--- title: "Fladrafinil (CRL-40,941): Dosing & Vendor Prices" description: "Fladrafinil (CRL-40,941): dosing protocols, mechanism & side effects. Compare 1 verified vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Fladrafinil (CRL-40,941)" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "Fladrafinil (CRL-40,941)", "description": "Fladrafinil, coded CRL-40,941, is the N-hydroxy analog of flmodafinil and the difluorinated counterpart of adrafinil. Flmodafinil was conceived at Laboratoire L. Lafon, the French company behind adrafinil and modafinil, and was never developed as a medicine (PMID: 30158846); the CRL-40,941 code of fladrafinil places it in the same series. Fladrafinil is sold today only as a research chemical or as an ingredient in unapproved supplements marketed for wakefulness and focus, and interest in it grew alongside the off-label use of modafinil as a cognitive enhancer (PMID: 27928893). Its pharmacology is best understood as prodrug chemistry. In a human administration study published in 2026, six volunteers each took a single 20 mg dose and gave urine and dried blood spot samples; fladrafinil was converted to flmodafinil, which was then oxidized to flmodafinil acid and flmodafinil sulfone, the same pattern adrafinil follows toward modafinil (PMID: 42210629). The activity therefore belongs mostly to flmodafinil rather than to the parent compound. For flmodafinil there is one useful animal study, published under the compound names lauflumide and NLS-4. In male C57BL/6J mice with EEG and EMG recording, an intraperitoneal dose of 64 mg/kg produced longer wakefulness than modafinil at 150 mg/kg, without hyperlocomotion and without rebound hypersomnia, and recovery sleep afterwards involved less non-REM sleep and less delta activity than after modafinil (PMID: 30158846). No comparable study exists for fladrafinil itself. Nothing about efficacy in people has been tested. The single human study measured concentrations and detection windows, not attention, wakefulness or performance (PMID: 42210629). For the class parent, positron emission tomography in ten healthy men showed that modafinil occupied dopamine transporters in caudate, putamen and nucleus accumbens and raised extracellular dopamine, a finding the authors linked to abuse potential (PMID: 19293415). Whether the fluorinated analogs behave the same way at the same exposures has not been measured in humans. Two practical points come out of the doping-control work. Product labels are unreliable: one supplement bought for that study was labeled at 50 mg/mL of flmodafinil and assayed at 95.7 mg/mL, close to double the stated content (PMID: 42210629). And anyone tested in sport should know that fladrafinil and flmodafinil were added to the 2026 World Anti-Doping Agency Prohibited List under class S6 stimulants and are prohibited in competition, with detection windows of up to a week for the parent compounds and about two weeks for the metabolites (PMID: 42210629). A retrospective screen of about 2000 in-competition samples collected in 2023 and 2024 found none of these compounds, so current use among tested athletes appears low. There is no FDA or EMA authorization for fladrafinil, no published safety trial, and no pregnancy, cardiac or hepatic data. It is a research-use-only compound in the US market, and the gap between what is claimed for it online and what has actually been measured is wide.", "url": "https://www.bodyhackguide.co/compound/fladrafinil", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "74.99", "highPrice": "74.99", "priceCurrency": "USD", "offerCount": "1", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "74.