--- title: "Kisspeptin-10 (KSPTN): Dosing & Vendor Prices" description: "Kisspeptin-10 (KSPTN): dosing protocols, mechanism & side effects. Compare 1 verified vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Kisspeptin-10 (KSPTN)" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "Kisspeptin-10 (KSPTN)", "description": "KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis. The research material sold under this code is typically kisspeptin-10, the active decapeptide fragment (YNWNSFGLRF-NH2, also called metastin 45-54) that stimulates GnRH release and, downstream, LH, FSH and the sex hormones. Unlike testosterone or hCG, kisspeptin acts at the very top of the axis and recruits the body's own GnRH pulse generator. It has been studied in human clinical trials for IVF egg-maturation triggering, hypogonadism, hypothalamic amenorrhea and sexual desire, but it is not an approved drug and is sold strictly for research use only (RUO).", "url": "https://www.bodyhackguide.co/compound/ksptn", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "29.00", "highPrice": "39.00", "priceCurrency": "USD", "offerCount": "2", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "29.00", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://ionpeptide.com/product/ksptn/?ref=reddit15", "seller": { "@type": "Organization", "name": "Ion Peptide", "url": "https://ionpeptide.com" }, "name": "Kisspeptin-10 (KSPTN) 5mg vial" }, { "@type": "Offer", "price": "39.00", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://ionpeptide.com/product/ksptn/?ref=reddit15", "seller": { "@type": "Organization", "name": "Ion Peptide", "url": "https://ionpeptide.com" }, "name": "Kisspeptin-10 (KSPTN) 10mg vial" } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Kisspeptin-10 (KSPTN)", "description": "KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis. The research material sold under this code is typically kisspeptin-10, the active decapeptide fragment (YNWNSFGLRF-NH2, also called metastin 45-54) that stimulates GnRH release and, downstream, LH, FSH and the sex hormones. Unlike testosterone or hCG, kisspeptin acts at the very top of the axis and recruits the body's own GnRH pulse generator. It has been studied in human clinical trials for IVF egg-maturation triggering, hypogonadism, hypothalamic amenorrhea and sexual desire, but it is not an approved drug and is sold strictly for research use only (RUO).", "lastReviewed": "2026-09-04T09:49:00.737Z", "url": "https://www.bodyhackguide.co/compound/ksptn", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "Kisspeptin-10 (KSPTN)", "alternateName": [ "KSPTN peptide", "Novel research peptide" ], "description": "KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis. The research material sold under this code is typically kisspeptin-10, the active decapeptide fragment (YNWNSFGLRF-NH2, also called metastin 45-54) that stimulates GnRH release and, downstream, LH, FSH and the sex hormones. Unlike testosterone or hCG, kisspeptin acts at the very top of the axis and recruits the body's own GnRH pulse generator. It has been studied in human clinical trials for IVF egg-maturation triggering, hypogonadism, hypothalamic amenorrhea and sexual desire, but it is not an approved drug and is sold strictly for research use only (RUO).", "activeIngredient": "Kisspeptin-10 (KSPTN)", "administrationRoute": "Subcutaneous", "mechanismOfAction": "Kisspeptin is the peptide product of the KISS1 gene and the endogenous ligand for the receptor KISS1R (formerly GPR54). The material sold as KSPTN is typically kisspeptin-10, the C-terminal decapeptide (YNWNSFGLRF-NH2, metastin 45-54) that retains full receptor activity; the parent 54-amino-acid peptide can be cleaved into kisspeptin-14, -13 and -10 with similar potency [PMID:18193176]. Kisspeptin-expressing neurons in the hypothalamus (arcuate and AVPV nuclei) sit upstream of gonadotropin-releasing hormone (GnRH) neurons. When kisspeptin binds KISS1R on those GnRH neurons it drives pulsatile GnRH secretion, which stimulates the anterior pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH); LH