--- title: "Indole-3-propionamide (IPAM): Dosing & Vendor Prices" description: "Indole-3-propionamide (IPAM): dosing protocols, mechanism & side effects. Compare 1 verified vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Indole-3-propionamide (IPAM)" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "Indole-3-propionamide (IPAM)", "description": "IPAM is the market abbreviation for indole-3-propionamide, the amide of indole-3-propionic acid and a close structural relative of melatonin. It is a defined and identifiable molecule, PubChem CID 351791, CAS 5814-93-7, but the literature behind it is unusually thin: essentially one substantive biological paper, published in 2010 (PMID: 20421998). That paper is worth describing carefully, because almost everything claimed for the compound traces back to it. The authors designed the amide from indole-3-propionic acid to obtain a less polar molecule that crosses membranes more easily, then discovered that it also occurs naturally. After an oral tryptophan load of 300 mg/kg in one-month-old male Sprague-Dawley rats, brain levels of indole-3-propionamide, melatonin and indole-3-propionic acid all rose to reproducibly measurable amounts. When 0.5 mg/kg was given intraperitoneally, indole-3-propionamide reached high brain concentrations at 2, 4 and 8 h while melatonin and indole-3-propionic acid at the same dose did not raise their own barely detectable baselines (PMID: 20421998). The proposed mechanism is mitochondrial rather than receptor-mediated. The compound appears to act at complex I of the respiratory chain as a recyclable electron and proton carrier, stabilizing electron flow and reducing electron leakage, so that fewer reactive oxygen species are produced in the first place rather than scavenged afterwards. In brain mitochondria from young and 20-month-old rats it antagonized the age-related fall in membrane potential and blocked the collapse of proton potential caused by doxorubicin, antimycin A and the uncoupler FCCP. In mouse brain mitochondria at 10 nM it increased complex I and complex IV activity. In a hydroxyl radical generating system it reduced radical formation without producing pro-oxidant intermediates, and it reduced hydroxyl radical mediated DNA damage in rat forebrain homogenate with an IC50 of 0.18 micromolar against 1.4 micromolar for melatonin (PMID: 20421998). The headline result in that paper is a lifespan experiment in the bdelloid rotifer Philodina acuticornis odiosa, where mean lifespan rose from 24.6 days to 90.5 days at the highest concentration tested, with larger body size and more offspring per animal. A rotifer is a very long way from a person, and no vertebrate lifespan or healthspan study has followed. Two cautions belong on this page. First, no toxicology study, no pharmacokinetic study beyond those brain concentration measurements in rats, and no human exposure of any kind has been published for this compound. Second, recent medicinal chemistry papers describing 1H-indole-3-propionamide compounds as selective NaV1.7 inhibitors for pain concern a series of substituted derivatives rather than indole-3-propionamide itself, and should not be read as evidence about this molecule (PMID: 39881860, PMID: 42503835). Indole-3-propionamide has no FDA or EMA record, no clinical development program and no registered trial, and material sold as IPAM is a research-use-only compound in the US market.", "url": "https://www.bodyhackguide.co/compound/indole-3-propionamide", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "64.99", "highPrice": "64.99", "priceCurrency": "USD", "offerCount": "1", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "64.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://disguisedalpha.com/product/ipam-indolepropionamide/?coupon=reddit", "seller": { "@type": "Organization", "name": "Disguised Alpha", "url": "https://disguisedalpha.com/?coupon=reddit" }, "name": "Indole-3-propionamide (IPAM) 10mg liquid" } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Indole-3-propionamide (IPAM)", "description": "IPAM is the market abbreviation for indole-3-propionamide, the amide of indole-3-propionic acid and a close structural relative of melatonin. It is a defined and identifiable molecule, PubChem CID 351791, CAS 5814-93-7, but the literature behind it is unusually thin: essentially one substantive biological paper, published in 