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://disguisedalpha.com/product/fladrafinil/?coupon=reddit", "seller": { "@type": "Organization", "name": "Disguised Alpha", "url": "https://disguisedalpha.com/?coupon=reddit" }, "name": "Fladrafinil (CRL-40,941) 3000mg liquid" } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Fladrafinil (CRL-40,941)", "description": "Fladrafinil, coded CRL-40,941, is the N-hydroxy analog of flmodafinil and the difluorinated counterpart of adrafinil. Flmodafinil was conceived at Laboratoire L. Lafon, the French company behind adrafinil and modafinil, and was never developed as a medicine (PMID: 30158846); the CRL-40,941 code of fladrafinil places it in the same series. Fladrafinil is sold today only as a research chemical or as an ingredient in unapproved supplements marketed for wakefulness and focus, and interest in it grew alongside the off-label use of modafinil as a cognitive enhancer (PMID: 27928893). Its pharmacology is best understood as prodrug chemistry. In a human administration study published in 2026, six volunteers each took a single 20 mg dose and gave urine and dried blood spot samples; fladrafinil was converted to flmodafinil, which was then oxidized to flmodafinil acid and flmodafinil sulfone, the same pattern adrafinil follows toward modafinil (PMID: 42210629). The activity therefore belongs mostly to flmodafinil rather than to the parent compound. For flmodafinil there is one useful animal study, published under the compound names lauflumide and NLS-4. In male C57BL/6J mice with EEG and EMG recording, an intraperitoneal dose of 64 mg/kg produced longer wakefulness than modafinil at 150 mg/kg, without hyperlocomotion and without rebound hypersomnia, and recovery sleep afterwards involved less non-REM sleep and less delta activity than after modafinil (PMID: 30158846). No comparable study exists for fladrafinil itself. Nothing about efficacy in people has been tested. The single human study measured concentrations and detection windows, not attention, wakefulness or performance (PMID: 42210629). For the class parent, positron emission tomography in ten healthy men showed that modafinil occupied dopamine transporters in caudate, putamen and nucleus accumbens and raised extracellular dopamine, a finding the authors linked to abuse potential (PMID: 19293415). Whether the fluorinated analogs behave the same way at the same exposures has not been measured in humans. Two practical points come out of the doping-control work. Product labels are unreliable: one supplement bought for that study was labeled at 50 mg/mL of flmodafinil and assayed at 95.7 mg/mL, close to double the stated content (PMID: 42210629). And anyone tested in sport should know that fladrafinil and flmodafinil were added to the 2026 World Anti-Doping Agency Prohibited List under class S6 stimulants and are prohibited in competition, with detection windows of up to a week for the parent compounds and about two weeks for the metabolites (PMID: 42210629). A retrospective screen of about 2000 in-competition samples collected in 2023 and 2024 found none of these compounds, so current use among tested athletes appears low. There is no FDA or EMA authorization for fladrafinil, no published safety trial, and no pregnancy, cardiac or hepatic data. It is a research-use-only compound in the US market, and the gap between what is claimed for it online and what has actually been measured is wide.", "lastReviewed": "2026-09-07T04:46:52.420Z", "url": "https://www.bodyhackguide.co/compound/fladrafinil", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "Fladrafinil (CRL-40,941)", "alternateName": [ "CRL-40,941", "CRL 40941", "Fluorafinil", "Bisfluoroadrafinil", "2-[bis(4-fluorophenyl)methylsulfinyl]-N-hydroxyacetamide" ], "description": "Fladrafinil, coded CRL-40,941, is the N-hydroxy analog of flmodafinil and the difluorinated counterpart of adrafinil. Flmodafinil was conceived at Laboratoire L. Lafon, the French company behind adrafinil and modafinil, and was never developed as a medicine (PMID: 30158846); the CRL-40,941 code of fladrafinil places it in the same series. Fladrafinil is sold today only as a research chemical or as an ingredient in unapproved supplements marketed for wakefulness and focus, and interest in it grew alongside the off-label use of modafinil as a cognitive enhancer (PMID: 27928893). Its pharmacology is best understood as prodrug chemistry. In a human administration study published in 2026, six volunteers each took a single 20 mg dose and gave urine and dried blood spot samples; fladrafinil was converted to flmodafinil, which was then oxidized to flmodafinil acid and flmodafinil sulfone, the same pattern adrafinil follows