--- title: "GHK-Cu: Dosing & Vendor Prices | BodyHackGuide" description: "GHK-Cu: dosing protocols, mechanism & side effects, 6 PubMed results. Compare 5 current vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "GHK-Cu" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "GHK-Cu", "description": "GHK-Cu is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, a molecule Pickart and Thaler first pulled out of human plasma in 1973. The free peptide (GHK, C14H24N6O4) weighs about 340.4 Da; bind it 1:1 to copper and you get the neutral GHK-Cu complex (C14H22CuN6O4) at roughly 401.9 Da. Circulating GHK sits around 200 ng/mL in young adults near age 20 and drops to about 80 ng/mL by age 60, which is where most of the 'it declines with age' framing comes from. On skin, GHK-Cu is a well-worn cosmetic ingredient (INCI: Copper tripeptide-1) with real human topical data behind it. Injected under the skin it is a different story: no human trials, no established dose, purely research-use-only biohacker practice. Everything about systemic use here is educational, not medical advice.", "url": "https://www.bodyhackguide.co/compound/ghk-cu", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "34.99", "highPrice": "119.99", "priceCurrency": "USD", "offerCount": "7", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "34.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://researchchemhq.co/product/ghk-cu-50mg/?ref=oyxnywoz", "seller": { "@type": "Organization", "name": "ResearchChemHQ", "url": "https://researchchemhq.co/?ref=oyxnywoz" }, "name": "GHK-Cu 50mg vial" }, { "@type": "Offer", "price": "34.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://optimumformula.co/product/ghk-cu/?ref=ruyhjwqh", "seller": { "@type": "Organization", "name": "Optimum Formula", "url": "https://optimumformula.co" }, "name": "GHK-Cu 50mg vial" }, { "@type": "Offer", "price": "39.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://www.vandl-labs.com/product/ghk-cu/?ref=choncho", "seller": { "@type": "Organization", "name": "VANDL Labs", "url": "https://www.vandl-labs.com/?ref=choncho" }, "name": "GHK-Cu 50mg vial" }, { "@type": "Offer", "price": "49.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://bhglabs.co/product/ghk-cu-50mg/?ref=zmgqyxku", "seller": { "@type": "Organization", "name": "BHG Labs", "url": "https://bhglabs.co/?ref=zmgqyxku" }, "name": "GHK-Cu 50mg vial" }, { "@type": "Offer", "price": "49.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://biomystlabs.com/product/ghk-cu-100mg/?ref=rxtkqorwv", "seller": { "@type": "Organization", "name": "BioMyst Labs", "url": "https://biomystlabs.com" }, "name": "GHK-Cu 100mg vial" }, { "@type": "Offer", "price": "69.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://biomystlabs.com/product/ghk-cu-100mg/?ref=rxtkqorwv", "seller": { "@type": "Organization", "name": "BioMyst Labs", "url": "https://biomystlabs.com" }, "name": "GHK-Cu 100mg vial" }, { "@type": "Offer", "price": "119.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://optimumformula.co/product/diamond-balm/", "seller": { "@type": "Organization", "name": "Optimum Formula", "url": "https://optimumformula.co" } } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "GHK-Cu", "description": "GHK-Cu is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, a molecule Pickart and Thaler first pulled out of human plasma in 1973. The free peptide (GHK, C14H24N6O4) weighs about 340.4 Da; bind it 1:1 to copper and you get the neutral GHK-Cu complex (C14H22CuN6O4) at roughly 401.9 Da. Circulating GHK sits around 200 ng/mL in young adults near age 20 and drops to about 80 ng/mL by age 60, which is where most of the 'it declines with age' framing comes from. On skin, GHK-Cu is a well-worn cosmetic ingredient (INCI: Copper tripeptide-1) with real human topical data behind it. Injected under the skin it is a different story: no human trials, no established dose, purely research-use-only biohacker practice. Everything about systemic use here is educational, not medical advice.", "lastReviewed": "2026-05-04T11:34:42.771+00:00", "url": "https://www.bodyhackguide.co/compound/ghk-cu", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "GHK-Cu", "alternateName": [ "Copper Peptide", "GHK Copper", "Copper tripeptide-1", "GHKCu" ], "description": "GHK-Cu is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, a molecule Pickart and Thaler first pulled out of human plasma in 1973. The free peptide (GHK, C14H24N6O4) weighs about 340.4 Da; bind it 1:1 to copper and you get the neutral GHK-Cu complex (C14H22CuN6O4) at roughly 401.9 Da. Circulating GHK sits around 200 ng/mL in young adults near age 20 and drops to about 80 ng/mL by age 60, which is where most of the 'it declines with age' framing comes from. On skin, GHK-Cu is a well-worn cosmetic ingredient (INCI: Copper tripeptide-1) with real human topical data behind it. Injected under the skin it is a different story: no human trials, no established dose, purely research-use-only biohacker practice. Everything about systemic