--- title: "Diisopropylamine dichloroacetate (DADA): Dosing & Vendor" description: "Diisopropylamine dichloroacetate (DADA): dosing protocols, mechanism & side effects. Compare 1 verified vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Diisopropylamine dichloroacetate (DADA)" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "Diisopropylamine dichloroacetate (DADA)", "description": "DADA is the abbreviation the research chemical market uses for diisopropylamine dichloroacetate, the diisopropylamine salt of dichloroacetic acid, CAS 660-27-5. The abbreviation is ambiguous in scientific writing, where DADA also stands for unrelated things, so identity is worth confirming by CAS number or molecular formula rather than by name. The compound itself is old. It has been marketed in Japan for decades as Liverall, where it holds a Japanese Accepted Name, sits in Japanese therapeutic category 3919 as a liver function improving agent and is classified as a third-class over-the-counter drug (KEGG DRUG D01816). It has also been sold under names such as dipromonium and kalodil, and in the supplement trade under the label vitamin B15 or pangamic acid, which is a marketing term rather than a vitamin classification. Its pharmacology comes from the dichloroacetate half of the salt. Dichloroacetate inhibits pyruvate dehydrogenase kinase, which leaves the pyruvate dehydrogenase complex in its active state, so pyruvate is directed toward acetyl-CoA and the citric acid cycle instead of being reduced to lactate. In a mouse model of severe influenza, DADA was characterized specifically as a pyruvate dehydrogenase kinase 4 inhibitor that restored pyruvate dehydrogenase activity and improved the metabolic disorder and multiorgan failure seen in that model (PMID: 24865588). Most recent work is oncology and immunology, and all of it is preclinical. DADA increased radiosensitivity in esophageal squamous cell carcinoma cells and xenografts by raising mitochondria-derived reactive oxygen species (PMID: 27626688). It outperformed sodium dichloroacetate in a subcutaneous mouse breast tumor transplantation model (PMID: 27582548), showed antitumor activity alone and combined with chemotherapy, radiotherapy or immunotherapy in non-small cell lung cancer models (PMID: 39267851), and acted synergistically with fenbendazole in A549 cells and in nude mice (PMID: 39477286, PMID: 40799435). A 2026 study reported that DADA drives the same metabolic shift inside CD8 T cells, raising oxidative phosphorylation and mitochondrial fitness, increasing progenitor exhausted T cells in mouse tumors and improving the effect of PD-1 blockade (PMID: 41758776). The human record is the weak part. The Japanese approval for chronic liver conditions long predates modern trial reporting standards, and no randomized controlled trial of DADA for any indication was found in the indexed literature. That leaves an unusual position: a compound with a genuine national approval, a clear biochemical mechanism and a growing preclinical oncology file, but no modern efficacy or safety trial that can be quoted. What is sold in capsules on the research chemical market is not the Japanese pharmaceutical product, and no FDA or EMA authorization exists. It is a research-use-only compound in the US market, and the tumor and immunology findings above are mouse and cell line results that have never been tested in people.", "url": "https://www.bodyhackguide.co/compound/dada", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "79.99", "highPrice": "79.99", "priceCurrency": "USD", "offerCount": "1", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "79.