2010 (PMID: 20421998). That paper is worth describing carefully, because almost everything claimed for the compound traces back to it. The authors designed the amide from indole-3-propionic acid to obtain a less polar molecule that crosses membranes more easily, then discovered that it also occurs naturally. After an oral tryptophan load of 300 mg/kg in one-month-old male Sprague-Dawley rats, brain levels of indole-3-propionamide, melatonin and indole-3-propionic acid all rose to reproducibly measurable amounts. When 0.5 mg/kg was given intraperitoneally, indole-3-propionamide reached high brain concentrations at 2, 4 and 8 h while melatonin and indole-3-propionic acid at the same dose did not raise their own barely detectable baselines (PMID: 20421998). The proposed mechanism is mitochondrial rather than receptor-mediated. The compound appears to act at complex I of the respiratory chain as a recyclable electron and proton carrier, stabilizing electron flow and reducing electron leakage, so that fewer reactive oxygen species are produced in the first place rather than scavenged afterwards. In brain mitochondria from young and 20-month-old rats it antagonized the age-related fall in membrane potential and blocked the collapse of proton potential caused by doxorubicin, antimycin A and the uncoupler FCCP. In mouse brain mitochondria at 10 nM it increased complex I and complex IV activity. In a hydroxyl radical generating system it reduced radical formation without producing pro-oxidant intermediates, and it reduced hydroxyl radical mediated DNA damage in rat forebrain homogenate with an IC50 of 0.18 micromolar against 1.4 micromolar for melatonin (PMID: 20421998). The headline result in that paper is a lifespan experiment in the bdelloid rotifer Philodina acuticornis odiosa, where mean lifespan rose from 24.6 days to 90.5 days at the highest concentration tested, with larger body size and more offspring per animal. A rotifer is a very long way from a person, and no vertebrate lifespan or healthspan study has followed. Two cautions belong on this page. First, no toxicology study, no pharmacokinetic study beyond those brain concentration measurements in rats, and no human exposure of any kind has been published for this compound. Second, recent medicinal chemistry papers describing 1H-indole-3-propionamide compounds as selective NaV1.7 inhibitors for pain concern a series of substituted derivatives rather than indole-3-propionamide itself, and should not be read as evidence about this molecule (PMID: 39881860, PMID: 42503835). Indole-3-propionamide has no FDA or EMA record, no clinical development program and no registered trial, and material sold as IPAM is a research-use-only compound in the US market.", "lastReviewed": "2026-09-07T04:48:29.378Z", "url": "https://www.bodyhackguide.co/compound/indole-3-propionamide", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "Indole-3-propionamide (IPAM)", "alternateName": [ "Indolepropionamide", "Indole-3-propionamide", "3-(1H-indol-3-yl)propanamide", "NSC523262" ], "description": "IPAM is the market abbreviation for indole-3-propionamide, the amide of indole-3-propionic acid and a close structural relative of melatonin. It is a defined and identifiable molecule, PubChem CID 351791, CAS 5814-93-7, but the literature behind it is unusually thin: essentially one substantive biological paper, published in 2010 (PMID: 20421998). That paper is worth describing carefully, because almost everything claimed for the compound traces back to it. The authors designed the amide from indole-3-propionic acid to obtain a less polar molecule that crosses membranes more easily, then discovered that it also occurs naturally. After an oral tryptophan load of 300 mg/kg in one-month-old male Sprague-Dawley rats, brain levels of indole-3-propionamide, melatonin and indole-3-propionic acid all rose to reproducibly measurable amounts. When 0.5 mg/kg was given intraperitoneally, indole-3-propionamide reached high brain concentrations at 2, 4 and 8 h while melatonin and indole-3-propionic acid at the same dose did not raise their own barely detectable baselines (PMID: 20421998). The proposed mechanism is mitochondrial rather than receptor-mediated. The compound appears to act at complex I of the respiratory chain as a recyclable electron and proton carrier, stabilizing electron flow and reducing electron leakage, so