and FSH then act on the gonads to raise testosterone in men or estradiol and progesterone in women, and at mid-cycle to trigger the ovulatory LH surge. Kisspeptin therefore acts as a master upstream regulator of the whole HPG axis rather than acting on the gonad directly. According to PubMed, acute intravenous kisspeptin-10 potently increases plasma LH, FSH and testosterone in healthy men [PMID:17323132]. A key pharmacological caveat: continuous or high-dose exposure desensitizes KISS1R and blunts the LH response, so the physiological signal is pulsatile rather than tonic.", "dosageForm": "vial", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is KSPTN?", "acceptedAnswer": { "@type": "Answer", "text": "KSPTN is vendor shorthand for kisspeptin, a peptide encoded by the KISS1 gene. The research material sold under this code is almost always kisspeptin-10, the active 10-amino-acid fragment (sequence YNWNSFGLRF-NH2, also called metastin 45-54). It is a potent agonist of the kisspeptin receptor KISS1R (GPR54)." } }, { "@type": "Question", "name": "What does kisspeptin actually do?", "acceptedAnswer": { "@type": "Answer", "text": "It acts upstream of the reproductive axis. Kisspeptin stimulates GnRH neurons in the hypothalamus, which drives the pituitary to release LH and FSH, which signal the gonads to make testosterone (men) or estrogen and progesterone and to trigger ovulation (women). According to PubMed, an IV dose of kisspeptin-10 potently raises LH and, in men, testosterone in healthy volunteers [PMID:17323132]." } }, { "@type": "Question", "name": "Is kisspeptin FDA-approved?", "acceptedAnswer": { "@type": "Answer", "text": "No. Kisspeptin is investigational. It has been studied in numerous human clinical trials - for IVF egg-maturation triggering, hypogonadism, hypothalamic amenorrhea and sexual desire - but it is not an approved drug, and material sold to consumers is labeled research use only." } }, { "@type": "Question", "name": "Can I inject it subcutaneously like other peptides?", "acceptedAnswer": { "@type": "Answer", "text": "There is no validated subcutaneous self-dosing protocol. Every human study of kisspeptin-10 used intravenous administration because the peptide is cleared within minutes. Kisspeptin-54 (a longer form) lasts longer and has been given subcutaneously in IVF trials. Community subcutaneous use of kisspeptin-10 is anecdotal and not supported by pharmacokinetic data." } }, { "@type": "Question", "name": "Will more kisspeptin give a bigger hormonal response?", "acceptedAnswer": { "@type": "Answer", "text": "Not necessarily. The kisspeptin receptor desensitizes with continuous or high-dose exposure, which can blunt the LH response. The natural signal is pulsatile, so overdosing tends to reduce, not amplify, the effect." } }, { "@type": "Question", "name": "How is kisspeptin different from gonadorelin or hCG?", "acceptedAnswer": { "@type": "Answer", "text": "Gonadorelin is GnRH itself, one step further down the axis, and hCG mimics LH directly at the gonad. Kisspeptin acts one step higher, on the GnRH neurons, so it recruits the body's own GnRH pulse generator. In IVF it has been studied as a gentler oocyte-maturation trigger than hCG, with lower ovarian-hyperstimulation risk [PMID:28393578]." } }, { "@type": "Question", "name": "What is the difference between kisspeptin-10 and kisspeptin-54?", "acceptedAnswer": { "@type": "Answer", "text": "The KISS1 gene makes a 54-amino-acid peptide (kisspeptin-54, or metastin) that can be cleaved into shorter fragments (kisspeptin-14, -13 and -10) sharing similar receptor potency [PMID:18193176]. Kisspeptin-10 is the short decapeptide most commonly sold as research material; kisspeptin-54 is longer-acting and used in several clinical trials." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" }, { "@context": "https://schema.org", "@type": "Product", "name": "Kisspeptin-10 (KSPTN)", "description": "KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis. 