--- title: "Levo-tetrahydropalmatine (l-THP): Dosing & Vendor Prices" description: "Levo-tetrahydropalmatine (l-THP): dosing protocols, mechanism & side effects. Compare 1 verified vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Levo-tetrahydropalmatine (l-THP)" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "Levo-tetrahydropalmatine (l-THP)", "description": "Levo-tetrahydropalmatine, usually written l-THP, is an isoquinoline alkaloid found in plants of the Corydalis and Stephania genera. It is not a new compound. It has been approved and used in China for decades under the drug name Rotundine for several clinical indications, mainly as an analgesic with sedative and hypnotic effects (PMID: 22300097, PMID: 27606501). Outside China it is known in two very different contexts: as a candidate treatment for cocaine and opioid addiction, and as the active constituent of the herbal product Jin Bu Huan that caused a cluster of poisonings in the United States during the 1990s. Its pharmacology is dopamine receptor antagonism. Radioligand and behavioral work in rats found higher-affinity antagonism at D1 receptors, lower-affinity antagonism at D2 receptors and interaction with D3 receptors, and reviews add activity at alpha adrenergic and serotonin receptors (PMID: 17361394, PMID: 22300097). In C57BL/6J mice, treatment reduced voluntary ethanol drinking and altered D2 receptor-linked protein kinase A signaling in the caudate-putamen but not the nucleus accumbens (PMID: 23376703). The animal addiction work is consistent. In rats, l-THP shifted the cocaine self-administration dose-response curve down and to the right and reduced cocaine-induced reinstatement at doses that did not change food-reinforced responding (PMID: 17361394); reduced reinstatement triggered by cocaine, stress or drug-associated cues after oral administration (PMID: 21196089); reduced cocaine self-administration under a progressive ratio schedule (PMID: 20816889); and reduced nicotine self-administration and reinstatement (PMID: 27817750). Human work is real but small. A randomized, double-blind, placebo-controlled study gave 24 adult male cocaine users l-THP 30 mg twice daily or placebo for four days, with an intranasal cocaine challenge on the fourth day. The short course was safe and well tolerated, side effect counts matched placebo, and l-THP did not change cocaine exposure or its acute cardiovascular effects (PMID: 27363313). Registered work at the University of Maryland includes that Phase 1 study (NCT01631383), a completed 63-participant study in schizophrenia (NCT02118610) and a Phase 2 cocaine use disorder trial that was withdrawn before enrolment (NCT02139761). No adequately powered efficacy trial has been published. The safety record deserves weight. Jin Bu Huan Anodyne tablets, which contain l-THP and were mislabelled on the package as a Lycopodium product, caused acute hepatitis in seven previously healthy adults after a mean of 20 weeks of use, with recurrence on rechallenge in two of them (PMID: 7944049). A separate case series described life-threatening neurological and cardiovascular effects including coma in three young children after single acute ingestions, alongside hepatitis in three adults on long-term use (PMID: 8774209), and chronic hepatitis with moderate fibrosis has been reported after two months of use (PMID: 9537855). In human liver microsomes, tetrahydropalmatine is a mechanism-based inhibitor of CYP2D6 and is itself metabolized by CYP2C19, CYP3A4, CYP1A2 and CYP2D6, which makes interaction with CYP2D6 substrates a live concern (PMID: 41876357). l-THP has no FDA or EMA authorization. Capsules sold on the research chemical and supplement market are not the Chinese pharmaceutical product and are not made to a pharmacopoeial standard.", "url": "https://www.bodyhackguide.co/compound/l-thp", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "59.99", "highPrice": "59.99", "priceCurrency": "USD", "offerCount": "1", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "59.