that fewer reactive oxygen species are produced in the first place rather than scavenged afterwards. In brain mitochondria from young and 20-month-old rats it antagonized the age-related fall in membrane potential and blocked the collapse of proton potential caused by doxorubicin, antimycin A and the uncoupler FCCP. In mouse brain mitochondria at 10 nM it increased complex I and complex IV activity. In a hydroxyl radical generating system it reduced radical formation without producing pro-oxidant intermediates, and it reduced hydroxyl radical mediated DNA damage in rat forebrain homogenate with an IC50 of 0.18 micromolar against 1.4 micromolar for melatonin (PMID: 20421998). The headline result in that paper is a lifespan experiment in the bdelloid rotifer Philodina acuticornis odiosa, where mean lifespan rose from 24.6 days to 90.5 days at the highest concentration tested, with larger body size and more offspring per animal. A rotifer is a very long way from a person, and no vertebrate lifespan or healthspan study has followed. Two cautions belong on this page. First, no toxicology study, no pharmacokinetic study beyond those brain concentration measurements in rats, and no human exposure of any kind has been published for this compound. Second, recent medicinal chemistry papers describing 1H-indole-3-propionamide compounds as selective NaV1.7 inhibitors for pain concern a series of substituted derivatives rather than indole-3-propionamide itself, and should not be read as evidence about this molecule (PMID: 39881860, PMID: 42503835). Indole-3-propionamide has no FDA or EMA record, no clinical development program and no registered trial, and material sold as IPAM is a research-use-only compound in the US market.", "activeIngredient": "Indole-3-propionamide (IPAM)", "administrationRoute": "Intraperitoneal injection (rodent studies), Oral (form sold on the research chemical market)", "mechanismOfAction": "Indole-3-propionamide is the amide of indole-3-propionic acid, a tryptophan-derived indole. The amide is less polar than the parent acid, which the authors of the only substantive study used to explain its ability to cross membranes and reach brain tissue after peripheral administration in rats. The proposed mechanism is not receptor-mediated: the compound appears to bind at complex I of the mitochondrial respiratory chain and act as a recyclable electron and proton carrier that stabilizes electron flow, reduces electron leakage and so lowers reactive oxygen species production, while increasing complex I and complex IV activity in mouse brain mitochondria at 10 nM (PMID: 20421998). In the same work it scavenged hydroxyl radicals without generating pro-oxidant intermediates, unlike serotonin, 6-hydroxymelatonin and several control indoles (PMID: 20421998).", "dosageForm": "liquid", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Indole-3-propionamide (IPAM) used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "IPAM is the market abbreviation for indole-3-propionamide, the amide of indole-3-propionic acid and a close structural relative of melatonin. It is a defined and identifiable molecule, PubChem CID 351791, CAS 5814-93-7, but the literature behind it is unusually thin: essentially one substantive biological paper, published in 2010 (PMID: 20421998). That paper is worth describing carefully, because almost everything claimed for the compound traces back to it. The authors designed the amide from indole-3-propionic acid to obtain a less polar molecule that crosses membranes more easily, then discovered that it also occurs naturally. After an oral tryptophan load of 300 mg/kg in one-month-old male Sprague-Dawley rats, brain levels of indole-3-propionamide, melatonin and indole-3-propionic acid all rose to reproducibly measurable amounts. When 0.5 mg/kg was given intraperitoneally, indole-3-propionamide reached high brain concentrations at 2, 4 and 8 h while melatonin and indole-3-propionic acid at the same dose did not raise their own barely detectable baselines (PMID: 20421998). The proposed mechanism is mitochondrial rather than receptor-mediated. The compound appears to act at complex I of the respiratory chain as a recyclable electron and proton carrier, stabilizing electron flow and reducing electron leakage, so that fewer reactive oxygen species are produced in the first place rather than scavenged afterwards. In