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://disguisedalpha.com/product/dada/?coupon=reddit", "seller": { "@type": "Organization", "name": "Disguised Alpha", "url": "https://disguisedalpha.com/?coupon=reddit" } } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Diisopropylamine dichloroacetate (DADA)", "description": "DADA is the abbreviation the research chemical market uses for diisopropylamine dichloroacetate, the diisopropylamine salt of dichloroacetic acid, CAS 660-27-5. The abbreviation is ambiguous in scientific writing, where DADA also stands for unrelated things, so identity is worth confirming by CAS number or molecular formula rather than by name. The compound itself is old. It has been marketed in Japan for decades as Liverall, where it holds a Japanese Accepted Name, sits in Japanese therapeutic category 3919 as a liver function improving agent and is classified as a third-class over-the-counter drug (KEGG DRUG D01816). It has also been sold under names such as dipromonium and kalodil, and in the supplement trade under the label vitamin B15 or pangamic acid, which is a marketing term rather than a vitamin classification. Its pharmacology comes from the dichloroacetate half of the salt. Dichloroacetate inhibits pyruvate dehydrogenase kinase, which leaves the pyruvate dehydrogenase complex in its active state, so pyruvate is directed toward acetyl-CoA and the citric acid cycle instead of being reduced to lactate. In a mouse model of severe influenza, DADA was characterized specifically as a pyruvate dehydrogenase kinase 4 inhibitor that restored pyruvate dehydrogenase activity and improved the metabolic disorder and multiorgan failure seen in that model (PMID: 24865588). Most recent work is oncology and immunology, and all of it is preclinical. DADA increased radiosensitivity in esophageal squamous cell carcinoma cells and xenografts by raising mitochondria-derived reactive oxygen species (PMID: 27626688). It outperformed sodium dichloroacetate in a subcutaneous mouse breast tumor transplantation model (PMID: 27582548), showed antitumor activity alone and combined with chemotherapy, radiotherapy or immunotherapy in non-small cell lung cancer models (PMID: 39267851), and acted synergistically with fenbendazole in A549 cells and in nude mice (PMID: 39477286, PMID: 40799435). A 2026 study reported that DADA drives the same metabolic shift inside CD8 T cells, raising oxidative phosphorylation and mitochondrial fitness, increasing progenitor exhausted T cells in mouse tumors and improving the effect of PD-1 blockade (PMID: 41758776). The human record is the weak part. The Japanese approval for chronic liver conditions long predates modern trial reporting standards, and no randomized controlled trial of DADA for any indication was found in the indexed literature. That leaves an unusual position: a compound with a genuine national approval, a clear biochemical mechanism and a growing preclinical oncology file, but no modern efficacy or safety trial that can be quoted. What is sold in capsules on the research chemical market is not the Japanese pharmaceutical product, and no FDA or EMA authorization exists. It is a research-use-only compound in the US market, and the tumor and immunology findings above are mouse and cell line results that have never been tested in people.", "lastReviewed": "2026-09-07T04:46:52.359Z", "url": "https://www.bodyhackguide.co/compound/dada", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "Diisopropylamine dichloroacetate (DADA)", "alternateName": [ "DADA", "Diisopropylammonium dichloroacetate", "Liverall", "Dipromonium", "Kalodil", "Vitamin B15 (market label)" ], "description": "DADA is the abbreviation the research chemical market uses for diisopropylamine dichloroacetate, the diisopropylamine salt of dichloroacetic acid, CAS 660-27-5. The abbreviation is ambiguous in scientific writing, where DADA also stands for unrelated things, so identity is worth confirming by CAS number or molecular formula rather than by name. The compound itself is old. It has been marketed in Japan for decades as Liverall, where it holds a Japanese Accepted Name, sits in Japanese therapeutic category 3919 as a liver function improving agent and is classified as a third-class over-the-counter drug (KEGG DRUG D01816). It has also been sold under names such as dipromonium and kalodil, and in the supplement trade under the label vitamin B15 or pangamic acid, which is a marketing term rather than a vitamin classification. Its pharmacology comes from the dichloroacetate half of the salt. Dichloroacetate inhibits pyruvate dehydrogenase kinase, which leaves the pyruvate dehydrogenase complex in its active state, so pyruvate is directed toward acetyl-CoA and the citric acid cycle instead of being reduced to lactate. In a mouse model