--- title: "Cortagen: Dosing & Vendor Prices — BodyHackGuide" description: "Cortagen: dosing protocols, mechanism & side effects. Compare 1 verified vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Cortagen" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "Cortagen", "description": "Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is organ-targeted to cardiac and coronary tissue, studied for cardiac function preservation and coronary artery health in aging and post-ischemic models. Like other Khavinson bioregulators (Pinealon, Bronchogen, Cartalax, Epithalon), Cortagen is proposed to act via direct gene-regulatory mechanisms in target tissue rather than classical receptor-ligand signaling. Russian clinical literature includes use in elderly patients with cardiovascular disease and post-myocardial infarction recovery. It is distinct from the cortex-targeting Khavinson peptide Cortexin.", "url": "https://www.bodyhackguide.co/compound/cortagen", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "79.00", "highPrice": "79.00", "priceCurrency": "USD", "offerCount": "1", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "79.00", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://ionpeptide.com/product/cortagen-20mg/?ref=reddit15", "seller": { "@type": "Organization", "name": "Ion Peptide", "url": "https://ionpeptide.com" }, "name": "Cortagen 20mg vial" } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Cortagen", "description": "Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is organ-targeted to cardiac and coronary tissue, studied for cardiac function preservation and coronary artery health in aging and post-ischemic models. Like other Khavinson bioregulators (Pinealon, Bronchogen, Cartalax, Epithalon), Cortagen is proposed to act via direct gene-regulatory mechanisms in target tissue rather than classical receptor-ligand signaling. Russian clinical literature includes use in elderly patients with cardiovascular disease and post-myocardial infarction recovery. It is distinct from the cortex-targeting Khavinson peptide Cortexin.", "lastReviewed": "2026-09-04T09:47:06.239Z", "url": "https://www.bodyhackguide.co/compound/cortagen", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "Cortagen", "alternateName": [ "Ala-Glu-Asp-Gly", "Cardiac Bioregulator", "Cortexin (related)", "Khavinson Cardiac Peptide" ], "description": "Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is organ-targeted to cardiac and coronary tissue, studied for cardiac function preservation and coronary artery health in aging and post-ischemic models. Like other Khavinson bioregulators (Pinealon, Bronchogen, Cartalax, Epithalon), Cortagen is proposed to act via direct gene-regulatory mechanisms in target tissue rather than classical receptor-ligand signaling. Russian clinical literature includes use in elderly patients with cardiovascular disease and post-myocardial infarction recovery. It is distinct from the cortex-targeting Khavinson peptide Cortexin.", "activeIngredient": "Cortagen", "administrationRoute": "Subcutaneous, Intramuscular", "mechanismOfAction": "Cortagen is a synthetic tetrapeptide, Ala-Glu-Asp-Pro (AEDP), created by the Khavinson group through directed synthesis based on the amino-acid composition of Cortexin, a polypeptide complex extracted from the cerebral cortex [PMID:15159690]. It is a brain-cortex bioregulator, NOT a cardiac peptide (the cardiac Khavinson analog is a different molecule, Cardiogen / Ala-Glu-Asp-Arg). Like other Khavinson 'short peptides,' Cortagen is proposed to act at the gene-regulatory level - entering cells and interacting with promoter/regulatory DNA regions to modulate tissue-specific gene expression - although a defined molecular receptor has not been established. In organotypic culture it selectively stimulates growth of brain-cortex explants, consistent with its cytomedin (Cortexin) origin [PMID:11713572]. Its best-documented actions are neural: acceleration of peripheral (sciatic) nerve regeneration and conduction recovery after injury in rats [PMID:11276314; PMID:12134478], antioxidant and neuroprotective effects in the cerebral cortex and in chronic brain-ischemia models [PMID:18239817; PMID:21476278], and modulation of immune signaling such as IL-2 mRNA expression (typically weaker than the related peptides Vilon and Epithalon) [PMID:16224591; PMID:12447482]. Anti-aging chromatin effects - decondensation of heterochromatin and reactivation of ribosomal genes - have been reported in lymphocytes from elderly donors [PMID:15085253; PMID:37042594]. Evidence is limited to Russian preclinical work and small clinical use; there are no rigorous Western controlled trials, and a molecular