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://disguisedalpha.com/product/l-thp/?coupon=reddit", "seller": { "@type": "Organization", "name": "Disguised Alpha", "url": "https://disguisedalpha.com/?coupon=reddit" } } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Levo-tetrahydropalmatine (l-THP)", "description": "Levo-tetrahydropalmatine, usually written l-THP, is an isoquinoline alkaloid found in plants of the Corydalis and Stephania genera. It is not a new compound. It has been approved and used in China for decades under the drug name Rotundine for several clinical indications, mainly as an analgesic with sedative and hypnotic effects (PMID: 22300097, PMID: 27606501). Outside China it is known in two very different contexts: as a candidate treatment for cocaine and opioid addiction, and as the active constituent of the herbal product Jin Bu Huan that caused a cluster of poisonings in the United States during the 1990s. Its pharmacology is dopamine receptor antagonism. Radioligand and behavioral work in rats found higher-affinity antagonism at D1 receptors, lower-affinity antagonism at D2 receptors and interaction with D3 receptors, and reviews add activity at alpha adrenergic and serotonin receptors (PMID: 17361394, PMID: 22300097). In C57BL/6J mice, treatment reduced voluntary ethanol drinking and altered D2 receptor-linked protein kinase A signaling in the caudate-putamen but not the nucleus accumbens (PMID: 23376703). The animal addiction work is consistent. In rats, l-THP shifted the cocaine self-administration dose-response curve down and to the right and reduced cocaine-induced reinstatement at doses that did not change food-reinforced responding (PMID: 17361394); reduced reinstatement triggered by cocaine, stress or drug-associated cues after oral administration (PMID: 21196089); reduced cocaine self-administration under a progressive ratio schedule (PMID: 20816889); and reduced nicotine self-administration and reinstatement (PMID: 27817750). Human work is real but small. A randomized, double-blind, placebo-controlled study gave 24 adult male cocaine users l-THP 30 mg twice daily or placebo for four days, with an intranasal cocaine challenge on the fourth day. The short course was safe and well tolerated, side effect counts matched placebo, and l-THP did not change cocaine exposure or its acute cardiovascular effects (PMID: 27363313). Registered work at the University of Maryland includes that Phase 1 study (NCT01631383), a completed 63-participant study in schizophrenia (NCT02118610) and a Phase 2 cocaine use disorder trial that was withdrawn before enrolment (NCT02139761). No adequately powered efficacy trial has been published. The safety record deserves weight. Jin Bu Huan Anodyne tablets, which contain l-THP and were mislabelled on the package as a Lycopodium product, caused acute hepatitis in seven previously healthy adults after a mean of 20 weeks of use, with recurrence on rechallenge in two of them (PMID: 7944049). A separate case series described life-threatening neurological and cardiovascular effects including coma in three young children after single acute ingestions, alongside hepatitis in three adults on long-term use (PMID: 8774209), and chronic hepatitis with moderate fibrosis has been reported after two months of use (PMID: 9537855). In human liver microsomes, tetrahydropalmatine is a mechanism-based inhibitor of CYP2D6 and is itself metabolized by CYP2C19, CYP3A4, CYP1A2 and CYP2D6, which makes interaction with CYP2D6 substrates a live concern (PMID: 41876357). l-THP has no FDA or EMA authorization. Capsules sold on the research chemical and supplement market are not the Chinese pharmaceutical product and are not made to a pharmacopoeial standard.", "lastReviewed": "2026-09-07T04:46:53.273Z", "url": "https://www.bodyhackguide.co/compound/l-thp", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "Levo-tetrahydropalmatine (l-THP)", "alternateName": [ "l-THP", "Rotundine", "(-)-Tetrahydropalmatine", "Gindarine", "Hyndarine", "Caseanine", "Jin Bu Huan (herbal product containing l-THP)" ], "description": "Levo-tetrahydropalmatine, usually written l-THP, is an isoquinoline alkaloid found in plants of the Corydalis and Stephania genera. It is not a new compound. It has been approved and used in China for decades under the drug name Rotundine for several clinical indications, mainly as an analgesic with sedative and hypnotic effects (PMID: 22300097, PMID: 27606501). Outside China it is known in two very different contexts: as a candidate treatment for cocaine and opioid addiction, and as the active constituent of the herbal product Jin Bu Huan that caused a cluster of poisonings in the United States during the 1990s. Its pharmacology is dopamine receptor antagonism. Radioligand and behavioral work in rats found higher-affinity antagonism at D1 