTN2-mediated transport, it accumulates in muscle during treatment and then leaves slowly by diffusion. In 32 healthy athlete volunteers given oral meldonium for three weeks, plasma steady state took several days and urinary elimination continued for months after the last dose (PMID: 30328291). In mice, giving carnitine or gamma-butyrobetaine speeds elimination by competing for the same transporter (PMID: 27983775). This is why athletes tested positive long after they stopped, and it is also why meldonium residues have been found in milk as a possible inadvertent doping route (PMID: 34448364). Capsules sold as meldonium dihydrate are a foreign prescription drug being distributed outside any prescribing system." } }, { "@type": "Question", "name": "What forms does Meldonium come in?", "acceptedAnswer": { "@type": "Answer", "text": "Meldonium is available in capsule form." } }, { "@type": "Question", "name": "How much does Meldonium cost?", "acceptedAnswer": { "@type": "Answer", "text": "Prices start at $69.99 across 1 verified vendor." } }, { "@type": "Question", "name": "How do I compare Meldonium vendors?", "acceptedAnswer": { "@type": "Answer", "text": "Compare prices, payment methods, shipping, and COA scores across 1 vendor." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompound%2Fmeldonium) 100K+ researchers trust BodyHackGuide — Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 2. [Compounds](/compare) 3. Meldonium [Where to buy Meldonium](/buy/meldonium) [Meldonium coupon codes](/coupons/meldonium) [Meldonium protocol](/protocol/meldonium) [Alternatives to Meldonium](/alternatives-to/meldonium) [Meldonium side effects](/side-effects/meldonium) 1. [Home](/) 3. [Compounds](/compare) 5. Meldonium ![Meldonium molecular structure](/assets/peptide-structure-placeholder-DUmZBF_j.png) # Meldonium Pharmaceutical Approved (Latvia) Download PDF Also known as: Mildronate, Meldonium dihydrate, MET-88, Quaterin, 3-(2,2,2-trimethylhydrazinium)propionate, THP Meldonium, sold as Mildronate, was developed at the Latvian Institute of Organic Synthesis (PMID: 12242052) and is a licensed cardiovascular medicine in Latvia and a number of eastern European and post-Soviet countries. It has never been approved in the United States or the European Union as a whole. Half-Life: Not a single simple value: in 32 healthy athlete volunteers taking oral meldonium for three weeks, plasma took several days to reach steady state and urinary elimination continued for several months after the last dose, because tissue clearance depends on slow diffusion rather than transport (PMID: 30328291) Route: Oral, Intravenous injection MW: 146.19 g/mol CAS: 76144-81-5 Last reviewed: Sep 7, 2026 [ Pharmaceutical Category ](/wiki#cat-pharmaceutical) Approved (Latvia) Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices1 Related ## Overview ### Best Price Available ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $69.99 60 capsules · capsule [Buy Now](https://disguisedalpha.com/product/meldonium-dihydrate/?coupon=reddit) Compare 1 vendor ### At A Glance Mechanism Meldonium is a structural analog of gamma-butyrobetaine, the precursor of carnitine. It inhibits gamma-butyrobetaine hydroxylase, reducing carnitine biosynthesis, and it is the most potent clinically used inhibitor of the organic cation transporter OCTN2 (SLC22A5), which handles … Half-Life Not a single simple value: in 32 healthy athlete volunteers taking oral meldonium for three weeks, plasma took several days to reach steady state and urinary elimination continued for several months after the last dose, because tissue clearance depends on slow diffusion rather than transport (PMID: 30328291) Routes Oral Intravenous injection Potential Benefits Increased total bicycle exercise time by a mean of 35 seconds versus a 7 second decrease on placebo in one dose group of 512 patients with stable angina over twelve weeks (PMID: 22186118) Lowered tissue carnitine and long-chain acylcarnitines, shifting cardiac energy metabolism toward glucose oxidation, as described in mechanism reviews of its cardioprotective action (PMID: 26850121) Reduced renal acute ischemia and reperfusion injury in rats (PMID: 31731785) Improved cardiac function during ischemia through carnitine lowering, as described in mechanism reviews of its cardioprotective action (PMID: 12242052) ### Overview Meldonium, sold as Mildronate, was developed at the Latvian Institute of Organic Synthesis (PMID: 12242052) and is a licensed cardiovascular medicine in Latvia and a number of eastern European and post-Soviet countries. It has never been approved in the United States or the European Union as a whole. Most English-speaking readers first heard of it in 2016, when it appeared on the WADA prohibited list and a wave of positive tests followed. Its mechanism is unusual and worth understanding. Meldonium is the most potent clinically used inhibitor of the