--- title: "Dihexa: Dosing & Vendor Prices | BodyHackGuide" url: https://www.bodyhackguide.co/compound/dihexa description: "Dihexa: dosing protocols, mechanism & side effects, 1 PubMed result. Compare 1 current vendor prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Image: Dihexa molecular structure (https://www.bodyhackguide.co/assets/peptide-structure-placeholder-DUmZBF_j.png) # Dihexa Nootropics (https://www.bodyhackguide.co/wiki#cat-nootropics)Preclinical Also known as: PNB-0408 Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models — reportedly 7 orders of magnitude more potent than BDNF at improving cognitive performance in rodent Alzheimer's models. Image: Disguised Alpha logo (https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Lowest price per mg $0.283/mg $84.99 for 300mg at Disguised Alpha Buy at Disguised Alpha: https://disguisedalpha.com/product/dihexa/?coupon=reddit Half-life: Not characterized in humans Route: Oral, Intranasal, Subcutaneous MW: 504.7 g/mol CAS: 1191170-93-0 1 PubMed result (https://pubmed.ncbi.nlm.nih.gov/?term=dihexa%20HGF%20c-Met%20synaptogenesis%20cognitive) Last reviewed: May 4, 2026 ## Overview ### At A Glance Mechanism Dihexa is a small-molecule analog derived from angiotensin IV (AngIV). It retains the Tyr-Ile core of Nle1-AngIV, with an N-terminal hexanoic acid cap and a C-terminal 6-aminohexanoic amide that give it metabolic stability and blood-brain-barrier penetration. In rodent studies it… Half-Life Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. Dosing Once daily (oral), typically in the morning Dose Range 5 to 40 mg oral per day (anecdotal range; no established human dose) Routes Oral Intranasal Subcutaneous Common Vials 50mg 100mg Potential Benefits Synaptogenesis: formation of new dendritic spines and functional synapses (preclinical) Memory and spatial-learning support in rodent models Potential research application in Alzheimer's and other neurodegenerative disease models HGF/c-Met and PI3K/Akt-linked neuroplasticity (mechanism proposed; key paper retracted) Safety Notes Common No controlled human safety data exists Anecdotal: headache, fatigue, irritability or anxiety, insomnia, vivid dreams ### Overview Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models — reportedly 7 orders of magnitude more potent than BDNF at improving cognitive performance in rodent Alzheimer's models. Exclusively used by the research and biohacking community with no human clinical trial data available. ### Potential Research Fields Alzheimer's disease Cognitive impairment Synaptogenesis Neurodegeneration ### What to Expect - • No human efficacy data exists, so any effect in people is anecdotal and unverified - • Anecdotal users describe subtle improvements in mental clarity or verbal fluency over days to weeks; these reports are unblinded and unreliable - • Effects, if any, are attributed to synaptic remodeling rather than acute stimulation - • Because safety is unstudied, treat any use as a personal experiment with unknown long-term risk Individual responses vary. Timeline based on commonly reported research observations. ## Chemical Information IUPAC Name N-hexanoic-Tyr-Ile-(6) aminohexanoic amide CAS Number 1191170-93-0 Molecular Formula C27H44N4O5 Molecular Mass 504.7 g/mol Image: Dihexa molecular structure (https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/44/PNG?image_size=300x300) View on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/129010512 Amino Acid Sequence N-hexanoyl-Tyr-Ile-(6)-aminohexanoic amide: a modified dipeptide derivative of angiotensin IV. It retains the Tyr-Ile core of Nle1-AngIV, capped at the N-terminus with hexanoic acid and at the C-terminus with a 6-aminohexanoic acid amide. Not a standard translatable peptide sequence. CAS 1401708-83-5; molecular formula C27H44N4O5. ## Dosing & Protocols ### Unlock the dosing protocols Enter your email to keep reading. It is free, and it opens these tabs on every compound