--- title: "LGD-4033 (Ligandrol): Dosing & Vendor Prices" description: "LGD-4033 (Ligandrol): dosing protocols, mechanism & side effects. Compare 1 verified vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "LGD-4033 (Ligandrol)" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "LGD-4033 (Ligandrol)", "description": "LGD-4033, usually sold as ligandrol, is a nonsteroidal selective androgen receptor modulator that Viking Therapeutics took into clinical development under the code VK5211 (NCT02578095). The stated development goal was an oral drug that produces the muscle and bone effects of testosterone with less action on prostate and skin, aimed at conditions such as recovery after hip fracture and other causes of muscle loss. It has not been approved by any regulator, and clinical development has not progressed past phase 2. Mechanistically it binds the androgen receptor with high affinity and selectivity and acts as an agonist in muscle and bone. The consequences of that binding are visible in the human phase 1 data: over three weeks of daily dosing in healthy young men, total testosterone, sex hormone binding globulin, HDL cholesterol and triglycerides all fell in a dose-dependent way, follicle-stimulating hormone and free testosterone fell at the top dose, and lean body mass rose without a change in fat mass (PMID: 22459616). Hormone levels and lipids returned to baseline after the drug was stopped in that 21-day study, which is a short exposure compared with how the compound is used outside research. Animal work supports an anabolic signal but is mixed on whether that translates to performance. In ovariectomized rats, ligandrol improved muscle tissue (PMID: 33042018) and improved trabecular bone structure at the highest dose tested in ovariectomized rats (PMID: 37407738). In male rats, however, ligandrol lowered endurance and worsened lipid and hormonal profiles (PMID: 40087185). Human safety reports are the strongest reason for caution. Published case reports describe severe cholestatic liver injury confirmed on biopsy after ligandrol use, including a 32-year-old man with cholestatic hepatitis and fibrosis (PMID: 32637435), a 37-year-old man with bilirubin about thirty times the upper limit of normal and ductopenia on biopsy (PMID: 36257328), a further case in an otherwise healthy adult (PMID: 39421081) and cases involving ligandrol together with post-cycle drugs (PMID: 34141767). A retrospective Australian series of drug-induced liver injury from anabolic steroids, SARMs and bodybuilding supplements collected 23 cases, most of whom were admitted to hospital, with a median 175 days to normal liver biochemistry and one liver transplant (PMID: 38372012). A self-reported case of ligandrol taken with the growth hormone secretagogue MK-677 recorded alanine aminotransferase up about 205 percent, HDL cholesterol down about 36 percent and total testosterone down about 62 percent (PMID: 36303408). In sport, LGD-4033 is prohibited at all times under the World Anti-Doping Agency class S1.2 and has been found in athlete urine samples (PMID: 27168428). Its human urinary metabolites are well characterized for testing purposes (PMID: 30255601). FDA has issued warning letters to firms selling it as an unapproved new drug (FDA warning letter to Titan SARMs LLC, 12 December 2025). What is sold as ligandrol is often mislabeled: in an analysis of 44 SARM-marketed products, only about half contained any SARM and the label amount matched the assay in 41 percent (PMID: 29183075).", "url": "https://www.bodyhackguide.co/compound/lgd-4033", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "84.99", "highPrice": "84.99", "priceCurrency": "USD", "offerCount": "1", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "84.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://disguisedalpha.com/product/lgd4033/?coupon=reddit", "seller": { "@type": "Organization", "name": "Disguised Alpha", "url": "https://disguisedalpha.com/?coupon=reddit" }, "name": "LGD-4033 (Ligandrol) 500mg liquid" } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "LGD-4033 (Ligandrol)", "description": "LGD-4033, usually sold as ligandrol, is a nonsteroidal selective androgen receptor modulator that Viking Therapeutics took into clinical development under the code VK5211 (NCT02578095). The stated development goal was an oral drug that produces the muscle and bone effects of testosterone with less action on prostate and skin, aimed at conditions such as recovery after hip fracture and other causes of