use here is educational, not medical advice.", "activeIngredient": "GHK-Cu", "administrationRoute": "Subcutaneous, Topical", "mechanismOfAction": "GHK-Cu works mostly as a copper shuttle and a signaling peptide. It binds Cu(II) with high affinity (log K around 16.4, close to albumin's 16.2) and can supply or regulate copper for copper-dependent enzymes like SOD1, lysyl oxidase, cytochrome c oxidase, and tyrosinase (PMID: 22666519). On the matrix side it stimulates type I collagen synthesis in fibroblasts at low nanomolar to picomolar concentrations (PMID: 3169264), raises glycosaminoglycans including dermatan and chondroitin sulfate, and upregulates decorin (PMID: 11121126). It modulates matrix metalloproteinases and their inhibitors TIMP-1/TIMP-2, with the strongest direct data on the MMP-9/TIMP-1 axis in a smoke-induced emphysema model (PMID: 35936787). It chemoattracts macrophages, mast cells, and capillary cells to sites of injury and pushes stemness markers and trophic-factor output (PMID: 18644225). On the antioxidant side it upregulates a panel of roughly 14 antioxidant-related genes (including metallothionein MT3, paraoxonases PON1/PON3, and the master regulator Nrf2/NFE2L2) rather than the heme-oxygenase/peroxiredoxin set sometimes claimed, and it activates Nrf2/Keap1 signaling in vivo (PMID: 25302294, 35936787). Its most-cited systems-level finding comes from the Broad Institute Connectivity Map, where GHK shifted expression by at least 50% in about 31% of assayed human genes (roughly 4,000+), including 47 DNA-repair genes, and reversed a COPD/emphysema gene signature (PMID: 25302294). Treat the Connectivity Map and DNA-repair figures as hypothesis-generating transcriptomic data from cancer cell lines, not proven clinical outcomes in people.", "dosageForm": "vial, topical", "legalStatus": "Not approved for human use (research chemical)", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Is injectable GHK-Cu clinically proven?", "acceptedAnswer": { "@type": "Answer", "text": "No. There are zero human clinical trials of injectable GHK-Cu and no established dose. Everything about subcutaneous use is community/biohacker practice framed as research-use-only. The real human evidence for GHK-Cu is topical (cosmetic anti-aging), not injected." } }, { "@type": "Question", "name": "What's the difference between topical and injectable GHK-Cu?", "acceptedAnswer": { "@type": "Answer", "text": "Topical GHK-Cu is a mainstream cosmetic ingredient (INCI: Copper tripeptide-1) with actual human data behind it, usually at 1-3% in serums and creams applied once or twice daily. Injectable use has no trials, no approved dose, and adds a copper-load concern because injection bypasses the gut's copper regulation. If you want the evidence-backed route, that's topical." } }, { "@type": "Question", "name": "Should I worry about copper overload?", "acceptedAnswer": { "@type": "Answer", "text": "It's a legitimate theoretical concern for injectable use specifically. Oral copper is tightly regulated by the gut; subcutaneous injection skips that, so repeated systemic dosing could accumulate copper. That's why community protocols run 4-8 week cycles with 4-6 week off-periods. Topical application doesn't carry the same systemic load. Anyone with a copper-metabolism disorder should avoid GHK-Cu entirely." } }, { "@type": "Question", "name": "Can I use GHK-Cu if I have Wilson's disease?", "acceptedAnswer": { "@type": "Answer", "text": "No. GHK-Cu is contraindicated in Wilson's disease and any other copper-metabolism disorder, because the whole point of the molecule is to bind and deliver copper. If you have a copper-handling condition, don't use it in any form." } }, { "@type": "Question", "name": "How do I reconstitute and store an injectable vial?", "acceptedAnswer": { "@type": "Answer", "text": "Use bacteriostatic water. A 50 mg vial plus 2 mL BAC water gives 25 mg/mL, so 250 mcg is 0.01 mL (1 unit on a U-100 insulin syringe) and 500 mcg is 0.02 mL (2 units). Keep the reconstituted vial refrigerated. This is reference information for research use, not a prescription." } }, { "@type": "Question", "name": "What can I stack GHK-Cu with?", "acceptedAnswer": { "@type": "Answer", "text": "Common community pairings (none clinically validated) include BPC-157 and TB-500 for tissue repair, KPV for anti-inflammatory support, and epithalon for anti-aging protocols. Topically it's often combined with microneedling to boost delivery, and hair users add minoxidil, finasteride, or RU-58841. Avoid layering GHK-Cu with strong acids, retinoids, or high-dose vitamin C in the same session, since those can break the copper complex apart." } }, { "@type": "Question", "name": "How long until I see results?", "acceptedAnswer": { "@type": "Answer", "text": "For topical use, most reported changes in texture and firmness show up over 8-12+ weeks of consistent daily application, and benefits fade if you stop. For injectable use there's no reliable timeline because there's no clinical data; any reported effects