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It has been studied in human clinical trials for IVF egg-maturation triggering, hypogonadism, hypothalamic amenorrhea and sexual desire, but it is not an approved drug and is sold strictly for research use only (RUO).", "url": "https://www.bodyhackguide.co/compound/ksptn", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "29.00", "highPrice": "39.00", "priceCurrency": "USD", "offerCount": "2", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "29.00", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://ionpeptide.com/product/ksptn/?ref=reddit15", "seller": { "@type": "Organization", "name": "Ion Peptide", "url": "https://ionpeptide.com" }, "name": "Kisspeptin-10 (KSPTN) 5mg vial" }, { "@type": "Offer", "price": "39.00", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://ionpeptide.com/product/ksptn/?ref=reddit15", "seller": { "@type": "Organization", "name": "Ion Peptide", "url": "https://ionpeptide.com" }, "name": "Kisspeptin-10 (KSPTN) 10mg vial" } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Kisspeptin-10 (KSPTN)", "description": "KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis. The research material sold under this code is typically kisspeptin-10, the active decapeptide fragment (YNWNSFGLRF-NH2, also called metastin 45-54) that stimulates GnRH release and, downstream, LH, FSH and the sex hormones. Unlike testosterone or hCG, kisspeptin acts at the very top of the axis and recruits the body's own GnRH pulse generator. It has been studied in human clinical trials for IVF egg-maturation triggering, hypogonadism, hypothalamic amenorrhea and sexual desire, but it is not an approved drug and is sold strictly for research use only (RUO).", "lastReviewed": "2026-09-04T09:49:00.737Z", "url": "https://www.bodyhackguide.co/compound/ksptn", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "Kisspeptin-10 (KSPTN)", "alternateName": [ "KSPTN peptide", "Novel research peptide" ], "description": "KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis. The research material sold under this code is typically kisspeptin-10, the active decapeptide fragment (YNWNSFGLRF-NH2, also called metastin 45-54) that stimulates GnRH release and, downstream, LH, FSH and the sex hormones. Unlike testosterone or hCG, kisspeptin acts at the very top of the axis and recruits the body's own GnRH pulse generator. It has been studied in human clinical trials for IVF egg-maturation triggering, hypogonadism, hypothalamic amenorrhea and sexual desire, but it is not an approved drug and is sold strictly for research use only (RUO).", "activeIngredient": "Kisspeptin-10 (KSPTN)", "administrationRoute": "Subcutaneous", "mechanismOfAction": "Kisspeptin is the peptide product of the KISS1 gene and the endogenous ligand for the receptor KISS1R (formerly GPR54). The material sold as KSPTN is typically kisspeptin-10, the C-terminal decapeptide (YNWNSFGLRF-NH2, metastin 45-54) that retains full receptor activity; the parent 54-amino-acid peptide can be cleaved into kisspeptin-14, -13 and -10 with similar potency [PMID:18193176]. Kisspeptin-expressing neurons in the hypothalamus (arcuate and AVPV nuclei) sit upstream of gonadotropin-releasing hormone (GnRH) neurons. When kisspeptin binds KISS1R on those GnRH neurons it drives pulsatile GnRH secretion, which stimulates the anterior pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH); LH and FSH then act on the gonads to raise testosterone in men or estradiol and progesterone in women, and at mid-cycle to trigger the ovulatory LH surge. Kisspeptin therefore acts as a master upstream regulator of the whole HPG axis rather than acting on the gonad directly. According to PubMed, acute intravenous kisspeptin-10 potently increases plasma LH, FSH and testosterone in healthy men [PMID:17323132]. A key pharmacological caveat: continuous or high-dose exposure desensitizes KISS1R and blunts the LH response, so the physiological signal is pulsatile rather than tonic.", "dosageForm": "vial", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is KSPTN?", "acceptedAnswer": { "@type": "Answer", "text": "KSPTN is vendor shorthand for kisspeptin, a peptide