muscle loss. It has not been approved by any regulator, and clinical development has not progressed past phase 2. Mechanistically it binds the androgen receptor with high affinity and selectivity and acts as an agonist in muscle and bone. The consequences of that binding are visible in the human phase 1 data: over three weeks of daily dosing in healthy young men, total testosterone, sex hormone binding globulin, HDL cholesterol and triglycerides all fell in a dose-dependent way, follicle-stimulating hormone and free testosterone fell at the top dose, and lean body mass rose without a change in fat mass (PMID: 22459616). Hormone levels and lipids returned to baseline after the drug was stopped in that 21-day study, which is a short exposure compared with how the compound is used outside research. Animal work supports an anabolic signal but is mixed on whether that translates to performance. In ovariectomized rats, ligandrol improved muscle tissue (PMID: 33042018) and improved trabecular bone structure at the highest dose tested in ovariectomized rats (PMID: 37407738). In male rats, however, ligandrol lowered endurance and worsened lipid and hormonal profiles (PMID: 40087185). Human safety reports are the strongest reason for caution. Published case reports describe severe cholestatic liver injury confirmed on biopsy after ligandrol use, including a 32-year-old man with cholestatic hepatitis and fibrosis (PMID: 32637435), a 37-year-old man with bilirubin about thirty times the upper limit of normal and ductopenia on biopsy (PMID: 36257328), a further case in an otherwise healthy adult (PMID: 39421081) and cases involving ligandrol together with post-cycle drugs (PMID: 34141767). A retrospective Australian series of drug-induced liver injury from anabolic steroids, SARMs and bodybuilding supplements collected 23 cases, most of whom were admitted to hospital, with a median 175 days to normal liver biochemistry and one liver transplant (PMID: 38372012). A self-reported case of ligandrol taken with the growth hormone secretagogue MK-677 recorded alanine aminotransferase up about 205 percent, HDL cholesterol down about 36 percent and total testosterone down about 62 percent (PMID: 36303408). In sport, LGD-4033 is prohibited at all times under the World Anti-Doping Agency class S1.2 and has been found in athlete urine samples (PMID: 27168428). Its human urinary metabolites are well characterized for testing purposes (PMID: 30255601). FDA has issued warning letters to firms selling it as an unapproved new drug (FDA warning letter to Titan SARMs LLC, 12 December 2025). What is sold as ligandrol is often mislabeled: in an analysis of 44 SARM-marketed products, only about half contained any SARM and the label amount matched the assay in 41 percent (PMID: 29183075).", "lastReviewed": "2026-09-07T04:47:49.549Z", "url": "https://www.bodyhackguide.co/compound/lgd-4033", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "LGD-4033 (Ligandrol)", "alternateName": [ "Ligandrol", "LGD4033", "LGD 4033", "VK5211", "VK-5211", "Anabolicum" ], "description": "LGD-4033, usually sold as ligandrol, is a nonsteroidal selective androgen receptor modulator that Viking Therapeutics took into clinical development under the code VK5211 (NCT02578095). The stated development goal was an oral drug that produces the muscle and bone effects of testosterone with less action on prostate and skin, aimed at conditions such as recovery after hip fracture and other causes of muscle loss. It has not been approved by any regulator, and clinical development has not progressed past phase 2. Mechanistically it binds the androgen receptor with high affinity and selectivity and acts as an agonist in muscle and bone. The consequences of that binding are visible in the human phase 1 data: over three weeks of daily dosing in healthy young men, total testosterone, sex hormone binding globulin, HDL cholesterol and triglycerides all fell in a dose-dependent way, follicle-stimulating hormone and free testosterone fell at the top dose, and lean body mass rose without a change in fat mass (PMID: 22459616). Hormone levels and lipids returned to baseline after the drug was stopped in that 21-day study, which is a short exposure compared with how the compound is used outside research. Animal work supports an anabolic signal but is mixed on whether that translates to performance. In ovariectomized rats, ligandrol improved muscle tissue (PMID: 33042018) and improved trabecular bone structure at the highest dose tested in