are anecdotal and unverified." } }, { "@type": "Question", "name": "Why does GHK matter for aging?", "acceptedAnswer": { "@type": "Answer", "text": "Circulating GHK runs around 200 ng/mL in your early twenties and falls to roughly 80 ng/mL by age 60, and the peptide influences collagen, antioxidant genes, and a large gene-expression signature in lab studies (PMID: 25302294). That age-related decline plus the mechanistic data is the basis for the anti-aging interest, though the systems-level gene findings come from cell lines and aren't proven clinical outcomes in people." } }, { "@type": "Question", "name": "I'm breaking out or getting sores at the corners of my mouth on GHK-Cu. Why?", "acceptedAnswer": { "@type": "Answer", "text": "That pattern (acne, cracked mouth corners, a sore tongue, or extra shedding) often points to zinc running low. GHK-Cu delivers copper, copper and zinc balance each other, and building collagen also pulls on your zinc stores, so if yours were borderline the extra demand shows up as those symptoms. The usual move is to check a zinc/copper/ceruloplasmin panel and add zinc (many use zinc bisglycinate). If it does not settle, GHK-Cu may just not be for you. Not medical advice." } }, { "@type": "Question", "name": "Does my age change whether GHK-Cu is worth running?", "acceptedAnswer": { "@type": "Answer", "text": "It can. Your body makes GHK on its own, levels are highest when you are young and start dropping in the mid-30s, faster for some people than others. Users past about 40 tend to notice more, while a lot of under-40 users report more side effects and less benefit because their own GHK is still high. If you are young and healthy, you may simply not need it." } }, { "@type": "Question", "name": "How do I know my vial actually contains what the label says?", "acceptedAnswer": { "@type": "Answer", "text": "You often do not without testing. Independent labs have reported GHK-Cu vials running anywhere from 30% to 95% underdosed, and because it is a copper compound, heavy-metal contamination is worth screening too. If you are going to run it, test for dose accuracy and heavy metals, and buy from sources that test their material." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, vendor price comparisons, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+, enter siteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompound%2Fghk-cu) Compare notes with other researchers. Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 3. [Compounds](/compare) 5. GHK-Cu R Featured vendor $0.70/mg Β· $34.99 for 50mg at ResearchChemHQ Across 5 vendors REDDIT[Buy at RC](https://www.bodyhackguide.co/go/researchchemhq?utm_source=compound-sticky-bar&utm_campaign=a1000000-0000-0000-0000-000000000010&utm_medium=best-price-cta) [πŸ›’ Where to buy GHK-Cu](/buy/ghk-cu)[🏷️ GHK-Cu coupon codes](/coupons/ghk-cu)[πŸ“‹ GHK-Cu protocol](/protocol/ghk-cu)[πŸ”„ Alternatives to GHK-Cu](/alternatives-to/ghk-cu)[⚠️ GHK-Cu side effects](/side-effects/ghk-cu) 1. [Home](/) 3. [Compounds](/compare) 5. GHK-Cu ![GHK-Cu molecular structure](/assets/peptide-structure-placeholder-DUmZBF_j.png) # GHK-Cu Skin, Hair & Aesthetics N/A for injectable (no Phase 1/2/3 injectable trials). One Phase 2 TOPICAL gel wound-healing trial is recruiting (NCT07437586); topical cosmetic use otherwise has small human studies with no drug-phase designation. Download PDF Also known as: Copper Peptide, GHK Copper, Copper tripeptide-1, GHKCu GHK-Cu is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, a molecule Pickart and Thaler first pulled out of human plasma in 1973. The free peptide (GHK, C14H24N6O4) weighs about 340.4 Da; bind it 1:1 to copper and you get the neutral GHK-Cu complex (C14H22CuN6O4) at roughly 401.9 Da. Half-Life: ~30-60 min (plasma; approximate legacy figure, no robust modern human PK study) Route: Subcutaneous, Topical MW: Free peptide (GHK): 340.38 Da (C14H24N6O4). Copper complex (GHK-Cu): 401.9 Da (C14H22CuN6O4, neutral 1:1 Cu(II) complex). CAS: 49557-75-7 (free GHK tripeptide; the marketed copper-acetate complex form carries CAS 89030-95-5) [6 PubMed Results](https://pubmed.ncbi.nlm.nih.gov/?term=GHK-Cu%20copper%20peptide%20skin%20aging) Last reviewed: May 4, 2026 [ 6 PubMed Results ](https://pubmed.ncbi.nlm.nih.gov/?term=GHK-Cu%20copper%20peptide%20skin%20aging)[ Skin, Hair & Aesthetics Category ](/wiki#cat-skin,-hair-&-aesthetics) N/A for injectable (no Phase 1/2/3 injectable trials). One Phase 2 TOPICAL gel wound-healing trial is recruiting (NCT07437586); topical cosmetic use otherwise has small human studies with no drug-phase designation. Research Stage [ Reconstitution Calculator for GHK-Cu Pre-filled Β· 5mg vial Β· 200mcg dose ](/tools/reconstitution/ghk-cu) OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices7 Related ## Overview ### Featured Vendor βš—οΈ ResearchChemHQ $34.99 1 vial Β· vial [Buy Now](https://researchchemhq.co/product/ghk-cu-50mg/?ref=oyxnywoz) Coupon: `REDDIT`Copy Compare 5 vendors ### At A Glance Mechanism GHK-Cu works mostly as a