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title: "Eloralintide (LY3841136): Dosing &amp; Vendor Prices"
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# Eloralintide (LY3841136)

Weight Loss Phase 3 

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Also known as: LY3841136, LY-3841136, AT53786, Eloralintida 

Eloralintide is an amylin analog developed by Eli Lilly and Company for weight management, given as a once-weekly subcutaneous injection. It is a 37 amino acid peptide containing three non-coded residues and a C20 fatty diacid that binds albumin, which is what stretches its action out to a week (PMID: 41109426).

Half-Life:  Terminal geometric mean half-life 310 to 366 hours, that is 12.9 to 15.3 days, across the doses tested in the phase 1 single-ascending-dose study in humans (PMID: 41109426) Route:  Subcutaneous injection MW:  4526 g/mol CAS:  2883634-40-8 

Last reviewed: Sep 7, 2026 

[

Weight Loss

Category



](/wiki#cat-weight-loss)

Phase 3

Research Stage

OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices1 Related

## Overview

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### At A Glance

Mechanism 

Eloralintide is a selective agonist at the amylin 1 receptor, a complex formed by the calcitonin receptor with receptor activity-modifying protein 1. Activating that receptor in the area postrema and related hindbrain circuits promotes satiation, slows gastric emptying and suppre… 

Half-Life 

Terminal geometric mean half-life 310 to 366 hours, that is 12.9 to 15.3 days, across the doses tested in the phase 1 single-ascending-dose study in humans (PMID: 41109426)

Routes 

Subcutaneous injection 

Potential Benefits 

Mean body weight change from baseline of about 9 percent to 20 percent across dose groups at 48 weeks against 0.4 percent on placebo in a 263-patient phase 2 trial in adults with obesity or overweight (PMID: 41207310) Weight reduction of 2.6 percent to 11.3 percent across dose groups at 12 weeks in 100 adults with obesity or overweight in a phase 1 multiple-ascending-dose study (PMID: 41559929) Week 4 weight reduction of 2.5 percent and 4.4 percent after single doses in healthy participants against a 0.6 percent gain on placebo (PMID: 41109426) Dose-dependent reduction in food intake and body weight, mainly through fat mass loss, in diet-induced obese rats (PMID: 41109426) Significantly less conditioned taste avoidance than cagrilintide in lean rats, a marker of reduced aversive signaling (PMID: 41109426) 

### Overview

Eloralintide is an amylin analog developed by Eli Lilly and Company for weight management, given as a once-weekly subcutaneous injection. It is a 37 amino acid peptide containing three non-coded residues and a C20 fatty diacid that binds albumin, which is what stretches its action out to a week (PMID: 41109426). It is investigational everywhere. No regulator has approved it, and it is in phase 3 trials as of 2026. Amylin is a hormone released from pancreatic beta cells alongside insulin. It slows gastric emptying, suppresses glucagon after meals and signals meal termination through the brainstem. Pramlintide, the first approved amylin analog, proved the concept but was limited by frequent dosing and modest effect. The newer analogs split into two groups: dual amylin and calcitonin receptor agonists such as cagrilintide, and selective amylin receptor agonists. Eloralintide belongs to the second group. In cells expressing human receptors it activated the amylin 1 receptor about 12-fold more potently than the calcitonin receptor and about 11-fold more potently than the amylin 3 receptor (PMID: 41109426). That selectivity is the design idea, because calcitonin receptor engagement is thought to contribute to nausea. Preclinical results back this up. In lean rats, eloralintide produced significantly less conditioned taste avoidance than cagrilintide, a marker of aversive signaling. In diet-induced obese rats it reduced food intake and lowered body weight in a dose-dependent way, mostly through loss of fat mass, and pharmacokinetics in rats and monkeys supported weekly dosing (PMID: 41109426). The human data are what make this compound notable. A phase 1 single-ascending-dose study in 48 healthy participants reported mostly mild adverse events and week 4 weight reduction of 2.5 percent and 4.4 percent in the two highest single-dose groups against a 0.6 percent gain on placebo (NCT05295940, PMID: 41109426). A 12-week multiple-ascending-dose study in 100 participants with obesity or overweight, run without dose escalation, reported weight reduction across dose groups ranging from 2.6 percent to 11.3 percent, with decreased appetite in 19 percent, headache in 12 percent and fatigue in 11 percent, and infrequent gastrointestinal events: diarrhea in 10 percent, nausea in 8 percent and vomiting in 4 percent (PMID: 41559929). A 48-week phase 2 trial randomized 263 adults across six dose or dose-escalation arms and placebo and reported mean weight change from baseline of about 9 percent to 20 percent against 0.4 percent on placebo, with nausea and fatigue the most common adverse events (NCT06230523, PMID: 41207310). A network meta-analysis of six trials in 4642 adults ranked high-dose eloralintide second only to amycretin for percent body weight reduction, ahead of semaglutide, while noting that gastrointestinal adverse events rose with high doses of amylin-based therapies and that the evidence is still sparse and low certainty (PMID: 42175595). Anything sold outside a trial is not the studied product and has no verified identity or purity.