brain mitochondria from young and 20-month-old rats it antagonized the age-related fall in membrane potential and blocked the collapse of proton potential caused by doxorubicin, antimycin A and the uncoupler FCCP. In mouse brain mitochondria at 10 nM it increased complex I and complex IV activity. In a hydroxyl radical generating system it reduced radical formation without producing pro-oxidant intermediates, and it reduced hydroxyl radical mediated DNA damage in rat forebrain homogenate with an IC50 of 0.18 micromolar against 1.4 micromolar for melatonin (PMID: 20421998). The headline result in that paper is a lifespan experiment in the bdelloid rotifer Philodina acuticornis odiosa, where mean lifespan rose from 24.6 days to 90.5 days at the highest concentration tested, with larger body size and more offspring per animal. A rotifer is a very long way from a person, and no vertebrate lifespan or healthspan study has followed. Two cautions belong on this page. First, no toxicology study, no pharmacokinetic study beyond those brain concentration measurements in rats, and no human exposure of any kind has been published for this compound. Second, recent medicinal chemistry papers describing 1H-indole-3-propionamide compounds as selective NaV1.7 inhibitors for pain concern a series of substituted derivatives rather than indole-3-propionamide itself, and should not be read as evidence about this molecule (PMID: 39881860, PMID: 42503835). Indole-3-propionamide has no FDA or EMA record, no clinical development program and no registered trial, and material sold as IPAM is a research-use-only compound in the US market." } }, { "@type": "Question", "name": "What forms does Indole-3-propionamide (IPAM) come in?", "acceptedAnswer": { "@type": "Answer", "text": "Indole-3-propionamide (IPAM) is available in liquid form." } }, { "@type": "Question", "name": "How much does Indole-3-propionamide (IPAM) cost?", "acceptedAnswer": { "@type": "Answer", "text": "Prices start at $64.99 across 1 verified vendor." } }, { "@type": "Question", "name": "How do I compare Indole-3-propionamide (IPAM) vendors?", "acceptedAnswer": { "@type": "Answer", "text": "Compare prices, payment methods, shipping, and COA scores across 1 vendor." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. 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Indole-3-propionamide (IPAM) ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Best price right now $6.50/mg · $64.99 for 10mg at Disguised Alpha [Buy at Disguised Alpha](https://www.bodyhackguide.co/go/disguised-alpha?utm_source=compound-sticky-bar&utm_campaign=980e7d63-b4fc-4d56-87a5-81222d177b3a&utm_medium=best-price-cta) [Where to buy Indole-3-propionamide (IPAM)](/buy/indole-3-propionamide) [Indole-3-propionamide (IPAM) coupon codes](/coupons/indole-3-propionamide) [Indole-3-propionamide (IPAM) protocol](/protocol/indole-3-propionamide) [Alternatives to Indole-3-propionamide (IPAM)](/alternatives-to/indole-3-propionamide) [Indole-3-propionamide (IPAM) side effects](/side-effects/indole-3-propionamide) 1. [Home](/) 3. [Compounds](/compare) 5. Indole-3-propionamide (IPAM) ![Indole-3-propionamide (IPAM) molecular structure](/assets/peptide-structure-placeholder-DUmZBF_j.png) # Indole-3-propionamide (IPAM) Other Preclinical Download PDF Also known as: Indolepropionamide, Indole-3-propionamide, 3-(1H-indol-3-yl)propanamide, NSC523262 IPAM is the market abbreviation for indole-3-propionamide, the amide of indole-3-propionic acid and a close structural relative of melatonin. It is a defined and identifiable molecule, PubChem CID 351791, CAS 5814-93-7, but the literature behind it is unusually thin: essentially one substantive biological paper, published in 2010 (PMID: 20421998). That paper is worth describing carefully, because almost everything claimed for the compound traces back to it. Half-Life: Not established in humans; after intraperitoneal administration of 0.5 mg/kg to one-month-old male Sprague-Dawley rats, brain concentrations were 691 pg indole per mg protein at 2 h, 562 at 4 h and 361 at 8 h, which the authors described as a long half-life relative to melatonin (PMID: 20421998) Route: Intraperitoneal injection (rodent studies), Oral (form sold on the research chemical market) MW: 188.23 g/mol CAS: 5814-93-7 Last reviewed: Sep 7, 2026 [ Other Category ](/wiki#cat-other) Preclinical Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices1 