carnitine transporter OCTN2, and it also inhibits gamma-butyrobetaine hydroxylase, the enzyme that makes carnitine. Blocking both lowers tissue carnitine, and since carnitine is the shuttle that carries long-chain fatty acids into mitochondria, the cell shifts from burning fat toward burning glucose (PMID: 12242052; PMID: 26850121). Under low-oxygen conditions glucose oxidation needs less oxygen per unit of ATP, which is the basis for the anti-ischemic claim. The best human trial is MILSS I, a randomized, double-blind, placebo-controlled study of 512 patients with stable angina across 72 centers in four countries, testing four daily doses against placebo on top of standard therapy over twelve weeks. The primary endpoint was change in bicycle exercise time. Two lower dose groups did not separate from placebo. The 1000 mg group increased total exercise time by a mean of 35 seconds compared with a 7 second decrease on placebo, and the highest dose group did worse than the middle one (PMID: 22186118). That is a real but modest effect in patients whose exercise was limited by cardiac ischemia. Whether it helps healthy athletes is a different question, and the sports medicine reviews are not encouraging. A narrative review concluded that the performance benefit is speculative and discussed without sound scientific evidence (PMID: 27465696), and a 2026 review revisiting the ergogenic evidence reached similar conclusions (PMID: 42344756). The pharmacokinetics are the strangest part. Because meldonium competes with carnitine for OCTN2-mediated transport, it accumulates in muscle during treatment and then leaves slowly by diffusion. In 32 healthy athlete volunteers given oral meldonium for three weeks, plasma steady state took several days and urinary elimination continued for months after the last dose (PMID: 30328291). In mice, giving carnitine or gamma-butyrobetaine speeds elimination by competing for the same transporter (PMID: 27983775). This is why athletes tested positive long after they stopped, and it is also why meldonium residues have been found in milk as a possible inadvertent doping route (PMID: 34448364). Capsules sold as meldonium dihydrate are a foreign prescription drug being distributed outside any prescribing system. ### Potential Research Fields Carnitine metabolism Cardioprotection Ischemia Sports drug testing ## Chemical Information IUPAC Name Not yet available CAS Number 76144-81-5 Molecular Formula C6H14N2O2 Molecular Mass 146.19 g/mol ![Meldonium molecular structure](https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/123868/PNG) [View on PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/123868) ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions ### Contraindications Regulatory rather than pharmacological in most cases: meldonium is prohibited at all times in tested sport and its months-long elimination window means stopping before competition does not clear it (PMID: 30328291). Mechanism-based caution applies to anyone with a carnitine deficiency disorder or on carnitine supplementation, since the drug directly opposes carnitine transport and biosynthesis (PMID: 27983775). It is not an approved medicine in the United States or the European Union, so no prescriber-supervised use exists there. No adequate pregnancy, lactation or pediatric data have been published in English-language literature. Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $69.99 Best $/mg — Vendors 1 Listings 1 capsule [Sign in for alerts ](/auth) Form Allcapsule Sort Price $/mg Vendor Vendor Product Form Qty Price $/mg Coupon ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) [Disguised Alpha](/vendor/disguised-alpha) [50 ](/vendor-trust-scorecard) 🇺🇸 US 🇪🇺 EU 🇬🇧 UK Meldonium dihydrate capsules (60) capsule 60 capsules ● In Stock $69.99 BEST — — [Buy](https://disguisedalpha.com/product/meldonium-dihydrate/?coupon=reddit) Get Meldonium Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $69.99 [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Meldonium. [Sign in](/auth) Current low $69.99 as of Sep 7, 2026 7-day low $69.99 30-day low $69.99 30-day change — baseline building Tracking since Sep 7, 2026 · 1 data point ### Vendors Selling Meldonium [ ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) #### Disguised Alpha 1 listing · from $69.99 ](/vendor/disguised-alpha) How we score these vendors Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. [View Scorecard](/vendors/scorecard) ### Related Compounds [View All](/wiki) [ ### Albuterol (salbutamol) Pharmaceutical FDA Approved Albuterol, called salbutamol outside the United States, is a beta-2 adrenergic agonist and a standard asthma medicine worldwide. t½ Mean terminal half-life 3.8 hours after intravenous administration in 16 healthy adult men, with absolute oral bioavailability of 44 percent and plasma peaks one to three hours after oral administration (PMID: 