--- title: "KW-6356: Dosing & Vendor Prices | BodyHackGuide" url: https://www.bodyhackguide.co/compound/kw-6356 description: "KW-6356: dosing protocols, mechanism & side effects. Compare 1 current vendor prices." lang: en --- Skip to content Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # KW-6356 Nootropics Phase 2b (program discontinued) Also known as: KW6356 KW-6356 is a selective adenosine A2A receptor antagonist/inverse agonist developed by Kyowa Kirin and studied for Parkinson's disease, both as monotherapy and as an add-on to levodopa. Adenosine A2A receptors are concentrated in the basal ganglia, where they oppose dopamine signaling, so blocking them is a non-dopaminergic way to support motor function. Route: Oral MW: 397.4 CAS: 858979-50-7 Last reviewed: Sep 26, 2026 Nootropics Category https://www.bodyhackguide.co/wiki#cat-nootropics Phase 2b (program discontinued) Research Stage ## Overview ### Lowest Price per mg Image: BHG Labs logo (https://bhglabs.co/store/wp-content/uploads/2026/06/logo-full.png) BHG Labs $109.99 1 bottle · capsule Coupon: `BHG20` ### At A Glance Mechanism KW-6356 binds adenosine A2A receptors as a high-affinity antagonist and inverse agonist, reducing both adenosine-stimulated and constitutive A2A signaling in striatal output pathways. By relieving A2A-mediated inhibition of dopaminergic motor circuits it improves motor output wit… Routes Oral Potential Benefits Selective adenosine A2A antagonism / inverse agonism Studied for motor symptoms in Parkinson's disease (Phase 2a monotherapy + Phase 2b adjunct) Non-dopaminergic mechanism Researched for the wakefulness / anti-fatigue effects of A2A blockade ### Overview KW-6356 is a selective adenosine A2A receptor antagonist/inverse agonist developed by Kyowa Kirin and studied for Parkinson's disease, both as monotherapy and as an add-on to levodopa. Adenosine A2A receptors are concentrated in the basal ganglia, where they oppose dopamine signaling, so blocking them is a non-dopaminergic way to support motor function. It is a structurally distinct successor to istradefylline (Nourianz). ## Chemical Information IUPAC Name Not yet available CAS Number 858979-50-7 Molecular Formula Not yet available Molecular Mass 397.4 g/mol ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data Create free account: https://www.bodyhackguide.co/auth Sign in: https://www.bodyhackguide.co/auth Join other researchers already signed up ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details ## Interactions ### Contraindications Investigational compound with no clinical-use guidance. Avoid in pregnancy/breastfeeding. Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $109.99 Best $/mg — Vendors 1 Listings 1 capsule Sign in for alerts: https://www.bodyhackguide.co/auth Form Sort | Vendor | Product | Form | Qty | Price | $/mg | Coupon | | | --- | --- | --- | --- | --- | --- | --- | --- | | Image: BHG Labs logo (https://bhglabs.co/store/wp-content/uploads/2026/06/logo-full.png) BHG Labs (https://www.bodyhackguide.co/vendors/bhg-labs) 70: https://www.bodyhackguide.co/vendor-trust-scorecard 🇺🇸 US | KW-6356 | capsule | 1 bottle ● In Stock | $109.99 BEST | — | BHG20 | Buy: https://bhglabs.co/product/kw-6356/?ref=zmgqyxku&coupon=BHG20 | Get KW-6356 Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $109.99 ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with KW-6356. Current low $109.99 as of Jul 1, 2026 7-day low — no 7d data yet 30-day low — no 30d data yet 30-day change — baseline building Tracking since Jul 1, 2026 · 1 data point ### Vendors Selling KW-6356 #### BHG Labs 4.8 1 listing · from $109.99 https://www.bodyhackguide.co/vendors/bhg-labs How we score these vendors Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. View Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ### Related Compounds View All (https://www.bodyhackguide.co/wiki) ### 9-Me-BC (9-Methyl-β-carboline) Nootropics Preclinical 9-Methyl--carboline (9-Me-BC) is a synthetic -carboline alkaloid that has drawn nootropic-community interest for a preclinical property that is genuinely unusual among -carbolines: in rodent and cell-culture studies it appears to stimulate the dopaminergic phenotype - raising tyrosine hydroxylase, the number of differentiated dopamine neurons and dopamine content - while also showing neuroprotective, neurorestorative and anti-inflammatory effects, plus in-vitro MAO-A/MAO-B inhibition [PMID:17913302, PMID:20374418, PMID:32285253]. t½ Not characterized in humans (no pharmacokinetic data). Community/anecdotal only: ~5-25 mg per day, oral. No validated or approved human dose exists. 6 PubMed View Profile https://www.bodyhackguide.co/compound/9-mbc ### Aniracetam Nootropics Approved (Italy) Aniracetam is a pyrrolidinone in the racetam family, developed by Hoffmann-La Roche under the code Ro 13-5057. t½ About half an hour for the parent drug in humans. Plasma elimination half-life was 0.47 to 0.49 hours after a single 400 mg oral dose in 20 healthy male volunteers (PMID: 19025058). Aniracetam is extensively metabolized to N-anisoyl-GABA and anisic acid; in six elderly hospitalized patients with cerebrovascular disease and reduced creatinine clearance, metabolite half-life was 4 to 7 times longer than in young volunteers (PMID: 9062694). Preclinical View Profile https://www.bodyhackguide.co/compound/aniracetam ### Bemethyl (bemitil) Nootropics Approved (Russia) Bemethyl, known in the Russian literature as bemitil and sold in the region under names including Metaprot, Bemactor and Antihot, is 2-ethylthiobenzimidazole, normally handled as the hydrobromide salt. t½ Not established in humans; in healthy volunteers given a single 250 mg oral dose of the Metaprot capsule form, peak serum ethylthiobenzimidazole averaged 0.91 microg/mL at about 1.06 h, and no terminal half-life was reported (PMID: 21870773) Preclinical View Profile https://www.bodyhackguide.co/compound/bemethyl ### Bromantane Nootropics Russia Approved Bromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten. 34 PubMed View Profile https://www.bodyhackguide.co/compound/bromantane ### Cyclazodone Nootropics Preclinical Cyclazodone is the N-cyclopropyl derivative of pemoline, a 4-oxazolidinone stimulant. Preclinical View Profile https://www.bodyhackguide.co/compound/cyclazodone ### Dihexa Nootropics Preclinical Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. t½ Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. 