target has not been confirmed.", "dosageForm": "vial", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Cortagen?", "acceptedAnswer": { "@type": "Answer", "text": "Cortagen is a synthetic short-peptide bioregulator with the sequence Ala-Glu-Asp-Pro (AEDP). It was designed by Vladimir Khavinson and colleagues to reproduce the activity of Cortexin, a polypeptide preparation extracted from the cerebral cortex. It is studied mainly for nerve repair, neuroprotection, and anti-aging (chromatin) effects." } }, { "@type": "Question", "name": "Is Cortagen a heart or cardiac peptide?", "acceptedAnswer": { "@type": "Answer", "text": "No. Cortagen is derived from brain-cortex peptides and acts mainly on nervous tissue. The Khavinson bioregulator aimed at cardiac tissue is a different peptide, Cardiogen (Ala-Glu-Asp-Arg). One exploratory mouse-microarray study reported that Cortagen changes some cardiac gene expression, but that is a screening result, not evidence of a cardioprotective indication." } }, { "@type": "Question", "name": "What does the research actually show?", "acceptedAnswer": { "@type": "Answer", "text": "Peer-reviewed evidence is almost entirely Russian and preclinical: faster sciatic-nerve regeneration in rats, antioxidant and neuroprotective effects in the cerebral cortex and brain-ischemia models, mild immune-signaling modulation, and chromatin decondensation in lymphocytes from elderly donors. There are no rigorous Western placebo-controlled clinical trials." } }, { "@type": "Question", "name": "Is Cortagen FDA-approved?", "acceptedAnswer": { "@type": "Answer", "text": "No. Cortagen is not approved by the FDA for any indication and is sold for research use only. It has been used clinically in Russia but has not been validated in Western controlled trials." } }, { "@type": "Question", "name": "How is Cortagen dosed?", "acceptedAnswer": { "@type": "Answer", "text": "There is no validated human dosing standard. The only peer-reviewed quantitative dose is preclinical (10 mcg/kg intramuscularly once daily for 10 days in rats). Russian bioregulator courses typically run about 10 days. Treat any specific human dose as anecdotal and research-use-only." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. 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It is distinct from the cortex-targeting Khavinson peptide Cortexin.", "url": "https://www.bodyhackguide.co/compound/cortagen", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "79.00", "highPrice": "79.00", "priceCurrency": "USD", "offerCount": "1", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "79.00", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://ionpeptide.com/product/cortagen-20mg/?ref=reddit15", "seller": { "@type": "Organization", "name": "Ion Peptide", "url": "https://ionpeptide.com" }, "name": "Cortagen 20mg vial" } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Cortagen", "description": "Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is organ-targeted to cardiac and coronary tissue, studied for cardiac function preservation and coronary artery health in aging and post-ischemic models. Like other Khavinson bioregulators (Pinealon, Bronchogen, Cartalax, Epithalon), Cortagen is proposed to act via direct gene-regulatory mechanisms in target tissue rather than classical receptor-ligand signaling. Russian clinical literature includes use in elderly patients with cardiovascular disease and post-myocardial infarction recovery. 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It is organ-targeted to cardiac and coronary tissue, studied for cardiac function preservation and coronary artery health in aging and post-ischemic models. Like other Khavinson bioregulators (Pinealon, Bronchogen, Cartalax, Epithalon), Cortagen is proposed to act via direct gene-regulatory mechanisms in target tissue rather than classical receptor-ligand signaling. Russian clinical literature includes use in elderly patients with cardiovascular disease and post-myocardial infarction recovery. It is distinct from the cortex-targeting Khavinson peptide Cortexin.", "activeIngredient": "Cortagen", "administrationRoute": "Subcutaneous, Intramuscular", "mechanismOfAction": "Cortagen is a synthetic tetrapeptide, Ala-Glu-Asp-Pro (AEDP), created by the Khavinson group through directed synthesis based on the amino-acid composition of Cortexin, a polypeptide complex extracted from the cerebral cortex [PMID:15159690]. It is a brain-cortex bioregulator, NOT a cardiac peptide (the cardiac Khavinson analog is a different molecule, Cardiogen / Ala-Glu-Asp-Arg). Like other Khavinson 'short peptides,' Cortagen is proposed to act at the gene-regulatory level - entering cells