receptors, lower-affinity antagonism at D2 receptors and interaction with D3 receptors, and reviews add activity at alpha adrenergic and serotonin receptors (PMID: 17361394, PMID: 22300097). In C57BL/6J mice, treatment reduced voluntary ethanol drinking and altered D2 receptor-linked protein kinase A signaling in the caudate-putamen but not the nucleus accumbens (PMID: 23376703). The animal addiction work is consistent. In rats, l-THP shifted the cocaine self-administration dose-response curve down and to the right and reduced cocaine-induced reinstatement at doses that did not change food-reinforced responding (PMID: 17361394); reduced reinstatement triggered by cocaine, stress or drug-associated cues after oral administration (PMID: 21196089); reduced cocaine self-administration under a progressive ratio schedule (PMID: 20816889); and reduced nicotine self-administration and reinstatement (PMID: 27817750). Human work is real but small. A randomized, double-blind, placebo-controlled study gave 24 adult male cocaine users l-THP 30 mg twice daily or placebo for four days, with an intranasal cocaine challenge on the fourth day. The short course was safe and well tolerated, side effect counts matched placebo, and l-THP did not change cocaine exposure or its acute cardiovascular effects (PMID: 27363313). Registered work at the University of Maryland includes that Phase 1 study (NCT01631383), a completed 63-participant study in schizophrenia (NCT02118610) and a Phase 2 cocaine use disorder trial that was withdrawn before enrolment (NCT02139761). No adequately powered efficacy trial has been published. The safety record deserves weight. Jin Bu Huan Anodyne tablets, which contain l-THP and were mislabelled on the package as a Lycopodium product, caused acute hepatitis in seven previously healthy adults after a mean of 20 weeks of use, with recurrence on rechallenge in two of them (PMID: 7944049). A separate case series described life-threatening neurological and cardiovascular effects including coma in three young children after single acute ingestions, alongside hepatitis in three adults on long-term use (PMID: 8774209), and chronic hepatitis with moderate fibrosis has been reported after two months of use (PMID: 9537855). In human liver microsomes, tetrahydropalmatine is a mechanism-based inhibitor of CYP2D6 and is itself metabolized by CYP2C19, CYP3A4, CYP1A2 and CYP2D6, which makes interaction with CYP2D6 substrates a live concern (PMID: 41876357). l-THP has no FDA or EMA authorization. Capsules sold on the research chemical and supplement market are not the Chinese pharmaceutical product and are not made to a pharmacopoeial standard.", "activeIngredient": "Levo-tetrahydropalmatine (l-THP)", "administrationRoute": "Oral", "mechanismOfAction": "l-THP is a non-selective dopamine receptor antagonist. Radioligand and behavioral work in rats identified higher-affinity antagonism at D1 receptors, lower-affinity antagonism at D2 receptors and interaction with D3 receptors (PMID: 17361394), and reviews add activity at alpha adrenergic and serotonin receptors (PMID: 22300097). In C57BL/6J mice, four consecutive days of treatment reduced ethanol drinking and increased phosphorylated protein kinase A in the caudate-putamen but not the nucleus accumbens, which the authors linked to D2 receptor-mediated signaling (PMID: 23376703). Separately, in human liver microsomes tetrahydropalmatine acts as a mechanism-based inhibitor of CYP2D6 and is oxidized by CYP2C19, CYP3A4, CYP1A2 and CYP2D6 (PMID: 41876357), which matters more for drug interactions than for its central effects.", "dosageForm": "capsule", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Levo-tetrahydropalmatine (l-THP) used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "Levo-tetrahydropalmatine, usually written l-THP, is an isoquinoline alkaloid found in plants of the Corydalis and Stephania genera. It is not a new compound. It has been approved and used in China for decades under the drug name Rotundine for several clinical indications, mainly as an analgesic with sedative and hypnotic effects (PMID: 22300097, PMID: 27606501). Outside China it is known in two very different contexts: as a candidate treatment for cocaine and opioid addiction, and as the active constituent of the herbal product Jin Bu Huan that caused a cluster of poisonings in the United States during the 1990s. Its pharmacology is dopamine receptor antagonism. Radioligand