page in this browser. - Dose, route, how often and how long - A titration schedule - Beginner, intermediate and advanced protocols - Reconstitution and handling notes You also get the free peptide cheat sheet by email. Unsubscribe anytime. Have an account? Sign in (https://www.bodyhackguide.co/auth) ## Research ### Unlock the research summary - A summary of the key research - Safety and side effects - A link to the PubMed results ## Interactions ### Interaction Matrix ### Contraindications Active cancer or a personal history of cancer (HGF/c-Met is an oncogenic pathway); do not use without oncologist oversight. Pregnancy or breastfeeding. History of seizures. Active neurodegenerative disease (unstudied interaction). Concurrent use of other potent nootropics without careful titration. When in doubt, do not use; there is no human safety data. Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $79.99 up to $99.99 Best $/mg $0.2833 Vendors 1 Listings 3 nasal, liquid Form Sort | Vendor | Product | Form | Qty | Price | $/mg | Coupon | | | --- | --- | --- | --- | --- | --- | --- | --- | | Image: Disguised Alpha logo (https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha (https://www.bodyhackguide.co/vendors/disguised-alpha) 50: https://www.bodyhackguide.co/vendor-trust-scorecard 🇺🇸 US 🇪🇺 EU 🇬🇧 UK | Dihexa Aerosol Spray | nasal | spray ● In Stock | $79.99 BEST | — | — | Buy: https://disguisedalpha.com/product/dihexaaerosol/?coupon=reddit | | Image: Disguised Alpha logo (https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha (https://www.bodyhackguide.co/vendors/disguised-alpha) 50: https://www.bodyhackguide.co/vendor-trust-scorecard 🇺🇸 US 🇪🇺 EU 🇬🇧 UK | Dihexa 10 mg/mL | liquid | 30 mL (10 mg/mL) ● In Stock | $84.99 VALUE | $0.283 | — | Buy: https://disguisedalpha.com/product/dihexa/?coupon=reddit | | Image: Disguised Alpha logo (https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha (https://www.bodyhackguide.co/vendors/disguised-alpha) 50: https://www.bodyhackguide.co/vendor-trust-scorecard 🇺🇸 US 🇪🇺 EU 🇬🇧 UK | Energize (Dihexa / Semax / Selank) Aerosol Spray | nasal | spray ● In Stock | $99.99 | — | — | Buy: https://disguisedalpha.com/product/dihexa-semax-selank-aerosol-spray/?coupon=reddit | ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Dihexa. Current low $79.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet Tracking since Sep 5, 2026 · 3 data points ### Vendors Selling Dihexa #### Disguised Alpha 3 listings · from $79.99 https://www.bodyhackguide.co/vendors/disguised-alpha How we score these vendors Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. View Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ### Related Compounds View All (https://www.bodyhackguide.co/wiki) ### 9-Me-BC (9-Methyl-β-carboline) Nootropics Preclinical 9-Methyl--carboline (9-Me-BC) is a synthetic -carboline alkaloid that has drawn nootropic-community interest for a preclinical property that is genuinely unusual among -carbolines: in rodent and cell-culture studies it appears to stimulate the dopaminergic phenotype - raising tyrosine hydroxylase, the number of differentiated dopamine neurons and dopamine content - while also showing neuroprotective, neurorestorative and anti-inflammatory effects, plus in-vitro MAO-A/MAO-B inhibition [PMID:17913302, PMID:20374418, PMID:32285253]. t½ Not characterized in humans (no pharmacokinetic data). Community/anecdotal only: ~5-25 mg per day, oral. No validated or approved human dose exists. 