of severe influenza, DADA was characterized specifically as a pyruvate dehydrogenase kinase 4 inhibitor that restored pyruvate dehydrogenase activity and improved the metabolic disorder and multiorgan failure seen in that model (PMID: 24865588). Most recent work is oncology and immunology, and all of it is preclinical. DADA increased radiosensitivity in esophageal squamous cell carcinoma cells and xenografts by raising mitochondria-derived reactive oxygen species (PMID: 27626688). It outperformed sodium dichloroacetate in a subcutaneous mouse breast tumor transplantation model (PMID: 27582548), showed antitumor activity alone and combined with chemotherapy, radiotherapy or immunotherapy in non-small cell lung cancer models (PMID: 39267851), and acted synergistically with fenbendazole in A549 cells and in nude mice (PMID: 39477286, PMID: 40799435). A 2026 study reported that DADA drives the same metabolic shift inside CD8 T cells, raising oxidative phosphorylation and mitochondrial fitness, increasing progenitor exhausted T cells in mouse tumors and improving the effect of PD-1 blockade (PMID: 41758776). The human record is the weak part. The Japanese approval for chronic liver conditions long predates modern trial reporting standards, and no randomized controlled trial of DADA for any indication was found in the indexed literature. That leaves an unusual position: a compound with a genuine national approval, a clear biochemical mechanism and a growing preclinical oncology file, but no modern efficacy or safety trial that can be quoted. What is sold in capsules on the research chemical market is not the Japanese pharmaceutical product, and no FDA or EMA authorization exists. It is a research-use-only compound in the US market, and the tumor and immunology findings above are mouse and cell line results that have never been tested in people.", "activeIngredient": "Diisopropylamine dichloroacetate (DADA)", "administrationRoute": "Oral, Intraperitoneal injection (animal studies)", "mechanismOfAction": "DADA is the diisopropylamine salt of dichloroacetic acid and acts through the dichloroacetate moiety as an inhibitor of pyruvate dehydrogenase kinase. Inhibiting that kinase leaves the pyruvate dehydrogenase complex in its active dephosphorylated state, so pyruvate is converted to acetyl-CoA and enters the citric acid cycle rather than being reduced to lactate, shifting cells from glycolysis toward oxidative phosphorylation. In a mouse model of severe influenza, DADA was characterized specifically as a pyruvate dehydrogenase kinase 4 inhibitor that restored pyruvate dehydrogenase activity and corrected the associated metabolic disorder (PMID: 24865588). In mouse tumor models the same metabolic shift raised oxidative phosphorylation and mitochondrial fitness inside CD8 T cells and increased the stem-like progenitor exhausted subset (PMID: 41758776).", "dosageForm": "capsule", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Diisopropylamine dichloroacetate (DADA) used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "DADA is the abbreviation the research chemical market uses for diisopropylamine dichloroacetate, the diisopropylamine salt of dichloroacetic acid, CAS 660-27-5. The abbreviation is ambiguous in scientific writing, where DADA also stands for unrelated things, so identity is worth confirming by CAS number or molecular formula rather than by name. The compound itself is old. It has been marketed in Japan for decades as Liverall, where it holds a Japanese Accepted Name, sits in Japanese therapeutic category 3919 as a liver function improving agent and is classified as a third-class over-the-counter drug (KEGG DRUG D01816). It has also been sold under names such as dipromonium and kalodil, and in the supplement trade under the label vitamin B15 or pangamic acid, which is a marketing term rather than a vitamin classification. Its pharmacology comes from the dichloroacetate half of the salt. Dichloroacetate inhibits pyruvate dehydrogenase kinase, which leaves the pyruvate dehydrogenase complex in its active state, so pyruvate is directed toward acetyl-CoA and the citric acid cycle instead of being reduced to lactate. In a mouse model of severe influenza, DADA