3653233) Preclinical View Profile ](/compound/albuterol)[ ### Clascoterone Pharmaceutical Preclinical Clascoterone (brand name Winlevi; development codes CB-03-01 and, for the alopecia formulation, Breezula) is a first-in-class topical androgen receptor (AR) antagonist approved by the U.S. 1188 studies View Profile ](/compound/clascoterone)[ ### Finasteride Pharmaceutical Preclinical Finasteride is an orally-active selective type II 5α-reductase inhibitor that blocks the conversion of testosterone to dihydrotestosterone (DHT), the primary androgenic driver of both benign prostatic hyperplasia (BPH) and androgenetic alopecia (male-pattern hair loss). Preclinical View Profile ](/compound/finasteride)[ ### Mirabegron Pharmaceutical FDA Approved Mirabegron is an approved prescription drug, not a research chemical. t½ Terminal half-life about 32 hours in one phase 1 multiple-dose study and about 60 hours in a second, with plasma peaks at three to five hours and steady state within seven days in healthy young and elderly adults (PMID: 23063375) Preclinical View Profile ](/compound/mirabegron)[ ### Tropisetron Pharmaceutical Approved (Japan) Tropisetron, coded ICS 205-930 during development and marketed as Navoban, is a serotonin 5-HT3 receptor antagonist approved as an antiemetic in Japan and in many other countries outside the United States, with ATC code A04AA03 (KEGG DRUG D02041, D02130). t½ About 5.7 h after a single 5 mg oral capsule and 5.6 h after 2 mg intravenously in 18 healthy volunteers; oral bioavailability averaged 0.60 with a range of 0.27 to 0.99 and was inversely related to CYP2D6 activity (PMID: 11736884) Preclinical View Profile ](/compound/tropisetron) [ View Full Dosage Guide → Protocols, calculator & safety for Meldonium ](/guides/dosage/meldonium) ### Best Price ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $69.99 [Buy Now](https://disguisedalpha.com/product/meldonium-dihydrate/?coupon=reddit) 1 vendors · 1 listings ### Research Score 30 0 PubMed studies ### Quality Indicators Data Completeness 63% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Studies Interactions Vendor Listings ### Quick Facts Half-Life Not a single simple value: in 32 healthy athlete volunteers taking oral meldonium for three weeks, plasma took several days to reach steady state and urinary elimination continued for several months after the last dose, because tissue clearance depends on slow diffusion rather than transport (PMID: 30328291) Molecular Weight 146.19 g/mol Administration Oral, Intravenous injection CAS Number 76144-81-5 Trial Phase Approved (Latvia) 0 [Full Dosage Guide](/guides/dosage/meldonium)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is Meldonium used for in research? Meldonium, sold as Mildronate, was developed at the Latvian Institute of Organic Synthesis (PMID: 12242052) and is a licensed cardiovascular medicine in Latvia and a number of eastern European and post-Soviet countries. It has never been approved in the United States or the European Union as a whole. Most English-speaking readers first heard of it in 2016, when it appeared on the WADA prohibited list and a wave of positive tests followed. Its mechanism is unusual and worth understanding. Meldonium is the most potent clinically used inhibitor of the carnitine transporter OCTN2, and it also inhibits gamma-butyrobetaine hydroxylase, the enzyme that makes carnitine. Blocking both lowers tissue carnitine, and since carnitine is the shuttle that carries long-chain fatty acids into mitochondria, the cell shifts from burning fat toward burning glucose (PMID: 12242052; PMID: 26850121). Under low-oxygen conditions glucose oxidation needs less oxygen per unit of ATP, which is the basis for the anti-ischemic claim. The best human trial is MILSS I, a randomized, double-blind, placebo-controlled study of 512 patients with stable angina across 72 centers in four countries, testing four daily doses against placebo on top of standard therapy over twelve weeks. The primary endpoint was change in bicycle exercise time. Two lower dose groups did not separate from placebo. The 1000 mg group increased total exercise time by a mean of 35 seconds compared with a 7 second decrease on placebo, and the highest dose group did worse than the middle one (PMID: 22186118). That is a real but modest effect in patients whose exercise was limited by cardiac ischemia. Whether it helps healthy athletes is a different question, and the sports medicine reviews are not encouraging. A narrative review concluded that the performance benefit is speculative and discussed without sound scientific evidence (PMID: 27465696), and a 2026 review revisiting the ergogenic evidence reached similar conclusions (PMID: 42344756). The pharmacokinetics are the strangest part. Because meldonium competes with carnitine for OCTN2-mediated transport, it accumulates in muscle during treatment and then leaves slowly by