and behavioral work in rats found higher-affinity antagonism at D1 receptors, lower-affinity antagonism at D2 receptors and interaction with D3 receptors, and reviews add activity at alpha adrenergic and serotonin receptors (PMID: 17361394, PMID: 22300097). In C57BL/6J mice, treatment reduced voluntary ethanol drinking and altered D2 receptor-linked protein kinase A signaling in the caudate-putamen but not the nucleus accumbens (PMID: 23376703). The animal addiction work is consistent. In rats, l-THP shifted the cocaine self-administration dose-response curve down and to the right and reduced cocaine-induced reinstatement at doses that did not change food-reinforced responding (PMID: 17361394); reduced reinstatement triggered by cocaine, stress or drug-associated cues after oral administration (PMID: 21196089); reduced cocaine self-administration under a progressive ratio schedule (PMID: 20816889); and reduced nicotine self-administration and reinstatement (PMID: 27817750). Human work is real but small. A randomized, double-blind, placebo-controlled study gave 24 adult male cocaine users l-THP 30 mg twice daily or placebo for four days, with an intranasal cocaine challenge on the fourth day. The short course was safe and well tolerated, side effect counts matched placebo, and l-THP did not change cocaine exposure or its acute cardiovascular effects (PMID: 27363313). Registered work at the University of Maryland includes that Phase 1 study (NCT01631383), a completed 63-participant study in schizophrenia (NCT02118610) and a Phase 2 cocaine use disorder trial that was withdrawn before enrolment (NCT02139761). No adequately powered efficacy trial has been published. The safety record deserves weight. Jin Bu Huan Anodyne tablets, which contain l-THP and were mislabelled on the package as a Lycopodium product, caused acute hepatitis in seven previously healthy adults after a mean of 20 weeks of use, with recurrence on rechallenge in two of them (PMID: 7944049). A separate case series described life-threatening neurological and cardiovascular effects including coma in three young children after single acute ingestions, alongside hepatitis in three adults on long-term use (PMID: 8774209), and chronic hepatitis with moderate fibrosis has been reported after two months of use (PMID: 9537855). In human liver microsomes, tetrahydropalmatine is a mechanism-based inhibitor of CYP2D6 and is itself metabolized by CYP2C19, CYP3A4, CYP1A2 and CYP2D6, which makes interaction with CYP2D6 substrates a live concern (PMID: 41876357). l-THP has no FDA or EMA authorization. Capsules sold on the research chemical and supplement market are not the Chinese pharmaceutical product and are not made to a pharmacopoeial standard." } }, { "@type": "Question", "name": "What forms does Levo-tetrahydropalmatine (l-THP) come in?", "acceptedAnswer": { "@type": "Answer", "text": "Levo-tetrahydropalmatine (l-THP) is available in capsule form." } }, { "@type": "Question", "name": "How much does Levo-tetrahydropalmatine (l-THP) cost?", "acceptedAnswer": { "@type": "Answer", "text": "Prices start at $59.99 across 1 verified vendor." } }, { "@type": "Question", "name": "How do I compare Levo-tetrahydropalmatine (l-THP) vendors?", "acceptedAnswer": { "@type": "Answer", "text": "Compare prices, payment methods, shipping, and COA scores across 1 vendor." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompound%2Fl-thp) 100K+ researchers trust BodyHackGuide — Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 2. [Compounds](/compare) 3. Levo-tetrahydropalmatine (l-THP) [Where to buy Levo-tetrahydropalmatine (l-THP)](/buy/l-thp) [Levo-tetrahydropalmatine (l-THP) coupon codes](/coupons/l-thp) [Levo-tetrahydropalmatine (l-THP) protocol](/protocol/l-thp) [Alternatives to Levo-tetrahydropalmatine (l-THP)](/alternatives-to/l-thp) [Levo-tetrahydropalmatine (l-THP) side effects](/side-effects/l-thp) 1. [Home](/) 3. [Compounds](/compare) 5. Levo-tetrahydropalmatine (l-THP) ![Levo-tetrahydropalmatine (l-THP) molecular structure](/assets/peptide-structure-placeholder-DUmZBF_j.png) # Levo-tetrahydropalmatine (l-THP) Nootropics Approved (China) Download PDF Also known as: l-THP, Rotundine, (-)-Tetrahydropalmatine, Gindarine, Hyndarine, Caseanine, Jin Bu Huan (herbal product containing l-THP) Levo-tetrahydropalmatine, usually written l-THP, is an isoquinoline alkaloid found in plants of the Corydalis and Stephania genera. It