was characterized specifically as a pyruvate dehydrogenase kinase 4 inhibitor that restored pyruvate dehydrogenase activity and improved the metabolic disorder and multiorgan failure seen in that model (PMID: 24865588). Most recent work is oncology and immunology, and all of it is preclinical. DADA increased radiosensitivity in esophageal squamous cell carcinoma cells and xenografts by raising mitochondria-derived reactive oxygen species (PMID: 27626688). It outperformed sodium dichloroacetate in a subcutaneous mouse breast tumor transplantation model (PMID: 27582548), showed antitumor activity alone and combined with chemotherapy, radiotherapy or immunotherapy in non-small cell lung cancer models (PMID: 39267851), and acted synergistically with fenbendazole in A549 cells and in nude mice (PMID: 39477286, PMID: 40799435). A 2026 study reported that DADA drives the same metabolic shift inside CD8 T cells, raising oxidative phosphorylation and mitochondrial fitness, increasing progenitor exhausted T cells in mouse tumors and improving the effect of PD-1 blockade (PMID: 41758776). The human record is the weak part. The Japanese approval for chronic liver conditions long predates modern trial reporting standards, and no randomized controlled trial of DADA for any indication was found in the indexed literature. That leaves an unusual position: a compound with a genuine national approval, a clear biochemical mechanism and a growing preclinical oncology file, but no modern efficacy or safety trial that can be quoted. What is sold in capsules on the research chemical market is not the Japanese pharmaceutical product, and no FDA or EMA authorization exists. It is a research-use-only compound in the US market, and the tumor and immunology findings above are mouse and cell line results that have never been tested in people." } }, { "@type": "Question", "name": "What forms does Diisopropylamine dichloroacetate (DADA) come in?", "acceptedAnswer": { "@type": "Answer", "text": "Diisopropylamine dichloroacetate (DADA) is available in capsule form." } }, { "@type": "Question", "name": "How much does Diisopropylamine dichloroacetate (DADA) cost?", "acceptedAnswer": { "@type": "Answer", "text": "Prices start at $79.99 across 1 verified vendor." } }, { "@type": "Question", "name": "How do I compare Diisopropylamine dichloroacetate (DADA) vendors?", "acceptedAnswer": { "@type": "Answer", "text": "Compare prices, payment methods, shipping, and COA scores across 1 vendor." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. 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Diisopropylamine dichloroacetate (DADA) [Where to buy Diisopropylamine dichloroacetate (DADA)](/buy/dada) [Diisopropylamine dichloroacetate (DADA) coupon codes](/coupons/dada) [Diisopropylamine dichloroacetate (DADA) protocol](/protocol/dada) [Alternatives to Diisopropylamine dichloroacetate (DADA)](/alternatives-to/dada) [Diisopropylamine dichloroacetate (DADA) side effects](/side-effects/dada) 1. [Home](/) 3. [Compounds](/compare) 5. Diisopropylamine dichloroacetate (DADA) ![Diisopropylamine dichloroacetate (DADA) molecular structure](/assets/peptide-structure-placeholder-DUmZBF_j.png) # Diisopropylamine dichloroacetate (DADA) Other Approved (Japan) Download PDF Also known as: DADA, Diisopropylammonium dichloroacetate, Liverall, Dipromonium, Kalodil, Vitamin B15 (market label) DADA is the abbreviation the research chemical market uses for diisopropylamine dichloroacetate, the diisopropylamine salt of dichloroacetic acid, CAS 660-27-5. The abbreviation is ambiguous in scientific writing, where DADA also stands for unrelated things, so identity is worth confirming by CAS number or molecular formula rather than by name. Route: Oral, Intraperitoneal injection (animal studies) MW: 230.13 g/mol CAS: 660-27-5 Last reviewed: Sep 7, 2026 [ Other Category ](/wiki#cat-other) Approved (Japan) Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices1 Related ## Overview ### Best Price Available ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $79.99 1 bottle (200 mg capsules) · capsule [Buy Now](https://disguisedalpha.com/product/dada/?coupon=reddit) Compare 1 vendor ### At A Glance Mechanism DADA is the diisopropylamine