ovariectomized rats (PMID: 37407738). In male rats, however, ligandrol lowered endurance and worsened lipid and hormonal profiles (PMID: 40087185). Human safety reports are the strongest reason for caution. Published case reports describe severe cholestatic liver injury confirmed on biopsy after ligandrol use, including a 32-year-old man with cholestatic hepatitis and fibrosis (PMID: 32637435), a 37-year-old man with bilirubin about thirty times the upper limit of normal and ductopenia on biopsy (PMID: 36257328), a further case in an otherwise healthy adult (PMID: 39421081) and cases involving ligandrol together with post-cycle drugs (PMID: 34141767). A retrospective Australian series of drug-induced liver injury from anabolic steroids, SARMs and bodybuilding supplements collected 23 cases, most of whom were admitted to hospital, with a median 175 days to normal liver biochemistry and one liver transplant (PMID: 38372012). A self-reported case of ligandrol taken with the growth hormone secretagogue MK-677 recorded alanine aminotransferase up about 205 percent, HDL cholesterol down about 36 percent and total testosterone down about 62 percent (PMID: 36303408). In sport, LGD-4033 is prohibited at all times under the World Anti-Doping Agency class S1.2 and has been found in athlete urine samples (PMID: 27168428). Its human urinary metabolites are well characterized for testing purposes (PMID: 30255601). FDA has issued warning letters to firms selling it as an unapproved new drug (FDA warning letter to Titan SARMs LLC, 12 December 2025). What is sold as ligandrol is often mislabeled: in an analysis of 44 SARM-marketed products, only about half contained any SARM and the label amount matched the assay in 41 percent (PMID: 29183075).", "activeIngredient": "LGD-4033 (Ligandrol)", "administrationRoute": "Oral", "mechanismOfAction": "LGD-4033 binds the androgen receptor with high affinity and selectivity and acts as a nonsteroidal agonist, driving transcription of androgen-responsive genes in skeletal muscle and bone while sparing prostate to a greater degree than testosterone (PMID: 22459616). Because the receptor it activates sits in the same feedback loop as endogenous androgens, agonism at the hypothalamus and pituitary suppresses gonadotropin output. That is what the phase 1 study measured directly: dose-dependent falls in total testosterone, sex hormone binding globulin, HDL cholesterol and triglycerides, with follicle-stimulating hormone and free testosterone falling at the highest dose tested, and lean body mass rising with no change in fat mass over 21 days (PMID: 22459616).", "dosageForm": "liquid", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is LGD-4033 (Ligandrol) used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "LGD-4033, usually sold as ligandrol, is a nonsteroidal selective androgen receptor modulator that Viking Therapeutics took into clinical development under the code VK5211 (NCT02578095). The stated development goal was an oral drug that produces the muscle and bone effects of testosterone with less action on prostate and skin, aimed at conditions such as recovery after hip fracture and other causes of muscle loss. It has not been approved by any regulator, and clinical development has not progressed past phase 2. Mechanistically it binds the androgen receptor with high affinity and selectivity and acts as an agonist in muscle and bone. The consequences of that binding are visible in the human phase 1 data: over three weeks of daily dosing in healthy young men, total testosterone, sex hormone binding globulin, HDL cholesterol and triglycerides all fell in a dose-dependent way, follicle-stimulating hormone and free testosterone fell at the top dose, and lean body mass rose without a change in fat mass (PMID: 22459616). Hormone levels and lipids returned to baseline after the drug was stopped in that 21-day study, which is a short exposure compared with how the compound is used outside research. Animal work supports an anabolic signal but is mixed on whether that translates to performance. In ovariectomized rats, ligandrol improved muscle tissue (PMID: 33042018) and improved trabecular bone structure at the highest dose tested in ovariectomized rats (PMID: 37407738). In male rats, however, ligandrol lowered endurance and worsened lipid and hormonal profiles (PMID: 40087185). Human safety reports are the strongest reason for caution. Published case reports describe severe cholestatic liver injury confirmed on biopsy after ligandrol use, including