6 PubMed View Profile https://www.bodyhackguide.co/compound/9-mbc ### Aniracetam Nootropics Approved (Italy) Aniracetam is a pyrrolidinone in the racetam family, developed by Hoffmann-La Roche under the code Ro 13-5057. t½ About half an hour for the parent drug in humans. Plasma elimination half-life was 0.47 to 0.49 hours after a single 400 mg oral dose in 20 healthy male volunteers (PMID: 19025058). Aniracetam is extensively metabolized to N-anisoyl-GABA and anisic acid; in six elderly hospitalized patients with cerebrovascular disease and reduced creatinine clearance, metabolite half-life was 4 to 7 times longer than in young volunteers (PMID: 9062694). Preclinical View Profile https://www.bodyhackguide.co/compound/aniracetam ### Bemethyl (bemitil) Nootropics Approved (Russia) Bemethyl, known in the Russian literature as bemitil and sold in the region under names including Metaprot, Bemactor and Antihot, is 2-ethylthiobenzimidazole, normally handled as the hydrobromide salt. t½ Not established in humans; in healthy volunteers given a single 250 mg oral dose of the Metaprot capsule form, peak serum ethylthiobenzimidazole averaged 0.91 microg/mL at about 1.06 h, and no terminal half-life was reported (PMID: 21870773) Preclinical View Profile https://www.bodyhackguide.co/compound/bemethyl ### Bromantane Nootropics Russia Approved Bromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten. 34 PubMed View Profile https://www.bodyhackguide.co/compound/bromantane ### Cyclazodone Nootropics Preclinical Cyclazodone is the N-cyclopropyl derivative of pemoline, a 4-oxazolidinone stimulant. Preclinical View Profile https://www.bodyhackguide.co/compound/cyclazodone ### Fasoracetam (NS-105) Nootropics Phase 2 Fasoracetam is a racetam developed by Nippon Shinyaku in Japan under the code NS-105 and taken into clinical development for vascular dementia. t½ Mean terminal half-life 4.82 hours, range 4.06 to 6.99 hours, after single oral doses in adolescents aged 12 to 17, with the drug excreted for the most part unchanged through the kidneys (PMID: 29339723). After intravenous dosing in animals, elimination half-life was 0.67 hours in rats, 2.1 hours in dogs and 1.3 hours in monkeys, with high systemic availability after oral dosing in all three species (PMID: 10604039). Preclinical View Profile https://www.bodyhackguide.co/compound/fasoracetam ### Side-by-Side Comparisons All Comparisons (https://www.bodyhackguide.co/compare) Dihexa vs Noopept: https://www.bodyhackguide.co/compare/dihexa-vs-noopept View Full Dosage Guide → Protocols, calculator & safety for Dihexa https://www.bodyhackguide.co/guides/dosage/dihexa ### Related Articles All Posts (https://www.bodyhackguide.co/blog) #### Cognitive Enhancers by Mechanism and Safety: A Reference Guide A mechanism-first reference that groups cognitive enhancers into seven pharmacological classes and compares each on how it works and its main safety consideration, with a master table and honest evidence labels. Not a ranking, and not medical advice. 7/1/2026 https://www.bodyhackguide.co/blog/cognitive-enhancers-by-mechanism-and-safety ### Lowest Price per mg Disguised Alpha $84.99($0.283/mg) 1 vendor · 3 listings ### Research Score 60 1 PubMed result ### Quality Indicators Data Completeness 100% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Results Interactions Vendor Listings Research Volume 1 PubMed results Limited research available ### Quick Facts Half-Life Molecular Weight 504.7 g/mol Administration Oral, Intranasal, Subcutaneous CAS Number 1191170-93-0 Trial Phase Preclinical ### Safety Profile Moderate Risk Common Side Effects - • No controlled human safety data exists - • Anecdotal: headache, fatigue, irritability or anxiety, insomnia, vivid dreams Stop Use If - CRITICAL: active cancer or cancer history; HGF/c-Met is a known oncogenic pathway; do not use without medical supervision - New or worsening neurological symptoms such as severe headache, mood change, or seizure Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions Is Dihexa approved or proven to work in humans? No. Dihexa has never been through a human clinical trial. All evidence is from rodent studies, and it is sold only for research use. Any human use is experimental and unproven. How does Dihexa work? In animal studies it promotes the growth of new synapses in the hippocampus. Its proposed mechanism is potentiation of the HGF/c-Met system with downstream PI3K/Akt