and interacting with promoter/regulatory DNA regions to modulate tissue-specific gene expression - although a defined molecular receptor has not been established. In organotypic culture it selectively stimulates growth of brain-cortex explants, consistent with its cytomedin (Cortexin) origin [PMID:11713572]. Its best-documented actions are neural: acceleration of peripheral (sciatic) nerve regeneration and conduction recovery after injury in rats [PMID:11276314; PMID:12134478], antioxidant and neuroprotective effects in the cerebral cortex and in chronic brain-ischemia models [PMID:18239817; PMID:21476278], and modulation of immune signaling such as IL-2 mRNA expression (typically weaker than the related peptides Vilon and Epithalon) [PMID:16224591; PMID:12447482]. Anti-aging chromatin effects - decondensation of heterochromatin and reactivation of ribosomal genes - have been reported in lymphocytes from elderly donors [PMID:15085253; PMID:37042594]. Evidence is limited to Russian preclinical work and small clinical use; there are no rigorous Western controlled trials, and a molecular target has not been confirmed.", "dosageForm": "vial", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Cortagen?", "acceptedAnswer": { "@type": "Answer", "text": "Cortagen is a synthetic short-peptide bioregulator with the sequence Ala-Glu-Asp-Pro (AEDP). It was designed by Vladimir Khavinson and colleagues to reproduce the activity of Cortexin, a polypeptide preparation extracted from the cerebral cortex. It is studied mainly for nerve repair, neuroprotection, and anti-aging (chromatin) effects." } }, { "@type": "Question", "name": "Is Cortagen a heart or cardiac peptide?", "acceptedAnswer": { "@type": "Answer", "text": "No. Cortagen is derived from brain-cortex peptides and acts mainly on nervous tissue. The Khavinson bioregulator aimed at cardiac tissue is a different peptide, Cardiogen (Ala-Glu-Asp-Arg). One exploratory mouse-microarray study reported that Cortagen changes some cardiac gene expression, but that is a screening result, not evidence of a cardioprotective indication." } }, { "@type": "Question", "name": "What does the research actually show?", "acceptedAnswer": { "@type": "Answer", "text": "Peer-reviewed evidence is almost entirely Russian and preclinical: faster sciatic-nerve regeneration in rats, antioxidant and neuroprotective effects in the cerebral cortex and brain-ischemia models, mild immune-signaling modulation, and chromatin decondensation in lymphocytes from elderly donors. There are no rigorous Western placebo-controlled clinical trials." } }, { "@type": "Question", "name": "Is Cortagen FDA-approved?", "acceptedAnswer": { "@type": "Answer", "text": "No. Cortagen is not approved by the FDA for any indication and is sold for research use only. It has been used clinically in Russia but has not been validated in Western controlled trials." } }, { "@type": "Question", "name": "How is Cortagen dosed?", "acceptedAnswer": { "@type": "Answer", "text": "There is no validated human dosing standard. The only peer-reviewed quantitative dose is preclinical (10 mcg/kg intramuscularly once daily for 10 days in rats). Russian bioregulator courses typically run about 10 days. Treat any specific human dose as anecdotal and research-use-only." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompound%2Fcortagen) 100K+ researchers trust BodyHackGuide — Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 2. [Compounds](/compare) 3. Cortagen ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Best price right now $3.95/mg · $79.00 for 20mg at Ion Peptide [Buy at Ion Peptide](https://www.bodyhackguide.co/go/ion-peptide?utm_source=compound-sticky-bar&utm_campaign=5f388af6-69c2-4026-8eec-201c61abdd5c&utm_medium=best-price-cta) [Where to buy Cortagen](/buy/cortagen) [Cortagen coupon codes](/coupons/cortagen) [Cortagen protocol](/protocol/cortagen) [Alternatives to Cortagen](/alternatives-to/cortagen) [Cortagen side effects](/side-effects/cortagen) 1. [Home](/) 3. [Compounds](/compare) 5. Cortagen # Cortagen Longevity Preclinical Download PDF Also known as: Ala-Glu-Asp-Gly, Cardiac Bioregulator, Cortexin (related), Khavinson Cardiac Peptide Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology. Half-Life: Unknown (tetrapeptide; estimated <4 hours) Route: Subcutaneous, Intramuscular MW: 430.4 g/mol (C17H26N4O9, PubChem CID 18439621) Last reviewed: Sep 3, 2026 [ Longevity Category ](/wiki#cat-longevity) Preclinical Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices1 Related ## Overview ### Best Price Available ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Ion Peptide $79.00 1 vial · vial [Buy