Related ## Overview ### Best Price Available ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $64.99 1 bottle (10 mg) · liquid [Buy Now](https://disguisedalpha.com/product/ipam-indolepropionamide/?coupon=reddit) Compare 1 vendor ### At A Glance Mechanism Indole-3-propionamide is the amide of indole-3-propionic acid, a tryptophan-derived indole. The amide is less polar than the parent acid, which the authors of the only substantive study used to explain its ability to cross membranes and reach brain tissue after peripheral adminis… Half-Life Not established in humans; after intraperitoneal administration of 0.5 mg/kg to one-month-old male Sprague-Dawley rats, brain concentrations were 691 pg indole per mg protein at 2 h, 562 at 4 h and 361 at 8 h, which the authors described as a long half-life relative to melatonin (PMID: 20421998) Routes Intraperitoneal injection (rodent studies) Oral (form sold on the research chemical market) Potential Benefits Reversed the age-related fall in mitochondrial membrane potential in brain mitochondria from young and 20-month-old Sprague-Dawley rats at 10 nM (PMID: 20421998) Prevented the collapse of mitochondrial proton potential caused by doxorubicin, antimycin A and FCCP in rat brain mitochondria (PMID: 20421998) Increased complex I and complex IV activity in brain mitochondria from young and old male Swiss Webster mice (PMID: 20421998) Extended mean lifespan of the bdelloid rotifer Philodina acuticornis odiosa from 24.6 to 90.5 days at the highest concentration tested, with increased body size and offspring number (PMID: 20421998) Reduced hydroxyl radical mediated DNA damage in rat forebrain homogenate with an IC50 of 0.18 micromolar, against 1.4 for melatonin and 7.46 for indole-3-propionic acid (PMID: 20421998) ### Overview IPAM is the market abbreviation for indole-3-propionamide, the amide of indole-3-propionic acid and a close structural relative of melatonin. It is a defined and identifiable molecule, PubChem CID 351791, CAS 5814-93-7, but the literature behind it is unusually thin: essentially one substantive biological paper, published in 2010 (PMID: 20421998). That paper is worth describing carefully, because almost everything claimed for the compound traces back to it. The authors designed the amide from indole-3-propionic acid to obtain a less polar molecule that crosses membranes more easily, then discovered that it also occurs naturally. After an oral tryptophan load of 300 mg/kg in one-month-old male Sprague-Dawley rats, brain levels of indole-3-propionamide, melatonin and indole-3-propionic acid all rose to reproducibly measurable amounts. When 0.5 mg/kg was given intraperitoneally, indole-3-propionamide reached high brain concentrations at 2, 4 and 8 h while melatonin and indole-3-propionic acid at the same dose did not raise their own barely detectable baselines (PMID: 20421998). The proposed mechanism is mitochondrial rather than receptor-mediated. The compound appears to act at complex I of the respiratory chain as a recyclable electron and proton carrier, stabilizing electron flow and reducing electron leakage, so that fewer reactive oxygen species are produced in the first place rather than scavenged afterwards. In brain mitochondria from young and 20-month-old rats it antagonized the age-related fall in membrane potential and blocked the collapse of proton potential caused by doxorubicin, antimycin A and the uncoupler FCCP. In mouse brain mitochondria at 10 nM it increased complex I and complex IV activity. In a hydroxyl radical generating system it reduced radical formation without producing pro-oxidant intermediates, and it reduced hydroxyl radical mediated DNA damage in rat forebrain homogenate with an IC50 of 0.18 micromolar against 1.4 micromolar for melatonin (PMID: 20421998). The headline result in that paper is a lifespan experiment in the bdelloid rotifer Philodina acuticornis odiosa, where mean lifespan rose from 24.6 days to 90.5 days at the highest concentration tested, with larger body size and more offspring per animal. A rotifer is a very long way from a person, and no vertebrate lifespan or healthspan study has followed. Two cautions belong on this page. First, no toxicology study, no pharmacokinetic study beyond those brain concentration measurements in rats, and no human exposure of any kind has been published for this