salt of dichloroacetic acid and acts through the dichloroacetate moiety as an inhibitor of pyruvate dehydrogenase kinase. Inhibiting that kinase leaves the pyruvate dehydrogenase complex in its active dephosphorylated state, so pyruvate is converted t… Routes Oral Intraperitoneal injection (animal studies) Potential Benefits Improved metabolic disorder and multiorgan failure in mice with severe influenza, attributed to restored pyruvate dehydrogenase activity (PMID: 24865588) Increased oxidative phosphorylation and accumulation of stem-like progenitor exhausted CD8 T cells in mouse tumors, improving the effect of PD-1 blockade (PMID: 41758776) Radiosensitization of esophageal squamous cell carcinoma cells and xenografts through higher mitochondria-derived reactive oxygen species (PMID: 27626688) Greater tumor growth inhibition than sodium dichloroacetate in a subcutaneous mouse breast tumor transplantation model (PMID: 27582548) Antitumor activity alone and combined with chemotherapy, radiotherapy or immunotherapy in Lewis lung carcinoma mouse models and non-small cell lung cancer cells (PMID: 39267851) ### Overview DADA is the abbreviation the research chemical market uses for diisopropylamine dichloroacetate, the diisopropylamine salt of dichloroacetic acid, CAS 660-27-5. The abbreviation is ambiguous in scientific writing, where DADA also stands for unrelated things, so identity is worth confirming by CAS number or molecular formula rather than by name. The compound itself is old. It has been marketed in Japan for decades as Liverall, where it holds a Japanese Accepted Name, sits in Japanese therapeutic category 3919 as a liver function improving agent and is classified as a third-class over-the-counter drug (KEGG DRUG D01816). It has also been sold under names such as dipromonium and kalodil, and in the supplement trade under the label vitamin B15 or pangamic acid, which is a marketing term rather than a vitamin classification. Its pharmacology comes from the dichloroacetate half of the salt. Dichloroacetate inhibits pyruvate dehydrogenase kinase, which leaves the pyruvate dehydrogenase complex in its active state, so pyruvate is directed toward acetyl-CoA and the citric acid cycle instead of being reduced to lactate. In a mouse model of severe influenza, DADA was characterized specifically as a pyruvate dehydrogenase kinase 4 inhibitor that restored pyruvate dehydrogenase activity and improved the metabolic disorder and multiorgan failure seen in that model (PMID: 24865588). Most recent work is oncology and immunology, and all of it is preclinical. DADA increased radiosensitivity in esophageal squamous cell carcinoma cells and xenografts by raising mitochondria-derived reactive oxygen species (PMID: 27626688). It outperformed sodium dichloroacetate in a subcutaneous mouse breast tumor transplantation model (PMID: 27582548), showed antitumor activity alone and combined with chemotherapy, radiotherapy or immunotherapy in non-small cell lung cancer models (PMID: 39267851), and acted synergistically with fenbendazole in A549 cells and in nude mice (PMID: 39477286, PMID: 40799435). A 2026 study reported that DADA drives the same metabolic shift inside CD8 T cells, raising oxidative phosphorylation and mitochondrial fitness, increasing progenitor exhausted T cells in mouse tumors and improving the effect of PD-1 blockade (PMID: 41758776). The human record is the weak part. The Japanese approval for chronic liver conditions long predates modern trial reporting standards, and no randomized controlled trial of DADA for any indication was found in the indexed literature. That leaves an unusual position: a compound with a genuine national approval, a clear biochemical mechanism and a growing preclinical oncology file, but no modern efficacy or safety trial that can be quoted. What is sold in capsules on the research chemical market is not the Japanese pharmaceutical product, and no FDA or EMA authorization exists. It is a research-use-only compound in the US market, and the tumor and immunology findings above are mouse and cell line results that have never been tested in people. ### Potential Research Fields Metabolic modulators Pyruvate dehydrogenase kinase inhibition