--- title: "Melanotan I: Dosage, Side Effects & Prices | BodyHackGuide" url: https://www.bodyhackguide.co/compound/melanotan-i description: "Melanotan I: dosing protocols, mechanism & side effects. Compare 2 current vendor prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Melanotan I Other: https://www.bodyhackguide.co/wiki#cat-other Status FDA Approved Evidence Not graded on a research bench yet Melanotan I (afamelanotide) is a linear synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) with the substitution of norleucine at position 4 and D-phenylalanine at position 7. Reviewed 25 October 2026 01 Overview ## What Melanotan I is Unlike Melanotan II (which is cyclic), Melanotan I is a linear peptide that is significantly more selective for MC1R over MC4R — making it a tanning/photoprotective agent with substantially less sexual and appetite-stimulating side effects. Afamelanotide was FDA-approved in October 2019 under the brand name Scenesse as an implant for erythropoietic protoporphyria (EPP), a rare photosensitivity disorder. Melanotan I is meaningfully different from Melanotan II in structure, selectivity, and side-effect profile and should not be confused with it. ### How it works Melanotan I is afamelanotide, i.e. [Nle4, D-Phe7]-alpha-MSH ('NDP-alpha-MSH'), a synthetic 13-amino-acid analog of alpha-melanocyte-stimulating hormone. The Nle4 and D-Phe7 substitutions make it resistant to enzymatic breakdown and roughly 10-100x more potent than native alpha-MSH. It agonizes the melanocortin-1 receptor (MC1R) on melanocytes; MC1R activation stimulates adenylyl cyclase, raising intracellular cAMP and activating protein kinase A (PKA), which in turn upregulates MITF and tyrosinase - the rate-limiting enzyme of melanogenesis - shifting pigment synthesis toward eumelanin (brown/black pigment) with or without UV exposure. This is the basis of its skin-darkening and photoprotective effects. Importantly, contrary to a widely repeated claim, Melanotan I is NOT MC1R-selective: NDP-alpha-MSH is a non-selective, superpotent agonist with nanomolar efficacy at every melanocortin receptor subtype except MC2R, meaning it also activates MC3R, MC4R and MC5R [PMID:9216831]. In practice it tends to cause fewer MC4R-mediated effects (spontaneous erections, heightened libido, pronounced nausea) than the cyclic analog Melanotan II - but this reflects Melanotan II's greater potency, metabolic stability and receptor residence rather than any true receptor selectivity of Melanotan I. ### Benefits listed - Increased melanin (eumelanin) production and skin darkening via MC1R activation, with a reduced UV requirement - FDA-approved photoprotection in erythropoietic protoporphyria (EPP) as the Scenesse 16 mg subcutaneous implant [PMID:26132941] - Reduced phototoxic pain and improved quality of life in EPP patients in randomized controlled trials [PMID:26132941] - Tends to produce fewer MC4R-type effects (spontaneous erections, strong libido, marked nausea) than the cyclic Melanotan II - attributable to Melanotan II's greater potency and metabolic stability, not to true MC1R selectivity of Melanotan I Show 1 more Show less - Investigated in research settings for photoprotection in UV-sensitive populations 02 Research Free with email ## What the research shows No research bench grades Melanotan I yet. Benches compare compounds people pair, with the evidence for each. ### Unlock the research summary Enter your email to keep reading. It is free, and it opens these sections on every compound page in this browser. - A summary of the key research - Safety and side effects - A link to the PubMed results You also get the free peptide cheat sheet by email. Unsubscribe anytime. Have an account? Sign in (https://www.bodyhackguide.co/auth) 03 Safety ## Melanotan I side effects and interactions ### Side effects #### Common - Nausea (typically milder and less frequent than with Melanotan II) - Facial flushing - Headache - Fatigue - Skin hyperpigmentation; darkening of existing moles, freckles and nevi #### Serious events - Darkening or change in appearance of moles/nevi - requires baseline and periodic full-skin dermatologic monitoring - Long-term safety of chronic melanocortin stimulation, including any