### Potential Research Fields

Obesity pharmacotherapy Amylin receptor pharmacology Metabolic disease Appetite regulation 

## Chemical Information

IUPAC Name

Not yet available 

CAS Number

2883634-40-8

Molecular Formula

C201H319N49O65S2

Molecular Mass

4526 g/mol

![Eloralintide (LY3841136) molecular structure](https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/175663130/PNG)

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## Interactions

### Contraindications

No labeled contraindications exist, since the drug is not approved. Trial-based and mechanism-based: the phase 2 program enrolled adults with obesity or overweight and excluded people outside those criteria, so nothing is known about use in people at a healthy weight. Because amylin receptor agonists slow gastric emptying, pre-existing gastroparesis or severe gastrointestinal disease is a mechanism-based reason for caution, and the ongoing program includes dedicated hepatic and renal impairment pharmacokinetic studies precisely because those populations have not been characterized (NCT07401862, NCT07426380). Pregnancy and breastfeeding have not been studied.

Research Disclaimer

This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.

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Current low

$179.99

as of Sep 7, 2026

7-day low

$179.99

30-day low

$179.99

30-day change

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baseline building

Tracking since Sep 7, 2026 · 1 data point

### Vendors Selling Eloralintide (LY3841136)

[

![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png)

#### Disguised Alpha

1 listing · from $179.99 





](/vendor/disguised-alpha)

How we score these vendors

Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.

[View Scorecard](/vendors/scorecard)

### Related Compounds

[View All](/wiki)

[

### 5-Amino-1MQ

Weight Loss Preclinical 

5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to form 1-methylnicotinamide (1-MNA) and S-adenosyl-L-homocysteine (SAH).

t½ ~6–12 hours (oral)  50 mg - 150 mg daily (oral or injection) 

Preclinical View Profile 

](/compound/5-amino-1mq)[

### BAM15

Weight Loss Preclinical 

BAM15 is a small-molecule mitochondrial protonophore uncoupler that was first described in 2014 as a tool compound for dissipating proton motive force selectively across the inner mitochondrial membrane without collapsing the plasma membrane electrochemical gradient (\[Kenwood et al., 2014\]).

Research compound — no established human doses. Animal studies use 10-100 mg/kg 

58 studies View Profile 

](/compound/bam15)[

### Exenatide

Weight Loss FDA-approved 

Exenatide (Byetta, Bydureon) is a synthetic exendin-4 GLP-1 receptor agonist, FDA-approved for type 2 diabetes, that lowers blood glucose and curbs appetite.

t½ Immediate-release (Byetta): terminal half-life about 2.4 hours, cleared mainly by the kidneys. Extended-release (Bydureon): the same peptide is released slowly from biodegradable microspheres over roughly 10 weeks, reaching steady-state plasma levels by about 6 to 7 weeks.  5 to 10 mcg twice daily (Byetta, immediate-release) or 2000 mcg (2 mg) once weekly (Bydureon, extended-release) 

Preclinical View Profile 

](/compound/exenatide)[

### L-Carnitine

Weight Loss Preclinical 

L-Carnitine is a naturally occurring quaternary ammonium compound synthesized in the body from the amino acids lysine and methionine, with essential cofactor roles in fatty acid metabolism, energy production, and cellular health.

