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title: "CJC-1295 No-DAC (Mod GRF 1-29): Dosing &amp; Vendor Prices"
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5.  CJC-1295 No-DAC (Mod GRF 1-29) 

# CJC-1295 No-DAC (Mod GRF 1-29)

GH Secretagogue Preclinical / Research peptide 

Download  PDF

Also known as: Mod GRF 1-29, CJC-1295 without DAC, Modified GRF 1-29, CJC No-DAC 

CJC-1295 No-DAC (also known as Mod GRF 1-29) is a 29-amino-acid synthetic peptide modeled on the active N-terminal fragment of human Growth Hormone Releasing Hormone (GHRH 1-29). Four amino acid substitutions stabilize the peptide against enzymatic degradation but, unlike CJC-1295 with DAC, this version does NOT carry the Drug Affinity Complex (DAC) - meaning it has a short serum half-life (~30 minutes) and produces a single physiological GH pulse rather than sustained GHRH stimulation. The short pulse profile is closer to natural pulsatile GHRH biology, which makes Mod GRF 1-29 the preferred choice when researchers want to amplify natural GH peaks (e.g., paired with ipamorelin pre-bed) without continuous GHRH receptor stimulation..

Half-Life:  ~30 minutes (no DAC means no extended binding) Route:  Subcutaneous MW:  3367.9 g/mol (average; molecular formula C152H252N44O42) 

Last reviewed: May 4, 2026 

[

GH Secretagogue

Category



](/wiki#cat-gh-secretagogue)

Preclinical / Research peptide

Research Stage

OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare PricesRelated

## Overview

### At A Glance

Mechanism 

Binds the GHRH receptor on anterior pituitary somatotrophs, triggering Gs-coupled cAMP signaling and pulsatile growth hormone release. Without DAC, the peptide clears within ~30 minutes, producing a single GH pulse and returning the GHRH receptor to baseline sensitivity. This con… 

Half-Life 

~30 minutes (no DAC means no extended binding)

Dosing 

Subcutaneous 2-3x per day (typical: AM, post-workout, pre-bed)

Dose Range 

100 mcg per dose, 2-3x dailymcg 

Routes 

Subcutaneous 

Common Vials 

2mgmg 5mgmg 

Potential Benefits 

Single GH pulse mimicking natural GHRH biology Synergistic with GHRP peptides (supra-additive GH release) No DAC = no receptor desensitization Pre-bed dosing supports deep sleep and recovery Improved body composition over 8-12 week cycles 

Safety Notes 

Common 

Injection site irritation Transient flushing post-injection Mild headache during first 1-2 weeks Mild water retention with long use 

Serious 

Carpal tunnel-like symptoms (rare, dose-related) Hyperinsulinemia with chronic high-dose use No long-term human safety data 

### Overview

CJC-1295 No-DAC (also known as Mod GRF 1-29) is a 29-amino-acid synthetic peptide modeled on the active N-terminal fragment of human Growth Hormone Releasing Hormone (GHRH 1-29). Four amino acid substitutions stabilize the peptide against enzymatic degradation but, unlike CJC-1295 with DAC, this version does NOT carry the Drug Affinity Complex (DAC) - meaning it has a short serum half-life (~30 minutes) and produces a single physiological GH pulse rather than sustained GHRH stimulation. The short pulse profile is closer to natural pulsatile GHRH biology, which makes Mod GRF 1-29 the preferred choice when researchers want to amplify natural GH peaks (e.g., paired with ipamorelin pre-bed) without continuous GHRH receptor stimulation.

### Potential Research Fields

Growth hormone biology GHRH receptor Pituitary somatotrophs Sleep architecture Recovery 

## Chemical Information

IUPAC Name

Not yet available 

CAS Number

Not yet available 

Molecular Formula

Not yet available 

Molecular Mass

3367.9 Da (average)

Amino Acid Sequence

Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 (tetrasubstituted \[D-Ala2, Gln8, Ala15, Leu27\]-hGRF(1-29)-NH2)

## Dosing & Protocols

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## Interactions

### Contraindications

Active malignancy. Pregnancy and breastfeeding. Active diabetic retinopathy. Active acromegaly or pituitary adenoma. Caution in T2D - GH antagonizes insulin action.

Research Disclaimer

This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.