a 32-year-old man with cholestatic hepatitis and fibrosis (PMID: 32637435), a 37-year-old man with bilirubin about thirty times the upper limit of normal and ductopenia on biopsy (PMID: 36257328), a further case in an otherwise healthy adult (PMID: 39421081) and cases involving ligandrol together with post-cycle drugs (PMID: 34141767). A retrospective Australian series of drug-induced liver injury from anabolic steroids, SARMs and bodybuilding supplements collected 23 cases, most of whom were admitted to hospital, with a median 175 days to normal liver biochemistry and one liver transplant (PMID: 38372012). A self-reported case of ligandrol taken with the growth hormone secretagogue MK-677 recorded alanine aminotransferase up about 205 percent, HDL cholesterol down about 36 percent and total testosterone down about 62 percent (PMID: 36303408). In sport, LGD-4033 is prohibited at all times under the World Anti-Doping Agency class S1.2 and has been found in athlete urine samples (PMID: 27168428). Its human urinary metabolites are well characterized for testing purposes (PMID: 30255601). FDA has issued warning letters to firms selling it as an unapproved new drug (FDA warning letter to Titan SARMs LLC, 12 December 2025). What is sold as ligandrol is often mislabeled: in an analysis of 44 SARM-marketed products, only about half contained any SARM and the label amount matched the assay in 41 percent (PMID: 29183075)." } }, { "@type": "Question", "name": "What forms does LGD-4033 (Ligandrol) come in?", "acceptedAnswer": { "@type": "Answer", "text": "LGD-4033 (Ligandrol) is available in liquid form." } }, { "@type": "Question", "name": "How much does LGD-4033 (Ligandrol) cost?", "acceptedAnswer": { "@type": "Answer", "text": "Prices start at $84.99 across 1 verified vendor." } }, { "@type": "Question", "name": "How do I compare LGD-4033 (Ligandrol) vendors?", "acceptedAnswer": { "@type": "Answer", "text": "Compare prices, payment methods, shipping, and COA scores across 1 vendor." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompound%2Flgd-4033) 100K+ researchers trust BodyHackGuide — Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 2. [Compounds](/compare) 3. LGD-4033 (Ligandrol) ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Best price right now $0.17/mg · $84.99 for 500mg at Disguised Alpha [Buy at Disguised Alpha](https://www.bodyhackguide.co/go/disguised-alpha?utm_source=compound-sticky-bar&utm_campaign=35f0be18-ba2a-4161-a26c-72dd054d3b52&utm_medium=best-price-cta) [Where to buy LGD-4033 (Ligandrol)](/buy/lgd-4033) [LGD-4033 (Ligandrol) coupon codes](/coupons/lgd-4033) [LGD-4033 (Ligandrol) protocol](/protocol/lgd-4033) [Alternatives to LGD-4033 (Ligandrol)](/alternatives-to/lgd-4033) [LGD-4033 (Ligandrol) side effects](/side-effects/lgd-4033) 1. [Home](/) 3. [Compounds](/compare) 5. LGD-4033 (Ligandrol) ![LGD-4033 (Ligandrol) molecular structure](/assets/peptide-structure-placeholder-DUmZBF_j.png) # LGD-4033 (Ligandrol) Performance Phase 2 Download PDF Also known as: Ligandrol, LGD4033, LGD 4033, VK5211, VK-5211, Anabolicum LGD-4033, usually sold as ligandrol, is a nonsteroidal selective androgen receptor modulator that Viking Therapeutics took into clinical development under the code VK5211 (NCT02578095). The stated development goal was an oral drug that produces the muscle and bone effects of testosterone with less action on prostate and skin, aimed at conditions such as recovery after hip fracture and other causes of muscle loss. Half-Life: Long elimination half-life in humans with dose-proportional accumulation over 21 days of daily dosing in healthy young men; the report describes the profile without giving a single value in its summary (PMID: 22459616) Route: Oral MW: 338.25 g/mol CAS: 1165910-22-4 Last reviewed: Sep 7, 2026 [ Performance Category ](/wiki#cat-performance) Phase 2 Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices1 Related ## Overview ### Best Price Available ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $84.99 10 mL (50 mg/mL) · liquid [Buy Now](https://disguisedalpha.com/product/lgd4033/?coupon=reddit) Compare 1 vendor ### At A Glance Mechanism LGD-4033 binds the androgen receptor with high affinity and selectivity and acts as a nonsteroidal agonist, driving transcription of androgen-responsive genes in skeletal muscle and bone while sparing prostate to a greater degree than testosterone (PMID: 22459616). Because the re… Half-Life Long elimination half-life in humans with dose-proportional accumulation