500 mg - 2000 mg daily (oral or injection) 

23241 studies View Profile 

](/compound/l-carnitine)[

### Lipo-C

Weight Loss No clinical trials of the blend (marketed compounded injection) 

Lipo-C (also sold as a MIC or "lipotropic" injection) is a compounded blend of methionine, inositol, and choline, usually with vitamin B12 and sometimes L-carnitine, marketed by medspas and weight-loss clinics to support fat metabolism and energy.

t½ Not applicable to the blend; the water-soluble components (choline, inositol, B-vitamins, carnitine) are cleared over hours to a few days, and excess is largely excreted.  1 mL of a compounded MIC blend intramuscularly, 1 to 2x per week. No standardized dose exists; concentrations vary by compounding pharmacy. 

Preclinical View Profile 

](/compound/lipo-c)[

### Mazdutide

Weight Loss Approved (China, NMPA 2025); investigational in US/EU 

Mazdutide (also known as IBI362, Lilly compound LY3305677) is a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist originally discovered by Eli Lilly and exclusively licensed to Innovent Biologics in 2019 for development and commercialization in Mainland China, Hong Kong, Macau, and Taiwan.

Research doses — clinical trial protocols vary 

39 studies View Profile 

](/compound/mazdutide)

[

View Full Dosage Guide →

Protocols, calculator & safety for Eloralintide (LY3841136)



](/guides/dosage/eloralintide)

### Best Price

![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png)

Disguised Alpha

$179.99

[Buy Now](https://disguisedalpha.com/product/eloralintide/?coupon=reddit)

1 vendors · 1 listings

### Research Score

30 

0 PubMed studies

### Quality Indicators

Data Completeness

63% 

Description 

Mechanism of Action 

Chemical Data 

Dosing Protocols 

Safety Profile 

PubMed Studies 

Interactions 

Vendor Listings 

### Quick Facts

Half-Life

Terminal geometric mean half-life 310 to 366 hours, that is 12.9 to 15.3 days, across the doses tested in the phase 1 single-ascending-dose study in humans (PMID: 41109426)

Molecular Weight

4526 g/mol

Administration

Subcutaneous injection

CAS Number

2883634-40-8

Trial Phase

Phase 3

0

[Full Dosage Guide](/guides/dosage/eloralintide)[Calculate Your Dose](/tools/reconstitution)

Research Disclaimer

This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

## Frequently Asked Questions

What is Eloralintide (LY3841136) used for in research?

Eloralintide is an amylin analog developed by Eli Lilly and Company for weight management, given as a once-weekly subcutaneous injection. It is a 37 amino acid peptide containing three non-coded residues and a C20 fatty diacid that binds albumin, which is what stretches its action out to a week (PMID: 41109426). It is investigational everywhere. No regulator has approved it, and it is in phase 3 trials as of 2026.

Amylin is a hormone released from pancreatic beta cells alongside insulin. It slows gastric emptying, suppresses glucagon after meals and signals meal termination through the brainstem. Pramlintide, the first approved amylin analog, proved the concept but was limited by frequent dosing and modest effect. The newer analogs split into two groups: dual amylin and calcitonin receptor agonists such as cagrilintide, and selective amylin receptor agonists. Eloralintide belongs to the second group. In cells expressing human receptors it activated the amylin 1 receptor about 12-fold more potently than the calcitonin receptor and about 11-fold more potently than the amylin 3 receptor (PMID: 41109426). That selectivity is the design idea, because calcitonin receptor engagement is thought to contribute to nausea.

Preclinical results back this up. In lean rats, eloralintide produced significantly less conditioned taste avoidance than cagrilintide, a marker of aversive signaling. In diet-induced obese rats it reduced food intake and lowered body weight in a dose-dependent way, mostly through loss of fat mass, and pharmacokinetics in rats and monkeys supported weekly dosing (PMID: 41109426).

The human data are what make this compound notable. A phase 1 single-ascending-dose study in 48 healthy participants reported mostly mild adverse events and week 4 weight reduction of 2.5 percent and 4.4 percent in the two highest single-dose groups against a 0.6 percent gain on placebo (NCT05295940, PMID: 41109426). A 12-week multiple-ascending-dose study in 100 participants with obesity or overweight, run without dose escalation, reported weight reduction across dose groups ranging from 2.6 percent to 11.3 percent, with decreased appetite in 19 percent, headache in 12 percent and fatigue in 11 percent, and infrequent gastrointestinal events: diarrhea in 10 percent, nausea in 8 percent and vomiting in 4 percent (PMID: 41559929). A 48-week phase 2 trial randomized 263 adults across six dose or dose-escalation arms and placebo and reported mean weight change from baseline of about 9 percent to 20 percent against 0.4 percent on placebo, with nausea and fatigue the most common adverse events (NCT06230523, PMID: 41207310).