copper shuttle and a signaling peptide. It binds Cu(II) with high affinity (log K around 16.4, close to albumin's 16.2) and can supply or regulate copper for copper-dependent enzymes like SOD1, lysyl oxidase, cytochrome c oxidase, and tyrosinase (PMID: 22… Half-Life ~30-60 min (plasma; approximate legacy figure, no robust modern human PK study) Dosing Once daily subcutaneous; some run 5 days on / 2 days off. Topical: 1-2x daily to cleansed skin. Dose Range 200-500 mcg SC daily (community/RUO; no clinically established injectable dose)mcg Routes Subcutaneous Topical Common Vials 50 mgmg 100 mgmg Potential Benefits Stimulates type I collagen synthesis in human fibroblasts at low nanomolar-to-picomolar concentrations (PMID: 3169264) Increases glycosaminoglycans (dermatan/chondroitin sulfate) and upregulates decorin in wound models (PMID: 11121126) Modulates matrix metalloproteinases and their inhibitors, partially correcting the MMP-9/TIMP-1 imbalance in a smoke-induced emphysema model (PMID: 35936787) Drives tissue remodeling and chemoattracts macrophages, mast cells, and capillary cells to injury sites (PMID: 18644225) Modulates expression of ~4,000+ human genes via the Broad Institute Connectivity Map, including DNA-repair and antioxidant genes (PMID: 25302294) Increases stemness and proliferative potential of epidermal basal cells and keratinocytes (PMID: 23019153) Acts as an antioxidant and anti-inflammatory copper regulator in the context of aging (PMID: 22666519) Broad skin-regeneration effects on collagen, proteoglycans, MMPs, and immune/endothelial cell recruitment (PMID: 26236730) Safety Notes Common Mild topical irritation or redness, usually transient (more likely with 4-5% formulations) Temporary blue-green tint at the injection site from the copper content Mild stinging when applied to broken skin Serious No serious adverse events reported in the cosmetic or preclinical literature Theoretical copper accumulation with repeated systemic (injected) use: monitor serum copper and ceruloplasmin, and watch zinc balance Low-zinc signs can surface (acne, cracked mouth corners, sore tongue, hair shedding) because GHK-Cu raises zinc demand; a zinc/copper/ceruloplasmin panel and added zinc usually address it Product quality varies: independent testing has found vials 30-95% underdosed, so test for dose accuracy and heavy metals Rare allergic contact dermatitis to copper-peptide products ### Overview GHK-Cu is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, a molecule Pickart and Thaler first pulled out of human plasma in 1973. The free peptide (GHK, C14H24N6O4) weighs about 340.4 Da; bind it 1:1 to copper and you get the neutral GHK-Cu complex (C14H22CuN6O4) at roughly 401.9 Da. Circulating GHK sits around 200 ng/mL in young adults near age 20 and drops to about 80 ng/mL by age 60, which is where most of the 'it declines with age' framing comes from. On skin, GHK-Cu is a well-worn cosmetic ingredient (INCI: Copper tripeptide-1) with real human topical data behind it. Injected under the skin it is a different story: no human trials, no established dose, purely research-use-only biohacker practice. Everything about systemic use here is educational, not medical advice. ### Potential Research Fields Skin, Hair & Aesthetics Wound Healing & Tissue Repair Anti-Aging Antioxidant / Gene Expression ### What to Expect Weeks 1-2 (topical) - β€’ Minimal visible change - β€’ Skin adjusting to the copper peptide - β€’ Possible mild irritation with higher-concentration serums Weeks 3-6 (topical) - β€’ Improved skin smoothness and hydration in some users - β€’ Early firmness changes as collagen/GAG synthesis ramps up - β€’ Reduced roughness Weeks 8-12+ (topical) - β€’ Fine-line softening and improved texture (strongest human evidence is here) - β€’ More even tone - β€’ Cumulative benefit; continued use needed to maintain Weeks 1-4 (injectable, RUO/community) - β€’ No validated clinical effect to expect (no human trials) - β€’ Users report subjective recovery/skin changes anecdotally - β€’ Watch injection sites; nothing here is clinically proven Weeks 4-8 (injectable, RUO/community) - β€’ End of a typical community cycle followed by a 4-6 week off-period - β€’ Off-cycling used as a precaution against theoretical copper accumulation - β€’ Any perceived benefits are unverified and not established by controlled studies Individual responses vary. Timeline based on commonly reported research observations. ## Chemical Information IUPAC Name glycyl-L-histidyl-L-lysine copper(II) complex CAS Number 49557-75-7 (free GHK tripeptide; the marketed copper-acetate complex form carries CAS 89030-95-5) Molecular Formula C14H22CuN6O4 Molecular Mass 401.91 g/mol ![GHK-Cu molecular structure](https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/165429100/PNG?image_size=300x300) [View on PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/165429100) Amino Acid Sequence Gly-His-Lys (GHK); glycyl-L-histidyl-L-lysine. GHK-Cu is the 1:1 copper(II) chelate of this tripeptide (INCI: Copper