over 21 days of daily dosing in healthy young men; the report describes the profile without giving a single value in its summary (PMID: 22459616) Routes Oral Potential Benefits Increased lean body mass without a change in fat mass over 21 days in healthy young men in a placebo-controlled phase 1 study (PMID: 22459616) Improved muscle tissue in ovariectomized rats (PMID: 33042018) Improved trabecular bone structural properties at the highest dose tested in ovariectomized rats (PMID: 37407738) ### Overview LGD-4033, usually sold as ligandrol, is a nonsteroidal selective androgen receptor modulator that Viking Therapeutics took into clinical development under the code VK5211 (NCT02578095). The stated development goal was an oral drug that produces the muscle and bone effects of testosterone with less action on prostate and skin, aimed at conditions such as recovery after hip fracture and other causes of muscle loss. It has not been approved by any regulator, and clinical development has not progressed past phase 2. Mechanistically it binds the androgen receptor with high affinity and selectivity and acts as an agonist in muscle and bone. The consequences of that binding are visible in the human phase 1 data: over three weeks of daily dosing in healthy young men, total testosterone, sex hormone binding globulin, HDL cholesterol and triglycerides all fell in a dose-dependent way, follicle-stimulating hormone and free testosterone fell at the top dose, and lean body mass rose without a change in fat mass (PMID: 22459616). Hormone levels and lipids returned to baseline after the drug was stopped in that 21-day study, which is a short exposure compared with how the compound is used outside research. Animal work supports an anabolic signal but is mixed on whether that translates to performance. In ovariectomized rats, ligandrol improved muscle tissue (PMID: 33042018) and improved trabecular bone structure at the highest dose tested in ovariectomized rats (PMID: 37407738). In male rats, however, ligandrol lowered endurance and worsened lipid and hormonal profiles (PMID: 40087185). Human safety reports are the strongest reason for caution. Published case reports describe severe cholestatic liver injury confirmed on biopsy after ligandrol use, including a 32-year-old man with cholestatic hepatitis and fibrosis (PMID: 32637435), a 37-year-old man with bilirubin about thirty times the upper limit of normal and ductopenia on biopsy (PMID: 36257328), a further case in an otherwise healthy adult (PMID: 39421081) and cases involving ligandrol together with post-cycle drugs (PMID: 34141767). A retrospective Australian series of drug-induced liver injury from anabolic steroids, SARMs and bodybuilding supplements collected 23 cases, most of whom were admitted to hospital, with a median 175 days to normal liver biochemistry and one liver transplant (PMID: 38372012). A self-reported case of ligandrol taken with the growth hormone secretagogue MK-677 recorded alanine aminotransferase up about 205 percent, HDL cholesterol down about 36 percent and total testosterone down about 62 percent (PMID: 36303408). In sport, LGD-4033 is prohibited at all times under the World Anti-Doping Agency class S1.2 and has been found in athlete urine samples (PMID: 27168428). Its human urinary metabolites are well characterized for testing purposes (PMID: 30255601). FDA has issued warning letters to firms selling it as an unapproved new drug (FDA warning letter to Titan SARMs LLC, 12 December 2025). What is sold as ligandrol is often mislabeled: in an analysis of 44 SARM-marketed products, only about half contained any SARM and the label amount matched the assay in 41 percent (PMID: 29183075). ### Potential Research Fields Muscle wasting and sarcopenia Bone and fracture recovery Sports drug testing Hepatotoxicity surveillance ## Chemical Information IUPAC Name Not yet available CAS Number 1165910-22-4 Molecular Formula C14H12F6N2O Molecular Mass 338.25 g/mol ![LGD-4033 (Ligandrol) molecular structure](https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/44137686/PNG) [View on PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/44137686) ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions ### Contraindications Mechanism-based: contraindicated in pregnancy because androgen receptor agonists can virilize a female fetus, and in men with known or suspected prostate cancer. Existing liver disease or raised transaminases is a case-report-based reason to avoid it (PMID: 32637435, PMID: 36257328). Because it suppresses endogenous testosterone and gonadotropins (PMID: 22459616), it works against men being treated for infertility. Prohibited for athletes in tested sport at all times (PMID: 28137616). Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $84.99 Best $/mg $0.1700 Vendors 1 Listings 1 liquid [Sign in for alerts ](/auth) Form Allliquid Sort Price $/mg Vendor Vendor Product Form Qty Price $/mg Coupon ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) [Disguised Alpha](/vendor/disguised-alpha) [50 ](/vendor-trust-scorecard) 🇺🇸 US 🇪🇺 EU 🇬🇧 UK LGD-4033 50 mg/mL, 10 mL liquid 10 mL (50 mg/mL) ● In Stock $84.99 BEST $0.170 — [Buy](https://disguisedalpha.com/product/lgd4033/?coupon=reddit) Get LGD-4033 (Ligandrol) Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $84.99 [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with LGD-4033 (Ligandrol). [Sign in](/auth) Current low $84.99 as of Sep 7, 2026 7-day low $84.99 30-day low $84.99 30-day change — baseline building Tracking since Sep 7, 2026 · 1 data point ### Vendors Selling LGD-4033 (Ligandrol) [ ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) #### Disguised Alpha 1 listing · from $84.99 ](/vendor/disguised-alpha) How we score these vendors Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. [View Scorecard](/vendors/scorecard) ### Related Compounds [View All](/wiki) [ ### ITPP Performance Preclinical ITPP (myo-inositol trispyrophosphate, sometimes written myo-inositol tripyrophosphate or OXY111A in NormOxys trial documents) is a small-molecule allosteric effector of hemoglobin designed to increase the amount of oxygen red blood cells release to tissues. Research compound — IV infusion in studies, no established oral doses 36 studies View Profile ](/compound/itpp)[ ### Ostarine (Enobosarm, MK-2866) Performance Phase 3 Ostarine is the market name for enobosarm, a nonsteroidal selective androgen receptor modulator first developed by GTx Inc under the codes GTx-024, MK-2866 and S-22. t½ Not established from a retrieved human report; in rats the mean elimination half-life of radiolabeled GTx-024 was 0.6 h in males and 16.4 h in females (PMID: 24074268). Human plasma pharmacokinetics were characterized in phase 1 drug-interaction studies (PMID: 27105861) Preclinical View Profile ](/compound/ostarine)[ ### PEG-MGF Performance Preclinical PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage. t½ Native MGF: very short (minutes) due to rapid proteolysis. PEG-MGF: PEGylation is intended to extend this substantially (community estimates up to roughly 1 day), but there are no published human pharmacokinetic data to confirm a specific value. 200 Preclinical View Profile ](/compound/peg-mgf)[ ### RAD-140 (Testolone) Performance Phase 1 RAD-140, sold as testolone and given the international nonproprietary name vosilasarm, is a nonsteroidal selective androgen receptor modulator developed at Radius Health, whose scientists reported the first-in-human trial (PMID: 34565686), and first described in the medicinal chemistry literature as a compound with an oxadiazole core designed for oral androgen receptor activity with tissue selectivity (PMID: 24900290). t½ Terminal half-life 44.7 hours in humans, measured in a first-in-human phase 1 study in postmenopausal women with metastatic breast cancer (PMID: 34565686) Preclinical View Profile ](/compound/rad-140)[ ### SLU-PP-332 Performance Preclinical SLU-PP-332 is the first-generation synthetic pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ) developed by the laboratory of Thomas Burris at Saint Louis University and reported in a landmark 2023 publication that established ERR pan-agonism as a pharmacologically tractable exercise-mimetic drug mechanism. Research compound — no established human doses. Animal studies: 10-50 mg/kg 8 studies View Profile ](/compound/slu-pp-332)[ ### YK-11 Performance Preclinical YK-11 is a synthetic steroid, not a nonsteroidal SARM, despite being sold alongside them. t½ Not established. In a human elimination study using deuterium-labeled YK-11, no intact parent compound was seen in urine; unconjugated metabolites disappeared within 24 hours and glucuronidated and sulfated metabolites remained traceable beyond 48 hours (PMID: 30379415) Preclinical View Profile ](/compound/yk-11) [ View Full Dosage Guide → Protocols, calculator & safety for LGD-4033 (Ligandrol) ](/guides/dosage/lgd-4033) ### Best Price ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $84.99 [Buy Now](https://disguisedalpha.com/product/lgd4033/?coupon=reddit) 