signaling, but the main paper establishing the HGF/c-Met binding target was retracted in 2025, so the exact target is unconfirmed. What is the biggest safety concern with Dihexa? The HGF/c-Met pathway it targets is also involved in tumor growth and metastasis, which creates a theoretical cancer risk with long-term use. Anyone with active or prior cancer should avoid it, and no one should assume it is safe, because there is no human safety data. What doses do people use? There is no established human dose. Anecdotal oral use ranges from about 5 to 40 mg once daily in short cycles. These figures are community-derived, not evidence-based. Is Dihexa the same as Athira's Alzheimer's drug? No. Athira Pharma (formerly M3 Biotechnology) grew out of the same Washington State University HGF/c-Met research, but its clinical candidate fosgonimeton (ATH-1017) is a different molecule. Dihexa itself remained preclinical. ## Research Tools ### Peptide Calculator Reconstitution & syringe units https://www.bodyhackguide.co/tools/reconstitution ### Reconstitution Guide How to mix, step by step https://www.bodyhackguide.co/guides/how-to-reconstitute-peptides ### Nasal Spray Calc mL per actuation https://www.bodyhackguide.co/tools/intranasal ### Half-Life Visualizer Decay curves https://www.bodyhackguide.co/tools/halflife ## Related Compounds ### 9-Me-BC (9-Methyl-β-carboline) Nootropics Preclinical ### Aniracetam Nootropics Approved (Italy) ### Bemethyl (bemitil) Nootropics Approved (Russia) ### Bromantane Nootropics Russia Approved ### Cyclazodone Nootropics Preclinical ### Fasoracetam (NS-105) Nootropics Phase 2 ## Side-by-Side Comparisons Compare Dihexa head-to-head: mechanism, half-life, dosing, safety, and vendor prices. Free 2026 Peptide Cheat Sheet (PDF) 38 compounds and blends: vial sizes, BAC water volumes, dosing ranges and bloodwork markers. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. Image: BodyHackGuide (https://www.bodyhackguide.co/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide #### Explore - Compare prices: https://www.bodyhackguide.co/compare - Vendors: https://www.bodyhackguide.co/vendors - Deals: https://www.bodyhackguide.co/deals - Coupons: https://www.bodyhackguide.co/coupons - Nootropics: https://www.bodyhackguide.co/nootropics - Brain health: https://www.bodyhackguide.co/brain-health - Blog: https://www.bodyhackguide.co/blog - Guides: https://www.bodyhackguide.co/guides #### Tools - Reconstitution: https://www.bodyhackguide.co/tools/reconstitution - Half-life visualizer: https://www.bodyhackguide.co/tools/halflife - COA reader: https://www.bodyhackguide.co/tools/coa - Cost calculator: https://www.bodyhackguide.co/tools/cost-calculator - Stack builder: https://www.bodyhackguide.co/stack-builder - All tools: https://www.bodyhackguide.co/tools #### Trust & vendors - Vendor directory: https://www.bodyhackguide.co/vendors - Trust scorecard: https://www.bodyhackguide.co/vendors/scorecard - Vendor trust badge: https://www.bodyhackguide.co/vendors/get-vetted - Scoring methodology: https://www.bodyhackguide.co/vendors/methodology - Peptide cheat sheet: https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download #### Company - About: https://www.bodyhackguide.co/about - Affiliate disclosure: https://www.bodyhackguide.co/affiliate-disclosure - Editorial standards: https://www.bodyhackguide.co/editorial-standards - Creators: https://www.bodyhackguide.co/creators - Coaches: https://www.bodyhackguide.co/coaches - 1-on-1 coaching: https://www.bodyhackguide.co/coaching - Privacy: https://www.bodyhackguide.co/privacy - Terms: https://www.bodyhackguide.co/terms - Full site directory: https://www.bodyhackguide.co/site-directory **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology), and we earn a commission from purchases made through some of our links at no extra cost to you. Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. 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