tripeptide-1). ## Dosing & Protocols ### Dosing Summary Dose 200-500 mcg SC daily (injectable, RUO) or a 1-2% topical serum Route Subcutaneous injection, topical serum/cream, or microneedling Frequency Once daily (injectable) or 1-2x daily (topical) Duration Injectable: 4-8 week cycles with a 4-6 week off-period. Topical: continuous over 8-12+ weeks ### Titration Schedule Step Weeks Dose Purpose Topical protocol β€” 1-2% GHK-Cu serum Skin regeneration and anti-aging: continuous use, strongest human evidence Injectable protocol (RUO) β€” 200-500 mcg SC Community anti-aging/recovery use: 4-8 week cycles plus a 4-6 week off-period; not clinically validated ### Beginner Protocol ### Intermediate Protocol ### Advanced Protocol ### Reconstitution Guide Solvent bacteriostatic water Volume 2 mL Storage Refrigerate (2-8Β°C) Stability Up to 30 days refrigerated Common Vial Sizes 50 mg 100 mg Instructions 1 Clean the vial stopper with an alcohol swab 2 Draw 2 mL bacteriostatic water into a syringe 3 Insert needle into vial and slowly inject solvent down the side wall 4 Gently swirl (never shake) until fully dissolved 5 Store refrigerate (2-8Β°c) after reconstitution Important - β€’ Never shake. Gently swirl to preserve peptide bonds - β€’ Use bacteriostatic water for multi-dose vials - β€’ Discard if solution appears cloudy or discolored [Open Reconstitution Calculator](/tools/reconstitution) ### Detailed Reconstitution Instructions ### Stacking Notes ### Additional Dosage Notes [Full GHK-Cu Dosing Guide](/guides/dosage/ghk-cu) ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) Join other researchers already signed up ## Research [6 PubMed Results](https://pubmed.ncbi.nlm.nih.gov/?term=GHK-Cu%20copper%20peptide%20skin%20aging)Last updated: May 4, 2026 ### Key Research Findings The strongest human evidence for GHK-Cu is topical, in cosmetic anti-aging and photoaging use (e.g., Leyden 2002). Mechanistic work is well developed: collagen stimulation in fibroblasts (PMID: 3169264), GAG/decorin upregulation in wound models (PMID: 11121126), MMP/TIMP modulation (PMID: 11045606, 35936787), tissue remodeling and cell recruitment (PMID: 18644225), Connectivity Map gene modulation and DNA-repair signatures (PMID: 25302294, 26236730), stem-cell and keratinocyte effects (PMID: 23019153), and antioxidant/anti-aging framing (PMID: 22666519). A systemic injection study exists in mice for pulmonary fibrosis (PMID: 31809714). There are no human clinical trials of injectable GHK-Cu. The one registered GHK-Cu-specific interventional trial is a recruiting Phase 2, randomized, vehicle-controlled split-wound study of a topical GHK-Cu gel for acute wound healing (NCT07437586, Hudson Biotech); it is still enrolling and has not reported results. Injectable GHK-Cu still has zero human trials. ### Safety & Side Effects Topical GHK-Cu is generally well tolerated; higher-concentration formulations (4-5%) raise the odds of irritation, redness, or stinging. Injectable use has no safety data from controlled trials; the main theoretical concern is copper accumulation with repeated systemic dosing, which is why community protocols cycle off. Anyone with a copper-metabolism disorder should avoid it entirely. Two practical cautions from the research community: vials are frequently underdosed (independent testing has reported 30-95% under label), so test for dose accuracy and heavy metals on a copper compound; and because GHK-Cu raises zinc demand, watch for low-zinc signs (acne, cracked mouth corners, sore tongue, hair shedding), which usually resolve with a zinc / copper / ceruloplasmin panel and added zinc. [Browse Studies on PubMed](https://pubmed.ncbi.nlm.nih.gov/?term=GHK-Cu%20copper%20peptide%20skin%20aging) ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) Join other researchers already signed up ## Interactions ### Interaction Matrix All(4) Compatible(4) CautionAvoid BPC-157 Synergistic TB-500 Synergistic LL-37 Compatible Epithalon Compatible ### Contraindications Contraindicated in Wilson's disease and other copper-metabolism disorders. Injectable use has no clinical validation and carries a theoretical copper-accumulation risk because subcutaneous delivery bypasses the gut's copper regulation. Avoid during pregnancy and breastfeeding: there is no safety data for systemic GHK-Cu, and copper handling shifts in pregnancy. Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $34.99 up to $119.99 Best $/mg $0.4999 Vendors 5 Listings 7 vial, topical [Sign in for alerts ](/auth) Dosage All50mg (4) 100mg (2) Form Allvialtopical Sort Price $/mg Vendor BHG Labs shares common ownership with BodyHackGuide, and we earn a commission on purchases through our links. Vendor Product Form Qty Price $/mg Coupon ![ResearchChemHQ logo](https://staging.researchchemhq.co/wp/wp-content/uploads/2024/08/cropped-RCHQ-Invert-Logo-e1724477505900.png) [ResearchChemHQ](/vendors/researchchemhq) [100 ](/vendor-trust-scorecard) πŸ‡ΊπŸ‡Έ US GHK-Cu 50mg vial 1 vial ● In Stock $34.99 BEST $0.700 REDDIT [Buy](https://researchchemhq.co/product/ghk-cu-50mg/?ref=oyxnywoz) ![BHG Labs logo](https://bhglabs.co/store/wp-content/uploads/2026/06/logo-full.png) [BHG Labs](/vendors/bhg-labs) [70 ](/vendor-trust-scorecard) πŸ‡ΊπŸ‡Έ US GHK-Cu 50mg vial 1 vial ● In Stock $49.99 $1.000 BHG20 [Buy](https://bhglabs.co/product/ghk-cu-50mg/?ref=zmgqyxku&coupon=BHG20) ![Optimum Formula logo](https://optimumformula.co/wp-content/uploads/2025/07/LOGO-OPTIMUM-NEW.png) [Optimum Formula](/vendors/optimum-formula) [100 ](/vendor-trust-scorecard) πŸ‡ΊπŸ‡Έ US GHK-Cu 50mg Vial vial 50mg ● In Stock $34.99 $0.700 REDDIT [Buy](https://optimumformula.co/product/ghk-cu/?ref=ruyhjwqh) ![Optimum Formula logo](https://optimumformula.co/wp-content/uploads/2025/07/LOGO-OPTIMUM-NEW.png) [Optimum Formula](/vendors/optimum-formula) [100 ](/vendor-trust-scorecard) πŸ‡ΊπŸ‡Έ US Diamond Balm topical 30ml ● In Stock $119.99 β€” REDDIT [Buy](https://optimumformula.co/product/diamond-balm/) ![BioMyst Labs logo](https://biomystlabs.com/wp-content/uploads/2025/12/Asset-36@3x-scaled.png) [BioMyst Labs](/vendors/biomyst-labs) [70 ](/vendor-trust-scorecard) πŸ‡ΊπŸ‡Έ US 🌍 International GHK-Cu 100mg vial 1 vial ● In Stock $49.99 VALUE $0.500 β€” [Buy](https://biomystlabs.com/product/ghk-cu-100mg/?ref=rxtkqorwv) ![BioMyst Labs logo](https://biomystlabs.com/wp-content/uploads/2025/12/Asset-36@3x-scaled.png) [BioMyst Labs](/vendors/biomyst-labs) [70 ](/vendor-trust-scorecard) πŸ‡ΊπŸ‡Έ US 🌍 International GHK-Cu 100mg vial 1 vial ● In Stock $69.99 $0.700 β€” [Buy](https://biomystlabs.com/product/ghk-cu-100mg/?ref=rxtkqorwv) ![VANDL Labs logo](https://www.vandl-labs.com/wp-content/uploads/2026/04/LogoPack_Logo-03-scaled-2.png) [VANDL Labs](/vendors/vandl-labs) [50 ](/vendor-trust-scorecard) πŸ‡ΊπŸ‡Έ US GHK-Cu 50mg vial 50mg vial ● In Stock $39.99 $0.800 CHON [Buy](https://www.vandl-labs.com/product/ghk-cu/?ref=choncho) Get GHK-Cu Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $34.99 [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with GHK-Cu. [Sign in](/auth) Current low $49.99 as of Jul 1, 2026 7-day low β€” no 7d data yet 30-day low β€” no 30d data yet 30-day change β€” baseline building Tracking since Mar 13, 2026 Β· 6 data points ## Price History 4 data points ### Vendors Selling GHK-Cu BHG Labs shares common ownership with BodyHackGuide, and we earn a commission on purchases through our links. [ ![ResearchChemHQ logo](https://staging.researchchemhq.co/wp/wp-content/uploads/2024/08/cropped-RCHQ-Invert-Logo-e1724477505900.png) #### ResearchChemHQ 4.7 1 listing Β· from $34.99 ](/vendors/researchchemhq)[ ![Optimum Formula logo](https://optimumformula.co/wp-content/uploads/2025/07/LOGO-OPTIMUM-NEW.png) #### Optimum Formula 4.9 2 listings Β· from $34.99 ](/vendors/optimum-formula)[ ![VANDL Labs logo](https://www.vandl-labs.com/wp-content/uploads/2026/04/LogoPack_Logo-03-scaled-2.png) #### VANDL Labs 1 listing Β· from $39.99 ](/vendors/vandl-labs)[ ![BHG Labs logo](https://bhglabs.co/store/wp-content/uploads/2026/06/logo-full.png) #### BHG Labs 4.8 1 listing Β· from $49.99 ](/vendors/bhg-labs)[ ![BioMyst Labs logo](https://biomystlabs.com/wp-content/uploads/2025/12/Asset-36@3x-scaled.png) #### BioMyst Labs 4.5 2 listings Β· from $49.99 ](/vendors/biomyst-labs) How we score these vendors Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. [View Scorecard](/vendors/scorecard) ### Related Compounds [View All](/wiki) [ ### Melanotan II Skin, Hair & Aesthetics Preclinical Melanotan-II (MT-II) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (Ξ±-MSH) engineered in the late 1980s by researchers at the University of Arizona, most prominently Mac Hadley and Victor Hruby, who were searching for a way to stimulate skin pigmentation pharmacologically as a potential skin-cancer prophylactic. tΒ½ Approximately 30-60 minutes (subcutaneous; limited published human pharmacokinetic data). Peak plasma levels occur ~1-2 hours after injection, and subjective effects typically persist 4-8 hours. 17 PubMed View Profile ](/compound/melanotan-ii)[ ### PT-141 (Bremelanotide) Skin, Hair & Aesthetics FDA Approved PT-141 (bremelanotide) is a cyclic 7-amino-acid synthetic melanocortin receptor agonist that acts centrally in the brain β€” not peripherally on genital tissue β€” to improve sexual desire, arousal, and responsiveness. tΒ½ ~2.7 hours 500–2,000 mcg (0.5–2 mg) per dose 40 PubMed View Profile ](/compound/pt-141) ### Side-by-Side Comparisons [All Comparisons](/compare) [GHK-Cu vs AHK-Cu](/compare/ghk-cu-vs-ahk-cu "GHK CU vs AHK CU") [ View Full Dosage Guide β†’ Protocols, calculator & safety for GHK-Cu ](/guides/dosage/ghk-cu) ### Related Articles [All Posts](/blog) [ #### The 8 Best Peptide Companies for Research: 2026 Purity & Price Comparison A data-driven comparison of every active peptide vendor we track: COA audit results, price-per-mg tables for 19 compounds, and a step-by-step purchase guide. 