diffusion. In 32 healthy athlete volunteers given oral meldonium for three weeks, plasma steady state took several days and urinary elimination continued for months after the last dose (PMID: 30328291). In mice, giving carnitine or gamma-butyrobetaine speeds elimination by competing for the same transporter (PMID: 27983775). This is why athletes tested positive long after they stopped, and it is also why meldonium residues have been found in milk as a possible inadvertent doping route (PMID: 34448364). Capsules sold as meldonium dihydrate are a foreign prescription drug being distributed outside any prescribing system. What forms does Meldonium come in? Meldonium is available in capsule form. How much does Meldonium cost? Prices start at $69.99 across 1 verified vendor. How do I compare Meldonium vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### Albuterol (salbutamol) Pharmaceutical FDA Approved Albuterol, called salbutamol outside the United States, is a beta-2 adrenergic agonist and a standard asthma medicine worldwide. t½ Mean terminal half-life 3.8 hours after intravenous administration in 16 healthy adult men, with absolute oral bioavailability of 44 percent and plasma peaks one to three hours after oral administration (PMID: 3653233) Preclinical View Profile ](/compound/albuterol)[ ### Clascoterone Pharmaceutical Preclinical Clascoterone (brand name Winlevi; development codes CB-03-01 and, for the alopecia formulation, Breezula) is a first-in-class topical androgen receptor (AR) antagonist approved by the U.S. 1188 studies View Profile ](/compound/clascoterone)[ ### Finasteride Pharmaceutical Preclinical Finasteride is an orally-active selective type II 5α-reductase inhibitor that blocks the conversion of testosterone to dihydrotestosterone (DHT), the primary androgenic driver of both benign prostatic hyperplasia (BPH) and androgenetic alopecia (male-pattern hair loss). Preclinical View Profile ](/compound/finasteride)[ ### Mirabegron Pharmaceutical FDA Approved Mirabegron is an approved prescription drug, not a research chemical. t½ Terminal half-life about 32 hours in one phase 1 multiple-dose study and about 60 hours in a second, with plasma peaks at three to five hours and steady state within seven days in healthy young and elderly adults (PMID: 23063375) Preclinical View Profile ](/compound/mirabegron)[ ### Tropisetron Pharmaceutical Approved (Japan) Tropisetron, coded ICS 205-930 during development and marketed as Navoban, is a serotonin 5-HT3 receptor antagonist approved as an antiemetic in Japan and in many other countries outside the United States, with ATC code A04AA03 (KEGG DRUG D02041, D02130). t½ About 5.7 h after a single 5 mg oral capsule and 5.6 h after 2 mg intravenously in 18 healthy volunteers; oral bioavailability averaged 0.60 with a range of 0.27 to 0.99 and was inversely related to CYP2D6 activity (PMID: 11736884) Preclinical View Profile ](/compound/tropisetron) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-meldonium) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. [Order Bloodwork](https://anabolicinsights.ai/?ref=nwm2zjb) ![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub — compound pricing, brain health protocols, dosing tools, and vendor reviews. [support@bodyhackguide.co](mailto:support@bodyhackguide.co) [](https://discord.gg/Mhq5UdRYBA)[](https://reddit.com/r/BodyHackGuide)[](https://x.com/bodyhackguide) Explore #### Explore - [Compare prices](/compare) - [Research suppliers](/vendors) - [Deals](/deals) - [Coupons](/coupons) - [Nootropics](/nootropics) - [Brain health](/brain-health) - [Blog](/blog) - [Guides](/guides) Tools #### Tools - [Reconstitution](/tools/reconstitution) - [Dosage calculator](/tools/dosage) - [Half-life visualizer](/tools/halflife) - [COA lookup](/tools/coa) - [Cost calculator](/tools/cost-calculator) - [Stack builder](/stack-builder) - [All tools →](/tools) Trust & vendors #### Trust & vendors - [Vendor directory](/vendors) - [Trust scorecard](/vendors/scorecard) - [Get BHG verified](/vendors/get-vetted) - [Scoring methodology](/vendors/methodology) - [Peptide cheatsheet](/guides/peptide-cheat-sheet-download) Company #### Company - [About](/about) - [Affiliate disclosure](/affiliate-disclosure) - [Editorial standards](/editorial-standards) - [Creators](/creators) - [Coaches](/coaches) - [Privacy](/privacy) - [Terms](/terms) - [Full site directory →](/site-directory) **Ownership & Affiliate Disclosure:** BodyHackGuide and BHG Labs share common ownership. We rank every vendor on the same public, reproducible [methodology](/vendors/methodology), and we earn a commission from purchases made through our links at no extra cost to you. Full details in our [affiliate disclosure](/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell, distribute, or promote any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. · [Terms](/terms) · [Privacy](/privacy) hi 👋