toward modafinil (PMID: 42210629). The activity therefore belongs mostly to flmodafinil rather than to the parent compound. For flmodafinil there is one useful animal study, published under the compound names lauflumide and NLS-4. In male C57BL/6J mice with EEG and EMG recording, an intraperitoneal dose of 64 mg/kg produced longer wakefulness than modafinil at 150 mg/kg, without hyperlocomotion and without rebound hypersomnia, and recovery sleep afterwards involved less non-REM sleep and less delta activity than after modafinil (PMID: 30158846). No comparable study exists for fladrafinil itself. Nothing about efficacy in people has been tested. The single human study measured concentrations and detection windows, not attention, wakefulness or performance (PMID: 42210629). For the class parent, positron emission tomography in ten healthy men showed that modafinil occupied dopamine transporters in caudate, putamen and nucleus accumbens and raised extracellular dopamine, a finding the authors linked to abuse potential (PMID: 19293415). Whether the fluorinated analogs behave the same way at the same exposures has not been measured in humans. Two practical points come out of the doping-control work. Product labels are unreliable: one supplement bought for that study was labeled at 50 mg/mL of flmodafinil and assayed at 95.7 mg/mL, close to double the stated content (PMID: 42210629). And anyone tested in sport should know that fladrafinil and flmodafinil were added to the 2026 World Anti-Doping Agency Prohibited List under class S6 stimulants and are prohibited in competition, with detection windows of up to a week for the parent compounds and about two weeks for the metabolites (PMID: 42210629). A retrospective screen of about 2000 in-competition samples collected in 2023 and 2024 found none of these compounds, so current use among tested athletes appears low. There is no FDA or EMA authorization for fladrafinil, no published safety trial, and no pregnancy, cardiac or hepatic data. It is a research-use-only compound in the US market, and the gap between what is claimed for it online and what has actually been measured is wide.", "activeIngredient": "Fladrafinil (CRL-40,941)", "administrationRoute": "Oral", "mechanismOfAction": "Fladrafinil is the N-hydroxy analog of flmodafinil and behaves as a prodrug: after oral administration to humans it is converted to flmodafinil, which is then oxidized to the inactive derivatives flmodafinil acid and flmodafinil sulfone, mirroring the way adrafinil is converted to modafinil (PMID: 42210629). Target-level pharmacology for fladrafinil itself has not been reported, and the compound is best treated as a delivery form for flmodafinil. For the parent compound of the class, positron emission tomography in 10 healthy men showed that modafinil occupied dopamine transporters in caudate, putamen and nucleus accumbens and increased extracellular dopamine, including in the nucleus accumbens (PMID: 19293415). Whether the difluorinated analogs act at the same site with the same potency has not been measured directly in humans.", "dosageForm": "liquid", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Fladrafinil (CRL-40,941) used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "Fladrafinil, coded CRL-40,941, is the N-hydroxy analog of flmodafinil and the difluorinated counterpart of adrafinil. Flmodafinil was conceived at Laboratoire L. Lafon, the French company behind adrafinil and modafinil, and was never developed as a medicine (PMID: 30158846); the CRL-40,941 code of fladrafinil places it in the same series. Fladrafinil is sold today only as a research chemical or as an ingredient in unapproved supplements marketed for wakefulness and focus, and interest in it grew alongside the off-label use of modafinil as a cognitive enhancer (PMID: 27928893). Its pharmacology is best understood as prodrug chemistry. In a human administration study published in 2026, six volunteers each took a single 20 mg dose and gave urine and dried blood spot samples; fladrafinil was converted to flmodafinil, which was then oxidized to flmodafinil acid and flmodafinil sulfone, the same pattern adrafinil follows toward modafinil (PMID: 42210629). The activity therefore belongs mostly to flmodafinil rather than to the parent compound. For flmodafinil there is one useful animal study, published under the compound names lauflumide and NLS-4. In male C57BL/6J mice with EEG and EMG recording, an intraperitoneal dose of 64 mg/kg produced longer wakefulness than modafinil at 150 mg/kg, without hyperlocomotion and without rebound hypersomnia, and recovery sleep afterwards involved less non-REM sleep and less delta activity than after modafinil (PMID: 30158846). No comparable study exists for fladrafinil itself. Nothing about efficacy in people has been tested. The single human study measured concentrations and detection windows, not attention, wakefulness or performance (PMID: 42210629). For the class parent, positron emission tomography in ten healthy men showed that modafinil occupied dopamine transporters in caudate, putamen and nucleus accumbens and raised extracellular dopamine, a finding the authors linked to abuse potential (PMID: 19293415). Whether the fluorinated analogs behave the same way at the same exposures has not been measured in humans. Two practical points come out of the doping-control work. Product labels are unreliable: one supplement bought for that study was labeled at 50 mg/mL of flmodafinil and assayed at 95.7 mg/mL, close to double the stated content (PMID: 42210629). And anyone tested in sport should know that fladrafinil and flmodafinil were added to the 2026 World Anti-Doping Agency Prohibited List under class S6 stimulants and are prohibited in competition, with detection windows of up to a week for the parent compounds and about two weeks for the metabolites (PMID: 42210629). A retrospective screen of about 2000 in-competition samples collected in 2023 and 2024 found none of these compounds, so current use among tested athletes appears low. There is no FDA or EMA authorization for fladrafinil, no published safety trial, and no pregnancy, cardiac or hepatic data. It is a research-use-only compound in the US market, and the gap between what is claimed for it online and what has actually been measured is wide." } }, { "@type": "Question", "name": "What forms does Fladrafinil (CRL-40,941) come in?", "acceptedAnswer": { "@type": "Answer", "text": "Fladrafinil (CRL-40,941) is available in liquid form." } }, { "@type": "Question", "name": "How much does Fladrafinil (CRL-40,941) cost?", "acceptedAnswer": { "@type": "Answer", "text": "Prices start at $74.99 across 1 verified vendor." } }, { "@type": "Question", "name": "How do I compare Fladrafinil (CRL-40,941) vendors?", "acceptedAnswer": { "@type": "Answer", "text": "Compare prices, payment methods, shipping, and COA scores across 1 vendor." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. 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Fladrafinil (CRL-40,941) ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Best price right now $0.02/mg · $74.99 for 3000mg at Disguised Alpha [Buy at Disguised Alpha](https://www.bodyhackguide.co/go/disguised-alpha?utm_source=compound-sticky-bar&utm_campaign=7c82dc87-ce7f-435f-96d7-faf99cf32a60&utm_medium=best-price-cta) [Where to buy Fladrafinil (CRL-40,941)](/buy/fladrafinil) [Fladrafinil (CRL-40,941) coupon codes](/coupons/fladrafinil) [Fladrafinil (CRL-40,941) protocol](/protocol/fladrafinil) [Alternatives to Fladrafinil (CRL-40,941)](/alternatives-to/fladrafinil) [Fladrafinil (CRL-40,941) side effects](/side-effects/fladrafinil) 1. [Home](/) 3. [Compounds](/compare) 5. Fladrafinil (CRL-40,941) ![Fladrafinil (CRL-40,941) molecular structure](/assets/peptide-structure-placeholder-DUmZBF_j.png) # Fladrafinil (CRL-40,941) Nootropics Preclinical Download PDF Also known as: CRL-40,941, CRL 40941, Fluorafinil, Bisfluoroadrafinil, 2-\[bis(4-fluorophenyl)methylsulfinyl\]-N-hydroxyacetamide Fladrafinil, coded CRL-40,941, is the N-hydroxy analog of flmodafinil and the difluorinated counterpart of adrafinil. Flmodafinil was conceived at Laboratoire L. Half-Life: Not established in humans; after a single 20 mg oral dose in six volunteers, urinary fladrafinil peaked at 2 to 4 h and stayed detectable for up to 12 h, while the metabolite flmodafinil was