effect on melanoma risk, is not established - In the pivotal EPP implant trials serious adverse events were not considered drug-related [PMID:26132941] ### Interactions Not in our record Our record lists no interactions for Melanotan I. That means none are recorded here, not that none exist. This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. Order Bloodwork (https://anabolicinsights.ai/?ref=nwm2zjb) 04 Dosing Free with email ## Melanotan I dosage and protocols Dose range 16 mg Dosing Every 1 to 4 weeks Common vials 5mg, 10mg ### Unlock the Dosing section - Dose, route and how often - Common vial sizes 05 Prices ## Melanotan I prices 4 listings from 2 vendors, opening in the Featured order. Pack prices $35.00 to $54.99 Lowest per mg $3.50/mg Vendors 2 Listings 4 (vial, nasal) Prices as the vendors list them, last recorded 7 September 2026. Size Form Sort | Vendor | Product | Price | Buy | | --- | --- | --- | --- | | Image: Disguised Alpha logo (https://disguisedalpha.com/wp-content/uploads/2026/10/disguised-logo-3x.webp) Disguised Alpha: https://www.bodyhackguide.co/vendors/disguised-alpha | Melanotan 1 vial, 1 vial In stock | $39.99 No mg count | Buy Melanotan 1 at Disguised Alpha: https://disguisedalpha.com/product/melanotan-1/?coupon=reddit | | Image: Disguised Alpha logo (https://disguisedalpha.com/wp-content/uploads/2026/10/disguised-logo-3x.webp) Disguised Alpha: https://www.bodyhackguide.co/vendors/disguised-alpha | MT-1 Aerosol Kit nasal, aerosol kit In stock | $54.99 No mg count | Buy MT-1 Aerosol Kit at Disguised Alpha: https://disguisedalpha.com/product/mt-1-aerosol-kit/?coupon=reddit | | Image: Ion Peptide logo (https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Ion Peptide: https://www.bodyhackguide.co/vendors/ion-peptide | Melanotan I 5mg vial, 1 vial Out of stock | $3.80/mg $19.00 | View Melanotan I 5mg at Ion Peptide: https://ionpeptide.com/product/melanotan-i/?ref=reddit15 | | Image: Ion Peptide logo (https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Ion Peptide: https://www.bodyhackguide.co/vendors/ion-peptide | Melanotan I 10mg vial, 1 vial In stock | $3.50/mg $35.00 Lowest per mg | Buy Melanotan I 10mg at Ion Peptide: https://ionpeptide.com/product/melanotan-i/?ref=reddit15 | Vendors selling Melanotan I(2: trust score, certificates, payment, shipping) - Ion Peptide (https://www.bodyhackguide.co/vendors/ion-peptide)2 listings, from $19.00 Trust Score 70/100 (https://www.bodyhackguide.co/vendor-trust-scorecard), no certificate records on file, pays by card, crypto, ACH, ships to the US, international destinations - Disguised Alpha (https://www.bodyhackguide.co/vendors/disguised-alpha)2 listings, from $39.99 Trust Score 50/100 (https://www.bodyhackguide.co/vendor-trust-scorecard), 0 of 36 certificate records read, pays by card, crypto, bank transfer, ships to the US, the EU, the UK Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. How we score these vendors (https://www.bodyhackguide.co/vendors/scorecard) Price history(2 days with a recorded price) Review Melanotan I ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Melanotan I. 06 Chemistry ## Chemistry and structure Molecular mass 1646.85 Da (C78H111N21O19; PubChem CID 16197727) Amino acid sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 ([Nle4, D-Phe7]-alpha-MSH / NDP-alpha-MSH; 13-residue analog of alpha-MSH, N-acetylated with a C-terminal amide) Half-life Controlled-release subcutaneous implant (Scenesse): high inter-subject variability; median Tmax ~36 h, mean Cmax ~3.7 ng/mL, apparent terminal half-life ~15 h, with plasma levels measurable to ~96 h post-dose (FDA pharmacokinetics, n=12). Injected/bolus free peptide: peak plasma at ~1-2 h with an elimination half-life of ~30 minutes; the Nle4/D-Phe7 modifications prolong biological (melanogenic) activity well beyond plasma clearance. 