encoded by the KISS1 gene. The research material sold under this code is almost always kisspeptin-10, the active 10-amino-acid fragment (sequence YNWNSFGLRF-NH2, also called metastin 45-54). It is a potent agonist of the kisspeptin receptor KISS1R (GPR54)." } }, { "@type": "Question", "name": "What does kisspeptin actually do?", "acceptedAnswer": { "@type": "Answer", "text": "It acts upstream of the reproductive axis. Kisspeptin stimulates GnRH neurons in the hypothalamus, which drives the pituitary to release LH and FSH, which signal the gonads to make testosterone (men) or estrogen and progesterone and to trigger ovulation (women). According to PubMed, an IV dose of kisspeptin-10 potently raises LH and, in men, testosterone in healthy volunteers [PMID:17323132]." } }, { "@type": "Question", "name": "Is kisspeptin FDA-approved?", "acceptedAnswer": { "@type": "Answer", "text": "No. Kisspeptin is investigational. It has been studied in numerous human clinical trials - for IVF egg-maturation triggering, hypogonadism, hypothalamic amenorrhea and sexual desire - but it is not an approved drug, and material sold to consumers is labeled research use only." } }, { "@type": "Question", "name": "Can I inject it subcutaneously like other peptides?", "acceptedAnswer": { "@type": "Answer", "text": "There is no validated subcutaneous self-dosing protocol. Every human study of kisspeptin-10 used intravenous administration because the peptide is cleared within minutes. Kisspeptin-54 (a longer form) lasts longer and has been given subcutaneously in IVF trials. Community subcutaneous use of kisspeptin-10 is anecdotal and not supported by pharmacokinetic data." } }, { "@type": "Question", "name": "Will more kisspeptin give a bigger hormonal response?", "acceptedAnswer": { "@type": "Answer", "text": "Not necessarily. The kisspeptin receptor desensitizes with continuous or high-dose exposure, which can blunt the LH response. The natural signal is pulsatile, so overdosing tends to reduce, not amplify, the effect." } }, { "@type": "Question", "name": "How is kisspeptin different from gonadorelin or hCG?", "acceptedAnswer": { "@type": "Answer", "text": "Gonadorelin is GnRH itself, one step further down the axis, and hCG mimics LH directly at the gonad. Kisspeptin acts one step higher, on the GnRH neurons, so it recruits the body's own GnRH pulse generator. In IVF it has been studied as a gentler oocyte-maturation trigger than hCG, with lower ovarian-hyperstimulation risk [PMID:28393578]." } }, { "@type": "Question", "name": "What is the difference between kisspeptin-10 and kisspeptin-54?", "acceptedAnswer": { "@type": "Answer", "text": "The KISS1 gene makes a 54-amino-acid peptide (kisspeptin-54, or metastin) that can be cleaved into shorter fragments (kisspeptin-14, -13 and -10) sharing similar receptor potency [PMID:18193176]. Kisspeptin-10 is the short decapeptide most commonly sold as research material; kisspeptin-54 is longer-acting and used in several clinical trials." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. 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Kisspeptin-10 (KSPTN) # Kisspeptin-10 (KSPTN) Other Clinical (investigational) Download PDF Also known as: KSPTN peptide, Novel research peptide KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis. The research material sold under this code is typically kisspeptin-10, the active decapeptide fragment (YNWNSFGLRF-NH2, also called metastin 45-54) that stimulates GnRH release and, downstream, LH, FSH and the sex hormones. Half-Life: Kisspeptin-10: very short, reported on the order of ~4 minutes (rapid plasma clearance). Kisspeptin-54 is longer-acting (tens of minutes). The brief half-life is why human studies dose it intravenously by bolus or continuous infusion. Route: Subcutaneous MW: 1302.5 g/mol (kisspeptin-10; molecular formula C63H83N17O14; CAS 374675-21-5) Last reviewed: Sep 4, 2026 [ Other Category ](/wiki#cat-other) Clinical (investigational) Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices2 Related ## Overview ### Best Price Available ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Ion Peptide $29.00 1 vial · vial [Buy Now](https://ionpeptide.com/product/ksptn/?ref=reddit15) Compare 1 vendor ### At A Glance Mechanism Kisspeptin is the peptide product of the KISS1 gene and the endogenous ligand for the receptor KISS1R (formerly GPR54). The material sold as KSPTN is typically kisspeptin-10, the C-terminal decapeptide (YNWNSFGLRF-NH2, metastin 45-54) that retains full receptor activity; the pare… Half-Life Kisspeptin-10: very short, reported on the order of ~4 minutes (rapid plasma clearance). Kisspeptin-54 is longer-acting (tens of minutes). The brief half-life is why human studies dose it intravenously by bolus or continuous infusion. Dosing No validated schedule for self-use. In research, kisspeptin has been given as a single IV bolus, as a continuous IV infusion over hours, or (kisspeptin-54) as a single subcutaneous injection to trigger ovulation. Single or pulsatile dosing is favored pharmacologically because continuous exposure desensitizes the receptor. Dose Range 20-100mcg Routes Subcutaneous Common Vials 5mg 10mg Potential Benefits Transiently stimulates the body's own LH and, in men, testosterone secretion by acting upstream on the reproductive axis rather than replacing hormones \[PMID:17323132, PMID:23153270\] Studied as a trigger for egg (oocyte) maturation in IVF, where kisspeptin-54 produced a physiological LH surge with lower ovarian-hyperstimulation risk than standard triggers \[PMID:28393578\] Restored LH pulsatility and raised testosterone in men with type 2 diabetes and mild central hypogonadism in a proof-of-concept study \[PMID:23153270\] Modulated sexual and attraction-related brain processing in women with hypoactive sexual desire disorder, and was well tolerated \[PMID:36287566\] Used to probe or stimulate a dormant reproductive axis in conditions such as hypothalamic amenorrhea \[PMID:28393578\] Because it recruits the body's own GnRH pulse generator, hormone responses stay within a physiological range and are self-limited by normal feedback Safety Notes Common Generally well tolerated in short-term clinical studies Possible transient flushing or warmth Mild infusion- or injection-site reactions Headache Short-lived changes in LH/testosterone or, in women, menstrual-cycle timing Serious No serious adverse events reported at doses tested in trials \[PMID:36287566, PMID:28186349\] Receptor desensitization with continuous or high dosing (blunted response) Long-term and repeated-dose safety in humans not established Acts on the fertility/reproductive axis - caution in anyone pregnant, breastfeeding, or trying to conceive ### Overview KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis. The research material sold under this code is typically kisspeptin-10, the active decapeptide fragment (YNWNSFGLRF-NH2, also called metastin 45-54) that stimulates GnRH release and, downstream, LH, FSH and the sex hormones. Unlike testosterone or hCG, kisspeptin acts at the very top of the axis and recruits the body's own GnRH pulse generator. It has been studied in human clinical trials for IVF egg-maturation triggering, hypogonadism, hypothalamic amenorrhea and sexual desire, but it is not an approved drug and is sold strictly for research use only (RUO). ### What to Expect - • In research settings a single intravenous dose raises LH within minutes, peaking early and fading quickly because the peptide clears in minutes \[PMID:17323132\] - • In men that LH rise can be followed by a modest, transient testosterone increase that is larger in younger men and weaker with age \[PMID:30590872\] - • Hormone levels tend to stay within a physiological range rather than spiking to supraphysiologic levels, because the effect works through the body's own axis - • The response is self-limiting: continuous or repeated high dosing desensitizes the receptor and reduces the effect instead of compounding it - • No validated response has been characterized for subcutaneous self-administration of kisspeptin-10; any such outcomes are anecdotal rather than clinical Individual responses