detectable for about 8 days and the acid and sulfone metabolites for about two weeks (PMID: 42210629) Route: Oral MW: 325.3 g/mol CAS: 90212-80-9 Last reviewed: Sep 7, 2026 [ Nootropics Category ](/wiki#cat-nootropics) Preclinical Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices1 Related ## Overview ### Best Price Available ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $74.99 30 mL (100 mg/mL) · liquid [Buy Now](https://disguisedalpha.com/product/fladrafinil/?coupon=reddit) Compare 1 vendor ### At A Glance Mechanism Fladrafinil is the N-hydroxy analog of flmodafinil and behaves as a prodrug: after oral administration to humans it is converted to flmodafinil, which is then oxidized to the inactive derivatives flmodafinil acid and flmodafinil sulfone, mirroring the way adrafinil is converted t… Half-Life Not established in humans; after a single 20 mg oral dose in six volunteers, urinary fladrafinil peaked at 2 to 4 h and stayed detectable for up to 12 h, while the metabolite flmodafinil was detectable for about 8 days and the acid and sulfone metabolites for about two weeks (PMID: 42210629) Routes Oral Potential Benefits Longer wake duration in male C57BL/6J mice than modafinil, with no rebound hypersomnia, for lauflumide (NLS-4), which is flmodafinil, the active metabolite of fladrafinil (PMID: 30158846) Less non-REM sleep and less delta activity during recovery sleep in mice than after modafinil, suggesting a lower recovery need despite longer induced wakefulness (PMID: 30158846) Confirmed conversion to flmodafinil in six healthy human volunteers after a single 20 mg oral dose, establishing that the prodrug step works in people (PMID: 42210629) For the class parent modafinil, dopamine transporter occupancy and increased brain dopamine in 10 healthy men, the presumed basis of the class effect (PMID: 19293415) ### Overview Fladrafinil, coded CRL-40,941, is the N-hydroxy analog of flmodafinil and the difluorinated counterpart of adrafinil. Flmodafinil was conceived at Laboratoire L. Lafon, the French company behind adrafinil and modafinil, and was never developed as a medicine (PMID: 30158846); the CRL-40,941 code of fladrafinil places it in the same series. Fladrafinil is sold today only as a research chemical or as an ingredient in unapproved supplements marketed for wakefulness and focus, and interest in it grew alongside the off-label use of modafinil as a cognitive enhancer (PMID: 27928893). Its pharmacology is best understood as prodrug chemistry. In a human administration study published in 2026, six volunteers each took a single 20 mg dose and gave urine and dried blood spot samples; fladrafinil was converted to flmodafinil, which was then oxidized to flmodafinil acid and flmodafinil sulfone, the same pattern adrafinil follows toward modafinil (PMID: 42210629). The activity therefore belongs mostly to flmodafinil rather than to the parent compound. For flmodafinil there is one useful animal study, published under the compound names lauflumide and NLS-4. In male C57BL/6J mice with EEG and EMG recording, an intraperitoneal dose of 64 mg/kg produced longer wakefulness than modafinil at 150 mg/kg, without hyperlocomotion and without rebound hypersomnia, and recovery sleep afterwards involved less non-REM sleep and less delta activity than after modafinil (PMID: 30158846). No comparable study exists for fladrafinil itself. Nothing about efficacy in people has been tested. The single human study measured concentrations and detection windows, not attention, wakefulness or performance (PMID: 42210629). For the class parent, positron emission tomography in ten healthy men showed that modafinil occupied dopamine transporters in caudate, putamen and nucleus accumbens and raised extracellular dopamine, a finding the authors linked to abuse potential (PMID: 19293415). Whether the fluorinated analogs behave the same way at the same exposures has not been measured in humans. Two practical points come out of the doping-control work. Product labels are unreliable: one supplement bought for that study was labeled at 50 mg/mL of flmodafinil and assayed at 95.7 mg/mL, close to double the stated content (PMID: 42210629). And anyone