Hepatology Tumor immunometabolism ## Chemical Information IUPAC Name Not yet available CAS Number 660-27-5 Molecular Formula C8H17Cl2NO2 Molecular Mass 230.13 g/mol ![Diisopropylamine dichloroacetate (DADA) molecular structure](https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/12617/PNG) [View on PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/12617) ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions ### Contraindications No sourced contraindication list was found in the indexed literature. Mechanism-based: the compound forces a metabolic shift from glycolysis toward oxidative phosphorylation through pyruvate dehydrogenase kinase inhibition (PMID: 24865588), so concurrent use of other dichloroacetate-containing products would stack the same mechanism. Not studied in pregnancy, in children, or in liver or kidney impairment beyond its Japanese hepatic indication. Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $79.99 Best $/mg — Vendors 1 Listings 1 capsule [Sign in for alerts ](/auth) Form Allcapsule Sort Price $/mg Vendor Vendor Product Form Qty Price $/mg Coupon ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) [Disguised Alpha](/vendor/disguised-alpha) [50 ](/vendor-trust-scorecard) 🇺🇸 US 🇪🇺 EU 🇬🇧 UK DADA 200 mg capsules capsule 1 bottle (200 mg capsules) ● In Stock $79.99 BEST — — [Buy](https://disguisedalpha.com/product/dada/?coupon=reddit) Get Diisopropylamine dichloroacetate (DADA) Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $79.99 [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Diisopropylamine dichloroacetate (DADA). [Sign in](/auth) Current low $79.99 as of Sep 7, 2026 7-day low $79.99 30-day low $79.99 30-day change — baseline building Tracking since Sep 7, 2026 · 1 data point ### Vendors Selling Diisopropylamine dichloroacetate (DADA) [ ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) #### Disguised Alpha 1 listing · from $79.99 ](/vendor/disguised-alpha) How we score these vendors Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. [View Scorecard](/vendors/scorecard) ### Related Compounds [View All](/wiki) [ ### Aminotadalafil Other Preclinical Aminotadalafil is an unapproved research analog of tadalafil, the PDE5 inhibitor marketed under the brand name Cialis for erectile dysfunction and under Adcirca for pulmonary arterial hypertension. 2.5 mg - 20 mg (oral) 9 studies View Profile ](/compound/aminotadalafil)[ ### B7-33 Other Preclinical B7-33 is a single-chain, 26-amino-acid peptide engineered as a functionally selective agonist of the relaxin family peptide receptor 1 (RXFP1), designed to recapitulate the therapeutic activity of human H2 relaxin — the endogenous peptide hormone that is naturally elevated during pregnancy and has broad cardioprotective, vasodilatory, and anti-fibrotic effects. t½ In vitro serum-stability half-life is approximately 6 minutes; B7-33 is rapidly degraded (a lipidated analog extended this to ~60 minutes in the same assay). Human in vivo pharmacokinetics are unpublished, and rapid clearance is expected for a small linear peptide (Praveen et al. 2023, PMID 37047588). 500-4000 mcg subcutaneous per injection (community/self-report research doses; most commonly ~1000 mcg / 1 mg once daily). No validated human dose exists - all figures are empirical extrapolations from rodent pharmacology. 11 studies View Profile ](/compound/b7-33)[ ### Indole-3-propionamide (IPAM) Other Preclinical IPAM is the market abbreviation for indole-3-propionamide, the amide of indole-3-propionic acid and a close structural relative of melatonin. t½ Not established in humans; after intraperitoneal administration of 0.5 mg/kg to one-month-old male Sprague-Dawley rats, brain concentrations were 691 pg indole per mg protein at 2 h, 562 at 4 h and 361 at 8 h, which the authors described as a long half-life relative to melatonin (PMID: 20421998) Preclinical View Profile ](/compound/indole-3-propionamide)[ ### Kisspeptin-10 (KSPTN) Other Clinical (investigational) KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis. t½ Kisspeptin-10: very short, reported on the order of ~4 minutes (rapid plasma clearance). Kisspeptin-54 is longer-acting (tens of minutes). The brief half-life is why human studies dose it intravenously by bolus or continuous infusion. 