vary. Timeline based on commonly reported research observations. ## Chemical Information IUPAC Name Not yet available CAS Number Not yet available Molecular Formula Not yet available Molecular Mass 1302.5 g/mol (kisspeptin-10; molecular formula C63H83N17O14; CAS 374675-21-5) Amino Acid Sequence YNWNSFGLRF-NH2 (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe, C-terminally amidated; kisspeptin-10 / metastin 45-54) ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions ### Interaction Matrix All(5) CompatibleCautionAvoid Caution Caution Caution Caution Caution ### Contraindications Research use only; not for human consumption. Kisspeptin directly stimulates the reproductive hormone axis, so it should not be used by anyone pregnant, breastfeeding, or trying to conceive outside medical supervision, nor by anyone with hormone-sensitive conditions (for example certain reproductive cancers) without specialist oversight. Its action on the HPG axis makes it inappropriate for minors. Anyone on hormonal therapy, fertility treatment, or with pituitary or reproductive disorders should not use it outside a controlled clinical setting. No validated dosing exists for self-administration. Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $29.00 up to $39.00 Best $/mg $3.9000 Vendors 1 Listings 2 vial [Sign in for alerts ](/auth) Dosage All5mg (1) 10mg (1) Form Allvial Sort Price $/mg Vendor Vendor Product Form Qty Price $/mg Coupon ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) [Ion Peptide](/vendor/ion-peptide) [70 ](/vendor-trust-scorecard) 🇺🇸 US 🌍 International KSPTN 5mg vial 1 vial ● In Stock $29.00 BEST $5.800 — [Buy](https://ionpeptide.com/product/ksptn/?ref=reddit15) ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) [Ion Peptide](/vendor/ion-peptide) [70 ](/vendor-trust-scorecard) 🇺🇸 US 🌍 International KSPTN 10mg vial 1 vial ● In Stock $39.00 VALUE $3.900 — [Buy](https://ionpeptide.com/product/ksptn/?ref=reddit15) Get Kisspeptin-10 (KSPTN) Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $29.00 [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Kisspeptin-10 (KSPTN). [Sign in](/auth) Current low $39.00 as of Apr 22, 2026 7-day low — no 7d data yet 30-day low — no 30d data yet 30-day change — baseline building Tracking since Apr 22, 2026 · 2 data points ### Vendors Selling Kisspeptin-10 (KSPTN) [ ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) #### Ion Peptide 4.5 2 listings · from $29.00 ](/vendor/ion-peptide) How we score these vendors Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. [View Scorecard](/vendors/scorecard) ### Related Compounds [View All](/wiki) [ ### Aminotadalafil Other Preclinical Aminotadalafil is an unapproved research analog of tadalafil, the PDE5 inhibitor marketed under the brand name Cialis for erectile dysfunction and under Adcirca for pulmonary arterial hypertension. 2.5 mg - 20 mg (oral) 9 studies View Profile ](/compound/aminotadalafil)[ ### B7-33 Other Preclinical B7-33 is a single-chain, 26-amino-acid peptide engineered as a functionally selective agonist of the relaxin family peptide receptor 1 (RXFP1), designed to recapitulate the therapeutic activity of human H2 relaxin — the endogenous peptide hormone that is naturally elevated during pregnancy and has broad cardioprotective, vasodilatory, and anti-fibrotic effects. t½ In vitro serum-stability half-life is approximately 6 minutes; B7-33 is rapidly degraded (a lipidated analog extended this to ~60 minutes in the same assay). Human in vivo pharmacokinetics are unpublished, and rapid clearance is expected for a small linear peptide (Praveen et al. 2023, PMID 37047588). 500-4000 mcg subcutaneous per injection (community/self-report research doses; most commonly ~1000 mcg / 1 mg once daily). No validated human dose exists - all figures are empirical extrapolations from rodent pharmacology. 