Now](https://ionpeptide.com/product/cortagen-20mg/?ref=reddit15) Compare 1 vendor ### At A Glance Mechanism Cortagen is a synthetic tetrapeptide, Ala-Glu-Asp-Pro (AEDP), created by the Khavinson group through directed synthesis based on the amino-acid composition of Cortexin, a polypeptide complex extracted from the cerebral cortex \[PMID:15159690\]. It is a brain-cortex bioregulator, NO… Half-Life Unknown (tetrapeptide; estimated <4 hours) Dosing once daily Dose Range 0mcg Routes Subcutaneous Intramuscular Common Vials 20mg Potential Benefits Peripheral nerve repair - accelerated axon regeneration and faster nerve-conduction recovery after injury in rat models \[PMID:11276314; PMID:12134478\] Neuroprotection and antioxidant activity in the cerebral cortex and in chronic brain-ischemia models (preclinical) \[PMID:18239817; PMID:21476278\] CNS/cognitive support as the synthetic short-peptide analog of the cortex-derived Russian drug Cortexin Anti-aging chromatin remodeling - reactivation of age-silenced ribosomal genes in lymphocytes from elderly donors \[PMID:15085253; PMID:37042594\] Mild immune-signaling modulation (IL-2 expression), generally weaker than Vilon or Epithalon \[PMID:12447482; PMID:16224591\] Longevity-protocol stacking as one of the Khavinson short-peptide bioregulators (commonly paired with Epitalon or Pinealon) Safety Notes Common Injection-site irritation possible Generally low adverse-event rate reported in the limited (mostly Russian) preclinical and clinical use Serious No serious adverse events documented in the small available literature Human safety data are limited and lack independent Western replication ### Overview Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is organ-targeted to cardiac and coronary tissue, studied for cardiac function preservation and coronary artery health in aging and post-ischemic models. Like other Khavinson bioregulators (Pinealon, Bronchogen, Cartalax, Epithalon), Cortagen is proposed to act via direct gene-regulatory mechanisms in target tissue rather than classical receptor-ligand signaling. Russian clinical literature includes use in elderly patients with cardiovascular disease and post-myocardial infarction recovery. It is distinct from the cortex-targeting Khavinson peptide Cortexin. ## Chemical Information IUPAC Name Not yet available CAS Number Not yet available Molecular Formula Not yet available Molecular Mass 430.4 g/mol Amino Acid Sequence Ala-Glu-Asp-Pro (AEDP); H-Ala-Glu-Asp-Pro-OH ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions Interaction and contraindication data is being compiled for Cortagen. Check back soon. General Safety Note Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented. Best Price $79.00 Best $/mg $3.9500 Vendors 1 Listings 1 vial [Sign in for alerts ](/auth) Form Allvial Sort Price $/mg Vendor Vendor Product Form Qty Price $/mg Coupon ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) [Ion Peptide](/vendor/ion-peptide) [70 ](/vendor-trust-scorecard) 🇺🇸 US 🌍 International Cortagen 20mg vial 1 vial ● In Stock $79.00 BEST $3.950 — [Buy](https://ionpeptide.com/product/cortagen-20mg/?ref=reddit15) Get Cortagen Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $79.00 [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Cortagen. [Sign in](/auth) Current low $79.00 as of Apr 22, 2026 7-day low — no 7d data yet 30-day low — no 30d data yet 30-day change — baseline building Tracking since Apr 22, 2026 · 1 data point ### Vendors Selling Cortagen [ ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) #### Ion Peptide 4.5 1 listing · from $79.00 ](/vendor/ion-peptide) How we score these vendors Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. [View Scorecard](/vendors/scorecard) ### Related Compounds [View All](/wiki) [ ### NAD+ Longevity Phase II NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a pyridine dinucleotide coenzyme essential to energy metabolism, DNA repair via PARP enzymes, sirtuin-mediated gene regulation, and calcium signaling via CD38. t½ Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent Oral precursors: NR 300-2,000 mg/day, NMN 250-900 mg/day, NAM 500-1,500 mg/day; IV NAD+ 500-1,500 mg per session. 