20-100 Preclinical View Profile ](/compound/ksptn)[ ### Melanotan I Other FDA Approved Melanotan I (afamelanotide) is a linear synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) with the substitution of norleucine at position 4 and D-phenylalanine at position 7. t½ Controlled-release subcutaneous implant (Scenesse): high inter-subject variability; median Tmax ~36 h, mean Cmax ~3.7 ng/mL, apparent terminal half-life ~15 h, with plasma levels measurable to ~96 h post-dose (FDA pharmacokinetics, n=12). Injected/bolus free peptide: peak plasma at ~1-2 h with an elimination half-life of ~30 minutes; the Nle4/D-Phe7 modifications prolong biological (melanogenic) activity well beyond plasma clearance. 16000 Preclinical View Profile ](/compound/melanotan-i)[ ### PNC-27 Other Preclinical PNC-27 is a p53-derived peptide that selectively induces membranolysis in cancer cells. t½ Unknown (no published PK data) 0 Preclinical View Profile ](/compound/pnc-27) [ View Full Dosage Guide → Protocols, calculator & safety for Diisopropylamine dichloroacetate (DADA) ](/guides/dosage/dada) ### Best Price ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $79.99 [Buy Now](https://disguisedalpha.com/product/dada/?coupon=reddit) 1 vendors · 1 listings ### Research Score 30 0 PubMed studies ### Quality Indicators Data Completeness 63% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Studies Interactions Vendor Listings ### Quick Facts Molecular Weight 230.13 g/mol Administration Oral, Intraperitoneal injection (animal studies) CAS Number 660-27-5 Trial Phase Approved (Japan) 0 [Full Dosage Guide](/guides/dosage/dada)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is Diisopropylamine dichloroacetate (DADA) used for in research? DADA is the abbreviation the research chemical market uses for diisopropylamine dichloroacetate, the diisopropylamine salt of dichloroacetic acid, CAS 660-27-5. The abbreviation is ambiguous in scientific writing, where DADA also stands for unrelated things, so identity is worth confirming by CAS number or molecular formula rather than by name. The compound itself is old. It has been marketed in Japan for decades as Liverall, where it holds a Japanese Accepted Name, sits in Japanese therapeutic category 3919 as a liver function improving agent and is classified as a third-class over-the-counter drug (KEGG DRUG D01816). It has also been sold under names such as dipromonium and kalodil, and in the supplement trade under the label vitamin B15 or pangamic acid, which is a marketing term rather than a vitamin classification. Its pharmacology comes from the dichloroacetate half of the salt. Dichloroacetate inhibits pyruvate dehydrogenase kinase, which leaves the pyruvate dehydrogenase complex in its active state, so pyruvate is directed toward acetyl-CoA and the citric acid cycle instead of being reduced to lactate. In a mouse model of severe influenza, DADA was characterized specifically as a pyruvate dehydrogenase kinase 4 inhibitor that restored pyruvate dehydrogenase activity and improved the metabolic disorder and multiorgan failure seen in that model (PMID: 24865588). Most recent work is oncology and immunology, and all of it is preclinical. DADA increased radiosensitivity in esophageal squamous cell carcinoma cells and xenografts by raising mitochondria-derived reactive oxygen species (PMID: 27626688). It outperformed sodium dichloroacetate in a subcutaneous mouse breast tumor transplantation model (PMID: 27582548), showed antitumor activity alone and combined with chemotherapy, radiotherapy or immunotherapy in non-small cell lung cancer models (PMID: 39267851), and acted synergistically with fenbendazole in A549 cells and in nude mice (PMID: 39477286, PMID: 40799435). A 2026 study reported that DADA drives the same metabolic shift inside CD8 T cells, raising oxidative phosphorylation and mitochondrial fitness, increasing progenitor exhausted T cells in mouse tumors and improving the effect of PD-1 blockade (PMID: 41758776). The human record is the weak part. The Japanese approval for chronic liver conditions long predates modern trial reporting standards, and no randomized controlled trial of DADA