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Protocols, calculator & safety for CJC-1295 No-DAC (Mod GRF 1-29)



](/guides/dosage/cjc-1295-no-dac)

### Research Score

45 

0 PubMed studies

### Quality Indicators

Data Completeness

50% 

Description 

Mechanism of Action 

Chemical Data 

Dosing Protocols 

Safety Profile 

PubMed Studies 

Interactions 

Vendor Listings 

### Quick Facts

Half-Life

~30 minutes (no DAC means no extended binding)

Molecular Weight

3367.9 Da (average)

Administration

Subcutaneous

Trial Phase

Preclinical / Research peptide

### Safety Profile

Common Side Effects

-   •  Injection site irritation
-   •  Transient flushing post-injection
-   •  Mild headache during first 1-2 weeks
-   •  Mild water retention with long use

[Full Dosage Guide](/guides/dosage/cjc-1295-no-dac)[Calculate Your Dose](/tools/reconstitution)

Research Disclaimer

This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

## Frequently Asked Questions

What is CJC-1295 No-DAC (Mod GRF 1-29) used for in research?

CJC-1295 No-DAC (also known as Mod GRF 1-29) is a 29-amino-acid synthetic peptide modeled on the active N-terminal fragment of human Growth Hormone Releasing Hormone (GHRH 1-29). Four amino acid substitutions stabilize the peptide against enzymatic degradation but, unlike CJC-1295 with DAC, this version does NOT carry the Drug Affinity Complex (DAC) - meaning it has a short serum half-life (~30 minutes) and produces a single physiological GH pulse rather than sustained GHRH stimulation.

The short pulse profile is closer to natural pulsatile GHRH biology, which makes Mod GRF 1-29 the preferred choice when researchers want to amplify natural GH peaks (e.g., paired with ipamorelin pre-bed) without continuous GHRH receptor stimulation.

What forms does CJC-1295 No-DAC (Mod GRF 1-29) come in?

CJC-1295 No-DAC (Mod GRF 1-29) is available in vials, capsules, and sprays forms.

How much does CJC-1295 No-DAC (Mod GRF 1-29) cost?

Pricing varies by vendor and form.

How do I compare CJC-1295 No-DAC (Mod GRF 1-29) vendors?

Compare prices, payment methods, shipping, and COA scores across 0 vendors.

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### BodyHackGuide

Your biohacking research hub — compound pricing, brain health protocols, dosing tools, and vendor reviews.

[support@bodyhackguide.co](mailto:support@bodyhackguide.co)

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Explore

#### Explore

-   [Compare prices](/compare)
-   [Research suppliers](/vendors)
-   [Deals](/deals)
-   [Coupons](/coupons)
-   [Nootropics](/nootropics)
-   [Brain health](/brain-health)
-   [Blog](/blog)
-   [Guides](/guides)

Tools

#### Tools

-   [Reconstitution](/tools/reconstitution)
-   [Dosage calculator](/tools/dosage)
-   [Half-life visualizer](/tools/halflife)
-   [COA lookup](/tools/coa)
-   [Cost calculator](/tools/cost-calculator)
-   [Stack builder](/stack-builder)
-   [All tools →](/tools)

Trust & vendors

#### Trust & vendors

-   [Vendor directory](/vendors)
-   [Trust scorecard](/vendors/scorecard)
-   [Get BHG verified](/vendors/get-vetted)
-   [Scoring methodology](/vendors/methodology)
-   [Peptide cheatsheet](/guides/peptide-cheat-sheet-download)

Company

#### Company

-   [About](/about)
-   [Affiliate disclosure](/affiliate-disclosure)
-   [Editorial standards](/editorial-standards)
-   [Creators](/creators)
-   [Coaches](/coaches)
-   [Privacy](/privacy)
-   [Terms](/terms)
-   [Full site directory →](/site-directory)

**Ownership & Affiliate Disclosure:** BodyHackGuide and BHG Labs share common ownership. We rank every vendor on the same public, reproducible [methodology](/vendors/methodology), and we earn a commission from purchases made through our links at no extra cost to you. Full details in our [affiliate disclosure](/affiliate-disclosure).

**Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell, distribute, or promote any products. Always consult a qualified healthcare professional and comply with local regulations.

© 2026 BodyHackGuide. All rights reserved. · [Terms](/terms) · [Privacy](/privacy)

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