tested in sport should know that fladrafinil and flmodafinil were added to the 2026 World Anti-Doping Agency Prohibited List under class S6 stimulants and are prohibited in competition, with detection windows of up to a week for the parent compounds and about two weeks for the metabolites (PMID: 42210629). A retrospective screen of about 2000 in-competition samples collected in 2023 and 2024 found none of these compounds, so current use among tested athletes appears low. There is no FDA or EMA authorization for fladrafinil, no published safety trial, and no pregnancy, cardiac or hepatic data. It is a research-use-only compound in the US market, and the gap between what is claimed for it online and what has actually been measured is wide. ### Potential Research Fields Wakefulness-promoting agents Anti-doping analysis Drug metabolism Cognitive enhancement ## Chemical Information IUPAC Name Not yet available CAS Number 90212-80-9 Molecular Formula C15H13F2NO3S Molecular Mass 325.3 g/mol ![Fladrafinil (CRL-40,941) molecular structure](https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/13316557/PNG) [View on PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/13316557) ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions ### Contraindications Mechanism-based: fladrafinil is converted to a compound of the modafinil class, and modafinil occupies dopamine transporters and raises brain dopamine in humans, an effect the investigators linked to abuse potential in vulnerable people (PMID: 19293415). Athletes subject to anti-doping testing should treat it as prohibited in competition (PMID: 42210629). No pregnancy, hepatic or cardiac safety data exist for fladrafinil in any species. Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $74.99 Best $/mg $0.0250 Vendors 1 Listings 1 liquid [Sign in for alerts ](/auth) Form Allliquid Sort Price $/mg Vendor Vendor Product Form Qty Price $/mg Coupon ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) [Disguised Alpha](/vendor/disguised-alpha) [50 ](/vendor-trust-scorecard) 🇺🇸 US 🇪🇺 EU 🇬🇧 UK Fladrafinil 100 mg/mL, 30 mL liquid 30 mL (100 mg/mL) ● In Stock $74.99 BEST $0.025 — [Buy](https://disguisedalpha.com/product/fladrafinil/?coupon=reddit) Get Fladrafinil (CRL-40,941) Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $74.99 [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Fladrafinil (CRL-40,941). [Sign in](/auth) Current low $74.99 as of Sep 7, 2026 7-day low $74.99 30-day low $74.99 30-day change — baseline building Tracking since Sep 7, 2026 · 1 data point ### Vendors Selling Fladrafinil (CRL-40,941) [ ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) #### Disguised Alpha 1 listing · from $74.99 ](/vendor/disguised-alpha) How we score these vendors Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. [View Scorecard](/vendors/scorecard) ### Related Compounds [View All](/wiki) [ ### 9-Me-BC (9-Methyl-β-carboline) Nootropics Preclinical 9-Methyl--carboline (9-Me-BC) is a synthetic -carboline alkaloid that has drawn nootropic-community interest for a preclinical property that is genuinely unusual among -carbolines: in rodent and cell-culture studies it appears to stimulate the dopaminergic phenotype - raising tyrosine hydroxylase, the number of differentiated dopamine neurons and dopamine content - while also showing neuroprotective, neurorestorative and anti-inflammatory effects, plus in-vitro MAO-A/MAO-B inhibition \[PMID:17913302, PMID:20374418, PMID:32285253\]. t½ Not characterized in humans (no pharmacokinetic data). Community/anecdotal only: ~5-25 mg per day, oral. No validated or approved human dose exists. 