5 to 40 mg oral per day (anecdotal range; no established human dose) 1 PubMed View Profile https://www.bodyhackguide.co/compound/dihexa View Full Dosage Guide → Protocols, calculator & safety for KW-6356 https://www.bodyhackguide.co/guides/dosage/kw-6356 ### Related Articles All Posts (https://www.bodyhackguide.co/blog) #### BHG Labs review: a small, COA-backed nootropics and peptides vendor (2026) BHG Labs is a small, US-focused research-chemical vendor selling atomized nasal sprays, single-compound nootropic capsules, and lyophilized peptides, all lot-numbered and third-party COA-linked. Everything is research-use-only. The catalog is curated rather than huge, and there's no large public review history yet, so it suits experienced self-experimenters more than first-timers. Code REDDIT takes 10% off. 6/30/2026 https://www.bodyhackguide.co/blog/bhg-labs-review ### Lowest Price per mg BHG Labs $109.99 1 vendors · 1 listings ### Research Score 30 0 PubMed results ### Quality Indicators Data Completeness 63% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Results Interactions Vendor Listings ### Quick Facts Molecular Weight 397.4 g/mol Administration Oral CAS Number 858979-50-7 Trial Phase Phase 2b (program discontinued) 0 Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is KW-6356 used for in research? What forms does KW-6356 come in? KW-6356 is available in capsule form. How much does KW-6356 cost? Prices start at $109.99 across 1 vendor. How do I compare KW-6356 vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. ## Research Tools ### Peptide Calculator Reconstitution & syringe units https://www.bodyhackguide.co/tools/reconstitution ### Reconstitution Guide How to mix, step by step https://www.bodyhackguide.co/guides/how-to-reconstitute-peptides ### Nasal Spray Calc mL per actuation https://www.bodyhackguide.co/tools/intranasal ### Half-Life Visualizer Decay curves https://www.bodyhackguide.co/tools/halflife ## Related Compounds ### 9-Me-BC (9-Methyl-β-carboline) Nootropics Preclinical ### Aniracetam Nootropics Approved (Italy) ### Bemethyl (bemitil) Nootropics Approved (Russia) ### Bromantane Nootropics Russia Approved ### Cyclazodone Nootropics Preclinical ### Dihexa Nootropics Preclinical ## Research Benches Reference pages that put KW-6356 next to the compounds people pair it with: roles, evidence, overlap and conflicts. No dosing. Research use only. Adenosine Bench KW-6356 next to caffeine and istradefylline, with the unpublished trials named research bench · no dosing https://www.bodyhackguide.co/stack/adenosine-bench Free 2026 Peptide Cheat Sheet (PDF) Reconstitution math, concentration charts, half-lives, and vendor links. The reference we wish we had on day one. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. Image: BodyHackGuide (https://www.bodyhackguide.co/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide #### Explore - Compare prices: https://www.bodyhackguide.co/compare - Research suppliers: https://www.bodyhackguide.co/vendors - Deals: https://www.bodyhackguide.co/deals - Coupons: https://www.bodyhackguide.co/coupons - Nootropics: https://www.bodyhackguide.co/nootropics - Brain health: https://www.bodyhackguide.co/brain-health - Blog: https://www.bodyhackguide.co/blog - Guides: https://www.bodyhackguide.co/guides #### Tools - Reconstitution: https://www.bodyhackguide.co/tools/reconstitution - Half-life visualizer: https://www.bodyhackguide.co/tools/halflife - COA lookup: https://www.bodyhackguide.co/tools/coa - Cost calculator: https://www.bodyhackguide.co/tools/cost-calculator - Stack builder: https://www.bodyhackguide.co/stack-builder - All tools →: https://www.bodyhackguide.co/tools #### Trust & vendors - Vendor directory: https://www.bodyhackguide.co/vendors - Trust scorecard: https://www.bodyhackguide.co/vendors/scorecard - Vendor trust badge: https://www.bodyhackguide.co/vendors/get-vetted - Scoring methodology: https://www.bodyhackguide.co/vendors/methodology - Peptide cheatsheet: https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download #### Company - About: https://www.bodyhackguide.co/about - Affiliate disclosure: https://www.bodyhackguide.co/affiliate-disclosure - Editorial standards: https://www.bodyhackguide.co/editorial-standards - Creators: https://www.bodyhackguide.co/creators - Coaches: https://www.bodyhackguide.co/coaches - Privacy: https://www.bodyhackguide.co/privacy - Terms: https://www.bodyhackguide.co/terms - Full site directory →: https://www.bodyhackguide.co/site-directory **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology), and we earn a commission from purchases made through our links at no extra cost to you. Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell, distribute, or promote any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. 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