--- title: "Cortexin: Dosing & Vendor Prices — BodyHackGuide" description: "Cortexin: dosing protocols, mechanism & side effects, 18 PubMed studies. Compare verified vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Cortexin" } ] }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Cortexin", "description": "Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors. It is not FDA-approved in the US and is sold as a research peptide. 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Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors. It is not FDA-approved in the US and is sold as a research peptide. Russian-language clinical literature is extensive; English-language peer-reviewed studies are limited but growing.", "activeIngredient": "Cortexin", "mechanismOfAction": "Mechanism of action — pharmacological summary: BDNF/NGF mimetic activity — short peptides in the complex mimic endogenous neurotrophic factor signaling Neuroprotective — reduced excitotoxicity and oxidative damage in models of ischemia GABA system modulation — increased GABAergic tone in clinical EEG studies Cholinergic enhancement — modulates acetylcholine pathways relevant to attention Anti-inflammatory — suppresses microglial activation post-injury", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Cortexin used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors. It is not FDA-approved in the US and is sold as a research peptide. Russian-language clinical literature is extensive; English-language peer-reviewed studies are limited but growing." } }, { "@type": "Question", "name": "What forms does Cortexin come in?", "acceptedAnswer": { "@type": "Answer", "text": "Cortexin is available in vials, capsules, and sprays forms." } }, { "@type": "Question", "name": "How much does Cortexin cost?", "acceptedAnswer": { "@type": "Answer", "text": "Pricing varies by vendor and form." } }, { "@type": "Question", "name": "How do I compare Cortexin vendors?", "acceptedAnswer": { "@type": "Answer", "text": "Compare prices, payment methods, shipping, and COA scores across 0 vendors." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. 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BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompound%2Fcortexin) 100K+ researchers trust BodyHackGuide — Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 2. [Compounds](/compare) 3. Cortexin [Where to buy Cortexin](/buy/cortexin) [Cortexin coupon codes](/coupons/cortexin) [Cortexin protocol](/protocol/cortexin) [Alternatives to Cortexin](/alternatives-to/cortexin) [Cortexin side effects](/side-effects/cortexin) 1. [Home](/) 3. [Compounds](/compare) 5. Cortexin # Cortexin Nootropic Peptide Marketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved) Download PDF Also known as: Cortexin, Cortex, Cerebral Cortex Peptides Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors. It is not FDA-approved in the US and is sold as a research peptide. Half-Life: ~2-3 hours (estimated from analog peptide preparations) MW: Complex of low-molecular-weight polypeptide fractions, ~1-10 kDa (no single defined MW). [18 PubMed Studies](https://pubmed.ncbi.nlm.nih.gov/?term=Cortexin) Last reviewed: Sep 6, 2026 [ 18 PubMed Studies ](https://pubmed.ncbi.nlm.nih.gov/?term=Cortexin)[ Nootropic Peptide Category ](/wiki#cat-nootropic-peptide) Marketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved) Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare PricesRelated ## Overview ### At A Glance Mechanism Mechanism of action — pharmacological summary:… Half-Life ~2-3 hours (estimated from analog peptide preparations) Safety Notes Common Mild injection site reaction ### Mechanism of Action **Mechanism of action — pharmacological summary:** - **BDNF/NGF mimetic activity** — short peptides in the complex mimic endogenous neurotrophic factor signaling - **Neuroprotective** — reduced excitotoxicity and oxidative damage in models of ischemia - **GABA system modulation** — increased GABAergic tone in clinical EEG studies - **Cholinergic enhancement** — modulates acetylcholine pathways relevant to attention - **Anti-inflammatory** — suppresses microglial activation post-injury ### Overview Cortexin is a **purified peptide preparation extracted from cattle and pig cerebral cortex tissue** — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like [Cerebrolysin](/compound/cerebrolysin), Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors. It is **not FDA-approved** in the US and is sold as a research peptide. Russian-language clinical literature is extensive; English-language peer-reviewed studies are limited but growing. ## Chemical Information IUPAC Name Not yet available CAS Number Not yet available Molecular Formula Not yet available Molecular Mass ~1-10 kDa (range of constituent polypeptide fractions; Cortexin is a peptide complex with no single defined mass) ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions ### Contraindications Per the Russian manufacturer's label (Geropharm), not from Western regulatory review: - Known hypersensitivity to Cortexin or any component of the preparation - Pregnancy (listed largely because of absent safety data rather than demonstrated harm) - Lactation / breastfeeding Caution: safety in these populations has not been established in controlled trials. These contraindications reflect the Russian product label, not FDA/EMA guidance. Cortexin is not approved for use outside Russia/CIS. Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. [Sign in for alerts ](/auth) No listings found for Cortexin. Get Cortexin Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Cortexin. [Sign in](/auth) ### Related Compounds [View All](/wiki) [ ### Adalank Nootropic Peptide Preclinical / Research compound Adalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog). t½ The commonly cited ~72-hour "functional duration" is an unverified community/vendor claim, not a measured value - no pharmacokinetic study of Adalank has ever been run. The figure is extrapolated from parent Adamax marketing claims. Actual serum half-life is unknown; there is no published PK data. 200-1200 mcg per dose (intranasal or subcutaneous), 1-2x daily Preclinical View Profile ](/compound/adalank)[ ### Adamax Nootropic Peptide Preclinical / Research compound Adamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax. t½ No pharmacokinetic data. Community reports describe a subjectively long duration of effect (~2-3 days), supporting every-other-day or 3x/week dosing; serum half-life not characterized. 500-2000 mcg subcutaneous (community research dosing) Preclinical View Profile ](/compound/adamax)[ ### Cerebrolysin Nootropic Peptide Clinical Cerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins. t½ ~2-4 hours (multi-component peptide mix) 85 studies View Profile ](/compound/cerebrolysin)[ ### NA-Semax Nootropic Peptide Preclinical NA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s. t½ ~20-30 minutes (intranasal, estimated from analog data) 3 studies View Profile ](/compound/na-semax)[ ### NA-Semax Amidate Nootropic Peptide Preclinical NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. t½ ~30-45 minutes (estimated, longer than standard Semax) 2 studies View Profile ](/compound/na-semax-amidate)[ ### P-21 Nootropic Peptide Preclinical P-21 is a synthetic cyclic dipeptide — Cyclo(L-prolyl-glycine) — derived from the Selank/Semax C-terminal Pro-Gly-Pro motif. t½ Not formally characterized in published work. P021 has only been studied in rodents (oral/dietary and subcutaneous dosing); no human pharmacokinetic data exist. 4 studies View Profile ](/compound/p21) [ View Full Dosage Guide → Protocols, calculator & safety for Cortexin ](/guides/dosage/cortexin) ### Research Score 47 18 PubMed studies ### Quality Indicators Data Completeness 63% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Studies Interactions Vendor Listings Research Credibility 18 PubMed studies ### Quick Facts Half-Life ~2-3 hours (estimated from analog peptide preparations) Molecular Weight ~1-10 kDa (range of constituent polypeptide fractions; Cortexin is a peptide complex with no single defined mass) Trial Phase Marketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved) ### Safety Profile Moderate Risk Common Side Effects - • Mild injection site reaction Stop Use If - Pregnancy/lactation - Active malignancy - Peptide allergy [Full Dosage Guide](/guides/dosage/cortexin)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is Cortexin used for in research? Cortexin is a **purified peptide preparation extracted from cattle and pig cerebral cortex tissue** — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like [Cerebrolysin](/compound/cerebrolysin), Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors. It is **not FDA-approved** in the US and is sold as a research peptide. Russian-language clinical literature is extensive; English-language peer-reviewed studies are limited but growing. What forms does Cortexin come in? Cortexin is available in vials, capsules, and sprays forms. How much does Cortexin cost? Pricing varies by vendor and form. How do I compare Cortexin vendors? Compare prices, payment methods, shipping, and COA scores across 0 vendors. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### Adalank Nootropic Peptide Preclinical / Research compound Adalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog). t½ The commonly cited ~72-hour "functional duration" is an unverified community/vendor claim, not a measured value - no pharmacokinetic study of Adalank has ever been run. The figure is extrapolated from parent Adamax marketing claims. Actual serum half-life is unknown; there is no published PK data. 200-1200 mcg per dose (intranasal or subcutaneous), 1-2x daily Preclinical View Profile ](/compound/adalank)[ ### Adamax Nootropic Peptide Preclinical / Research compound Adamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax. t½ No pharmacokinetic data. Community reports describe a subjectively long duration of effect (~2-3 days), supporting every-other-day or 3x/week dosing; serum half-life not characterized. 500-2000 mcg subcutaneous (community research dosing) Preclinical View Profile ](/compound/adamax)[ ### Cerebrolysin Nootropic Peptide Clinical Cerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins. t½ ~2-4 hours (multi-component peptide mix) 85 studies View Profile ](/compound/cerebrolysin)[ ### NA-Semax Nootropic Peptide Preclinical NA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s. t½ ~20-30 minutes (intranasal, estimated from analog data) 3 studies View Profile ](/compound/na-semax)[ ### NA-Semax Amidate Nootropic Peptide Preclinical NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. t½ ~30-45 minutes (estimated, longer than standard Semax) 2 studies View Profile ](/compound/na-semax-amidate)[ ### P-21 Nootropic Peptide Preclinical P-21 is a synthetic cyclic dipeptide — Cyclo(L-prolyl-glycine) — derived from the Selank/Semax C-terminal Pro-Gly-Pro motif. t½ Not formally characterized in published work. P021 has only been studied in rodents (oral/dietary and subcutaneous dosing); no human pharmacokinetic data exist. 4 studies View Profile ](/compound/p21) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one. 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