is not a new compound. Half-Life: Not established in the sources retrieved; a randomized, double-blind, placebo-controlled human study collected full plasma pharmacokinetic profiles in 19 cocaine users receiving l-THP 30 mg twice daily for 4 days but did not report a terminal half-life (PMID: 27363313) Route: Oral MW: 355.43 g/mol CAS: 483-14-7 Last reviewed: Sep 7, 2026 [ Nootropics Category ](/wiki#cat-nootropics) Approved (China) Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices1 Related ## Overview ### Best Price Available ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $59.99 60 capsules · capsule [Buy Now](https://disguisedalpha.com/product/l-thp/?coupon=reddit) Compare 1 vendor ### At A Glance Mechanism l-THP is a non-selective dopamine receptor antagonist. Radioligand and behavioral work in rats identified higher-affinity antagonism at D1 receptors, lower-affinity antagonism at D2 receptors and interaction with D3 receptors (PMID: 17361394), and reviews add activity at alpha ad… Half-Life Not established in the sources retrieved; a randomized, double-blind, placebo-controlled human study collected full plasma pharmacokinetic profiles in 19 cocaine users receiving l-THP 30 mg twice daily for 4 days but did not report a terminal half-life (PMID: 27363313) Routes Oral Potential Benefits Reduced cocaine self-administration and cocaine-induced reinstatement in rats at doses that did not change food-reinforced responding (PMID: 17361394) Reduced reinstatement of extinguished cocaine seeking triggered by cocaine, stress or drug-associated cues in rats after oral administration (PMID: 21196089) Reduced nicotine self-administration and reinstatement in rats (PMID: 27817750) Reduced voluntary ethanol drinking in C57BL/6J mice in a two-bottle choice test (PMID: 23376703) Safe and well tolerated over a short course in 24 adult male cocaine users, without changing cocaine pharmacokinetics or its acute cardiovascular effects (PMID: 27363313) ### Overview Levo-tetrahydropalmatine, usually written l-THP, is an isoquinoline alkaloid found in plants of the Corydalis and Stephania genera. It is not a new compound. It has been approved and used in China for decades under the drug name Rotundine for several clinical indications, mainly as an analgesic with sedative and hypnotic effects (PMID: 22300097, PMID: 27606501). Outside China it is known in two very different contexts: as a candidate treatment for cocaine and opioid addiction, and as the active constituent of the herbal product Jin Bu Huan that caused a cluster of poisonings in the United States during the 1990s. Its pharmacology is dopamine receptor antagonism. Radioligand and behavioral work in rats found higher-affinity antagonism at D1 receptors, lower-affinity antagonism at D2 receptors and interaction with D3 receptors, and reviews add activity at alpha adrenergic and serotonin receptors (PMID: 17361394, PMID: 22300097). In C57BL/6J mice, treatment reduced voluntary ethanol drinking and altered D2 receptor-linked protein kinase A signaling in the caudate-putamen but not the nucleus accumbens (PMID: 23376703). The animal addiction work is consistent. In rats, l-THP shifted the cocaine self-administration dose-response curve down and to the right and reduced cocaine-induced reinstatement at doses that did not change food-reinforced responding (PMID: 17361394); reduced reinstatement triggered by cocaine, stress or drug-associated cues after oral administration (PMID: 21196089); reduced cocaine self-administration under a progressive ratio schedule (PMID: 20816889); and reduced nicotine self-administration and reinstatement (PMID: 27817750). Human work is real but small. A randomized, double-blind, placebo-controlled study gave 24 adult male cocaine users l-THP 30 mg twice daily or placebo for four days, with an intranasal cocaine challenge on the fourth day. The short course was safe and well tolerated, side effect counts matched placebo, and l-THP did not change cocaine exposure or its acute cardiovascular effects (PMID: 27363313). Registered work at the University of Maryland includes that Phase 1 study (NCT01631383), a completed 63-participant study in schizophrenia (NCT02118610) and a Phase 2 cocaine use disorder trial that was withdrawn before enrolment (NCT02139761). No adequately powered efficacy trial has been published. The safety record deserves weight. Jin Bu Huan Anodyne tablets, which contain l-THP