9/16/2026 ](/blog/best-peptide-companies-2026)[ #### Gut Healing Supplements & Peptides: What the Research Actually Supports (2026) Most "gut healing" supplements and peptides are sold on animal studies and mechanism, not human results. The interventions with real human trial data are unglamorous and cheap: zinc-L-carnosine for the stomach lining, L-glutamine for a measured leaky gut, strain-specific probiotics, enteric-coated peppermint oil and the low-FODMAP diet for IBS, and soluble fiber done right. The hyped peptides (BPC-157, KPV) are almost entirely rat-and-petri-dish so far. And if your "stomach problem" is unexplained low iron or B12, the real issue might be too little stomach acid, which no supplement aisle fixes. 7/7/2026 ](/blog/gut-healing-supplements-research-guide)[ #### GHK-Cu (Copper Peptide): What It Is and What It's Researched For GHK-Cu is a naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine bound to copper ions) that circulates in human plasma and declines with age. It's studied mainly as a copper-delivery and extracellular-matrix signaling molecule in skin repair, wound healing, hair-follicle, and antioxidant research. It is a research compound and cosmetic ingredient, not a therapeutic drug, and much of the injectable evidence is preliminary compared to the topical literature. 7/1/2026 ](/blog/ghk-cu-copper-peptide-guide) ### Featured Price βš—οΈ ResearchChemHQ $34.99 [Buy Now](https://researchchemhq.co/product/ghk-cu-50mg/?ref=oyxnywoz) 5 vendors Β· 7 listings ### Research Score 61 6 PubMed results ### Quality Indicators Data Completeness 100% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Results Interactions Vendor Listings COA Verification 10 Verified COAs 2 Vendors w/ COA High verification rate (83%) Latest test: 3/1/2026 Research Volume 6 PubMed results Limited research available ### Quick Facts Half-Life ~30-60 min (plasma; approximate legacy figure, no robust modern human PK study) Molecular Weight 401.91 g/mol Administration Subcutaneous, Topical CAS Number 49557-75-7 (free GHK tripeptide; the marketed copper-acetate complex form carries CAS 89030-95-5) Trial Phase N/A for injectable (no Phase 1/2/3 injectable trials). One Phase 2 TOPICAL gel wound-healing trial is recruiting (NCT07437586); topical cosmetic use otherwise has small human studies with no drug-phase designation. ### Safety Profile Common Side Effects - β€’ Mild topical irritation or redness, usually transient (more likely with 4-5% formulations) - β€’ Temporary blue-green tint at the injection site from the copper content - β€’ Mild stinging when applied to broken skin [Full Dosage Guide](/guides/dosage/ghk-cu)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions Is injectable GHK-Cu clinically proven? No. There are zero human clinical trials of injectable GHK-Cu and no established dose. Everything about subcutaneous use is community/biohacker practice framed as research-use-only. The real human evidence for GHK-Cu is topical (cosmetic anti-aging), not injected. What's the difference between topical and injectable GHK-Cu? Topical GHK-Cu is a mainstream cosmetic ingredient (INCI: Copper tripeptide-1) with actual human data behind it, usually at 1-3% in serums and creams applied once or twice daily. Injectable use has no trials, no approved dose, and adds a copper-load concern because injection bypasses the gut's copper regulation. If you want the evidence-backed route, that's topical. Should I worry about copper overload? It's a legitimate theoretical concern for injectable use specifically. Oral copper is tightly regulated by the gut; subcutaneous injection skips that, so repeated systemic dosing could accumulate copper. That's why community protocols run 4-8 week cycles with 4-6 week off-periods. Topical application doesn't carry the same systemic load. Anyone with a copper-metabolism disorder should avoid GHK-Cu entirely. Can I use GHK-Cu if I have Wilson's disease? No. GHK-Cu is contraindicated in Wilson's disease and any other copper-metabolism disorder, because the whole point of the molecule is to bind and deliver copper. If you have a copper-handling condition, don't use it in any form. How do I reconstitute and store an injectable vial? Use bacteriostatic water. A 50 mg vial plus 2 mL BAC water gives 25 mg/mL, so 250 mcg is 0.01 mL (1 unit on a U-100 insulin syringe) and 500 mcg is 0.02 mL (2 units). Keep the reconstituted vial refrigerated. This is reference information for research use, not a prescription. What can I stack GHK-Cu with? Common community pairings (none clinically validated) include BPC-157 and TB-500 for tissue repair, KPV for anti-inflammatory support, and epithalon for anti-aging protocols. Topically it's often combined with microneedling to boost delivery, and hair users add minoxidil, finasteride, or RU-58841. Avoid layering GHK-Cu with strong acids, retinoids, or high-dose vitamin C in the same session, since those can break the copper complex apart. How long until I see results? For topical use, most reported changes in texture and firmness show up over 8-12+ weeks of consistent daily application, and benefits fade if you stop. For injectable use there's no reliable timeline