07 Related ## Related to Melanotan I ### In the same category - AminotadalafilPreclinical Aminotadalafil is an unapproved research analog of tadalafil, the PDE5 inhibitor marketed under the brand name Cialis for erectile dysfunction and under Adcirca for pulmonary arterial hypertension.: https://www.bodyhackguide.co/compound/aminotadalafil - B7-33Preclinical B7-33 is a single-chain, 26-amino-acid peptide engineered as a functionally selective agonist of the relaxin family peptide receptor 1 (RXFP1), designed to recapitulate the therapeutic activity of human H2 relaxin — the endogenous peptide hormone that is naturally elevated during pregnancy and has broad cardioprotective, vasodilatory, and anti-fibrotic effects.: https://www.bodyhackguide.co/compound/b7-33 - Diisopropylamine dichloroacetate (DADA)Approved DADA is the abbreviation the research chemical market uses for diisopropylamine dichloroacetate, the diisopropylamine salt of dichloroacetic acid, CAS 660-27-5.: https://www.bodyhackguide.co/compound/dada - Indole-3-propionamide (IPAM)Preclinical IPAM is the market abbreviation for indole-3-propionamide, the amide of indole-3-propionic acid and a close structural relative of melatonin.: https://www.bodyhackguide.co/compound/indole-3-propionamide - Kisspeptin-10 (KSPTN)Clinical KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis.: https://www.bodyhackguide.co/compound/ksptn - PNC-27Preclinical PNC-27 is a p53-derived peptide that selectively induces membranolysis in cancer cells.: https://www.bodyhackguide.co/compound/pnc-27 All compounds (https://www.bodyhackguide.co/wiki) ### Compare Melanotan I - Melanotan I vs Melanotan II: https://www.bodyhackguide.co/compare/melanotan-i-vs-melanotan-ii - Alternatives to Melanotan I: https://www.bodyhackguide.co/alternatives-to/melanotan-i All comparisons (https://www.bodyhackguide.co/compare) ### Research tools - Peptide Calculator Reconstitution and syringe units: https://www.bodyhackguide.co/tools/reconstitution - Reconstitution Guide How to mix, step by step: https://www.bodyhackguide.co/guides/how-to-reconstitute-peptides - Nasal Spray Calc mL per actuation: https://www.bodyhackguide.co/tools/intranasal - Half-Life Visualizer Decay curves: https://www.bodyhackguide.co/tools/halflife All articles (https://www.bodyhackguide.co/blog) 08 Questions ## Frequently asked questions What is Melanotan I used for in research? Melanotan I (afamelanotide) is a linear synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) with the substitution of norleucine at position 4 and D-phenylalanine at position 7. Unlike Melanotan II (which is cyclic), Melanotan I is a linear peptide that is significantly more selective for MC1R over MC4R — making it a tanning/photoprotective agent with substantially less sexual and appetite-stimulating side effects. Afamelanotide was FDA-approved in October 2019 under the brand name Scenesse as an implant for erythropoietic protoporphyria (EPP), a rare photosensitivity disorder. Melanotan I is meaningfully different from Melanotan II in structure, selectivity, and side-effect profile and should not be confused with it. What forms does Melanotan I come in? Melanotan I is available in vial, nasal forms. How do I compare Melanotan I vendors? Compare prices, payment methods, shipping, and COA scores across 2 vendors. How many vendors sell Melanotan I, and what does it cost per mg? 2 of the vendors BodyHackGuide tracks list Melanotan I (4 listings). Among BodyHackGuide's Melanotan I listings recorded as in stock with a milligram count, the lowest price per milligram is $3.50/mg at Ion Peptide and the median is $3.50/mg. The Melanotan I prices on BodyHackGuide are vendors' listed prices as BodyHackGuide last recorded them, not transactions; the most recent recorded change to a Melanotan I listing is dated 7 September 2026. Which vendors have third-party COAs for Melanotan I on file at BodyHackGuide? BodyHackGuide holds 59 third-party certificate records for Melanotan I, from. No editor has read any of BodyHackGuide's 59 certificate records for Melanotan I. The laboratory named on BodyHackGuide's Melanotan I certificate records is Freedom Diagnostics Testing, and the newest test date on them is 2 October 2026. Each vendor page on BodyHackGuide shows how many certificate records BodyHackGuide holds for that vendor and links to each record that has its own page. Related ## Articles on Melanotan I - The Best Peptide Nasal Sprays of 2026, Ranked by Evidence Peptides, 21 April 2026: https://www.bodyhackguide.co/blog/best-peptide-nasal-sprays-2026 - How to Make a Peptide Nasal Spray at Home: The Complete DIY Guide (2026) Guides, 21 April 2026: https://www.bodyhackguide.co/blog/how-to-make-peptide-nasal-spray-at-home - The Complete Peptide Reconstitution Guide (2026): Ratios, Math, and Common Mistakes Guides, 21 April 2026: https://www.bodyhackguide.co/blog/complete-peptide-reconstitution-guide-2026 Free 2026 Peptide Cheat Sheet (PDF) 38 compounds and blends: vial sizes, BAC water volumes, dosing ranges and bloodwork markers. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. - Terms: https://www.bodyhackguide.co/terms - Privacy: https://www.bodyhackguide.co/privacy ## Structured data ```json [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Melanotan I" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "Melanotan I", "description": "Melanotan I (afamelanotide) is a linear synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) with the substitution of norleucine at position 4 and D-phenylalanine at position 7. 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Unlike Melanotan II (which is cyclic), Melanotan I is a linear peptide that is significantly more selective for MC1R over MC4R — making it a tanning/photoprotective agent with substantially less sexual and appetite-stimulating side effects. Afamelanotide was FDA-approved in October 2019 under the brand name Scenesse as an implant for erythropoietic protoporphyria (EPP), a rare photosensitivity disorder. 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Unlike Melanotan II (which is cyclic), Melanotan I is a linear peptide that is significantly more selective for MC1R over MC4R — making it a tanning/photoprotective agent with substantially less sexual and appetite-stimulating side effects. Afamelanotide was FDA-approved in October 2019 under the brand name Scenesse as an implant for erythropoietic protoporphyria (EPP), a rare photosensitivity disorder. Melanotan I is meaningfully different from Melanotan II in structure, selectivity, and side-effect profile and should not be confused with it.", "activeIngredient": "Melanotan I", "administrationRoute": "Subcutaneous, Intramuscular", "mechanismOfAction": "Melanotan I is afamelanotide, i.e. [Nle4, D-Phe7]-alpha-MSH ('NDP-alpha-MSH'), a synthetic 13-amino-acid analog of alpha-melanocyte-stimulating hormone. The Nle4 and D-Phe7 substitutions make it resistant to enzymatic breakdown and roughly 10-100x more potent than native alpha-MSH. It agonizes the melanocortin-1 receptor (MC1R) on melanocytes; MC1R activation stimulates adenylyl cyclase, raising intracellular cAMP and activating protein kinase A (PKA), which in turn upregulates MITF and tyrosinase - the rate-limiting enzyme of melanogenesis - shifting pigment synthesis toward eumelanin (brown/black pigment) with or without UV exposure. This is the basis of its skin-darkening and photoprotective effects. Importantly, contrary to a widely repeated claim, Melanotan I is NOT MC1R-selective: NDP-alpha-MSH is a non-selective, superpotent agonist with nanomolar efficacy at every melanocortin receptor subtype except MC2R, meaning it also activates MC3R, MC4R and MC5R [PMID:9216831]. In practice it tends to cause fewer MC4R-mediated effects (spontaneous erections, heightened libido, pronounced nausea) than the cyclic analog Melanotan II - but this reflects Melanotan II's greater potency, metabolic stability and receptor residence rather than any true receptor selectivity of Melanotan I.", "dosageForm": "vial, nasal", "legalStatus": "FDA Approved" } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Melanotan I used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "Melanotan I (afamelanotide) is a linear synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) with the substitution of norleucine at position 4 and D-phenylalanine at position 7. Unlike Melanotan II (which is cyclic), Melanotan I is a linear peptide that is significantly more selective for MC1R over MC4R — making it a tanning/photoprotective agent with substantially less sexual and appetite-stimulating side effects. Afamelanotide was FDA-approved in October 2019 under the brand name Scenesse as an implant for erythropoietic protoporphyria (EPP), a rare photosensitivity disorder. 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