compound. Second, recent medicinal chemistry papers describing 1H-indole-3-propionamide compounds as selective NaV1.7 inhibitors for pain concern a series of substituted derivatives rather than indole-3-propionamide itself, and should not be read as evidence about this molecule (PMID: 39881860, PMID: 42503835). Indole-3-propionamide has no FDA or EMA record, no clinical development program and no registered trial, and material sold as IPAM is a research-use-only compound in the US market. ### Potential Research Fields Mitochondrial bioenergetics Antioxidant chemistry Aging research Tryptophan metabolites ## Chemical Information IUPAC Name Not yet available CAS Number 5814-93-7 Molecular Formula C11H12N2O Molecular Mass 188.23 g/mol ![Indole-3-propionamide (IPAM) molecular structure](https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/351791/PNG) [View on PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/351791) ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions ### Contraindications None established, because no study has looked. Mechanism-based: the compound acts at mitochondrial complex I (PMID: 20421998), so anyone taking drugs that act on the respiratory chain, and anyone with a mitochondrial disorder, would be an untested case. Nothing is known about pregnancy, hepatic or renal handling, or long-term exposure. Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $64.99 Best $/mg $6.4990 Vendors 1 Listings 1 liquid [Sign in for alerts ](/auth) Form Allliquid Sort Price $/mg Vendor Vendor Product Form Qty Price $/mg Coupon ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) [Disguised Alpha](/vendor/disguised-alpha) [50 ](/vendor-trust-scorecard) 🇺🇸 US 🇪🇺 EU 🇬🇧 UK IPAM (Indole-3-propionamide) 10 mg liquid 1 bottle (10 mg) ● In Stock $64.99 BEST $6.499 — [Buy](https://disguisedalpha.com/product/ipam-indolepropionamide/?coupon=reddit) Get Indole-3-propionamide (IPAM) Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $64.99 [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Indole-3-propionamide (IPAM). [Sign in](/auth) Current low $64.99 as of Sep 7, 2026 7-day low $64.99 30-day low $64.99 30-day change — baseline building Tracking since Sep 7, 2026 · 1 data point ### Vendors Selling Indole-3-propionamide (IPAM) [ ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) #### Disguised Alpha 1 listing · from $64.99 ](/vendor/disguised-alpha) How we score these vendors Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. [View Scorecard](/vendors/scorecard) ### Related Compounds [View All](/wiki) [ ### Aminotadalafil Other Preclinical Aminotadalafil is an unapproved research analog of tadalafil, the PDE5 inhibitor marketed under the brand name Cialis for erectile dysfunction and under Adcirca for pulmonary arterial hypertension. 2.5 mg - 20 mg (oral) 9 studies View Profile ](/compound/aminotadalafil)[ ### B7-33 Other Preclinical B7-33 is a single-chain, 26-amino-acid peptide engineered as a functionally selective agonist of the relaxin family peptide receptor 1 (RXFP1), designed to recapitulate the therapeutic activity of human H2 relaxin — the endogenous peptide hormone that is naturally elevated during pregnancy and has broad cardioprotective, vasodilatory, and anti-fibrotic effects. t½ In vitro serum-stability half-life is approximately 6 minutes; B7-33 is rapidly degraded (a lipidated analog extended this to ~60 minutes in the same assay). Human in vivo pharmacokinetics are unpublished, and rapid clearance is expected for a small linear peptide (Praveen et al. 2023, PMID 37047588). 500-4000 mcg subcutaneous per injection (community/self-report research doses; most commonly ~1000 mcg / 1 mg once daily). No validated human dose exists - all figures are empirical extrapolations from rodent pharmacology. 11 studies View Profile ](/compound/b7-33)[ ### Diisopropylamine dichloroacetate (DADA) Other Approved (Japan) DADA is the abbreviation the research chemical market uses for diisopropylamine dichloroacetate, the diisopropylamine salt of dichloroacetic acid, CAS 660-27-5. Preclinical View Profile ](/compound/dada)[ ### Kisspeptin-10 (KSPTN) Other Clinical (investigational) KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis. t½ Kisspeptin-10: very short, reported on the order of ~4 minutes (rapid plasma clearance). Kisspeptin-54 is longer-acting (tens of minutes). The brief half-life is why human studies dose it intravenously by bolus or continuous infusion. 