11 studies View Profile ](/compound/b7-33)[ ### Melanotan I Other FDA Approved Melanotan I (afamelanotide) is a linear synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) with the substitution of norleucine at position 4 and D-phenylalanine at position 7. t½ Controlled-release subcutaneous implant (Scenesse): high inter-subject variability; median Tmax ~36 h, mean Cmax ~3.7 ng/mL, apparent terminal half-life ~15 h, with plasma levels measurable to ~96 h post-dose (FDA pharmacokinetics, n=12). Injected/bolus free peptide: peak plasma at ~1-2 h with an elimination half-life of ~30 minutes; the Nle4/D-Phe7 modifications prolong biological (melanogenic) activity well beyond plasma clearance. 16000 Preclinical View Profile ](/compound/melanotan-i)[ ### PNC-27 Other Preclinical PNC-27 is a p53-derived peptide that selectively induces membranolysis in cancer cells. t½ Unknown (no published PK data) 0 Preclinical View Profile ](/compound/pnc-27)[ ### Prostamax Other Preclinical Prostamax is a short synthetic peptide developed in Russia by Vladimir Khavinson and collaborators at the St. t½ Not characterized in published pharmacokinetic literature 10 mg oral capsule, 1-2 daily for 10-30 days 6 studies View Profile ](/compound/prostamax)[ ### RU-58841 Other Preclinical RU-58841 (also known as PSK-3841 or HMR-3841, and commonly written simply as RU in hair-loss forums) is a non-steroidal androgen receptor antagonist originally developed by Roussel Uclaf (later absorbed into Sanofi) in the late 1980s and early 1990s. 25 mg - 50 mg topical daily (dissolved in vehicle) 11 studies View Profile ](/compound/ru-58841) [ View Full Dosage Guide → Protocols, calculator & safety for Kisspeptin-10 (KSPTN) ](/guides/dosage/ksptn) ### Best Price ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Ion Peptide $29.00 [Buy Now](https://ionpeptide.com/product/ksptn/?ref=reddit15) 1 vendors · 2 listings ### Research Score 45 0 PubMed studies ### Quality Indicators Data Completeness 75% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Studies Interactions Vendor Listings ### Quick Facts Half-Life Kisspeptin-10: very short, reported on the order of ~4 minutes (rapid plasma clearance). Kisspeptin-54 is longer-acting (tens of minutes). The brief half-life is why human studies dose it intravenously by bolus or continuous infusion. Molecular Weight 1302.5 g/mol (kisspeptin-10; molecular formula C63H83N17O14; CAS 374675-21-5) Administration Subcutaneous Trial Phase Clinical (investigational) ### Safety Profile Common Side Effects - • Generally well tolerated in short-term clinical studies - • Possible transient flushing or warmth - • Mild infusion- or injection-site reactions - • Headache - • Short-lived changes in LH/testosterone or, in women, menstrual-cycle timing [Full Dosage Guide](/guides/dosage/ksptn)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is KSPTN? KSPTN is vendor shorthand for kisspeptin, a peptide encoded by the KISS1 gene. The research material sold under this code is almost always kisspeptin-10, the active 10-amino-acid fragment (sequence YNWNSFGLRF-NH2, also called metastin 45-54). It is a potent agonist of the kisspeptin receptor KISS1R (GPR54). What does kisspeptin actually do? It acts upstream of the reproductive axis. Kisspeptin stimulates GnRH neurons in the hypothalamus, which drives the pituitary to release LH and FSH, which signal the gonads to make testosterone (men) or estrogen and progesterone and to trigger ovulation (women). According to PubMed, an IV dose of kisspeptin-10 potently raises LH and, in men, testosterone in healthy volunteers \[PMID:17323132\]. Is kisspeptin FDA-approved? No. Kisspeptin is investigational. It has been studied in numerous human clinical trials - for IVF egg-maturation triggering, hypogonadism, hypothalamic amenorrhea and sexual desire - but it is not an approved drug, and material sold to consumers is labeled research use only. Can I inject it subcutaneously like other peptides? There is no validated subcutaneous self-dosing protocol. Every human study of kisspeptin-10 used intravenous administration because the peptide is cleared within minutes. Kisspeptin-54 (a longer form) lasts longer and has been given subcutaneously in IVF trials. Community subcutaneous use of kisspeptin-10 is anecdotal and not supported by pharmacokinetic