1 vendors · 1 listings ### Research Score 30 0 PubMed studies ### Quality Indicators Data Completeness 63% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Studies Interactions Vendor Listings ### Quick Facts Half-Life Long elimination half-life in humans with dose-proportional accumulation over 21 days of daily dosing in healthy young men; the report describes the profile without giving a single value in its summary (PMID: 22459616) Molecular Weight 338.25 g/mol Administration Oral CAS Number 1165910-22-4 Trial Phase Phase 2 0 [Full Dosage Guide](/guides/dosage/lgd-4033)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is LGD-4033 (Ligandrol) used for in research? LGD-4033, usually sold as ligandrol, is a nonsteroidal selective androgen receptor modulator that Viking Therapeutics took into clinical development under the code VK5211 (NCT02578095). The stated development goal was an oral drug that produces the muscle and bone effects of testosterone with less action on prostate and skin, aimed at conditions such as recovery after hip fracture and other causes of muscle loss. It has not been approved by any regulator, and clinical development has not progressed past phase 2. Mechanistically it binds the androgen receptor with high affinity and selectivity and acts as an agonist in muscle and bone. The consequences of that binding are visible in the human phase 1 data: over three weeks of daily dosing in healthy young men, total testosterone, sex hormone binding globulin, HDL cholesterol and triglycerides all fell in a dose-dependent way, follicle-stimulating hormone and free testosterone fell at the top dose, and lean body mass rose without a change in fat mass (PMID: 22459616). Hormone levels and lipids returned to baseline after the drug was stopped in that 21-day study, which is a short exposure compared with how the compound is used outside research. Animal work supports an anabolic signal but is mixed on whether that translates to performance. In ovariectomized rats, ligandrol improved muscle tissue (PMID: 33042018) and improved trabecular bone structure at the highest dose tested in ovariectomized rats (PMID: 37407738). In male rats, however, ligandrol lowered endurance and worsened lipid and hormonal profiles (PMID: 40087185). Human safety reports are the strongest reason for caution. Published case reports describe severe cholestatic liver injury confirmed on biopsy after ligandrol use, including a 32-year-old man with cholestatic hepatitis and fibrosis (PMID: 32637435), a 37-year-old man with bilirubin about thirty times the upper limit of normal and ductopenia on biopsy (PMID: 36257328), a further case in an otherwise healthy adult (PMID: 39421081) and cases involving ligandrol together with post-cycle drugs (PMID: 34141767). A retrospective Australian series of drug-induced liver injury from anabolic steroids, SARMs and bodybuilding supplements collected 23 cases, most of whom were admitted to hospital, with a median 175 days to normal liver biochemistry and one liver transplant (PMID: 38372012). A self-reported case of ligandrol taken with the growth hormone secretagogue MK-677 recorded alanine aminotransferase up about 205 percent, HDL cholesterol down about 36 percent and total testosterone down about 62 percent (PMID: 36303408). In sport, LGD-4033 is prohibited at all times under the World Anti-Doping Agency class S1.2 and has been found in athlete urine samples (PMID: 27168428). Its human urinary metabolites are well characterized for testing purposes (PMID: 30255601). FDA has issued warning letters to firms selling it as an unapproved new drug (FDA warning letter to Titan SARMs LLC, 12 December 2025). What is sold as ligandrol is often mislabeled: in an analysis of 44 SARM-marketed products, only about half contained any SARM and the label amount matched the assay in 41 percent (PMID: 29183075). What forms does LGD-4033 (Ligandrol) come in? LGD-4033 (Ligandrol) is available in liquid form. How much does LGD-4033 (Ligandrol) cost? Prices start at $84.99 across 1 verified vendor. How do I compare LGD-4033 (Ligandrol) vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### ITPP Performance Preclinical ITPP (myo-inositol trispyrophosphate, sometimes written myo-inositol tripyrophosphate or OXY111A in NormOxys trial documents) is a small-molecule allosteric effector of hemoglobin designed to increase the amount of oxygen red blood cells release to tissues. Research compound — IV infusion in studies, no established oral doses 36 