and were mislabelled on the package as a Lycopodium product, caused acute hepatitis in seven previously healthy adults after a mean of 20 weeks of use, with recurrence on rechallenge in two of them (PMID: 7944049). A separate case series described life-threatening neurological and cardiovascular effects including coma in three young children after single acute ingestions, alongside hepatitis in three adults on long-term use (PMID: 8774209), and chronic hepatitis with moderate fibrosis has been reported after two months of use (PMID: 9537855). In human liver microsomes, tetrahydropalmatine is a mechanism-based inhibitor of CYP2D6 and is itself metabolized by CYP2C19, CYP3A4, CYP1A2 and CYP2D6, which makes interaction with CYP2D6 substrates a live concern (PMID: 41876357). l-THP has no FDA or EMA authorization. Capsules sold on the research chemical and supplement market are not the Chinese pharmaceutical product and are not made to a pharmacopoeial standard. ### Potential Research Fields Addiction pharmacotherapy Dopamine receptor antagonists Herbal medicine safety Analgesia and sedation ## Chemical Information IUPAC Name Not yet available CAS Number 483-14-7 Molecular Formula C21H25NO4 Molecular Mass 355.43 g/mol ![Levo-tetrahydropalmatine (l-THP) molecular structure](https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/72301/PNG) [View on PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/72301) ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions ### Contraindications Sourced: liver disease or concurrent hepatotoxic exposure, given documented hepatitis after prolonged use of l-THP-containing herbal products (PMID: 7944049, PMID: 9537855), and children, given reported coma and cardiovascular collapse after single ingestions in three young children (PMID: 8774209). Mechanism-based: tetrahydropalmatine is a mechanism-based CYP2D6 inhibitor in human liver microsomes, so drugs cleared by CYP2D6 are an interaction concern (PMID: 41876357), and dopamine receptor antagonism is a mechanism-based concern for anyone taking dopaminergic or antipsychotic medication (PMID: 17361394). Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $59.99 Best $/mg — Vendors 1 Listings 1 capsule [Sign in for alerts ](/auth) Form Allcapsule Sort Price $/mg Vendor Vendor Product Form Qty Price $/mg Coupon ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) [Disguised Alpha](/vendor/disguised-alpha) [50 ](/vendor-trust-scorecard) 🇺🇸 US 🇪🇺 EU 🇬🇧 UK L-THP capsules (60) capsule 60 capsules ● In Stock $59.99 BEST — — [Buy](https://disguisedalpha.com/product/l-thp/?coupon=reddit) Get Levo-tetrahydropalmatine (l-THP) Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $59.99 [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Levo-tetrahydropalmatine (l-THP). [Sign in](/auth) Current low $59.99 as of Sep 7, 2026 7-day low $59.99 30-day low $59.99 30-day change — baseline building Tracking since Sep 7, 2026 · 1 data point ### Vendors Selling Levo-tetrahydropalmatine (l-THP) [ ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) #### Disguised Alpha 1 listing · from $59.99 ](/vendor/disguised-alpha) How we score these vendors Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. [View Scorecard](/vendors/scorecard) ### Related Compounds [View All](/wiki) [ ### 9-Me-BC (9-Methyl-β-carboline) Nootropics Preclinical 9-Methyl--carboline (9-Me-BC) is a synthetic -carboline alkaloid that has drawn nootropic-community interest for a preclinical property that is genuinely unusual among -carbolines: in rodent and cell-culture studies it appears to stimulate the dopaminergic phenotype - raising tyrosine hydroxylase, the number of differentiated dopamine neurons and dopamine content - while also showing neuroprotective, neurorestorative and anti-inflammatory effects, plus in-vitro MAO-A/MAO-B inhibition \[PMID:17913302, PMID:20374418, PMID:32285253\]. t½ Not characterized in humans (no pharmacokinetic data). Community/anecdotal only: ~5-25 mg per day, oral. No validated or approved human dose exists. 