because there's no clinical data; any reported effects are anecdotal and unverified. Why does GHK matter for aging? Circulating GHK runs around 200 ng/mL in your early twenties and falls to roughly 80 ng/mL by age 60, and the peptide influences collagen, antioxidant genes, and a large gene-expression signature in lab studies (PMID: 25302294). That age-related decline plus the mechanistic data is the basis for the anti-aging interest, though the systems-level gene findings come from cell lines and aren't proven clinical outcomes in people. I'm breaking out or getting sores at the corners of my mouth on GHK-Cu. Why? That pattern (acne, cracked mouth corners, a sore tongue, or extra shedding) often points to zinc running low. GHK-Cu delivers copper, copper and zinc balance each other, and building collagen also pulls on your zinc stores, so if yours were borderline the extra demand shows up as those symptoms. The usual move is to check a zinc/copper/ceruloplasmin panel and add zinc (many use zinc bisglycinate). If it does not settle, GHK-Cu may just not be for you. Not medical advice. Does my age change whether GHK-Cu is worth running? It can. Your body makes GHK on its own, levels are highest when you are young and start dropping in the mid-30s, faster for some people than others. Users past about 40 tend to notice more, while a lot of under-40 users report more side effects and less benefit because their own GHK is still high. If you are young and healthy, you may simply not need it. How do I know my vial actually contains what the label says? You often do not without testing. Independent labs have reported GHK-Cu vials running anywhere from 30% to 95% underdosed, and because it is a copper compound, heavy-metal contamination is worth screening too. If you are going to run it, test for dose accuracy and heavy metals, and buy from sources that test their material. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### Melanotan II Skin, Hair & Aesthetics Preclinical Melanotan-II (MT-II) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (Ξ±-MSH) engineered in the late 1980s by researchers at the University of Arizona, most prominently Mac Hadley and Victor Hruby, who were searching for a way to stimulate skin pigmentation pharmacologically as a potential skin-cancer prophylactic. tΒ½ Approximately 30-60 minutes (subcutaneous; limited published human pharmacokinetic data). Peak plasma levels occur ~1-2 hours after injection, and subjective effects typically persist 4-8 hours. 17 PubMed View Profile ](/compound/melanotan-ii)[ ### PT-141 (Bremelanotide) Skin, Hair & Aesthetics FDA Approved PT-141 (bremelanotide) is a cyclic 7-amino-acid synthetic melanocortin receptor agonist that acts centrally in the brain β€” not peripherally on genital tissue β€” to improve sexual desire, arousal, and responsiveness. tΒ½ ~2.7 hours 500–2,000 mcg (0.5–2 mg) per dose 40 PubMed View Profile ](/compound/pt-141) ## Side-by-Side Comparisons [All Comparisons](/compare) Compare GHK-Cu head-to-head: mechanism, half-life, dosing, safety, and vendor prices. [GHK-Cu vs AHK-Cu](/compare/ghk-cu-vs-ahk-cu "GHK CU vs AHK CU") ## Research Benches Reference pages that put GHK-Cu next to the compounds people pair it with: roles, evidence, overlap and conflicts. No dosing. Research use only. [ Tissue Repair Bench KLOW, GHK-Cu, BPC-157, TB-500, KPV and ARA-290, one name at a time research bench Β· no dosing ](/stack/tissue-repair-bench) Free 2026 Peptide Cheat Sheet (PDF) Reconstitution math, concentration charts, half-lives, and vendor links. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-ghk-cu) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. [Order Bloodwork](https://anabolicinsights.ai/?ref=nwm2zjb) ![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. [support@bodyhackguide.co](mailto:support@bodyhackguide.co) [](https://discord.gg/Mhq5UdRYBA)[](https://reddit.com/r/BodyHackGuide) Explore #### Explore - [Compare prices](/compare) - [Research suppliers](/vendors) - [Deals](/deals) - [Coupons](/coupons) - [Nootropics](/nootropics) - [Brain health](/brain-health) - [Blog](/blog) - [Guides](/guides) Tools #### Tools - [Reconstitution](/tools/reconstitution) - [Half-life visualizer](/tools/halflife) - [COA lookup](/tools/coa) - [Cost calculator](/tools/cost-calculator) - [Stack builder](/stack-builder) - [All tools β†’](/tools) Trust & vendors #### Trust & vendors - [Vendor directory](/vendors) - [Trust scorecard](/vendors/scorecard) - [Vendor trust badge](/vendors/get-vetted) - [Scoring methodology](/vendors/methodology) - [Peptide cheatsheet](/guides/peptide-cheat-sheet-download) Company #### Company - [About](/about) - [Affiliate disclosure](/affiliate-disclosure) - [Editorial standards](/editorial-standards) - [Creators](/creators) - [Coaches](/coaches) - [Privacy](/privacy) - [Terms](/terms) - [Full site directory β†’](/site-directory) **Ownership & Affiliate Disclosure:** BodyHackGuide and BHG Labs share common ownership. 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