data. Will more kisspeptin give a bigger hormonal response? Not necessarily. The kisspeptin receptor desensitizes with continuous or high-dose exposure, which can blunt the LH response. The natural signal is pulsatile, so overdosing tends to reduce, not amplify, the effect. How is kisspeptin different from gonadorelin or hCG? Gonadorelin is GnRH itself, one step further down the axis, and hCG mimics LH directly at the gonad. Kisspeptin acts one step higher, on the GnRH neurons, so it recruits the body's own GnRH pulse generator. In IVF it has been studied as a gentler oocyte-maturation trigger than hCG, with lower ovarian-hyperstimulation risk \[PMID:28393578\]. What is the difference between kisspeptin-10 and kisspeptin-54? The KISS1 gene makes a 54-amino-acid peptide (kisspeptin-54, or metastin) that can be cleaved into shorter fragments (kisspeptin-14, -13 and -10) sharing similar receptor potency \[PMID:18193176\]. Kisspeptin-10 is the short decapeptide most commonly sold as research material; kisspeptin-54 is longer-acting and used in several clinical trials. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### Aminotadalafil Other Preclinical Aminotadalafil is an unapproved research analog of tadalafil, the PDE5 inhibitor marketed under the brand name Cialis for erectile dysfunction and under Adcirca for pulmonary arterial hypertension. 2.5 mg - 20 mg (oral) 9 studies View Profile ](/compound/aminotadalafil)[ ### B7-33 Other Preclinical B7-33 is a single-chain, 26-amino-acid peptide engineered as a functionally selective agonist of the relaxin family peptide receptor 1 (RXFP1), designed to recapitulate the therapeutic activity of human H2 relaxin — the endogenous peptide hormone that is naturally elevated during pregnancy and has broad cardioprotective, vasodilatory, and anti-fibrotic effects. t½ In vitro serum-stability half-life is approximately 6 minutes; B7-33 is rapidly degraded (a lipidated analog extended this to ~60 minutes in the same assay). Human in vivo pharmacokinetics are unpublished, and rapid clearance is expected for a small linear peptide (Praveen et al. 2023, PMID 37047588). 500-4000 mcg subcutaneous per injection (community/self-report research doses; most commonly ~1000 mcg / 1 mg once daily). No validated human dose exists - all figures are empirical extrapolations from rodent pharmacology. 11 studies View Profile ](/compound/b7-33)[ ### Melanotan I Other FDA Approved Melanotan I (afamelanotide) is a linear synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) with the substitution of norleucine at position 4 and D-phenylalanine at position 7. t½ Controlled-release subcutaneous implant (Scenesse): high inter-subject variability; median Tmax ~36 h, mean Cmax ~3.7 ng/mL, apparent terminal half-life ~15 h, with plasma levels measurable to ~96 h post-dose (FDA pharmacokinetics, n=12). Injected/bolus free peptide: peak plasma at ~1-2 h with an elimination half-life of ~30 minutes; the Nle4/D-Phe7 modifications prolong biological (melanogenic) activity well beyond plasma clearance. 16000 Preclinical View Profile ](/compound/melanotan-i)[ ### PNC-27 Other Preclinical PNC-27 is a p53-derived peptide that selectively induces membranolysis in cancer cells. t½ Unknown (no published PK data) 0 Preclinical View Profile ](/compound/pnc-27)[ ### Prostamax Other Preclinical Prostamax is a short synthetic peptide developed in Russia by Vladimir Khavinson and collaborators at the St. t½ Not characterized in published pharmacokinetic literature 10 mg oral capsule, 1-2 daily for 10-30 days 6 studies View Profile ](/compound/prostamax)[ ### RU-58841 Other Preclinical RU-58841 (also known as PSK-3841 or HMR-3841, and commonly written simply as RU in hair-loss forums) is a non-steroidal androgen receptor antagonist originally developed by Roussel Uclaf (later absorbed into Sanofi) in the late 1980s and early 1990s. 25 mg - 50 mg topical daily (dissolved in vehicle) 11 studies View Profile ](/compound/ru-58841) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. 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