20-100 Preclinical View Profile ](/compound/ksptn)[ ### Melanotan I Other FDA Approved Melanotan I (afamelanotide) is a linear synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) with the substitution of norleucine at position 4 and D-phenylalanine at position 7. t½ Controlled-release subcutaneous implant (Scenesse): high inter-subject variability; median Tmax ~36 h, mean Cmax ~3.7 ng/mL, apparent terminal half-life ~15 h, with plasma levels measurable to ~96 h post-dose (FDA pharmacokinetics, n=12). Injected/bolus free peptide: peak plasma at ~1-2 h with an elimination half-life of ~30 minutes; the Nle4/D-Phe7 modifications prolong biological (melanogenic) activity well beyond plasma clearance. 16000 Preclinical View Profile ](/compound/melanotan-i)[ ### PNC-27 Other Preclinical PNC-27 is a p53-derived peptide that selectively induces membranolysis in cancer cells. t½ Unknown (no published PK data) 0 Preclinical View Profile ](/compound/pnc-27) [ View Full Dosage Guide → Protocols, calculator & safety for Indole-3-propionamide (IPAM) ](/guides/dosage/indole-3-propionamide) ### Best Price ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $64.99 [Buy Now](https://disguisedalpha.com/product/ipam-indolepropionamide/?coupon=reddit) 1 vendors · 1 listings ### Research Score 30 0 PubMed studies ### Quality Indicators Data Completeness 63% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Studies Interactions Vendor Listings ### Quick Facts Half-Life Not established in humans; after intraperitoneal administration of 0.5 mg/kg to one-month-old male Sprague-Dawley rats, brain concentrations were 691 pg indole per mg protein at 2 h, 562 at 4 h and 361 at 8 h, which the authors described as a long half-life relative to melatonin (PMID: 20421998) Molecular Weight 188.23 g/mol Administration Intraperitoneal injection (rodent studies), Oral (form sold on the research chemical market) CAS Number 5814-93-7 Trial Phase Preclinical 0 [Full Dosage Guide](/guides/dosage/indole-3-propionamide)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is Indole-3-propionamide (IPAM) used for in research? IPAM is the market abbreviation for indole-3-propionamide, the amide of indole-3-propionic acid and a close structural relative of melatonin. It is a defined and identifiable molecule, PubChem CID 351791, CAS 5814-93-7, but the literature behind it is unusually thin: essentially one substantive biological paper, published in 2010 (PMID: 20421998). That paper is worth describing carefully, because almost everything claimed for the compound traces back to it. The authors designed the amide from indole-3-propionic acid to obtain a less polar molecule that crosses membranes more easily, then discovered that it also occurs naturally. After an oral tryptophan load of 300 mg/kg in one-month-old male Sprague-Dawley rats, brain levels of indole-3-propionamide, melatonin and indole-3-propionic acid all rose to reproducibly measurable amounts. When 0.5 mg/kg was given intraperitoneally, indole-3-propionamide reached high brain concentrations at 2, 4 and 8 h while melatonin and indole-3-propionic acid at the same dose did not raise their own barely detectable baselines (PMID: 20421998). The proposed mechanism is mitochondrial rather than receptor-mediated. The compound appears to act at complex I of the respiratory chain as a recyclable electron and proton carrier, stabilizing electron flow and reducing electron leakage, so that fewer reactive oxygen species are produced in the first place rather than scavenged afterwards. In brain mitochondria from young and 20-month-old rats it antagonized the age-related fall in membrane potential and blocked the collapse of proton potential caused by doxorubicin, antimycin A and the uncoupler FCCP. In mouse brain mitochondria at 10 nM it increased complex I and complex IV activity. In a hydroxyl radical generating system it reduced radical formation without producing pro-oxidant intermediates, and it reduced hydroxyl radical mediated DNA damage in rat forebrain homogenate with an IC50 of 0.18 micromolar against 1.4 micromolar for melatonin (PMID: 20421998). The headline result in that paper is a lifespan experiment in the bdelloid rotifer Philodina acuticornis odiosa, where mean lifespan rose from 24.6 days to 90.5 days at the highest concentration tested, with