for any indication was found in the indexed literature. That leaves an unusual position: a compound with a genuine national approval, a clear biochemical mechanism and a growing preclinical oncology file, but no modern efficacy or safety trial that can be quoted. What is sold in capsules on the research chemical market is not the Japanese pharmaceutical product, and no FDA or EMA authorization exists. It is a research-use-only compound in the US market, and the tumor and immunology findings above are mouse and cell line results that have never been tested in people. What forms does Diisopropylamine dichloroacetate (DADA) come in? Diisopropylamine dichloroacetate (DADA) is available in capsule form. How much does Diisopropylamine dichloroacetate (DADA) cost? Prices start at $79.99 across 1 verified vendor. How do I compare Diisopropylamine dichloroacetate (DADA) vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### Aminotadalafil Other Preclinical Aminotadalafil is an unapproved research analog of tadalafil, the PDE5 inhibitor marketed under the brand name Cialis for erectile dysfunction and under Adcirca for pulmonary arterial hypertension. 2.5 mg - 20 mg (oral) 9 studies View Profile ](/compound/aminotadalafil)[ ### B7-33 Other Preclinical B7-33 is a single-chain, 26-amino-acid peptide engineered as a functionally selective agonist of the relaxin family peptide receptor 1 (RXFP1), designed to recapitulate the therapeutic activity of human H2 relaxin — the endogenous peptide hormone that is naturally elevated during pregnancy and has broad cardioprotective, vasodilatory, and anti-fibrotic effects. t½ In vitro serum-stability half-life is approximately 6 minutes; B7-33 is rapidly degraded (a lipidated analog extended this to ~60 minutes in the same assay). Human in vivo pharmacokinetics are unpublished, and rapid clearance is expected for a small linear peptide (Praveen et al. 2023, PMID 37047588). 500-4000 mcg subcutaneous per injection (community/self-report research doses; most commonly ~1000 mcg / 1 mg once daily). No validated human dose exists - all figures are empirical extrapolations from rodent pharmacology. 11 studies View Profile ](/compound/b7-33)[ ### Indole-3-propionamide (IPAM) Other Preclinical IPAM is the market abbreviation for indole-3-propionamide, the amide of indole-3-propionic acid and a close structural relative of melatonin. t½ Not established in humans; after intraperitoneal administration of 0.5 mg/kg to one-month-old male Sprague-Dawley rats, brain concentrations were 691 pg indole per mg protein at 2 h, 562 at 4 h and 361 at 8 h, which the authors described as a long half-life relative to melatonin (PMID: 20421998) Preclinical View Profile ](/compound/indole-3-propionamide)[ ### Kisspeptin-10 (KSPTN) Other Clinical (investigational) KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis. t½ Kisspeptin-10: very short, reported on the order of ~4 minutes (rapid plasma clearance). Kisspeptin-54 is longer-acting (tens of minutes). The brief half-life is why human studies dose it intravenously by bolus or continuous infusion. 20-100 Preclinical View Profile ](/compound/ksptn)[ ### Melanotan I Other FDA Approved Melanotan I (afamelanotide) is a linear synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) with the substitution of norleucine at position 4 and D-phenylalanine at position 7. t½ Controlled-release subcutaneous implant (Scenesse): high inter-subject variability; median Tmax ~36 h, mean Cmax ~3.7 ng/mL, apparent terminal half-life ~15 h, with plasma levels measurable to ~96 h post-dose (FDA pharmacokinetics, n=12). Injected/bolus free peptide: peak plasma at ~1-2 h with an elimination half-life of ~30 minutes; the Nle4/D-Phe7 modifications prolong biological (melanogenic) activity well beyond plasma clearance. 16000 Preclinical View Profile ](/compound/melanotan-i)[ ### PNC-27 Other Preclinical PNC-27 is a p53-derived peptide that selectively induces membranolysis in cancer cells. t½ Unknown (no published PK data) 0 Preclinical View Profile ](/compound/pnc-27) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-dada) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. 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