6 studies View Profile ](/compound/9-mbc)[ ### Aniracetam Nootropics Approved (Italy) Aniracetam is a pyrrolidinone in the racetam family, developed by Hoffmann-La Roche under the code Ro 13-5057. t½ About half an hour for the parent drug in humans. Plasma elimination half-life was 0.47 to 0.49 hours after a single 400 mg oral dose in 20 healthy male volunteers (PMID: 19025058). Aniracetam is extensively metabolized to N-anisoyl-GABA and anisic acid; in six elderly hospitalized patients with cerebrovascular disease and reduced creatinine clearance, metabolite half-life was 4 to 7 times longer than in young volunteers (PMID: 9062694). Preclinical View Profile ](/compound/aniracetam)[ ### Bemethyl (bemitil) Nootropics Approved (Russia) Bemethyl, known in the Russian literature as bemitil and sold in the region under names including Metaprot, Bemactor and Antihot, is 2-ethylthiobenzimidazole, normally handled as the hydrobromide salt. t½ Not established in humans; in healthy volunteers given a single 250 mg oral dose of the Metaprot capsule form, peak serum ethylthiobenzimidazole averaged 0.91 microg/mL at about 1.06 h, and no terminal half-life was reported (PMID: 21870773) Preclinical View Profile ](/compound/bemethyl)[ ### Bromantane Nootropics Russia Approved Bromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten. 34 studies View Profile ](/compound/bromantane)[ ### Cyclazodone Nootropics Preclinical Cyclazodone is the N-cyclopropyl derivative of pemoline, a 4-oxazolidinone stimulant. Preclinical View Profile ](/compound/cyclazodone)[ ### Dihexa Nootropics Preclinical Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. t½ Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. 5 to 40 mg oral per day (anecdotal range; no established human dose) 1 studies View Profile ](/compound/dihexa) [ View Full Dosage Guide → Protocols, calculator & safety for Fladrafinil (CRL-40,941) ](/guides/dosage/fladrafinil) ### Best Price ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $74.99 [Buy Now](https://disguisedalpha.com/product/fladrafinil/?coupon=reddit) 1 vendors · 1 listings ### Research Score 30 0 PubMed studies ### Quality Indicators Data Completeness 63% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Studies Interactions Vendor Listings ### Quick Facts Half-Life Not established in humans; after a single 20 mg oral dose in six volunteers, urinary fladrafinil peaked at 2 to 4 h and stayed detectable for up to 12 h, while the metabolite flmodafinil was detectable for about 8 days and the acid and sulfone metabolites for about two weeks (PMID: 42210629) Molecular Weight 325.3 g/mol Administration Oral CAS Number 90212-80-9 Trial Phase Preclinical 0 [Full Dosage Guide](/guides/dosage/fladrafinil)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is Fladrafinil (CRL-40,941) used for in research? Fladrafinil, coded CRL-40,941, is the N-hydroxy analog of flmodafinil and the difluorinated counterpart of adrafinil. Flmodafinil was conceived at Laboratoire L. Lafon, the French company behind adrafinil and modafinil, and was never developed as a medicine (PMID: 30158846); the CRL-40,941 code of fladrafinil places it in the same series. Fladrafinil is sold today only as a research chemical or as an ingredient in unapproved supplements marketed for wakefulness and focus, and interest in it grew alongside the off-label use of modafinil as a cognitive enhancer (PMID: 27928893). Its pharmacology is best understood as prodrug chemistry. In a human administration study published in 2026, six volunteers each took a single 20 mg dose and gave urine and dried blood spot samples; fladrafinil was converted to flmodafinil, which was then oxidized to flmodafinil acid and flmodafinil sulfone, the same pattern adrafinil follows toward modafinil (PMID: 42210629). The activity therefore belongs mostly to flmodafinil rather than to the parent compound. For flmodafinil there is one useful animal study, published under the compound names lauflumide and NLS-4. In male C57BL/6J mice with EEG and EMG recording, an intraperitoneal dose of 64 mg/kg produced longer wakefulness than modafinil at 150 mg/kg, without hyperlocomotion and without rebound hypersomnia, and recovery sleep afterwards involved less non-REM sleep and less delta activity than after modafinil (PMID: 30158846). No comparable study exists for fladrafinil itself. Nothing about efficacy in people has been tested. The single human study measured concentrations and detection windows, not attention, wakefulness or performance (PMID: 42210629). For the class parent, positron emission tomography in ten healthy men showed that modafinil occupied dopamine transporters in caudate, putamen and nucleus accumbens and raised extracellular dopamine, a finding