studies View Profile ](/compound/itpp)[ ### Ostarine (Enobosarm, MK-2866) Performance Phase 3 Ostarine is the market name for enobosarm, a nonsteroidal selective androgen receptor modulator first developed by GTx Inc under the codes GTx-024, MK-2866 and S-22. t½ Not established from a retrieved human report; in rats the mean elimination half-life of radiolabeled GTx-024 was 0.6 h in males and 16.4 h in females (PMID: 24074268). Human plasma pharmacokinetics were characterized in phase 1 drug-interaction studies (PMID: 27105861) Preclinical View Profile ](/compound/ostarine)[ ### PEG-MGF Performance Preclinical PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage. t½ Native MGF: very short (minutes) due to rapid proteolysis. PEG-MGF: PEGylation is intended to extend this substantially (community estimates up to roughly 1 day), but there are no published human pharmacokinetic data to confirm a specific value. 200 Preclinical View Profile ](/compound/peg-mgf)[ ### RAD-140 (Testolone) Performance Phase 1 RAD-140, sold as testolone and given the international nonproprietary name vosilasarm, is a nonsteroidal selective androgen receptor modulator developed at Radius Health, whose scientists reported the first-in-human trial (PMID: 34565686), and first described in the medicinal chemistry literature as a compound with an oxadiazole core designed for oral androgen receptor activity with tissue selectivity (PMID: 24900290). t½ Terminal half-life 44.7 hours in humans, measured in a first-in-human phase 1 study in postmenopausal women with metastatic breast cancer (PMID: 34565686) Preclinical View Profile ](/compound/rad-140)[ ### SLU-PP-332 Performance Preclinical SLU-PP-332 is the first-generation synthetic pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ) developed by the laboratory of Thomas Burris at Saint Louis University and reported in a landmark 2023 publication that established ERR pan-agonism as a pharmacologically tractable exercise-mimetic drug mechanism. Research compound — no established human doses. Animal studies: 10-50 mg/kg 8 studies View Profile ](/compound/slu-pp-332)[ ### YK-11 Performance Preclinical YK-11 is a synthetic steroid, not a nonsteroidal SARM, despite being sold alongside them. t½ Not established. In a human elimination study using deuterium-labeled YK-11, no intact parent compound was seen in urine; unconjugated metabolites disappeared within 24 hours and glucuronidated and sulfated metabolites remained traceable beyond 48 hours (PMID: 30379415) Preclinical View Profile ](/compound/yk-11) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-lgd-4033) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. [Order Bloodwork](https://anabolicinsights.ai/?ref=nwm2zjb) ![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub — compound pricing, brain health protocols, dosing tools, and vendor reviews. [support@bodyhackguide.co](mailto:support@bodyhackguide.co) [](https://discord.gg/Mhq5UdRYBA)[](https://reddit.com/r/BodyHackGuide)[](https://x.com/bodyhackguide) Explore #### Explore - [Compare prices](/compare) - [Research suppliers](/vendors) - [Deals](/deals) - [Coupons](/coupons) - [Nootropics](/nootropics) - [Brain health](/brain-health) - [Blog](/blog) - [Guides](/guides) Tools #### Tools - [Reconstitution](/tools/reconstitution) - [Dosage calculator](/tools/dosage) - [Half-life visualizer](/tools/halflife) - [COA lookup](/tools/coa) - [Cost calculator](/tools/cost-calculator) - [Stack builder](/stack-builder) - [All tools →](/tools) Trust & vendors #### Trust & vendors - [Vendor directory](/vendors) - [Trust scorecard](/vendors/scorecard) - [Get BHG verified](/vendors/get-vetted) - [Scoring methodology](/vendors/methodology) - [Peptide cheatsheet](/guides/peptide-cheat-sheet-download) Company #### Company - [About](/about) - [Affiliate disclosure](/affiliate-disclosure) - [Editorial standards](/editorial-standards) - [Creators](/creators) - [Coaches](/coaches) - [Privacy](/privacy) - [Terms](/terms) - [Full site directory →](/site-directory) **Ownership & Affiliate Disclosure:** BodyHackGuide and BHG Labs share common ownership. We rank every vendor on the same public, reproducible [methodology](/vendors/methodology), and we earn a commission from purchases made through our links at no extra cost to you. Full details in our [affiliate disclosure](/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell, distribute, or promote any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. · [Terms](/terms) · [Privacy](/privacy) hi 👋