6 studies View Profile ](/compound/9-mbc)[ ### Aniracetam Nootropics Approved (Italy) Aniracetam is a pyrrolidinone in the racetam family, developed by Hoffmann-La Roche under the code Ro 13-5057. t½ About half an hour for the parent drug in humans. Plasma elimination half-life was 0.47 to 0.49 hours after a single 400 mg oral dose in 20 healthy male volunteers (PMID: 19025058). Aniracetam is extensively metabolized to N-anisoyl-GABA and anisic acid; in six elderly hospitalized patients with cerebrovascular disease and reduced creatinine clearance, metabolite half-life was 4 to 7 times longer than in young volunteers (PMID: 9062694). Preclinical View Profile ](/compound/aniracetam)[ ### Bemethyl (bemitil) Nootropics Approved (Russia) Bemethyl, known in the Russian literature as bemitil and sold in the region under names including Metaprot, Bemactor and Antihot, is 2-ethylthiobenzimidazole, normally handled as the hydrobromide salt. t½ Not established in humans; in healthy volunteers given a single 250 mg oral dose of the Metaprot capsule form, peak serum ethylthiobenzimidazole averaged 0.91 microg/mL at about 1.06 h, and no terminal half-life was reported (PMID: 21870773) Preclinical View Profile ](/compound/bemethyl)[ ### Bromantane Nootropics Russia Approved Bromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten. 34 studies View Profile ](/compound/bromantane)[ ### Cyclazodone Nootropics Preclinical Cyclazodone is the N-cyclopropyl derivative of pemoline, a 4-oxazolidinone stimulant. Preclinical View Profile ](/compound/cyclazodone)[ ### Dihexa Nootropics Preclinical Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. t½ Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. 5 to 40 mg oral per day (anecdotal range; no established human dose) 1 studies View Profile ](/compound/dihexa) [ View Full Dosage Guide → Protocols, calculator & safety for Levo-tetrahydropalmatine (l-THP) ](/guides/dosage/l-thp) ### Best Price ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $59.99 [Buy Now](https://disguisedalpha.com/product/l-thp/?coupon=reddit) 1 vendors · 1 listings ### Research Score 30 0 PubMed studies ### Quality Indicators Data Completeness 63% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Studies Interactions Vendor Listings ### Quick Facts Half-Life Not established in the sources retrieved; a randomized, double-blind, placebo-controlled human study collected full plasma pharmacokinetic profiles in 19 cocaine users receiving l-THP 30 mg twice daily for 4 days but did not report a terminal half-life (PMID: 27363313) Molecular Weight 355.43 g/mol Administration Oral CAS Number 483-14-7 Trial Phase Approved (China) 0 [Full Dosage Guide](/guides/dosage/l-thp)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is Levo-tetrahydropalmatine (l-THP) used for in research? Levo-tetrahydropalmatine, usually written l-THP, is an isoquinoline alkaloid found in plants of the Corydalis and Stephania genera. It is not a new compound. It has been approved and used in China for decades under the drug name Rotundine for several clinical indications, mainly as an analgesic with sedative and hypnotic effects (PMID: 22300097, PMID: 27606501). Outside China it is known in two very different contexts: as a candidate treatment for cocaine and opioid addiction, and as the active constituent of the herbal product Jin Bu Huan that caused a cluster of poisonings in the United States during the 1990s. Its pharmacology is dopamine receptor antagonism. Radioligand and behavioral work in rats found higher-affinity antagonism at D1 receptors, lower-affinity antagonism at D2 receptors and interaction with D3 receptors, and reviews add activity at alpha adrenergic and serotonin receptors (PMID: 17361394, PMID: 22300097). In C57BL/6J mice, treatment reduced voluntary ethanol drinking and altered D2 receptor-linked protein kinase A signaling in the caudate-putamen but not the nucleus accumbens (PMID: 23376703). The animal addiction work is consistent. In rats, l-THP shifted the cocaine self-administration dose-response curve down and to the right and reduced cocaine-induced reinstatement at doses that did not change food-reinforced responding (PMID: 17361394); reduced reinstatement triggered by cocaine, stress or drug-associated cues after oral administration (PMID: 21196089); reduced cocaine self-administration under a progressive ratio schedule (PMID: 20816889); and reduced nicotine self-administration and reinstatement (PMID: 27817750). Human work is real but small. A randomized, double-blind, placebo-controlled study gave 24 adult male cocaine users l-THP 30 mg twice daily or placebo for four days, with an intranasal cocaine challenge on the fourth day. The short course was safe and well tolerated, side effect counts matched placebo, and l-THP did not change cocaine exposure or its acute