A network meta-analysis of six trials in 4642 adults ranked high-dose eloralintide second only to amycretin for percent body weight reduction, ahead of semaglutide, while noting that gastrointestinal adverse events rose with high doses of amylin-based therapies and that the evidence is still sparse and low certainty (PMID: 42175595). Anything sold outside a trial is not the studied product and has no verified identity or purity.

What forms does Eloralintide (LY3841136) come in?

Eloralintide (LY3841136) is available in vial form.

How much does Eloralintide (LY3841136) cost?

Prices start at $179.99 across 1 verified vendor.

How do I compare Eloralintide (LY3841136) vendors?

Compare prices, payment methods, shipping, and COA scores across 1 vendor.

## Research Tools

[

### Peptide Calculator

Reconstitution & syringe units



](/tools/reconstitution)[

### Reconstitution Guide

How to mix, step by step



](/guides/how-to-reconstitute-peptides)[

### Nasal Spray Calc

mL per actuation



](/tools/intranasal)[

### Half-Life Visualizer

Decay curves



](/tools/halflife)

## Related Compounds

[View All](/wiki)

[

### 5-Amino-1MQ

Weight Loss Preclinical 

5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to form 1-methylnicotinamide (1-MNA) and S-adenosyl-L-homocysteine (SAH).

t½ ~6–12 hours (oral)  50 mg - 150 mg daily (oral or injection) 

Preclinical View Profile 

](/compound/5-amino-1mq)[

### BAM15

Weight Loss Preclinical 

BAM15 is a small-molecule mitochondrial protonophore uncoupler that was first described in 2014 as a tool compound for dissipating proton motive force selectively across the inner mitochondrial membrane without collapsing the plasma membrane electrochemical gradient (\[Kenwood et al., 2014\]).

Research compound — no established human doses. Animal studies use 10-100 mg/kg 

58 studies View Profile 

](/compound/bam15)[

### Exenatide

Weight Loss FDA-approved 

Exenatide (Byetta, Bydureon) is a synthetic exendin-4 GLP-1 receptor agonist, FDA-approved for type 2 diabetes, that lowers blood glucose and curbs appetite.

t½ Immediate-release (Byetta): terminal half-life about 2.4 hours, cleared mainly by the kidneys. Extended-release (Bydureon): the same peptide is released slowly from biodegradable microspheres over roughly 10 weeks, reaching steady-state plasma levels by about 6 to 7 weeks.  5 to 10 mcg twice daily (Byetta, immediate-release) or 2000 mcg (2 mg) once weekly (Bydureon, extended-release) 

Preclinical View Profile 

](/compound/exenatide)[

### L-Carnitine

Weight Loss Preclinical 

L-Carnitine is a naturally occurring quaternary ammonium compound synthesized in the body from the amino acids lysine and methionine, with essential cofactor roles in fatty acid metabolism, energy production, and cellular health.

500 mg - 2000 mg daily (oral or injection) 

23241 studies View Profile 

](/compound/l-carnitine)[

### Lipo-C

Weight Loss No clinical trials of the blend (marketed compounded injection) 

Lipo-C (also sold as a MIC or "lipotropic" injection) is a compounded blend of methionine, inositol, and choline, usually with vitamin B12 and sometimes L-carnitine, marketed by medspas and weight-loss clinics to support fat metabolism and energy.

t½ Not applicable to the blend; the water-soluble components (choline, inositol, B-vitamins, carnitine) are cleared over hours to a few days, and excess is largely excreted.  1 mL of a compounded MIC blend intramuscularly, 1 to 2x per week. No standardized dose exists; concentrations vary by compounding pharmacy. 

Preclinical View Profile 

](/compound/lipo-c)[

### Mazdutide

Weight Loss Approved (China, NMPA 2025); investigational in US/EU 

Mazdutide (also known as IBI362, Lilly compound LY3305677) is a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist originally discovered by Eli Lilly and exclusively licensed to Innovent Biologics in 2019 for development and commercialization in Mainland China, Hong Kong, Macau, and Taiwan.

Research doses — clinical trial protocols vary 

39 studies View Profile 

](/compound/mazdutide)

Free 2026 Peptide Cheat Sheet — 50 pages, PDF

Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one.

[Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-eloralintide)

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