the authors linked to abuse potential (PMID: 19293415). Whether the fluorinated analogs behave the same way at the same exposures has not been measured in humans. Two practical points come out of the doping-control work. Product labels are unreliable: one supplement bought for that study was labeled at 50 mg/mL of flmodafinil and assayed at 95.7 mg/mL, close to double the stated content (PMID: 42210629). And anyone tested in sport should know that fladrafinil and flmodafinil were added to the 2026 World Anti-Doping Agency Prohibited List under class S6 stimulants and are prohibited in competition, with detection windows of up to a week for the parent compounds and about two weeks for the metabolites (PMID: 42210629). A retrospective screen of about 2000 in-competition samples collected in 2023 and 2024 found none of these compounds, so current use among tested athletes appears low. There is no FDA or EMA authorization for fladrafinil, no published safety trial, and no pregnancy, cardiac or hepatic data. It is a research-use-only compound in the US market, and the gap between what is claimed for it online and what has actually been measured is wide. What forms does Fladrafinil (CRL-40,941) come in? Fladrafinil (CRL-40,941) is available in liquid form. How much does Fladrafinil (CRL-40,941) cost? Prices start at $74.99 across 1 verified vendor. How do I compare Fladrafinil (CRL-40,941) vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### 9-Me-BC (9-Methyl-β-carboline) Nootropics Preclinical 9-Methyl--carboline (9-Me-BC) is a synthetic -carboline alkaloid that has drawn nootropic-community interest for a preclinical property that is genuinely unusual among -carbolines: in rodent and cell-culture studies it appears to stimulate the dopaminergic phenotype - raising tyrosine hydroxylase, the number of differentiated dopamine neurons and dopamine content - while also showing neuroprotective, neurorestorative and anti-inflammatory effects, plus in-vitro MAO-A/MAO-B inhibition \[PMID:17913302, PMID:20374418, PMID:32285253\]. t½ Not characterized in humans (no pharmacokinetic data). Community/anecdotal only: ~5-25 mg per day, oral. No validated or approved human dose exists. 6 studies View Profile ](/compound/9-mbc)[ ### Aniracetam Nootropics Approved (Italy) Aniracetam is a pyrrolidinone in the racetam family, developed by Hoffmann-La Roche under the code Ro 13-5057. t½ About half an hour for the parent drug in humans. Plasma elimination half-life was 0.47 to 0.49 hours after a single 400 mg oral dose in 20 healthy male volunteers (PMID: 19025058). Aniracetam is extensively metabolized to N-anisoyl-GABA and anisic acid; in six elderly hospitalized patients with cerebrovascular disease and reduced creatinine clearance, metabolite half-life was 4 to 7 times longer than in young volunteers (PMID: 9062694). Preclinical View Profile ](/compound/aniracetam)[ ### Bemethyl (bemitil) Nootropics Approved (Russia) Bemethyl, known in the Russian literature as bemitil and sold in the region under names including Metaprot, Bemactor and Antihot, is 2-ethylthiobenzimidazole, normally handled as the hydrobromide salt. t½ Not established in humans; in healthy volunteers given a single 250 mg oral dose of the Metaprot capsule form, peak serum ethylthiobenzimidazole averaged 0.91 microg/mL at about 1.06 h, and no terminal half-life was reported (PMID: 21870773) Preclinical View Profile ](/compound/bemethyl)[ ### Bromantane Nootropics Russia Approved Bromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten. 34 studies View Profile ](/compound/bromantane)[ ### Cyclazodone Nootropics Preclinical Cyclazodone is the N-cyclopropyl derivative of pemoline, a 4-oxazolidinone stimulant. Preclinical View Profile ](/compound/cyclazodone)[ ### Dihexa Nootropics Preclinical Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. t½ Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. 5 to 40 mg oral per day (anecdotal range; no established human dose) 1 studies View Profile ](/compound/dihexa) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-fladrafinil) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. 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