cardiovascular effects (PMID: 27363313). Registered work at the University of Maryland includes that Phase 1 study (NCT01631383), a completed 63-participant study in schizophrenia (NCT02118610) and a Phase 2 cocaine use disorder trial that was withdrawn before enrolment (NCT02139761). No adequately powered efficacy trial has been published. The safety record deserves weight. Jin Bu Huan Anodyne tablets, which contain l-THP and were mislabelled on the package as a Lycopodium product, caused acute hepatitis in seven previously healthy adults after a mean of 20 weeks of use, with recurrence on rechallenge in two of them (PMID: 7944049). A separate case series described life-threatening neurological and cardiovascular effects including coma in three young children after single acute ingestions, alongside hepatitis in three adults on long-term use (PMID: 8774209), and chronic hepatitis with moderate fibrosis has been reported after two months of use (PMID: 9537855). In human liver microsomes, tetrahydropalmatine is a mechanism-based inhibitor of CYP2D6 and is itself metabolized by CYP2C19, CYP3A4, CYP1A2 and CYP2D6, which makes interaction with CYP2D6 substrates a live concern (PMID: 41876357). l-THP has no FDA or EMA authorization. Capsules sold on the research chemical and supplement market are not the Chinese pharmaceutical product and are not made to a pharmacopoeial standard. What forms does Levo-tetrahydropalmatine (l-THP) come in? Levo-tetrahydropalmatine (l-THP) is available in capsule form. How much does Levo-tetrahydropalmatine (l-THP) cost? Prices start at $59.99 across 1 verified vendor. How do I compare Levo-tetrahydropalmatine (l-THP) vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### 9-Me-BC (9-Methyl-β-carboline) Nootropics Preclinical 9-Methyl--carboline (9-Me-BC) is a synthetic -carboline alkaloid that has drawn nootropic-community interest for a preclinical property that is genuinely unusual among -carbolines: in rodent and cell-culture studies it appears to stimulate the dopaminergic phenotype - raising tyrosine hydroxylase, the number of differentiated dopamine neurons and dopamine content - while also showing neuroprotective, neurorestorative and anti-inflammatory effects, plus in-vitro MAO-A/MAO-B inhibition \[PMID:17913302, PMID:20374418, PMID:32285253\]. t½ Not characterized in humans (no pharmacokinetic data). Community/anecdotal only: ~5-25 mg per day, oral. No validated or approved human dose exists. 6 studies View Profile ](/compound/9-mbc)[ ### Aniracetam Nootropics Approved (Italy) Aniracetam is a pyrrolidinone in the racetam family, developed by Hoffmann-La Roche under the code Ro 13-5057. t½ About half an hour for the parent drug in humans. Plasma elimination half-life was 0.47 to 0.49 hours after a single 400 mg oral dose in 20 healthy male volunteers (PMID: 19025058). Aniracetam is extensively metabolized to N-anisoyl-GABA and anisic acid; in six elderly hospitalized patients with cerebrovascular disease and reduced creatinine clearance, metabolite half-life was 4 to 7 times longer than in young volunteers (PMID: 9062694). Preclinical View Profile ](/compound/aniracetam)[ ### Bemethyl (bemitil) Nootropics Approved (Russia) Bemethyl, known in the Russian literature as bemitil and sold in the region under names including Metaprot, Bemactor and Antihot, is 2-ethylthiobenzimidazole, normally handled as the hydrobromide salt. t½ Not established in humans; in healthy volunteers given a single 250 mg oral dose of the Metaprot capsule form, peak serum ethylthiobenzimidazole averaged 0.91 microg/mL at about 1.06 h, and no terminal half-life was reported (PMID: 21870773) Preclinical View Profile ](/compound/bemethyl)[ ### Bromantane Nootropics Russia Approved Bromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten. 34 studies View Profile ](/compound/bromantane)[ ### Cyclazodone Nootropics Preclinical Cyclazodone is the N-cyclopropyl derivative of pemoline, a 4-oxazolidinone stimulant. Preclinical View Profile ](/compound/cyclazodone)[ ### Dihexa Nootropics Preclinical Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. t½ Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. 5 to 40 mg oral per day (anecdotal range; no established human dose) 1 studies View Profile ](/compound/dihexa) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-l-thp) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. 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