75447 studies View Profile ](/compound/nad)[ ### NMN Longevity Preclinical Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide derived from ribose and nicotinamide, serving as the direct biosynthetic precursor to nicotinamide adenine dinucleotide (NAD+) via a single enzymatic step catalyzed by nicotinamide mononucleotide adenylyltransferase (NMNAT). Preclinical View Profile ](/compound/nmn)[ ### Rapamycin Longevity Preclinical Rapamycin is a macrocyclic lactone antibiotic discovered in 1972 in soil samples from Rapa Nui (Easter Island) by a bacteriology survey team investigating indigenous Streptomyces species. Preclinical View Profile ](/compound/rapamycin) [ View Full Dosage Guide → Protocols, calculator & safety for Cortagen ](/guides/dosage/cortagen) ### Related Articles [All Posts](/blog) [ #### Ion Peptide Review 2026: BPC-157, GLP-1s, Buccal Strips & Bioregulators A complete look at Ion Peptide (ionpeptide.com) — 92 products spanning research peptides, GLP-1 agonists, NAD+/B12/glutathione buccal strips, copper peptide topicals, Khavinson bioregulators, and PDRN. We cover pricing, testing, shipping, unique offerings, and how they compare to other vendors on BodyHackGuide. 4/21/2026 ](/blog/ion-peptide-review-2026) ### Best Price ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Ion Peptide $79.00 [Buy Now](https://ionpeptide.com/product/cortagen-20mg/?ref=reddit15) 1 vendors · 1 listings ### Research Score 45 0 PubMed studies ### Quality Indicators Data Completeness 63% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Studies Interactions Vendor Listings ### Quick Facts Half-Life Unknown (tetrapeptide; estimated <4 hours) Molecular Weight 430.4 g/mol Administration Subcutaneous, Intramuscular Trial Phase Preclinical ### Safety Profile Common Side Effects - • Injection-site irritation possible - • Generally low adverse-event rate reported in the limited (mostly Russian) preclinical and clinical use [Full Dosage Guide](/guides/dosage/cortagen)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is Cortagen? Cortagen is a synthetic short-peptide bioregulator with the sequence Ala-Glu-Asp-Pro (AEDP). It was designed by Vladimir Khavinson and colleagues to reproduce the activity of Cortexin, a polypeptide preparation extracted from the cerebral cortex. It is studied mainly for nerve repair, neuroprotection, and anti-aging (chromatin) effects. Is Cortagen a heart or cardiac peptide? No. Cortagen is derived from brain-cortex peptides and acts mainly on nervous tissue. The Khavinson bioregulator aimed at cardiac tissue is a different peptide, Cardiogen (Ala-Glu-Asp-Arg). One exploratory mouse-microarray study reported that Cortagen changes some cardiac gene expression, but that is a screening result, not evidence of a cardioprotective indication. What does the research actually show? Peer-reviewed evidence is almost entirely Russian and preclinical: faster sciatic-nerve regeneration in rats, antioxidant and neuroprotective effects in the cerebral cortex and brain-ischemia models, mild immune-signaling modulation, and chromatin decondensation in lymphocytes from elderly donors. There are no rigorous Western placebo-controlled clinical trials. Is Cortagen FDA-approved? No. Cortagen is not approved by the FDA for any indication and is sold for research use only. It has been used clinically in Russia but has not been validated in Western controlled trials. How is Cortagen dosed? There is no validated human dosing standard. The only peer-reviewed quantitative dose is preclinical (10 mcg/kg intramuscularly once daily for 10 days in rats). Russian bioregulator courses typically run about 10 days. Treat any specific human dose as anecdotal and research-use-only. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### NAD+ Longevity Phase II NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a pyridine dinucleotide coenzyme essential to energy metabolism, DNA repair via PARP enzymes, sirtuin-mediated gene regulation, and calcium signaling via CD38. t½ Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent Oral precursors: NR 300-2,000 mg/day, NMN 250-900 mg/day, NAM 500-1,500 mg/day; IV NAD+ 500-1,500 mg per session. 75447 studies View Profile ](/compound/nad)[ ### NMN Longevity Preclinical Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide derived from ribose and nicotinamide, serving as the direct biosynthetic precursor to nicotinamide adenine dinucleotide (NAD+) via a single enzymatic step catalyzed by nicotinamide mononucleotide adenylyltransferase (NMNAT). Preclinical View Profile ](/compound/nmn)[ ### Rapamycin Longevity Preclinical Rapamycin is a macrocyclic lactone antibiotic discovered in 1972 in soil samples from Rapa Nui (Easter Island) by a bacteriology survey team investigating indigenous Streptomyces species. Preclinical View Profile ](/compound/rapamycin) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-cortagen) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. [Order Bloodwork](https://anabolicinsights.ai/?ref=nwm2zjb) ![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub — compound pricing, brain health protocols, dosing tools, and vendor reviews. 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