larger body size and more offspring per animal. A rotifer is a very long way from a person, and no vertebrate lifespan or healthspan study has followed. Two cautions belong on this page. First, no toxicology study, no pharmacokinetic study beyond those brain concentration measurements in rats, and no human exposure of any kind has been published for this compound. Second, recent medicinal chemistry papers describing 1H-indole-3-propionamide compounds as selective NaV1.7 inhibitors for pain concern a series of substituted derivatives rather than indole-3-propionamide itself, and should not be read as evidence about this molecule (PMID: 39881860, PMID: 42503835). Indole-3-propionamide has no FDA or EMA record, no clinical development program and no registered trial, and material sold as IPAM is a research-use-only compound in the US market. What forms does Indole-3-propionamide (IPAM) come in? Indole-3-propionamide (IPAM) is available in liquid form. How much does Indole-3-propionamide (IPAM) cost? Prices start at $64.99 across 1 verified vendor. How do I compare Indole-3-propionamide (IPAM) vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### Aminotadalafil Other Preclinical Aminotadalafil is an unapproved research analog of tadalafil, the PDE5 inhibitor marketed under the brand name Cialis for erectile dysfunction and under Adcirca for pulmonary arterial hypertension. 2.5 mg - 20 mg (oral) 9 studies View Profile ](/compound/aminotadalafil)[ ### B7-33 Other Preclinical B7-33 is a single-chain, 26-amino-acid peptide engineered as a functionally selective agonist of the relaxin family peptide receptor 1 (RXFP1), designed to recapitulate the therapeutic activity of human H2 relaxin — the endogenous peptide hormone that is naturally elevated during pregnancy and has broad cardioprotective, vasodilatory, and anti-fibrotic effects. t½ In vitro serum-stability half-life is approximately 6 minutes; B7-33 is rapidly degraded (a lipidated analog extended this to ~60 minutes in the same assay). Human in vivo pharmacokinetics are unpublished, and rapid clearance is expected for a small linear peptide (Praveen et al. 2023, PMID 37047588). 500-4000 mcg subcutaneous per injection (community/self-report research doses; most commonly ~1000 mcg / 1 mg once daily). No validated human dose exists - all figures are empirical extrapolations from rodent pharmacology. 11 studies View Profile ](/compound/b7-33)[ ### Diisopropylamine dichloroacetate (DADA) Other Approved (Japan) DADA is the abbreviation the research chemical market uses for diisopropylamine dichloroacetate, the diisopropylamine salt of dichloroacetic acid, CAS 660-27-5. Preclinical View Profile ](/compound/dada)[ ### Kisspeptin-10 (KSPTN) Other Clinical (investigational) KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis. t½ Kisspeptin-10: very short, reported on the order of ~4 minutes (rapid plasma clearance). Kisspeptin-54 is longer-acting (tens of minutes). The brief half-life is why human studies dose it intravenously by bolus or continuous infusion. 20-100 Preclinical View Profile ](/compound/ksptn)[ ### Melanotan I Other FDA Approved Melanotan I (afamelanotide) is a linear synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) with the substitution of norleucine at position 4 and D-phenylalanine at position 7. t½ Controlled-release subcutaneous implant (Scenesse): high inter-subject variability; median Tmax ~36 h, mean Cmax ~3.7 ng/mL, apparent terminal half-life ~15 h, with plasma levels measurable to ~96 h post-dose (FDA pharmacokinetics, n=12). Injected/bolus free peptide: peak plasma at ~1-2 h with an elimination half-life of ~30 minutes; the Nle4/D-Phe7 modifications prolong biological (melanogenic) activity well beyond plasma clearance. 16000 Preclinical View Profile ](/compound/melanotan-i)[ ### PNC-27 Other Preclinical PNC-27 is a p53-derived peptide that selectively induces membranolysis in cancer cells. t½ Unknown (no published PK data) 0 Preclinical View Profile ](/compound/pnc-27) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-indole-3-propionamide) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. [Order Bloodwork](https://anabolicinsights.ai/?ref=nwm2zjb) ![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub — compound pricing, brain health protocols, dosing tools, and vendor reviews. 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